A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19823 results in Negative / Null Result Report · page 223 of 661
Tateno M, Mizuno K, Date M et al. · 2026 · Preprint
Background: Secondhand exposure to heated tobacco products (HTPs) is increasingly common, but its impact on human milk composition is unclear. We investigated whether secondhand exposure to HTP aerosols affects major human milk components…
Steuber T, Graetz C, Springer C et al. · 2026 · International journal of dental hygiene
Objective This two-centre, double-blind, randomized, parallel-group study compared the efficacy and safety of a novel powered full-mouth cleaning device system (FMCD) with habitual toothbrushing (CG) in patients with generalized gingivitis…
Okazaki T, Imagama T, Matsuki Y et al. · 2026 · The Journal of arthroplasty
Background The use of highly-porous acetabular components in total hip arthroplasty (THA) has gained popularity. To elucidate the clinical and radiological outcomes of three-dimensional (3D)-printing highly porous cups, we compared…
Zullo F, Chen H, Hoffman MK et al. · 2026 · Preprint
Objective: To ascertain if the adverse outcomes differ significantly in individuals without versus with one prior cesarean delivery(CD). Design: Population-based, retrospective cohort. Setting: U.S. Vital-Statistics birth-infant…
Patel AA, Levi JR, Weber PC · 2026 · The Annals of otology, rhinology, and laryngology
Objective While prior literature has demonstrated that patients of lower socioeconomic groups may have larger tumors on presentation and poorer outcomes, there is limited literature on the impact of race and ethnicity on management of…
Heinrich C, Hofstaetter H, Puschkasch-Möck S et al. · 2026 · European journal of applied physiology
Objective To evaluate conventional hamstring-to-quadriceps ratio across the menstrual cycle in distinct angular velocities in an eumenorrheic, physically active population. Design Repeated measures within-subjects design. Methods…
Avsar FN, Erinc O, Sahutoglu T · 2026 · Hemodialysis international. International Symposium on Home Hemodialysis
Introduction Depression is prevalent in maintenance hemodialysis patients and is influenced by the interplay of physical and mental health. Rather than a direct antidepressant effect of dialyzer membrane type, improved clearance of middle…
Pontecorvo AA, Cornejo J, Tsenteradze T et al. · 2026 · Journal of robotic surgery
This study aimed to evaluate and compare perioperative outcomes of robotic versus laparoscopic cholecystectomy in patients with acute cholecystitis within an Acute Care Surgery setting. A retrospective cohort study was conducted including…
Iurchenkov A, Danilova A, Shilo P et al. · 2026 · Cancers
Background : Immune checkpoint inhibitors have significantly improved survival in metastatic melanoma. Combination nivolumab plus ipilimumab demonstrated superior efficacy in randomized trials, including CheckMate 067, but data beyond the…
harada k, ikeda s, makino j · 2026 · Preprint
Abstract Background Prolonged intensive care unit (ICU) stays are associated with increased mortality and functional decline. Time-limited trials (TLTs) support decision-making under prognostic uncertainty; however, uncertainty may persist…
Guan X, Li X, Yue M et al. · 2026 · Scientific reports
Pressure injury (PI) prevention requires sustained nursing behaviors from patients, caregivers, and nurses. This single-center quasi-experimental, non-randomized, non-equivalent control group study enrolled 60 inpatients with PI or high PI…
Chen Z, Wang S, Palus S et al. · 2026 · Journal of cachexia, sarcopenia and muscle
Background Cancer cachexia is associated with rapid body wasting and cardiac dysfunction. Bisoprolol (BIS) and megestrol acetate (MA) improve selected cachexia phenotypes in the Yoshida AH-130 model, but their combined effects are not…
Choi D, Jung CW, Jang JH · 2026 · Preprint
Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a cornerstone of therapy for adult B-cell acute lymphoblastic leukemia (B-ALL), yet simultaneous comparisons across all four major donor categories…
Vlachodimitropoulou E, Dagli SN, Huang GNY et al. · 2026 · Fetal diagnosis and therapy
Introduction Twin-twin transfusion syndrome (TTTS) may complicate triplet pregnancies with a monochorionic component; however, data on foetoscopic laser ablation (FLA) in this setting remain limited. This study evaluated perinatal outcomes…
Kasanmonadi RYN, Kamperman AM, Koch BCP et al. · 2026 · Journal of clinical psychopharmacology
Purpose/background Although combined plasma levels of imipramine and its metabolite desipramine are routinely assessed during therapeutic drug monitoring (TDM) of imipramine treatment, individual plasma levels are often overlooked.…
Altan E, Küçüktağ Z, Arslankoz S et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: Sinonasal inverted papillomas (IPs) and nasal polyps (NPs) represent distinct benign lesions with different biological behaviors. P-glycoprotein (P-gp), a multidrug resistance transporter, has been implicated in inflammatory and…
Kano T, Kawaguchi Y, Nishioka Y et al. · 2026 · Surgery today
PURPOSE: To address our hypothesis that increased surgical costs for robotic liver resection would be compensated by reduced postoperative care expenses, we compared the economic outcomes of robotic, laparoscopic, and open liver resection…
Kaya G, Oskay PÖ, Mert NK et al. · 2026 · BMC infectious diseases
Background Coronavirus disease 2019 (COVID-19), first identified in Wuhan, China, in December 2019, rapidly evolved into a global pandemic with substantial morbidity and mortality. Severe COVID-19 cases, particularly those with pneumonia…
Üstün Y, Yanık S, Uçar F et al. · 2026 · BMC gastroenterology
Background Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic disorders with relapsing and remitting disease courses. Several clinical indicators and biomarkers have been evaluated…
Miyauchi K, Narita T, Morishita S et al. · 2026 · Preprint
Abstract Background Whether initial dose reduction of apalutamide compromises clinical outcomes in patients with androgen pathway modulation–naïve metastatic prostate cancer remains uncertain. In routine practice, reduced dosing is often…
Oloruntoba AI, Rodrigues M · 2026 · Journal of cosmetic dermatology
Background Fractional CO 2 laser is an effective treatment for skin rejuvenation, although pigmentary complications remain a clinical consideration. Newer generation fractional CO 2 laser systems include pulse modes such as HighPulse (HP),…
Çarikçi F, Girgin BA, Harmanci NF et al. · 2026 · Child abuse & neglect
Aim To examine and compare the proficiency of pediatric physicians and nurses in recognizing the signs of and risk factors for child maltreatment, as well as to determine the relationship between this proficiency and their reporting…
Inokuchi T, Hiraoka S, Oshima N et al. · 2026 · Gerontology
Introduction We previously reported the findings of a multicenter retrospective cohort study investigating the efficacy of oral tacrolimus induction therapy in patients with ulcerative colitis (UC). In this subanalysis, we specifically…
Nishino S, Asada Y, Nishino C et al. · 2026 · Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
Background Isolated atrial amyloidosis is characterized by atrial natriuretic peptide- (ANP-) amyloid deposition confined to the atria and has been primarily linked to atrial fibrillation. However, its relationship with atrial mechanical…
Hegde P, Acharya SR, Mayya A et al. · 2026 · International journal of dentistry
Background White spot lesions (WSLs) represent the earliest clinical manifestations of enamel demineralization. Resin infiltration (RI) is a minimally invasive method used to mask WSLs for esthetic improvement; however, infiltrated enamel…
Li H · 2026 · Archives of sexual behavior
Previous research has shown that people tend to associate higher vertical spatial positions with male and lower positions with female. In this study, we document an understudied vertical representation of gender within Azhaliism, a…
Fentahun M · 2026 · Scientific reports
Traditionally fermented beverages are potential sources of industrially relevant microorganisms. Among alternative energy sources, biofuels have gained increasing attention as replacements for fossil fuels. This study aimed to investigate…
Lee J, Hwang HS, Li Y et al. · 2026 · Archives of insect biochemistry and physiology
Nesidiocoris tenuis is an important natural enemy widely used for the biological control of small pests in vegetable crop systems. Its successful implementation in commercial programs depends on reliable and cost-effective mass rearing,…
Park SJ, Kim JY, Yun S et al. · 2026 · Journal of clinical medicine
Background/Objectives : Trauma triggers complex early immune responses. However, the relationship among trauma severity, changes in immune cell survival, and circulating inflammatory mediators remains unclear. This study compared early…
Gülegen HÇ, Temelli G, Ucuz İ et al. · 2026 · Epilepsy & behavior : E&B
Objective Cognitive and behavioral difficulties in pediatric epilepsy extend beyond seizures. Although executive dysfunction is well recognized, Cognitive Disengagement Syndrome (CDS) remains understudied. We examined CDS-related symptoms…