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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 231 of 675

Negative / Null Result ReportMedicine

Clinical Effects of Angulated Single-Implant Crowns With Different Retention Methods in the Aesthetic Area: A Retrospective Cohort Study With 12-24 Months Follow-Up.

Ding X, Wang Y, Choi M et al. · 2026 · Clinical oral implants research

Objective The objective of this study is to evaluate the clinical efficacy of angulated single-implant crowns using the hybrid retention versus pure screw-retained restorations in the aesthetic area. Materials and methods A retrospective…

View details →DOI: 10.1111/clr.70128
Negative / Null Result ReportMedicine

One-stage hepatectomy may be a safe and feasible alternative to ALPPS for hepatocellular carcinoma with liver fibrosis or cirrhosis and FLR/SLV ratio of 30% - 40% - A multicenter study.

Yang H, Gao J, Mo S et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Objective and background The optimal surgical strategy for patients with hepatocellular carcinoma (HCC) and liver fibrosis/cirrhosis presenting with a future liver remnant to standard liver volume (FLR/SLV) ratio of 30%-40% remains a…

View details →DOI: 10.1016/j.ejso.2026.111946
Negative / Null Result ReportOpen accessMedicine

Prognostic Utility of Albumin and the C-Reactive Protein-to-Albumin Ratio for Predicting Intravenous Steroid Response in Acute Severe Ulcerative Colitis.

Süleyman S, Emin P, Hüseyin A et al. · 2026 · Journal of clinical medicine

Background/Objectives: Acute severe ulcerative colitis (ASUC) is a high-risk condition associated with intense inflammation and a substantial risk of early colectomy. Intravenous steroids (IVS) remain the first-line therapy; however,…

View details →DOI: 10.3390/jcm15072730
Negative / Null Result ReportMedicine

Serum PTH, vitamin D, and calcium levels in patients with medication-related osteonecrosis of the jaw: A case-control study.

Leizaola-Cardesa IO, Gómez-Moreno G, Hernando J et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery

Background To determine serum parathyroid hormone (PTH), vitamin D, and calcium levels in patients with medication related osteonecrosis of the jaw (MRONJ), compared with patients receiving similar medication but without MRONJ; also, to…

View details →DOI: 10.1016/j.jormas.2026.102806
Negative / Null Result ReportMedicine

The effect of empagliflozin on inflammation and oxidative stress in patients undergoing percutaneous coronary intervention, a randomized controlled trial.

Darroudi S, Ghazaee H, Babaei N et al. · 2026 · Scientific reports

Empagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has demonstrated cardioprotective effects beyond glycemic control. Empagliflozin has anti-inflammatory and antioxidant effects in long-term administration; however, current…

View details →DOI: 10.1038/s41598-026-44492-7
Negative / Null Result ReportMedicine

Fibroblast growth factor 23 is associated with cardiac disease severity in transthyretin amyloid cardiomyopathy.

Eslami M, Ermolaev N, Kronberger C et al. · 2026 · Scientific reports

Fibroblast growth factor 23 (FGF23), a bone-derived hormone, is emerging as a potential biomarker in cardiovascular disease. However, its role in transthyretin amyloid cardiomyopathy (ATTR-CM), a progressive infiltrative cardiomyopathy,…

View details →DOI: 10.1038/s41598-026-51879-z
Negative / Null Result ReportOpen accessMedicine

Real-World Comparison of PD-1 and PD-L1 Inhibitor Monotherapy in Metastatic Non-Small Cell Lung Cancer with High PD-L1 Expression.

Marković F, Bojić Z, Stjepanović M et al. · 2026 · Cancers

Background: Immune checkpoint inhibitor monotherapy targeting the PD-1/PD-L1 axis is a standard first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) and high PD-L1 expression. However, comparative…

View details →DOI: 10.3390/cancers18071153
Negative / Null Result ReportMedicine

Risk of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in Children With Hypoxic-Ischemic Encephalopathy.

Chow SCW, Wang Y, Leung OLK et al. · 2026 · Journal of autism and developmental disorders

Purpose This study investigated the risk of ASD and ADHD in children who have survived hypoxic-ischemic encephalopathy (HIE), one of the common conditions during birth resulting in neonatal brain injury. Methods A population-based cohort…

View details →DOI: 10.1007/s10803-026-07347-8
Negative / Null Result ReportMedicine

Dapagliflozin is associated with a reduction in left atrial volume index in type 2 diabetes mellitus without established cardiovascular disease.

Çakır B, Polat F, Karataş MB et al. · 2026 · Acta diabetologica

Background Diabetic cardiomyopathy (DCM) frequently begins with diastolic dysfunction (DD), which leads to increased left ventricular filling pressures and subsequent left atrial enlargement, quantified by the left atrial volume index…

View details →DOI: 10.1007/s00592-026-02707-3
Negative / Null Result ReportMedicine

Effects of multistrain probiotics on metabolic biomarkers, inflammation, and antioxidant system in patients with type 2 diabetes mellitus: a prospective controlled trial in Türkiye.

Kilavuz A, Zorbozan O, Yildirim Simsir I et al. · 2026 · BMC nutrition

Background Recent evidence suggests that the gut microbiota plays a crucial role in the development and progression type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of multi-strain probiotic supplementation on…

View details →DOI: 10.1186/s40795-026-01354-9
Negative / Null Result ReportMedicine

Periprocedural Outcomes of Carotid Artery Stenting According to Embolic Protection Strategy: A 20-Year Single-Center Experience.

Tajima Y, Kubota M, Yoshida Y et al. · 2026 · World neurosurgery

Objective This study aimed to evaluate the impact of embolic protection strategies on outcomes in asymptomatic patients undergoing carotid artery stenting (CAS). Methods We retrospectively analyzed 312 consecutive asymptomatic patients…

View details →DOI: 10.1016/j.wneu.2026.124997
Negative / Null Result ReportMedicine

The weekend effect in internal medicine admissions: A limited impact at a large tertiary-care center.

Feigin L, Feigin E, Bronstein Y · 2026 · The American journal of medicine

Background This study was conducted to examine whether a "weekend effect" exists in internal medicine departments of a large tertiary medical center in Israel. Methods We conducted a retrospective cohort study of patients > 18 admitted to…

View details →DOI: 10.1016/j.amjmed.2026.03.005
Negative / Null Result ReportMedicine

NEUTROPHIL-TO-LYMPHOCYTE RATIO AS A POTENTIAL PREDICTOR OF IN-HOSPITAL MORTALITY AMONG ISCHEMIC STROKE PATIENTS: A PROSPECTIVE COHORT STUDY.

Urasheva Z, Khamidulla A, Yermagambetova A et al. · 2026 · Georgian medical news

Background Ischemic stroke is a major cause of death and disability worldwide. Recent evidence highlights the role of systemic inflammation in stroke pathophysiology and prognosis. The neutrophil-to-lymphocyte ratio (NLR), an accessible…

Negative / Null Result ReportMedicine

The Immediate Impact of Hemodialysis on Gait Metrics.

Cernes R, Hershkovich O, Tsehovsky T et al. · 2026 · The Israel Medical Association journal : IMAJ

Background Gait disturbances are common in patients undergoing hemodialysis and are associated with increased fall risk, mobility decline, and adverse health outcomes. Prior research suggests that hemodialysis may impact gait parameters…

Negative / Null Result ReportMedicine

Right Ventricular Functional Changes in Patients Undergoing Bone Marrow Transplantation: An Advanced Echocardiographic Analysis.

Ugurluoglu G, Ulutas Z, Yigit Y et al. · 2026 · Echocardiography (Mount Kisco, N.Y.)

Objective This study aimed to evaluate right ventricular (RV) function pre and post bone marrow transplantation (BMT) using transthoracic echocardiography (TTE), in order to detect subclinical or clinical RV dysfunction that may occur in…

View details →DOI: 10.1111/echo.70437
Negative / Null Result ReportMedicine

Relaxing Environment Lowers Anxiety During Chemodenervation: a Randomized Trial.

Franks E, Rigdon J, Kennelly M et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Importance Intradetrusor chemodenervation with onabotulinumtoxinA (BOTOX) injections, a common office-based procedure for overactive bladder (OAB), is associated with patient anxiety and discomfort. Aromatherapy and music have been shown…

View details →DOI: 10.1097/spv.0000000000001809
Negative / Null Result ReportOpen accessMedicine

Periodontal Status of Patients with Celiac Disease and Non-Celiac Gluten Sensitivity: A Literature Review.

Angelopoulou T, Bobetsis YA · 2026 · Journal of clinical medicine

Background/Objectives : Celiac disease (CD) is a chronic, immune-mediated enteropathy induced by dietary gluten exposure in genetically predisposed individuals. Along with non-celiac gluten sensitivity (NCGS), these disorders present with…

View details →DOI: 10.3390/jcm15082828
Negative / Null Result ReportMedicine

Endoscopic-Assisted Osteotomy with Absorbable Plate as Internal Attachment Point for External Spring Distraction Osteogenesis in the Treatment of Sagittal Synostosis in Infants.

Shen W, Cui J, Ji Y et al. · 2026 · World neurosurgery

Background Sagittal synostosis (SS) is the premature closure of sagittal sutures. To investigate the use of absorbable plates as internal attachment points for external spring (ES) traction in the treatment of sagittal craniosynostosis in…

View details →DOI: 10.1016/j.wneu.2026.124977
Negative / Null Result ReportOpen accessMedicine

Postoperative Outcomes After Rectal Cancer Surgery With or Without Primary Anastomosis: A Propensity Score-Weighted Study.

Sanda NA, Filip PV, Bobirca FT et al. · 2026 · Diagnostics (Basel, Switzerland)

Background: The role of primary anastomosis in rectal cancer surgery remains debated, particularly due to concerns regarding postoperative morbidity. Evidence from randomized trials is limited, and observational studies are frequently…

View details →DOI: 10.3390/diagnostics16101533
Negative / Null Result ReportMedicine

Role of Tumor Volume and Prolactin Ratios in Differentiating Prolactinomas and Predicting Response to Cabergoline.

García-Sáenz MR, Castro-Murillo JI, Mercado M et al. · 2026 · Archives of medical research

Introduction Predicting resistance to cabergoline in prolactinomas remains a challenge. While prolactin (PRL)-based ratios help differentiate prolactinomas from non-functioning pituitary adenomas (NFPAs), their role in forecasting…

View details →DOI: 10.1016/j.arcmed.2026.103427
Negative / Null Result ReportMedicine

Clinical outcomes and prognostic factors in hematologic malignancy patients with probable CMV pneumonia.

Aydın Güçlü Ö, Demirdöğen E, Hunutlu FÇ et al. · 2026 · BMC infectious diseases

Background Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality among immunocompromised patients, particularly those with hematologic malignancies. The present study aims to evaluate the clinical features,…

View details →DOI: 10.1186/s12879-026-13708-6
Negative / Null Result ReportMedicine

The Association Between Neonatal Jaundice and Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: Findings From the Millennium Cohort Study.

Lee A, Higgins S, O'Driscoll D et al. · 2026 · Journal of autism and developmental disorders

OBJECTIVE: To examine the association between neonatal jaundice requiring hospital treatment and autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring by age 14 years. METHODS: We used data from…

View details →DOI: 10.1007/s10803-026-07317-0
Negative / Null Result ReportMedicine

A study comparing the efficacy of R-CHOP and R-DA-EPOCH regimens in young, high-risk treatment-naïve diffuse large B-cell lymphoma patients: a multicenter retrospective analysis.

Lan H, Ding Y, Liu M · 2026 · American journal of cancer research

Background Patients with high-risk diffuse large B-cell lymphoma (DLBCL) have poor prognoses, and the comparative efficacy between R-CHOP and R-DA-EPOCH regimens remains controversial. Objective To compare the efficacy and safety of R-CHOP…

View details →DOI: 10.62347/rivm5316
Negative / Null Result ReportMedicine

Novel use of intrauterine instillation of Hyaluronan enriched media on clinical outcomes of intrauterine insemination treatment: a pilot randomized controlled trial.

Yadav D, Ghuman NK, Kathuria P et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objective To study the effect of intrauterine instillation of Hyaluronan enriched media on reproductive outcomes of intrauterine insemination treatment. Design and participants 100 couples with unexplained infertility were approached and…

View details →DOI: 10.1016/j.ejogrb.2026.115100
Negative / Null Result ReportOpen accessMedicine

The Impact of MOUD Initiation in Patients With Injection Drug Use-Associated Infective Endocarditis.

Losiewicz S, Collis B, El-Dalati S et al. · 2026 · Open forum infectious diseases

This single-center retrospective study evaluated 218 patients with injection drug use-associated infective endocarditis, 169 of whom received medications for opioid use disorder (MOUD). Initiation of MOUD was associated with a…

View details →DOI: 10.1093/ofid/ofag288
Negative / Null Result ReportMedicine

Methylprednisolone Taper After Total Knee Arthroplasty: A Prospective Single-Blinded Randomized Trial.

Premkumar A, Arellano E, Heo KY et al. · 2026 · The Journal of arthroplasty

Background The use of short-term postoperative corticosteroid regimens has been reported to improve pain control and decrease opioid consumption following total knee arthroplasty (TKA). The purpose of this study was to evaluate the effect…

View details →DOI: 10.1016/j.arth.2026.04.076
Negative / Null Result ReportOpen accessMedicine

Screening and Cohorting of CRE Patients: The Strategic Role of Bed Management in a Monocentric Pre-Post Observational Study.

Altavilla S, Di Pietro N, Loconsole D et al. · 2026 · Antibiotics (Basel, Switzerland)

Background Carbapenem-resistant Enterobacterales (CRE) require early identification and appropriate patient placement to prevent in-hospital transmission. Bed Management plays a key organizational role in coordinating screening results and…

View details →DOI: 10.3390/antibiotics15030290
Negative / Null Result ReportMedicine

The clinicopathologic characteristics and outcomes of uncommon KRAS mutations in patients with non-small cell lung cancer.

Zhang Y, Zhao J, Gao Q et al. · 2026 · Virchows Archiv : an international journal of pathology

Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25-30% of non-small cell lung cancer (NSCLC) patients. Pooled analyses in previous research have largely focused on the prognostic and predictive value of overall or…

View details →DOI: 10.1007/s00428-026-04475-5
Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of PHPV Fusion Factor Vaginal Gel (PHPV®) in Clearing Cervical Persistent High-Risk Human Papillomavirus Infection: A Randomized Controlled Clinical Trial.

Yan L, Yin H, Shi L et al. · 2026 · Drug design, development and therapy

Purpose To evaluate the efficacy and safety of PHPV in the treatment of persistent high-risk papillomavirus (hrHPV) infection of the cervix. Patients and methods A randomized controlled trial (RCT) was conducted on patients with persistent…

View details →DOI: 10.2147/dddt.s542859
Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Bloom's Taxonomy-Based Occupational Exposure Prevention in Oral Emergency Departments: A Quasi-Experimental Study.

Shi Y, Shen Y, Zhou X et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective To evaluate a Bloom's Taxonomy-based occupational exposure (OE) prevention program's impact on dental trainees' competencies compared to conventional training, assessing knowledge, skills, satisfaction, and exposure rates to…

View details →DOI: 10.1111/eje.70138