A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19823 results in Negative / Null Result Report · page 217 of 661
Isaacs J, Bendale G, Reiter C et al. · 2025 · Journal of reconstructive microsurgery
Polyethylene glycol (PEG) hydrogel is capable of fusing transected axons and restoring axonal continuity. The technique requires precise nerve coaptation alignment and stability, which is difficult to achieve utilizing conventional…
Kar N, Rana SS, Gupta R et al. · 2026 · Pancreas
Background and aims Endoscopic ultrasound (EUS)-guided drainage using a lumen-apposing metal stent (LAMS) has become the standard of care in managing symptomatic walled-off necrosis (WON). However, the role of nasocystic drainage (NCD) in…
Morningstar M, Edwards M, Yang L et al. · 2026 · CJEM
Objectives To systematically identify and describe optimal methodology used to improve the diagnostic accuracy of high-sensitivity cardiac troponin for diagnosis of myocardial infarction in patients with kidney dysfunction. Methods…
Sroypechr K, Hutchinson C, Satheannoppakao W et al. · 2026 · BMC nutrition
Background The folate status of women of reproductive age (WRA) in Thailand is suboptimal for reducing risk of neural tube defects (NTD). This research aimed to compare the effect of dietary folate education based on the health belief…
Thurm C, Keating LH, Raja MU et al. · 2026 · Respiratory medicine
Rationale Although low-dose computed tomography (LDCT) performed for lung cancer screening (LCS) frequently identifies previously unrecognized significant incidental findings (SIFs), the most effective way to report these findings remains…
Hong S, Lee S, Park JS et al. · 2026 · Journal of clinical medicine
Background : We evaluated whether adding S100B to NSE improved discrimination or high-specificity rule-in of poor neurological outcome after out-of-hospital cardiac arrest (OHCA). Methods : In this single-center retrospective cohort study,…
Fesseler L, Patzak A, Heinz V et al. · 2026 · Experimental physiology
High-intensity exercise induces systemic acidosis, which contributes to muscular performance decline. Controlled pre-exercise hyperventilation has been proposed as a non-invasive intervention to induce respiratory alkalosis and counteract…
Leake HB, Wallwork SB, Moseley GL · 2026 · The journal of pain
Pain science education (PSE) aims to shift unhelpful beliefs about pain and improve clinical outcomes. However, some people report little improvement after receiving PSE-informed care. Understanding their perspectives may help refine…
Song BM, Ford CA, Schneider AM et al. · 2026 · The Journal of arthroplasty
Background Inflammatory arthritis (IA) has been considered an absolute indication for patellar resurfacing (PR) in total knee arthroplasty (TKA), yet limited data supports this. The purpose of this study was (1) to compare outcomes of TKA…
Seo S, Lee S, Lee N et al. · 2026 · Preprint
Choice overload occurs when an ever-growing number of options impairs decision quality, because evaluating options taxes cognitive resources. We investigated whether reducing cognitive demand could mitigate overload by encouraging greater…
Sileika E, Cerkauskaite D, Bausys A et al. · 2026 · International journal of colorectal disease
Background The optimal interval between neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) in locally advanced rectal cancer (LARC) remains controversial. This randomized controlled trial evaluated whether prolonging…
Blackman J, Friesen D, Sikkel MB et al. · 2026 · Applied clinical informatics
Objectives The objective of this study is to evaluate whether ChatGPT models can reliably apply the DISCERN instrument, a 16-question human-scored rubric developed in 1999 to evaluate consumer health information, and assess the impact of…
Stewart KM, Sawicki GS, Young AJ et al. · 2026 · Journal of biomechanics
Individuals post-stroke with hemiparetic gait often experience impaired mobility, which can be restored using powered exoskeletons. Specifically, hip exoskeletons can deliver positive work to the leg to help initiate leg swing; however, it…
Norling M, Eriksson N, Westerberg E et al. · 2026 · Muscle & nerve
Introduction/aims Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a…
Amir H, Martini A, Médevielle V et al. · 2026 · Preprint
The rehabilitation of mine-impacted areas through ecological restoration can ensure long-term ecosystem resilience by reestablishing at least part of the original biodiversity. In New Caledonia, large surfaces of mined land need to be…
Orlowska M, Saleh MHA, Decker A et al. · 2026 · Journal of periodontology
Background This randomized controlled trial aims to evaluate alveolar ridge preservation (ARP) with or without a biologically active amnion-chorion membrane (BACM). Methods Thirty patients requiring tooth extraction in the esthetic zone…
Nehme Z, Mahony E, Nehme E et al. · 2026 · Resuscitation
Aim To determine whether defibrillation with manual pressure augmentation (MPA) reduces transthoracic impedance and improves cardioversion and survival from initially shockable out-of-hospital cardiac arrest (OHCA) compared with standard…
Betat A, Santos VD, Oliveira CGA et al. · 2026 · Journal of hypertension
Background Arterial hypertension has been linked to cognitive decline, potentially through cerebrovascular alterations and associations with Alzheimer's disease. A positive correlation between elevated serum cholesterol levels and…
Allende JB, Campos-Bijit V, Morales-Gómez C et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective To synthesize umbrella-level evidence on laser or light activation and photobiomodulation in in-office dental bleaching, including whitening efficacy, tooth sensitivity, and biological safety. Systematic reviews were searched in…
Melamed A, Small K, McCourt C et al. · 2026 · Midwifery
Problem Antenatal risk assessment and classification dominates midwifery care but may not be improving outcomes and may introduce iatrogenic harm. Background Midwifery-led care and birth settings promote good birth outcomes and women's…
Seffen AE, König LM, Dohle S · 2026 · Preprint
An increasing number of individuals aim to reduce their meat consumption, but implementing this is challenging. Self-control strategies could support this change; however, their effectiveness remains understudied. This study examines…
Kiraly P, Lippera M, Ally N et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To assess whether external drainage of subretinal fluid (SRF) improves anatomical or visual outcomes in scleral buckle surgery for rhegmatogenous retinal detachment (RRD). Methods Retrospective review of 609 primary scleral buckles…
Azulay N, Singstad BJ, Schirmer H et al. · 2026 · Scientific reports
In Norway, NORRISK2 is the government-recommended risk model for predicting an individual's 10-year probability of getting cardiovascular disease (CVD). This study aims to investigate the potential for improvement of CVD prediction by…
Furukawa M, Narita M, Sakamoto I et al. · 2026 · Preprint
Abstract Background Six months of adjuvant S-1 is the standard treatment for resected pancreatic cancer in Japan. Metformin has demonstrated potential anticancer effects in preclinical and observational studies. This study aimed to…
Bröer S, Filor V, Bäumer W · 2026 · Journal of veterinary pharmacology and therapeutics
According to the European Association of Establishments for Veterinary Education (EAEVE), a graduate of veterinary medicine should be able to prescribe and dispense "medicines correctly and responsibly in accordance with legislation and…
Jegarl AM, Martin M, Cormier NR et al. · 2026 · Anesthesiology
Background Whether adding a bilateral superficial cervical plexus block to a thyroidectomy enhanced recovery pathway improves postoperative quality of recovery remains uncertain. Methods In a single-center prospective, randomized,…
Jecan A, Melinte RM, Tomoaia G et al. · 2026 · Journal of clinical medicine
Background : Vitamin K2 (menaquinone) has been studied as a molecule with important effects on bone metabolism and has been proposed as a potential adjuvant in fracture healing, particularly under osteoporotic conditions. However, its…
Kılıç HS · 2026 · European journal of dentistry
Objective This article aims to compare the polymerization effectiveness of two curing modes of a polywave LED unit in four conventional resin composites at a 2-mm increment thickness, using bottom/top microhardness ratios as the evaluation…
Chang JJ, Foreman B, Kepplinger D et al. · 2026 · Neurosurgical review
Pressure reactivity index (PRx) is a surrogate for cerebral autoregulation and has been used for prognostication in aneurysmal subarachnoid hemorrhage (SAH). We examined patient-specific temporal courses of PRx and identified time…
Chun SH, Seo S, Cho JH et al. · 2026 · Head & neck
Background The benefit of consolidation programmed cell death protein 1 (PD-1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II-IVB NPC were…