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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 224 of 661

Negative / Null Result ReportMedicine

Longitudinal Changes in Health Utility Scores During the Perioperative Period Among Patients With Oral Cancer: An Analysis of the Effect of Older Age and Social Background.

Sasaki M, Aoki T, Uchibori M et al. · 2026 · Oral diseases

Objective Many countries have implemented health technology assessment of their public medical insurance programs owing to rising social security costs from ageing populations and expensive emerging medical technologies. Clarifying factors…

View details →DOI: 10.1111/odi.70298
Negative / Null Result ReportOpen accessMedicine

Effects of insect-derived protein form and replacement level on growth performance and skeletal traits in broiler pheasants (Phasianus colchicus).

Osiak-Wicha C, Kras K, Tomaszewska E et al. · 2026 · Poultry science

This study evaluated black soldier fly (Hermetia illucens) products as alternatives to soybean meal protein in broiler pheasants, focusing on growth performance and skeletal traits in both sexes. Birds were assigned to five dietary…

View details →DOI: 10.1016/j.psj.2026.107078
Negative / Null Result ReportMedicine

Comparison of Dexmedetomidine Administration Strategy for Propofol-Based Pediatric Sedation for Magnetic Resonance Imaging: A Retrospective Study.

Kim TW, Ji SH, Park JB et al. · 2026 · Paediatric anaesthesia

Background Intravenous dexmedetomidine is a safe and effective adjunct in propofol-based sedation. Dexmedetomidine is typically administered as a loading dose, followed by continuous infusion or not. Whether the addition of a maintenance…

View details →DOI: 10.1002/pan.70180
Negative / Null Result ReportMedicine

Immune-impulsivity link: association between peripheral inflammatory ratios and borderline personality disorder.

Raj R, Nabi J, Gidwani S et al. · 2026 · East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan

Objectives To determine associations between impulsivity and peripheral inflammatory ratios in patients with borderline personality disorder (BPD). Methods Consecutive patients aged ≥18 years with a diagnosis of BPD who presented to the…

View details →DOI: 10.12809/eaap25128
Negative / Null Result ReportMedicine

Management and outcomes of infective endocarditis in a community hospital and its cardiac surgery referral centre.

Jufresa-Michavila B, Bayés-Ricart C, Grillo S et al. · 2026 · Scientific reports

Despite advances in diagnosis and management, infective endocarditis (IE) remains a life-threatening condition with a high mortality rate. Most data originate from cardiac surgery centres, limiting our understanding of outcomes in…

View details →DOI: 10.1038/s41598-026-50918-z
Negative / Null Result ReportOpen accessMedicine

Comparative Effectiveness of Azithromycin versus Erythromycin for Latency Prolongation in Preterm Prelabor Rupture of Membranes < 34 Weeks of Gestation.

Chawanpaiboon S, Pooliam J · 2026 · International journal of women's health

Objective Preterm prelabor rupture of membranes (PPROM) is a major contributor to preterm birth and neonatal morbidity. Although azithromycin is increasingly used as an alternative to erythromycin for latency antibiotic therapy,…

View details →DOI: 10.2147/ijwh.s603582
Negative / Null Result ReportOpen accessMedicine

Acute Phase Proteins in Cats Naturally Infected or Seropositive for <i>Leishmania infantum</i>.

Spada E, Castelli G, Bruno F et al. · 2026 · Animals : an open access journal from MDPI

Feline leishmaniosis (FeL) caused by Leishmania infantum is increasingly recognized in endemic areas, but the inflammatory profile during infection remains poorly defined. This case-control study evaluated the acute phase proteins (APPs)…

View details →DOI: 10.3390/ani16111625
Negative / Null Result ReportMedicine

The effect of two types of pyramidal and reverse pyramidal loading on spine and pelvis coordination variability during deadlift.

Sajedi Nia M, Khaleghi Tazji M, Abbasi A · 2026 · BMC musculoskeletal disorders

Purpose To investigate the effects of pyramidal and reverse pyramidal loading on spine and pelvis coordination patterns and their variability during deadlift. Methods Twelve trained male powerlifters performed deadlifts under two loading…

View details →DOI: 10.1186/s12891-026-10111-9
Negative / Null Result ReportOpen accessMedicine

Dimensional accuracy of dental impression materials evaluated using a standardized CAD based method across materials tray types and techniques.

Wassermann C, Rosenberger N, Gerhardt M et al. · 2026 · Scientific reports

In this in vitro study, a CAD-based test workflow was established to evaluate the dimensional accuracy of conventional dental impression materials under standardized laboratory conditions. Ninety double-mix impressions were made from a…

View details →DOI: 10.1038/s41598-026-58096-8
Negative / Null Result ReportMedicine

Comparison of mechanical complications between metal-ceramic and monolithic zirconia implant-supported prostheses: A retrospective split-mouth study.

Park JO, Park YB, Yoon JH et al. · 2026 · The Journal of prosthetic dentistry

Statement of problem Comparative studies assessing monolithic zirconia and metal-ceramic for implant-supported fixed prostheses remain limited. Purpose This retrospective study aimed to compare the survival and success of metal-ceramic and…

View details →DOI: 10.1016/j.prosdent.2026.02.024
Negative / Null Result ReportMedicine

Age-stratified clinical outcomes and adverse events in patients with metastatic castration-sensitive prostate cancer receiving triplet therapy with darolutamide, androgen deprivation therapy, and docetaxel.

Uchimoto T, Hirosuna K, Niigawa H et al. · 2026 · Japanese journal of clinical oncology

Background Triplet therapy with darolutamide, androgen deprivation therapy, and docetaxel (DOC) has emerged as an intensified treatment option for metastatic castration-sensitive prostate cancer (mCSPC). This study evaluated real-world…

View details →DOI: 10.1093/jjco/hyag011
Negative / Null Result Report

Association of second-trimester APRI and FIB-4 scores with intrahepatic cholestasis of pregnancy: a retrospective case–control study

Özceyran C, Sonu NC, Öcal FD et al. · 2026 · Preprint

Abstract Background: To evaluate whether second-trimester aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) scores can predict subsequent development of intrahepatic cholestasis of pregnancy (ICP). Methods:…

View details →DOI: 10.21203/rs.3.rs-9702763/v1
Negative / Null Result ReportMedicine

Effect of postural conditions on pinch strength and manual dexterity in young adults: a cross-sectional study.

Büğüşan Oruç S, Akdağ Mirzaoğlu N, Yakut Y · 2026 · International journal of occupational safety and ergonomics : JOSE

Objectives . This study aimed to investigate pinch strength and manual dexterity in different postures among young adults. Methods . A total of 200 individuals aged 18-45 years participated. Key, tip and palmar pinch strengths were…

View details →DOI: 10.1080/10803548.2026.2679347
Negative / Null Result ReportOpen accessMedicine

A comparative evaluation of ChatGPT and Gemini for stroke caregiver support: accuracy, safety, and response characteristics.

Karaca O, Torlak MS, Tekin AN · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective The use of large language models is increasing in healthcare. The aim of this study was to evaluate and compare the responses provided by ChatGPT (OpenAI) and Gemini (Google) to frequently asked questions about stroke and its…

View details →DOI: 10.1590/1806-9282.20251488
Negative / Null Result ReportMedicine

Comparative evaluation of root dentin thickness following hand and rotary instrumentation of primary molar root canals using cone-beam computed tomography - an invitro study.

Thomas RM, Nayak R, Madi M et al. · 2026 · BMC oral health

Remaining Root Dentin Thickness (RRDT) after root canal instrumentation is an important parameter to be assessed with newer file systems. This study aimed to evaluate the root dentin thickness following instrumentation of primary molar…

View details →DOI: 10.1186/s12903-026-09005-y
Negative / Null Result ReportMedicine

Age-stratified comparison of visual function between eyes with an enhanced monofocal intraocular lens and phakic eyes.

Hayashi K, Yoshida M, Hayashi S et al. · 2026 · Japanese journal of ophthalmology

Purpose To compare visual function between pseudophakic eyes with enhanced monofocal intraocular lenses (IOLs) and phakic eyes with clear lenses among patients in their 50s, 60s, and 70s. Study design Prospective comparative study. Methods…

View details →DOI: 10.1007/s10384-025-01321-0
Negative / Null Result ReportMedicine

Comparative study of prosthesis implantation, latissimus dorsi flap, and combined reconstruction immediately after breast cancer surgery: A retrospective, single-center, observational cohort study.

Zhang Y, Yu W, Shen W · 2026 · Medicine

This study aimed to explore the effects of 3 immediate reconstruction methods - prosthesis implantation, latissimus dorsi flap (LDF), or their combination - on postoperative outcomes following breast cancer (BC) surgery. A retrospective,…

View details →DOI: 10.1097/md.0000000000049090