Negative / Null Result ReportOpen accessMedicine
Alvarez AM, Vega M, Valencia-Shelton F et al. · 2026 · Cureus
Background The evaluation of neonatal herpes simplex virus (HSV) includes HSV culture and/or polymerase chain reaction (PCR) of different surfaces, cerebrospinal fluid (CSF), and blood. However, the impact of blood HSV PCR for the…
View details →DOI: 10.7759/cureus.102996 Negative / Null Result Report
Alger JR, Gupta I, Farkouh L et al. · 2026 · Preprint
Background Prior neuroimaging suggests brain differences between children with attention deficit hyperactivity disorder due to prenatal alcohol exposure (ADHD+PAE) and non-exposed children with ADHD due to other, e.g., familial, causes…
View details →DOI: 10.64898/2026.05.25.26354065 Negative / Null Result ReportMedicine
Dellbrügge F, Schaumann N, Kruppa M et al. · 2026 · Pneumologie (Stuttgart, Germany)
Abstract We present the case of a 39-year-old Indian female patient diagnosed with tuberculous mastitis and lymph node tuberculosis. The patient had a history of tuberculosis infection treatment as a newborn. She initially presented with…
View details →DOI: 10.1055/a-2845-3440 Negative / Null Result ReportMedicine
Li X, Huang Y, Hao J et al. · 2026 · Current HIV research
Background Married Men who have Sex with Men (MSM) constitute a bridge population for HIV diffusion into low-risk groups, with spousal non-disclosure rates exceeding 60% in China. It will increase the risk of secondary transmission within…
View details →DOI: 10.2174/011570162x444930260409114355 Negative / Null Result ReportMedicine
Tsang SM, Merino Gutierrez V, Yu J et al. · 2026 · Veterinary sciences
Canine babesiosis caused by Babesia gibsoni is prevalent in Hong Kong. While molecular diagnosis via PCR is highly sensitive, it typically requires reference laboratory access, delaying clinical decisions. This study evaluated the…
View details →DOI: 10.3390/vetsci13060548 Negative / Null Result ReportMedicine
Hijaze E, Razi T, Arbel R et al. · 2026 · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
Objective To evaluate the diagnostic performance of BioPlex 2200 multiplex immunoassay (BI) for detecting antinuclear antibodies (ANA), compared with the gold standard, the indirect immunofluorescence assay (IIF), as a screening…
View details →DOI: 10.1097/rhu.0000000000002372 Negative / Null Result ReportMedicine
Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology
Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…
View details →DOI: 10.1007/s10140-026-02504-z Negative / Null Result ReportMedicine
Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…
View details →DOI: 10.3760/cma.j.cn112338-20250626-00436 Negative / Null Result Report
TEZCE A, DURMUŞ E · 2026 · Preprint
Abstract Purpose The objective of this study is to compare the diagnostic efficacy of Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) in detecting lumbar spondylolysis among patients presenting with chronic low back pain, and…
View details →DOI: 10.21203/rs.3.rs-9247900/v1 Negative / Null Result Report
Livorsi DJ, Ritter S, Lund BC et al. · 2026 · Preprint
Abstract Background: The pneumococcal urinary antigen test can help rapidly identify Streptococcus pneumoniae as the cause of community-acquired pneumonia (CAP). In this study, we assessed the utility of this test across an integrated…
View details →DOI: 10.21203/rs.3.rs-9267869/v1 Negative / Null Result ReportOpen accessMedicine
Zorlutuna Kaymak N, Pekel İ, Demir Tekol S et al. · 2026 · BMC ophthalmology
Purpose To evaluate the diagnostic utility and real-world clinical impact of polymerase chain reaction (PCR) analysis of aqueous humor (AH) and vitreous samples in patients with uveitis including suspected infectious and mixed…
View details →DOI: 10.1186/s12886-026-05002-5 Negative / Null Result ReportMedicine
Mangiameli G, Brascia D, Re Cecconi E et al. · 2026 · Updates in surgery
The role of surgery in malignant pleural mesothelioma (MPM) remains controversial, particularly after the negative results of the MARS 1 and 2 trials. Lung-sparing cytoreductive procedures such as extended pleurectomy/decortication (eP/D)…
View details →DOI: 10.1007/s13304-026-02666-y Negative / Null Result ReportOpen accessMedicine
Feng Q, Liu B, Liu H et al. · 2025 · Frontiers in microbiology
Background Accurately diagnosing central nervous system (CNS) infections remains challenging. This study aimed to evaluate the effectiveness of metagenomic next-generation sequencing (mNGS) in diagnosing suspected CNS infections and its…
View details →DOI: 10.3389/fmicb.2025.1689253 Negative / Null Result ReportOpen accessMedicine
Tsutsumi Y, Nagasaki T, Muraki M et al. · 2026 · Internal medicine (Tokyo, Japan)
Rapid molecular and immunological assays for tuberculosis, including loop-mediated isothermal amplification (LAMP) and T-SPOT.TB assays, may yield false-negative results. We herein report a 62-year-old immunocompetent man with a productive…
View details →DOI: 10.2169/internalmedicine.6076-25 Negative / Null Result ReportOpen accessMedicine
Novy E, Schaeffer A, Nguyen M et al. · 2026 · Critical care (London, England)
BACKGROUND: Intra-abdominal candidiasis (IAC) is a severe form of invasive candidiasis that affects critically ill patients and is associated with a high mortality rate and persistent diagnostic delays. Conventional fungal culture from…
View details →DOI: 10.1186/s13054-026-05882-5 Negative / Null Result ReportMedicine
Tomlinson J, Roberson E, Klee V et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective: Assess the accuracy of ALS patient recall of genetic testing results and evaluate comprehension of key implications of results. Methods: Participants were recruited from the Center for Disease Control's National ALS Registry. A…
View details →DOI: 10.1080/21678421.2025.2582829 Negative / Null Result ReportMedicine
Alvarez Mulett S, Molina Garcia S, Abu Saleh O et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed. Traditional cerebrospinal fluid diagnostic methods for CNS infections have limited sensitivity.…
View details →DOI: 10.1093/cid/ciaf390 Negative / Null Result ReportOpen accessMedicine
Lükewille L, Wiegand S, Fazel A et al. · 2026 · Journal of cancer research and clinical oncology
Purpose Sentinel lymph node biopsy (SLNB) is a standard procedure for nodal staging in cutaneous melanoma. However, its diagnostic performance in the head and neck region remains limited due to complex lymphatic drainage patterns. This…
View details →DOI: 10.1007/s00432-026-06499-5 Negative / Null Result ReportMedicine
Zhang J, Su M, Zhang Y et al. · 2025 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To explore the reasons for false negative results by Optical genome mapping (OGM) analysis of three cases and propose strategies for handling them. Methods Three patients presented at the Affiliated Hospital of Nantong University…
View details →DOI: 10.3760/cma.j.cn511374-20250725-00455 Negative / Null Result ReportMedicine
Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics
The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…
View details →DOI: 10.1158/1535-7163.mct-25-0941 Negative / Null Result ReportMedicine
Genetic And Metabolic Disorders Screening Subgroup Of The Birth Defects Prevention And Control Committee Chinese Preventive Medicine Association, Rare Diseases Branch Of Shandong Medical Association, Genetic Metabolism Branch Of Shandong Provincial Rare Disease Association et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
High-throughput sequencing technology has recently been used in neonatal disease screening. To address the issues related to the screening process, interpretation of screening results, and recall of positive cases in neonatal genetic…
View details →DOI: 10.3760/cma.j.cn511374-20250922-00559 Negative / Null Result ReportMedicine
Inácio ML, Rusinque L, Nóbrega F et al. · 2026 · Plant disease
Aphelenchoides besseyi , the causal agent of the white-tip disease, is a quarantine nematode known to affect rice ( Oryza sativa ) by colonizing leaf tips and panicles. In January 2021, A. besseyi was detected in Portugal in imported…
View details →DOI: 10.1094/pdis-07-25-1513-sc Negative / Null Result ReportMedicine
Goren T, Vashdi DR, Beeri I · 2026 · Social science & medicine (1982)
Political trust is considered crucial for enhancing civic compliance with government policies and instructions, particularly during a health crisis. However, evidence from the COVID-19 pandemic, a major global health crisis, suggest a more…
View details →DOI: 10.1016/j.socscimed.2026.119093 Negative / Null Result ReportMedicine
Mohanta S, Tye KM · 2025 · Neuron
In this issue of Neuron, Biane et al. 1 used cellular-resolution recordings in ventral CA1 (vCA1) to comprehensively establish that it encodes stimulus features and identity, but not a generalized abstraction of valence. This suggests a…
View details →DOI: 10.1016/j.neuron.2025.08.024 Negative / Null Result ReportMedicine
Zhou G, Dael N, Verweij S et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background: The rapid emergence of immune-evasive SARS-CoV-2 variants necessitates the identification of accessible, low-cost prophylactic strategies. While drug repurposing offers a time-efficient alternative to novel drug development,…
View details →DOI: 10.3390/ph19060861 Negative / Null Result ReportMedicine
Brent DA · 2026 · Journal of the American Academy of Child and Adolescent Psychiatry
In this issue of JAACAP, Asarnow and colleagues report the results of their innovative, elegantly conducted clinical trial that assessed the added value of stratified, stepped care (SSC) for youth at risk for suicidal behavior in a health…
View details →DOI: 10.1016/j.jaac.2026.02.001 Negative / Null Result ReportMedicine
Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications
Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…
View details →DOI: 10.1097/mnm.0000000000002158 Negative / Null Result ReportOpen accessMedicine
Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology
Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…
View details →DOI: 10.1007/s10140-025-02387-6 Negative / Null Result ReportMedicine
Bafaraj SM · 2025 · Current problems in diagnostic radiology
The primary aim of this study is to assess how well ultrasonography and 99mTc-sestamibi scintigraphy perform as diagnostic tools for hyperparathyroidism (HPT) when compared to the clinical measurements of parathyroid hormone (PTH) levels.…
View details →DOI: 10.1067/j.cpradiol.2025.09.001 Negative / Null Result ReportOpen accessMedicine
Kwatra D, Wakeford W, Ally M et al. · 2026 · BMC endocrine disorders
BACKGROUND: To evaluate the concordance of the NBCL CONNECT Point-of-Care (POC) Intraoperative Parathyroid Hormone (IOPTH) assay with a Central Laboratory standard, with a focus on percentage drops and the usefulness of POC testing in…
View details →DOI: 10.1186/s12902-025-02112-x 