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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 229 of 661

Negative / Null Result ReportMedicine

Spinal motion restriction in the emergency healthcare setting: A cross-sectional study of knowledge, attitudes, and practices.

Oteir A, Husein M, Alhawatmeh H et al. · 2026 · International emergency nursing

Background Spinal motion restriction (SMR) remains a fundamental component of trauma care, yet its routine application has been increasingly questioned. Evidence supporting selective SMR has grown; however, limited data exist on the…

View details →DOI: 10.1016/j.ienj.2026.101857
Negative / Null Result ReportMedicine

Factors associated with mortality in pancreatic adenocarcinoma patients achieving pathologic complete response after neoadjuvant therapy.

Suraju MO, Longbottom B, Peteson JA et al. · 2026 · American journal of surgery

Introduction Factors influencing mortality among pancreatic ductal adenocarcinoma (PDAC) patients who achieve pathologic complete response (pCR) following neoadjuvant therapy have not been previously well studied. Methods Adult PDAC…

View details →DOI: 10.1016/j.amjsurg.2026.117093
Negative / Null Result ReportMedicine

Impact of Contact Lens Use on Clinical Profile and Outcomes of Fungal Keratitis: An 8-Year Retrospective Study.

Kate A, Wannapanich T, Mandell J et al. · 2026 · American journal of ophthalmology

Purpose To compare clinical characteristics, microbiological profiles, treatment strategies, and outcomes between contact lens-associated (CL) and non-contact lens-associated (non-CL) fungal keratitis. Design Retrospective, comparative…

View details →DOI: 10.1016/j.ajo.2026.06.017
Negative / Null Result ReportMedicine

Metrics and insulin variations in women with type 1 diabetes on automated insulin delivery system during strict peripartum period.

Fresa R, Napoli A, Bitterman O · 2026 · Acta diabetologica

Introduction the use of Automated Insulin Delivery (AID) systems has increased in pregnant women with type 1 diabetes (DM1). To date, little data exist regarding glucose control and insulin modifications with AID in automode during…

View details →DOI: 10.1007/s00592-026-02733-1
Negative / Null Result ReportMedicine

Changes in Patient Characteristics and Early Clinical Outcomes Among Emergency Department-Admitted Inpatients During the 2024 Medical Workforce Crisis in South Korea.

Lee YJ, Moon SW · 2026 · Journal of clinical medicine

Background/Objectives : In February 2024, a nationwide medical crisis in South Korea caused a massive withdrawal of resident physicians. We described changes in patient characteristics and early clinical outcomes among emergency department…

View details →DOI: 10.3390/jcm15124804
Negative / Null Result ReportMedicine

Associations between discrimination and mental healthcare utilization among racial and ethnic minority cancer survivors in the All of Us Research Program.

Wen YP, Brauer ER, Choi S et al. · 2026 · BMC public health

Background Cancer survivors are twice as likely to experience psychological distress, with racial and ethnic minorities reporting higher distress and healthcare needs compared to non-Hispanic White Americans. However, this group is more…

View details →DOI: 10.1186/s12889-026-28276-2
Negative / Null Result ReportMedicine

Clinical and radiographic outcomes of cannulated cancellous screw osteosynthesis with and without side-plate for nondisplaced femoral neck fractures: a multicenter propensity score-matched study.

Maeda K, Funahashi H, Tokutake K et al. · 2026 · International orthopaedics

Purpose This study aimed to evaluate postoperative outcomes, including clinical results, radiological assessments, and complications, in patients over 50 years old with nondisplaced femoral neck fractures (Garden classification I-II)…

View details →DOI: 10.1007/s00264-026-06870-8
Negative / Null Result ReportMedicine

Efficacy and Safety of Denosumab versus Zoledronic Acid in the Treatment of Hypercalcemia in Primary Hyperparathyroidism: A Retrospective Comparative Study.

Liu Y, Liu L, Wang J et al. · 2026 · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Objective Nephrotoxicity of bisphosphonates limits their utility in the management of severe hypercalcemia among patients with primary hyperparathyroidism (PHPT) and impaired renal function. It remains unclear whether denosumab is an…

View details →DOI: 10.1016/j.eprac.2026.05.034
Negative / Null Result ReportMedicine

Clinical outcomes of a Locator-bilateral segmental bar concept versus a conventional rigid bar concept for maxillary implant-supported overdentures: a retrospective cohort study.

Zheng J, Chen M, Fu J · 2026 · BMC oral health

Background This retrospective cohort study evaluated a Locator-bilateral segmental bar concept (LBSB) for maxillary implant-supported overdentures and compared it with a conventional rigid bar concept (CRB) in terms of implant survival,…

View details →DOI: 10.1186/s12903-026-08764-y
Negative / Null Result ReportMedicine

Effectiveness of Audiovisual Distraction During Dental Treatment Under Nitrous Oxide/Oxygen Conscious Sedation in Paediatric Patients: A Randomized Crossover Clinical Trial.

Gentile T, Vanacore S, Caputo M et al. · 2026 · Children (Basel, Switzerland)

Background/objectives Dental anxiety represents a major challenge in paediatric dentistry and is a frequent cause of non-cooperative behaviour during dental treatment. Nitrous oxide/oxygen inhalation conscious sedation is widely used to…

View details →DOI: 10.3390/children13060812
Negative / Null Result Report

Functional Outcome and Discharge Destination in Elderly Patients with Spinal Cord Injury: A Retrospective Cohort Study Manuscript Type: Original Article

Kurz S, Habich O, Brauer K et al. · 2026 · Preprint

Abstract Purpose To evaluate whether patients aged > 75 years with spinal cord injury (SCI) benefit from specialized inpatient rehabilitation, focusing on functional outcomes and discharge destination. Methods This retrospective…

View details →DOI: 10.21203/rs.3.rs-9332195/v1
Negative / Null Result ReportMedicine

The trajectories of relative concentrations of antirhodococcal immunoglobulin A differ from those of immunoglobulin G subisotypes in bronchoalveolar lavage fluid but not serum of foals.

Aucoin AA, Zhidkov V, Legere RM et al. · 2026 · American journal of veterinary research

Objective To characterize age-related trajectories of the relative concentrations of anti-virulence-associated protein A (VapA) immunoglobulin (Ig)-G1, IgG3/5, IgG4/7, and IgA in serum and bronchoalveolar lavage fluid (BALF) as indicators…

View details →DOI: 10.2460/ajvr.25.11.0402
Negative / Null Result ReportMedicine

Combined Pain Neuroscience Education and Progressive Muscle Relaxation for Post-Thoracoscopic Pain.

Wang X, Li W, Wang F et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Purpose The objective of this study was to evaluate whether combining pain neuroscience education (PNE) with progressive muscle relaxation (PMR) could reduce acute pain after thoracoscopic lung resection, alleviate psychological distress,…

View details →DOI: 10.1016/j.pmn.2026.03.024
Negative / Null Result ReportMedicine

Comparing Spinal and General Anesthesia for Prone Percutaneous Nephrolithotomy: A Propensity Score-Matched Study.

Chen L, Xu D, Hou L · 2026 · Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Background/objective Prone percutaneous nephrolithotomy (PCNL) is commonly performed under general anesthesia (GA); however, increasing evidence supports the feasibility of PCNL under spinal anesthesia (SA). This study presents our…

View details →DOI: 10.1159/000552326
Negative / Null Result ReportMedicine

Development and Preliminary Clinical Evaluation of a Multifunctional Operative Support Arm in Reproductive Laparoscopic Surgery: A Randomized Controlled Study.

Mao W, Lu N · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Objective To evaluate short-term clinical outcomes, surgeon-reported fatigue, and staff user experience associated with a multifunctional operative support arm in reproductive laparoscopic surgery. Design Single-center, parallel-group…

View details →DOI: 10.1080/08941939.2026.2668806
Negative / Null Result ReportMedicine

Noninferiority trial of low-dose intravenous dexamethasone on the analgesic effect of caudal block in children undergoing day-case orchiopexy: a randomized clinical trial.

Lee JR, Choi H, Eum D et al. · 2026 · Anesthesia and pain medicine

Background Intravenous (IV) administration of dexamethasone has been reported to prolong the analgesic duration of a caudal block. The aim of this study was to compare the analgesic effects of IV low-dose and high-dose dexamethasone in…

View details →DOI: 10.17085/apm.25382
Negative / Null Result ReportMedicine

Impact of the amotosalen/UVA process to reduce pathogens in platelet concentrates on transfusion efficiency in cardiac surgery.

Bouali B, Rezzaoui A, Hamzeh-Cognasse H et al. · 2026 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

Background Pathogen reduction treatment (PRT) of platelet concentrates (PC) is one of the most recent advances in improving blood safety and lowering the risk of transfusion-transmitted diseases. The characteristics of PR-treated PC differ…

View details →DOI: 10.1016/j.tracli.2026.02.005
Negative / Null Result Report

Salivary Prevotella qPCR Signal as an Exploratory Non-Invasive Diagnostic Adjunct for Rotterdam Phenotype Stratification in Women with Polycystic Ovary Syndrome

Tunjungseto A, Hadi OA, Pratiwi IW et al. · 2026 · Preprint

Background: /Objectives: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine-metabolic disorder, and Rotterdam-defined phenotypes may require more refined non-invasive adjunctive signals for phenotypic stratification. Saliva is a…

View details →DOI: 10.20944/preprints202606.0029.v1
Negative / Null Result ReportMedicine

The Efficacy of Local Treatment for Recurrent Endometrial Cancer.

Igasaki M, Furusawa A, Kunishi M et al. · 2026 · The journal of obstetrics and gynaecology research

Aim This study aimed to evaluate the efficacy of local treatment in patients with sporadic recurrent endometrial cancer. Methods We retrospectively reviewed patients who received treatment for first recurrence of endometrial cancer at our…

View details →DOI: 10.1111/jog.70354
Negative / Null Result ReportMedicine

Hip Fracture Risk Following Lumbar Fusion: A Retrospective Cohort Study of Construct Length and Age-Stratified Outcomes.

Anundson J, Lee L, Bae S et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Introduction Lumbar fusion alters spinal biomechanics and may increase hip loading, especially with long-segment constructs. We used a large administrative database to evaluate hip fracture risk after lumbar fusion and assess whether…

View details →DOI: 10.1007/s00590-026-04791-1
Negative / Null Result ReportMedicine

Effectiveness of a standardized patient simulation training programme on nursing students' skill in dementia screening in Malawi: A quasi-experimental study.

Chiona BC, Mbakaya BC, Liu MF · 2026 · Nurse education in practice

Aim To evaluate the effectiveness of Standardized Patient Simulation (SPS) compared with lecture-based teaching in improving dementia knowledge, dementia screening skills and mild cognitive impairment (MCI) classification accuracy among…

View details →DOI: 10.1016/j.nepr.2026.104884
Negative / Null Result ReportMedicine

Marginal Bone Loss Around Bone-Level Fully Guided Implants With Direct Implant Connection Versus Intermediate Abutment: A Randomized Clinical Trial.

Gargallo-Albiol J, Zilleruelo-Pozo MJ, Treserra-Parra A et al. · 2026 · Clinical oral implants research

Objective To determine the influence of an intermediate prosthetic abutment on peri-implant marginal bone loss (MBL) around two implant-supported fixed restorations in the posterior area. Material and methods This study included patients…

View details →DOI: 10.1111/clr.70141
Negative / Null Result ReportMedicine

Marginal and internal fit and fracture resistance of lithium disilicate laminate veneers for teeth with proximal cavities: an in-vitro comparative study.

Taş MO, Güleryüz A · 2026 · BMC oral health

Background The management of proximal cavities under porcelain laminate veneers remains a clinical challenge. Conventional strategies-such as placing an intermediate composite restoration or extending the preparation-require additional…

View details →DOI: 10.1186/s12903-026-08841-2