Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Maximiliano A. Hawkes, Mauricio F. Farez, Ismael L. Calandri et al. · Arquivos de Neuro-Psiquiatria
ABSTRACT Lack of stroke awareness and slow activation of emergency medical services (EMS) are frequently reported reasons for delayed arrival to the hospital. We evaluated these variables in our population. Methods Review of hospital records and structured telephone interviews of 100 consecutive stroke patients. Forward stepwise logistic regression was used for the statistical analysis. Results Seventy patients (75%) arrived at the hospital 4.5 hours after stroke symptoms onset. The use of EMS did not improve arrival times. Most patients who recognized their symptoms did not use EMS (p < 0.02)
View details →DOI: 10.1590/0004-282x20160142 Negative / Null Result ReportMedicine
Suda Y, Ishida K, Shibanuma N et al. · 2026 · BMC musculoskeletal disorders
Background Previously, it was reported that preoperative medial tibial bone marrow lesions (BMLs) were not associated with worse postoperative outcomes after medial unicompartmental knee arthroplasty (UKA). However, the effect of BMLs in…
View details →DOI: 10.1186/s12891-026-10001-0 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Qirui Chen, Yan Liu, Yi Liu et al. · 2023 · Thoracic Cancer
Abstract Background To investigate the effect of continuous oral aspirin in perioperative period on bleeding in pneumonectomy. Methods A total of 170 patients who underwent pneumonectomy in our hospital from March 2021 to March 2022 were selected as the study objects. All patients took oral aspirin before surgery and did not take other antiplatelet agent or anticoagulants at the same time. The continuation group included 85 cases and continued to take aspirin 100 mg/day during the perioperative period, and the interruption group included 85 cases who stopped aspirin for 7 days before surgery a
View details →DOI: 10.1111/1759-7714.14846 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
C. Rust, D. Tonge, L. L. van denHeuvel et al. · 2025 · Brain and Behavior
ABSTRACT Introduction Recent studies have challenged the idea of sterile blood, suggesting the presence of a blood microbiome. The detection of microbial nucleic acids in blood is thought to reflect the status of distant microbial niches, including the gut. However, the origins and viability of these microbes remain debated. In this study, blood microbiome signatures in Parkinson's disease (PD), schizophrenia (SCZ), and posttraumatic stress disorder (PTSD) were evaluated by extracting RNA‐sequencing (RNA‐seq) reads that did not map to the human genome. Furthermore, we investigated the correlat
View details →DOI: 10.1002/brb3.70629 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Srija Balachandran, Kerstin Forsberg, Tom Lemaître et al. · 2021 · Metals
Selective leaching of Li from spent LIBs thermally pretreated by pyrolysis and incineration between 400 and 700 °C for 30, 60, and 90 min followed by water leaching at high temperature and high L/S ratio was examined. During the thermal pretreatment Li 2 CO 3 and LiF were leached. Along with Li salts, AlF 3 was also found to be leached with an efficiency not higher than 3.5%. The time of thermal pretreatment did not have a significant effect on Li leaching efficiency. The leaching efficiency of Li was higher with a higher L/S ratio. At a higher leaching temperature (80 °C), the leaching of Li
View details →DOI: 10.3390/met11081240 Negative / Null Result ReportMedicine
Fontaine E · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review Many clinical trials have failed to demonstrate the superiority of one nutritional protocol over another. This raises questions about the assessment tools used. In particular, intention-to-treat data analysis can mask…
View details →DOI: 10.1097/mco.0000000000001145 Negative / Null Result ReportOpen accessMedicine
Shi-gui Yang, Bin Cao, Li-rong Liang et al. · 2012 · PLoS ONE
BACKGROUND: There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. METHODS: During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. RESULTS: 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy
View details →DOI: 10.1371/journal.pone.0029652 Negative / Null Result ReportOpen accessAnimal culture
Samadi F, Sahneh M · 2015 · Poultry Science Journal
A total of 240, one-day-old quail chicks (Coturnix coturnix japonica) were used to study the effects of Artichoke leaf meal (ALM) and vitamin E in diet on growth performance, ileal microbial populations and intestinal morphology in a 42-d trial. This experiment was performed as a completely randomized design with 4 replicates of 15 quails each, using a 4 × 2 factorial arrangement with diet and gender as the main effects. Four dietary treatments were formulated by addition of 2 levels (1.5 and 3 percent) of ALM and 300 mg/Kg vitamin E to the basal diet. Supplementing basal diet with ALM did not
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Oh Young Bang, Mi Ji Lee, Sookyung Ryoo et al. · 2015 · Journal of Stroke
Patent foramen ovale (PFO) is growing in clinical interest because of a renewed focus on embolic stroke of undetermined source (ESUS), the PFO attributable fraction (the 10-point Risk of Paradoxical Embolism score), technical advances in PFO diagnosis, and the emergence of endovascular device closure as a treatment option. However, recent randomized controlled trials of the management of patients with ESUS and PFO failed to demonstrate the superiority of closure over medical treatment. The mechanisms of stroke other than paradoxical embolism may be important in patients with ESUS and PFO. This
View details →DOI: 10.5853/jos.2015.17.3.229 Negative / Null Result ReportOpen accessEcology
Sánchez-Ledesma Judith A., Águila Bernardo, Garibay-Orijel Roberto et al. · 2025 · Folia Oecologica
Using ITS1-based metabarcoding, we investigated the structure of the soil fungal communities in the central and peripheral zones of a 25-hectare pecan nut (Carya illinoinensis) orchard located in the arid region of Coahuila, Mexico. While environmental conditions such as soil moisture and temperature varied between zones, physicochemical soil properties (pH, organic carbon, total carbon, organic matter, electrical conductivity, and zinc) remained homogeneous. A total of 4,443 fungal OTUs were detected at 97% similarity. Alpha diversity indices did not differ significantly between zones. The fu
View details →DOI: 10.2478/foecol-2025-0015 Negative / Null Result ReportOpen accessChemistry
Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society
Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a
View details →DOI: 10.2298/jsc110905207y Negative / Null Result ReportMedicine
Mazdarani, Miles · 2026 · Veterinary research communications
Cranial cruciate ligament (CCL) rupture is uncommon in cats but may cause persistent stifle instability. Previous ex vivo assessments of tibial plateau levelling osteotomy and tibial tuberosity advancement have failed to restore stability…
View details →DOI: 10.1007/s11259-026-11361-7 Negative / Null Result ReportMedicine
Janz C, Timpka J, Storch A et al. · 2026 · Journal of Parkinson's disease
BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient…
View details →DOI: 10.1177/1877718x261461073 Negative / Null Result ReportOpen accessMedicine
Le J, Patel M, Atschinow A et al. · 2026 · Cureus
The platelet-rich plasma in achilles tendon healing 2 (PATH-2) trial is the largest randomized study of platelet-rich plasma (PRP) in acute Achilles tendon rupture. While the original frequentist analysis showed no significant benefit,…
View details →DOI: 10.7759/cureus.102519 Negative / Null Result ReportOpen access
Vilela, Judith M · 1984
The activity of beta-amylase in crosses of Saccharum spontaneum L. and S. officinarum L. and their hybrids was determined. Results showed that the parents did not differ significantly in their enzyme activity. Variability in enzyme…
Negative / Null Result ReportOpen access
Robert Ladouceur, Marie Mayrand · 1987
The perceptions of control regarding an objectively uncontrollable task (American Roulette) by depressive and nondepressive subjects were compared. Monetary risk behavior and subjective control did not differ significantly between the two…
View details →DOI: 10.2466/pr0.1987.60.3.1019 Negative / Null Result ReportOpen accessMedicine
Wang J, Liu LL, Huang L et al. · 2026 · BMC nephrology
Background The European STOP study showed that glucocorticoids (with/without immunosuppressants) did not delay disease progression in adults with IgA nephropathy (IgAN). However, pediatric IgAN is characterized by more severe acute…
View details →DOI: 10.1186/s12882-026-05101-x Negative / Null Result ReportOpen accessMedicine
Park HJ, Park S, Heo S et al. · 2026 · Journal of microbiology and biotechnology
Leuconostoc lactis DMLL10 is a novel strain isolated from kimchi. The strain did not exhibit toxicity in genetic tests. This study aims to conduct a preclinical safety assessment by performing repeated-dose toxicity studies in animals. In…
View details →DOI: 10.4014/jmb.2601.01021 Negative / Null Result ReportMedicine
Peker Y, Saygin M, Celik Y et al. · 2026 · Annals of the American Thoracic Society
Rationale Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate since publication of the results. Objectives To…
View details →DOI: 10.1093/annalsats/aaoag072 Negative / Null Result ReportMedicine
Sumner C, Patel P, Spencer A et al. · 2026 · Journal of pediatric urology
Introduction Circumcision is a common surgical intervention, and pain is the most common complaint. Poorly managed pain can increase morbidity and reduce patient and parent satisfaction. Ketorolac, a non-steroidal anti-inflammatory drug…
View details →DOI: 10.1016/j.jpurol.2026.106034 Negative / Null Result ReportMedicine
Gaub M, Shaffer KV, Patel P et al. · 2026 · Clinical neurology and neurosurgery
Objective EC-IC bypass for symptomatic atherosclerotic internal carotid and middle cerebral artery chronic occlusion (AIMCAO) failed to show benefit over medical management in previous randomized controlled trials. We explored how a…
View details →DOI: 10.1016/j.clineuro.2026.109417 Negative / Null Result ReportMedicine
Lim W · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Background and purpose Joint position sense (JPS) is frequently assessed using joint position reproduction (JPR); however, JPR has limitations, where reference angles are typically unavailable. This study aimed to examine the accuracy of…
View details →DOI: 10.1002/pri.70198 Negative / Null Result ReportMedicine
Lachowski K, Naja KM, Prill R et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose Robotic-assisted (RA) surgery allows for higher accuracy in total knee arthroplasty (TKA) and for better standardization of alignment concepts. It was hypothesized that the more personalized component placement in functional…
View details →DOI: 10.1002/ksa.70380 Negative / Null Result ReportMedicine
Murray AL, Dryburgh K, Sonuga-Barke EJS · 2026 · Journal of attention disorders
Objective ADHD and internalising symptoms such as anxiety and depression are known to be associated in adolescence and understanding the mechanisms linking them is important for improving mental health outcomes for adolescents with ADHD…
View details →DOI: 10.1177/10870547261419589 Negative / Null Result ReportMedicine
Yoo S, von Keyserlingk MAG, Weary DM · 2026 · Journal of dairy science
Hot-iron disbudding is the most commonly used method for horn bud removal in dairy calves. Although factors such as post-treatment care, calf age, and the type of hot iron used have been studied in relation to wound healing, procedural…
View details →DOI: 10.3168/jds.2025-27866 Negative / Null Result ReportMedicine
Van Epps VM, Daur-Schierholz M, Dortenzio M et al. · 2026 · International journal of speech-language pathology
Purpose This pragmatic clinical trial examined the functional impact of a modified speech-language pathology intervention delivery model (including telepractice, reduced therapy frequency, and emphasised home programmes with parent…
View details →DOI: 10.1080/17549507.2026.2630835 Negative / Null Result ReportMedicine
Dockery R, Zevallos M, McNulty C et al. · 2026 · Developmental biology
All eukaryotes possess the essential mRNA cap-binding protein eIF4E, which initiates translation. This protein is highly conserved, with versions from zebrafish and humans able to rescue yeast. All fish also have an ancestral eIF4E family,…
View details →DOI: 10.1016/j.ydbio.2026.02.014 Negative / Null Result ReportOpen accessMedicine
Jiwane M, Karunanithy P, Goonawardhana D et al. · 2026 · Journal of surgical case reports
IgG4-related disease (IgG4-RD) is a multi-system disorder that rarely presents with gastric manifestations. A 26 year old woman presented with post-prandial symptoms of dyspepsia, dysphagia and reflux with a proximal submucosal gastric…
View details →DOI: 10.1093/jscr/rjag465 Negative / Null Result ReportMedicine
Htoo PT, Patorno E, Schneeweiss S et al. · 2026 · Clinical pharmacology and therapeutics
Benchmarking evidence from nonrandomized healthcare database studies against randomized clinical trials could strengthen confidence that database studies can reproduce known trial results and extend analyses to questions not directly…
View details →DOI: 10.1002/cpt.70241 Negative / Null Result Report
Yaghini O, Eslamian R, Abadi RNS et al. · 2026 · Preprint
Abstract Objective This study investigates the neurodevelopmental outcomes of infants with non-syndromic trigonocephaly managed surgically and conservatively. The aim is to assess whether earlier surgical intervention influences cognitive,…
View details →DOI: 10.21203/rs.3.rs-8631558/v1 