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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 233 of 675

Negative / Null Result ReportOpen accessMedicine

Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.

Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…

View details →DOI: 10.1210/clinem/dgaf687
Negative / Null Result ReportOpen accessMedicine

Ejaculate Ejection by Female Fruit Flies Does Not Correlate With Mating Latency or Male Presence, Irrespective of How Ejection Is Measured.

Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution

Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…

View details →DOI: 10.1002/ece3.72281
Negative / Null Result ReportOpen accessMedicine

Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer.

Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology

Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…

View details →DOI: 10.1177/03946320251324821
Negative / Null Result ReportOpen accessMedicine

Association of Previne Brasil Program with prenatal care and maternal-child mortality.

Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica

Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…

View details →DOI: 10.11606/s1518-8787.2025059006735
Negative / Null Result ReportOpen accessMedicine

Association of p53 Pro72Arg Polymorphism with Hepatocellular Carcinoma Risk in Hepatitis B Across Multiethnic Populations.

Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers

Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…

View details →DOI: 10.3390/cancers18030380
Negative / Null Result ReportMedicine

Somatic symptom distress is not related to cardioceptive accuracy.

Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research

Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…

View details →DOI: 10.1016/j.jpsychores.2024.111655
Negative / Null Result ReportMedicine

Efficacy of Low-dose Aspirin in Preventing Hypertensive Disorders of Pregnancy in Women with Systemic Lupus Erythematosus: A Single-Center Retrospective Cohort Study.

Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology

Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…

View details →DOI: 10.1093/mr/roag028
Negative / Null Result ReportOpen accessMedicine

Lurasidone

· 2006

Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…

Negative / Null Result ReportOpen accessMedicine

The Effects of Nitrate on Brown Fat Fraction and Activation in Older Adults With Type 2 Diabetes: A Randomised, Double-Blind and Placebo-Controlled Crossover Trial.

Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…

View details →DOI: 10.1002/ejsc.70117
Negative / Null Result ReportMedicine

Role of Antipsychotic Agents for Adjunct Sedation.

DeGrado J, Devlin JW · 2025 · Critical care clinics

Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…

View details →DOI: 10.1016/j.ccc.2025.07.001
Negative / Null Result ReportOpen accessMedicine

Angiogenesis Inhibitors and Arterial Dissection or Aneurysm in Patients With Metastatic Colorectal Cancer.

Singier A, Jarne Munoz A, Maumus-Robert S et al. · 2025 · JAMA network open

Importance Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further…

View details →DOI: 10.1001/jamanetworkopen.2025.46960
Negative / Null Result ReportOpen accessMedicine

Evidence of spontaneous mentalizing in children with Cornelia de Lange and fragile X syndromes, but not autistic children.

Ellis K, Moss J, Dziwisz M et al. · 2025 · Oxford open neuroscience

It has been suggested that mentalizing abilities underlie the distinct profiles of autism characteristics observed between Cornelia de Lange (CdLS) and fragile X syndromes (FXS) and autistic people without a genetic syndrome. However,…

View details →DOI: 10.1093/oons/kvaf003
Negative / Null Result ReportOpen accessMedicine

Assessment of Eating Behavior and Genetic Risk Factors for Metabolic Syndrome.

Turmanbayeva A, Sadykova K, Nuskabayeva G et al. · 2026 · Journal of clinical medicine

Background : Metabolic syndrome (MetS) is influenced by behavioral and genetic factors, yet evidence on eating behavior patterns and related genetic polymorphisms in Central Asian populations remains limited. Aim: The aim of this study was…

View details →DOI: 10.3390/jcm15020739
Negative / Null Result ReportOpen accessMedicine

Visual processing and interference performance influences on knee angular impulse in ACLR individuals: a cognitive-biomechanical analysis of drop-jumps.

Santamaria-Guzman K, Holmes H, Kosek J et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Visual processing speed and cognitive interference control are critical for athletic performance and Anterior Cruciate Ligament (ACL) injury risk. However, how these cognitive functions relate to biomechanical performance…

View details →DOI: 10.1007/s00402-026-06353-w
Negative / Null Result ReportOpen accessMedicine

A high-risk perioperative atrial fibrillation phenotype and early outcomes after isolated coronary artery bypass grafting.

Khalil E, Yüksel B · 2026 · Archives of medical sciences. Atherosclerotic diseases

Introduction Perioperative atrial fibrillation (POAF) remains the most common arrhythmic complication occurring in the setting of isolated coronary artery bypass grafting (CABG), and it is now being increasingly recognised as a marker of…

View details →DOI: 10.5114/amsad/220354
Negative / Null Result ReportOpen accessMedicine

Association between Levels of Alcohol Use, Perceived HIV Risk, and Untreated HIV Among Persons at Alcohol-Serving Venues in Kenya and Uganda.

Beesiga B, Litunya J, Nakato JZ et al. · 2026 · AIDS and behavior

Alcohol-serving venues in East Africa are high-risk environments for HIV transmission but few studies in sub-Saharan Africa (SSA) have examined perceived HIV risk and sexual risk behaviors by alcohol use levels on a broader population of…

View details →DOI: 10.1007/s10461-026-05056-y
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Emotion-Focused Cognitive Behaviour Therapy on Emotional Hyporexia Among Adolescent Girls with Eating Problems: A Pilot Study.

Shinde SS, Naik NS, Adhyapak SU et al. · 2025 · Journal of pharmacy & bioallied sciences

Background Emotional hyporexia, a form of intentional food avoidance triggered by emotional distress, presents a growing health concern among adolescent girls. Addressing this behavior through psychological intervention is essential for…

View details →DOI: 10.4103/jpbs.jpbs_899_25
Negative / Null Result ReportOpen accessMedicine

Blood omega-3 fatty acids and coronary artery stenosis: a postmortem study.

Randall B, Leković A, Nikolić S et al. · 2025 · Lipids in health and disease

The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich…

View details →DOI: 10.1186/s12944-025-02697-1
Negative / Null Result ReportMedicine

Lack of Association of Initial Vasopressor Dosing with Survival and Cardiac Re-Arrest Likelihood After Return of Spontaneous Circulation.

Sharpe AR, Richardson K, Stanton M et al. · 2023 · The Journal of emergency medicine

Background Cardiac arrest occurs in approximately 350,000 patients outside the hospital and approximately 30,000 patients in the emergency department (ED) annually in the United States. When return of spontaneous circulation (ROSC) is…

View details →DOI: 10.1016/j.jemermed.2023.05.002
Negative / Null Result ReportMedicine

Coagulation factor XI in cirrhosis does not predict thrombo-hemorrhagic complications and hepatic decompensation.

Zanetto A, Campello E, Spiezia L et al. · 2024 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Introduction Factor XI (FXI) is associated with thrombosis in patients without liver disease, but it alterations and prognostic value in cirrhosis are uncertain. Patients and methods We studied a prospective cohort of cirrhosis patients…

View details →DOI: 10.1016/j.dld.2024.05.020
Negative / Null Result ReportOpen accessMedicine

Dietary Diversity Score and Its Sociodemographic Determinants in School-Aged Children: Cross-Sectional Baseline Findings From a Quasi-experimental Study.

Singh T, Kumar S, Sinha S et al. · 2025 · Cureus

Background Dietary diversity is an essential component of nutritional adequacy, particularly for school-aged children who are undergoing rapid physical and cognitive development. Inadequate dietary diversity can lead to micronutrient…

View details →DOI: 10.7759/cureus.85804
Negative / Null Result ReportMedicine

Place of Death, Care Intensity, Symptom Prevalence, and Symptom Management for Patients With Stroke at End-of-Life.

Ramsburg H, Hinkle JL, MacKenzie Greenle M · 2026 · The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses

Background Each year in the United States, 795,000 people are diagnosed with a new or recurrent stroke, resulting in 165,393 deaths. However, little is known about the quality of end-of-life (EOL) care in this population, including the…

View details →DOI: 10.1097/jnn.0000000000000883