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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 222 of 661

Negative / Null Result ReportMedicine

[Mandibular donor site healing after bone graft harvesting in cleft patients: a comparative study of rotary bur and piezoelectric osteotomy techniques].

Ivanov AL, Reshetnyak EI, Sukacheva SA · 2026 · Stomatologiia

Objective To evaluate mandibular donor site healing after cortical bone graft harvesting in cleft patients, comparing outcomes of osteotomies performed with rotary burs and piezosurgery. Material and methods Fifty-three patients (64 bone…

View details →DOI: 10.17116/stomat202610501137
Negative / Null Result ReportMedicine

Motivational Interviewing and Cognitive Behavioural Therapy in the Auckland Cardiac Rehabilitation Programme: A Propensity Score-Matched Study.

Marshall PW, Benatar JR, O'Halloran P et al. · 2026 · Heart, lung & circulation

Aim Suboptimal enrolment and engagement in cardiac rehabilitation remains a persistent issue worldwide. This study evaluated the impact of a nurse-specialist-delivered motivational interviewing (MI) and cognitive behavioural therapy (CBT)…

View details →DOI: 10.1016/j.hlc.2025.10.006
Negative / Null Result ReportMedicine

Exploring iridotrabecular contact index and related factors in primary angle closure disease: a swept-source anterior segment OCT study.

Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology

Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…

View details →DOI: 10.1136/bjo-2024-326725
Negative / Null Result ReportMedicine

Impact of a Prenatal Nutrition Package with Balanced Energy Supplementation on Gestational Weight Gain in Amhara, Ethiopia.

Kang Y, Workneh F, Yibeltal K et al. · 2026 · The Journal of nutrition

Background Suboptimal gestational weight gain (GWG) is associated with adverse pregnancy outcomes; however, evidence on the impact of nutritional interventions on GWG in low-income settings remains limited. Objectives This study aims to…

View details →DOI: 10.1016/j.tjnut.2026.101653
Negative / Null Result ReportOpen accessMedicine

Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study.

Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open

Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…

View details →DOI: 10.1136/bmjno-2026-001547
Negative / Null Result Report

Addressing Unanswered Questions About the Shift of Strategy Approach: A Multi-Study Investigation of Approach Variations, Repeated Interviews, and Innocent Versus Guilty Responses

Nyström L, Granhag A, Neofotistos E et al. · 2026 · Preprint

Introduction. The Shift-of-Strategy (SoS) approach aims to obtain concealed information from semi-cooperative suspects by prompting them to shift toward more forthcoming counter-interrogation strategies. While previous studies on the…

View details →DOI: 10.31234/osf.io/8uzbn_v2
Negative / Null Result ReportMedicine

IgA nephropathy occurrence, treatment, and prognosis in the last two decades in Denmark.

Ystrøm IK, Jensen SK, Andersen IT et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis IgA nephropathy (IgAN) is the leading cause of primary glomerulonephritis; however, reported incidences and prevalences vary substantially across countries. This study assessed the epidemiology of IgAN including…

View details →DOI: 10.1093/ndt/gfag021
Negative / Null Result ReportMedicine

Intravenous IRON supplementation in Heart Failure with Preserved Ejection Fraction and iron deficiency (IRON-HFpEF): a comprehensive phase II multicentre placebo-controlled randomised clinical trial.

van de Bovenkamp AA, Nassiri S, de Man FS et al. · 2026 · European journal of heart failure

Aims Iron deficiency (ID) is common in patients with heart failure with preserved ejection fraction (HFpEF). The IRON-HFpEF trial aimed to evaluate the mechanistic effects of intravenous iron supplementation on cardiovascular function and…

View details →DOI: 10.1093/ejhf/xuag162
Negative / Null Result ReportMedicine

Evaluation of a structured type 1 diabetes education program for adolescents and parents: Teens Empowered to Actively Manage Type 1 (TEAM T1).

Hagger V, Hendrieckx C, Cotterill A et al. · 2026 · Diabetic medicine : a journal of the British Diabetic Association

Aim To examine changes in psychological and clinical outcomes among adolescents and parents after structured type 1 diabetes education delivered in routine care. Methods Teens Empowered to Actively Manage Type 1 Diabetes (TEAM T1) is a…

View details →DOI: 10.1111/dme.70244
Negative / Null Result ReportMedicine

Prophylactic cavotricuspid isthmus ablation in addition to pulmonary vein isolation is associated with improved recurrence-free survival in patients aged > 70 years with paroxysmal atrial fibrillation.

Li JL, Wu JH, Zhao X et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND: The role of prophylactic cavotricuspid isthmus (CTI) ablation remains controversial in atrial fibrillation (AF) patients without atrial flutter (AFL). Given the strong association between AF, AFL, and age, this study aimed to…

View details →DOI: 10.1007/s10840-026-02305-x
Negative / Null Result ReportOpen accessMedicine

Effect of short-term supplemental oxygen therapy on 6-min walk distance in highlanders at risk for pulmonary hypertension: a randomised, crossover trial.

Hertig D, Furian M, Müller J et al. · 2026 · ERJ open research

Background Little is known about the effects of portable supplemental oxygen therapy (SOT) to improve exercise performance in highlanders at risk for high-altitude pulmonary hypertension (HAPH). We aimed to investigate whether SOT improves…

View details →DOI: 10.1183/23120541.00724-2025
Negative / Null Result ReportMedicine

Effects of propionic acid inclusion and ensiling time on in situ ruminal starch degradability of high-moisture flint corn grain silage.

Martins BM, Vieira RAM, Bittencourt CS et al. · 2025 · Journal of dairy science

This study evaluated the effects of propionic acid inclusion (PAI; 0, 0.25, and 0.50% of fresh matter) and ensiling time (ENT; 30, 60, 90, 120, 150, and 180 d) on the chemical composition, fermentation profile, DM losses, and in situ…

View details →DOI: 10.3168/jds.2025-26841
Negative / Null Result ReportMedicine

Postoperative Radiotherapy May Improve Survival in Certain Patients with pN2 Non-Small Cell Lung Cancer Who Do Not Have Extranodal Extension.

Jeon SH, Song C, Jeon JH et al. · 2026 · Cancer research and treatment

Purpose The aim of this study was to identify subgroups of patients with pathologic N2 (pN2) non-small cell lung cancer (NSCLC) who may benefit from postoperative radiotherapy (PORT). Particular attention was given to evaluating whether…

View details →DOI: 10.4143/crt.2025.644
Negative / Null Result ReportMedicine

Cranial-to-caudal approach in laparoscopic surgery for left-sided colon cancer: Longer specimens and higher lymph node yield.

Goksoy B, Ofluoglu CB, Azamat IF et al. · 2026 · Surgical oncology

Background Medial-to-lateral (ML) approach is the standard technique in laparoscopic surgery for left-sided colon cancer. However, it can be technically challenging; such as in patients with intra-abdominal adhesions or during splenic…

View details →DOI: 10.1016/j.suronc.2026.102354
Negative / Null Result ReportMedicine

Effects of guanidinoacetic acid and methionine supplementation in low-forage diets on ruminal fermentation and performance of feedlot-finished steers

Andriotti NM, Paris W, Maia FJ et al. · 2026 · Animal Feed Science and Technology.

Feed additives that improve energy metabolism efficiency can enhance cattle performance and nitrogen use. This study evaluated the effects of guanidinoacetic acid (GAA) and methionine (MET) supplementation, alone or combined, on…

Negative / Null Result ReportMedicine

Circulating immune cell biomarkers in Psoriatic Arthritis: associations with clinical manifestations and treatment response in the TOFA-PREDICT trial.

Perton FT, Pouw JN, Spierings J et al. · 2026 · Arthritis research & therapy

Background To investigate the associations of circulating immune cell biomarkers with clinical manifestations and treatment response in Psoriatic Arthritis (PsA), and to evaluate whether these biomarkers improve prediction of individual…

View details →DOI: 10.1186/s13075-026-03833-7
Negative / Null Result ReportMedicine

Stigma in functional neurological disorder; a longitudinal study.

Mcloughlin C, Ramsay N, Tak L et al. · 2026 · Journal of psychosomatic research

Background Stigma in Functional Neurological Disorder has been consistently reported by patient organisations as one of their biggest challenges. We aimed to longitudinally evaluate different components of stigma, namely perceived,…

View details →DOI: 10.1016/j.jpsychores.2026.112550
Negative / Null Result ReportMedicine

Effects of Acute Caffeine Supplementation on Integrated Biathlon Performance in Elite Male Athletes.

Engel H, Yilmaz C, Appelhans D et al. · 2026 · International journal of sport nutrition and exercise metabolism

Caffeine enhances endurance performance but may impair shooting accuracy, creating a potential trade-off for overall biathlon performance. In a randomized, placebo-controlled, crossover study, seven elite male biathletes consumed caffeine…

View details →DOI: 10.1123/ijsnem.2025-0138
Negative / Null Result ReportMedicine

Accuracy of thoracolumbar pedicle screw placement using intraoperative CT navigation versus 3D-printed patient-specific guides integrated with virtual surgical planning: a comparative study.

Pairojboriboon S, Charakorn K, Promoppatum P · 2026 · Expert review of medical devices

Background 3D-printed patient-specific pedicle screw guides (3DPSG) may provide accuracy comparable to intraoperative CT navigation (CTNav). Our 3DPSG workflow incorporates a virtual surgical planning (VSP) platform that uses deep-learning…

View details →DOI: 10.1080/17434440.2026.2687808
Negative / Null Result ReportMedicine

Outcome after cardiac surgery in Jehovah's Witnesses.

Karlsson E, Dalén M, Svenarud P et al. · 2026 · Scandinavian cardiovascular journal : SCJ

Objectives Jehovah's Witnesses categorically refuse allogenic blood transfusions on religious grounds, a major challenge if intervention for heart disease is required. We retrospectively analyzed outcome after open-heart surgery in 26…

View details →DOI: 10.1080/14017431.2026.2690764
Negative / Null Result ReportMedicine

Correlation between viral load and cervical squamous lesion severity in single and multiple infections: a large-scale analysis.

Xu T, Zhao J, Wu J et al. · 2026 · Infectious agents and cancer

Objective This study examined the association between high risk human papillomavirus viral load and cervical squamous lesions using the Cobas 4800 assay and evaluated its potential as an indicator for identifying CIN2+, and analyzed the…

View details →DOI: 10.1186/s13027-026-00770-7