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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19823 results in Negative / Null Result Report · page 216 of 661

Negative / Null Result ReportMedicine

Bovine colostrum as a human milk fortifier for very preterm infants with slow feeding advancement: a randomized controlled trial.

Jiang PP, Huang HY, Zhao L et al. · 2026 · Pediatric research

Background Fortification of human milk for very preterm infants (VPIs) with alternatives to conventional bovine milk-based fortifiers remains minimally studied. This trial tested whether fortification with protein-rich bovine colostrum…

View details →DOI: 10.1038/s41390-026-04768-0
Negative / Null Result ReportMedicine

Safety and outcome of transscleral fine-needle aspiration biopsy in uveal melanoma: 10-year experience in 347 cases.

Bourdin A, Dureau S, Algret N et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose To report safety outcomes of transscleral fine-needle aspiration biopsy (FNAB) followed by irradiation for uveal melanoma (UM) in a tertiary ocular oncology center over 10 years, and assess whether FNAB modified the overall…

View details →DOI: 10.1097/iae.0000000000004906
Negative / Null Result ReportMedicine

Acute effects of an individually timed lower-limb post-activation performance enhancement protocol on 50 m front crawl performance and race kinematics in national-level swimmers.

Stanula A, Strzała M, Sadowski W et al. · 2026 · Scientific reports

Post-activation performance enhancement (PAPE) has been proposed as an acute strategy to improve explosive performance, yet its effects on sprint-swimming performance remain unclear, particularly when individualized recovery timing is…

View details →DOI: 10.1038/s41598-026-51746-x
Negative / Null Result Report

Belgian endive-derived biostimulant activity in Arabidopsis, lettuce and sweet pepper at different developmental stages, environmental conditions, and application methods

Ogunsanya HY, Petit C, Audenaert K et al. · 2026 · Preprint

Belgian endive-derived biostimulant (BEE) was previously shown to enhance root and shoot growth of Arabidopsis thaliana and Plectranthus esculentus in in vitro culturing conditions. In this study, we evaluated the effect of BEE on A.…

View details →DOI: 10.64898/2026.04.15.717650
Negative / Null Result ReportMedicine

<i>Enterobacter</i>-based dietary supplements in both larvae and adult diet affect thermal response of sterile males.

Papadogiorgou G, Koskinioti P, Rodovitis V et al. · 2026 · Bulletin of entomological research

Thermal stress can affect the field performance of sterile males used in the sterile insect technique (SIT). We tested whether adding autoclaved Enterobacter as a dietary supplement improves thermal tolerance in sterile Vienna 8 genetic…

View details →DOI: 10.1017/s0007485326101035
Negative / Null Result ReportOpen accessMedicine

Multiple Arterial Grafting in Hemodialysis Patients.

Hachiro K, Takashima N, Kamiya K et al. · 2026 · Circulation reports

Background The effectiveness of multiple arterial grafting (MAG) for hemodialysis (HD) patients is unclear. Methods and results We retrospectively analyzed 149 HD patients who underwent either MAG (n=97) or single arterial grafting (SAG)…

View details →DOI: 10.1253/circrep.cr-25-0302
Negative / Null Result ReportMedicine

Evaluation of postoperative analgesia with perioperative electroacupuncture in clinical dog patients undergoing surgery for cranial cruciate ligament rupture (Tibial Tuberosity Advancement).

Lienert M, Stadler L, Kipfer N et al. · 2026 · Veterinary journal (London, England : 1997)

Objectives To investigate the effect of electroacupuncture on postoperative analgesia in dogs undergoing Tibial Tuberosity Advancement surgery. We hypothesise that acupuncture will reduce pain scores and the need for rescue analgesia…

View details →DOI: 10.1016/j.tvjl.2026.106712
Negative / Null Result ReportMedicine

Correcting photoreceptor diseases at their source: CRISPR strategies for cone-rod dystrophy and achromatopsia.

Zaki HF, Bishri J, Abdul Muqtadir M et al. · 2026 · Experimental eye research

Background Cone-rod dystrophy (CORD) and achromatopsia (ACHM) are inherited retinal dystrophies for which conventional adeno-associated virus (AAV) gene augmentation has important limitations, particularly in autosomal-dominant…

View details →DOI: 10.1016/j.exer.2026.111119
Negative / Null Result ReportMedicine

Responsiveness and Minimal Important Change of the Haemophilia Activities List in Patients With Inherited Bleeding Disorders.

Blokzijl J, Kuijlaars IAR, Pisters MF et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia

Introduction The Haemophilia Activities List (HAL) is a disease-specific patient-reported outcome measure (PROM) that is widely used in both healthcare and research in people with inherited bleeding disorders (PWBD), but information on…

View details →DOI: 10.1111/hae.70327
Negative / Null Result ReportMedicine

Effect of Piperine Codelivery on the Oral Bioavailability of Cannabidiol: Insights from <i>In Vitro</i> Digestion and <i>In Vivo</i> Pharmacokinetics.

Vardanega R, Lüdtke FL, Loureiro L et al. · 2026 · Journal of agricultural and food chemistry

This study investigated whether coencapsulation of cannabidiol (CBD) and piperine (PIP) in food-grade nanostructured lipid carriers (NLCs) enhances the CBD oral bioavailability. NLCs containing long-chain fatty acids were formulated with…

View details →DOI: 10.1021/acs.jafc.6c02678
Negative / Null Result Report

Health System and Socioeconomic Determinants of Delayed Initiation of Breastfeeding Among Cesarean Deliveries in Kenya: Analysis of the 2022 Kenya Demographic and Health Survey

Wanjiku C · 2026 · Preprint

Abstract Background Timely initiation of breastfeeding within one hour of birth reduces neonatal mortality and supports optimal child development. Women who deliver by cesarean section (CS) face disproportionate barriers to early…

View details →DOI: 10.21203/rs.3.rs-9186315/v1
Negative / Null Result ReportMedicine

Impact of continuous serratus plane analgesia on quality of recovery after video-assisted thoracic surgery: a prospective double-blind, randomized, placebo-controlled trial.

Biswas A, Zidan H, Kolodzey L et al. · 2026 · Regional anesthesia and pain medicine

Background Video-assisted thoracoscopic surgery (VATS) offers numerous advantages over open surgery; nevertheless, it remains associated with significant postoperative pain. Multiple regional anesthesia techniques have been explored, and…

View details →DOI: 10.1136/rapm-2026-107618
Negative / Null Result ReportMedicine

Adjuvant Radiotherapy and Survival in Parotid Gland Adenoid Cystic Carcinoma: A National Cancer Database Analysis.

Kominsky E, Ansari M, Moore M et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Objective To determine the association of positive margins and adjuvant radiotherapy on overall survival in parotid gland adenoid cystic carcinoma. Study design Retrospective cohort analysis. Setting National Cancer Database from 2004 to…

View details →DOI: 10.1002/ohn.70264
Negative / Null Result ReportMedicine

Does Sequential Use of Multiple Chatbots Influence Emergency Guidance for Dental Avulsion?

Buldur M, Sezer B · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background/aim Artificial intelligence-based chatbot systems are increasingly used for dental emergency guidance, yet the clinical value of sequential consultation remains unclear. This study investigated whether response order influences…

View details →DOI: 10.1111/edt.70072
Negative / Null Result ReportMedicine

A Randomized Controlled Trial of Ultrasound-Assisted versus Traditional Landmark Lumbar Puncture in the Neonatal and Infant Population.

Ekhaguere OA, Kesman R, Reiter J et al. · 2026 · The Journal of pediatrics

Objective To evaluate whether static ultrasound improves first-attempt, nontraumatic lumbar puncture (LP) success compared with the traditional landmark technique in infants admitted to a neonatal intensive care unit (NICU). Study design…

View details →DOI: 10.1016/j.jpeds.2026.115139
Negative / Null Result ReportMedicine

Feasibility of the Mindfulness Self-Compassionate Care program: a randomized controlled trial to address dementia caregiver stress.

Vranceanu AM, Szapary C, Crean M et al. · 2026 · The Gerontologist

Background and objectives We tested the feasibility and preliminary effects of the Mindfulness Self-Compassionate Care (MASC) program for dementia caregivers' stress triggered by the care recipients' neuropsychiatric symptoms. Research…

View details →DOI: 10.1093/geront/gnag111
Negative / Null Result ReportMedicine

Mortality Risk Prediction from Dense PICU Data from Patients with Suspected Infection: Data-Derived Physiological Trajectories Outperform Expert Assessments When Temporal Resolution Is High.

Velez T, Badaki-Makun O, Hirsch D et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objective Early identification of mortality risk in critically ill children with suspected infection remains challenging. Whether severity scores (SIRS, pSOFA, Phoenix) add incremental value beyond data-derived physiologic features in…

View details →DOI: 10.1016/j.ijid.2026.108899
Negative / Null Result ReportMedicine

Is There an Added Value of Dual-Time-Point [<sup>68</sup>Ga]Ga-Fibroblast Activation Protein Inhibitor (FAPI) PET/CT in Differentiating Malignant and Benign Uptake Findings?

Al-Ibraheem A, Moghrabi S, Alsyouf B et al. · 2026 · Cancers

Background : [ 68 Ga]Ga-FAPI PET/CT demonstrates high sensitivity for tumor detection but limited specificity because benign fibro-inflammatory conditions may also show tracer uptake. Dual-time-point imaging has been proposed to improve…

View details →DOI: 10.3390/cancers18121963
Negative / Null Result ReportMedicine

Beyond microprocessor knees: exploring the potential of fully powered prosthetic legs.

Embry KR, Jayaraman C, Yang C et al. · 2026 · Journal of neuroengineering and rehabilitation

Background Powered knee and ankle prostheses generate mechanical energy to replicate biological leg function, yet direct comparisons with more commonly prescribed microprocessor-controlled knee prostheses are limited by methodological…

View details →DOI: 10.1186/s12984-026-02042-2
Negative / Null Result ReportMedicine

High-dose metoclopramide versus placebo for gastroduodenal visualization during endoscopy in patients with acute upper gastrointestinal bleeding. A triple-blind, randomized clinical trial.

Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)

Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…

View details →DOI: 10.1016/j.rgmxen.2026.05.005
Negative / Null Result ReportMedicine

Striatal DAT-SPECT texture beyond mean binding in major depressive disorder.

Tamura T, Abe S, Matsui H et al. · 2026 · Journal of affective disorders

Background Dopaminergic dysfunction has been implicated in major depressive disorder (MDD), but dopamine transporter (DAT) imaging studies using conventional mean binding have yielded inconsistent findings. One possible contributor is that…

View details →DOI: 10.1016/j.jad.2026.122099
Negative / Null Result ReportMedicine

Platelet-rich plasma versus plasma gel for fat graft survival under cigarette smoke exposure: An experimental study.

Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…

View details →DOI: 10.1016/j.bjps.2026.05.060
Negative / Null Result ReportMedicine

Clinical Features Outperform MRI Radiomics for Predicting Intra-Articular Hyaluronic Acid Response in Knee Osteoarthritis.

Alkhatatbeh T, Alkhatatbeh A, Liao Y et al. · 2026 · Annals of the New York Academy of Sciences

Intra-articular hyaluronic acid (IAHA) injections are used for knee osteoarthritis, but clinical response is highly variable. This study evaluated whether quantitative magnetic resonance imaging (MRI) radiomics provides incremental…

View details →DOI: 10.1111/nyas.70288
Negative / Null Result ReportMedicine

Survival Trends of People With Spina Bifida From 1950-2020.

Schlaepfer CH, Lange SM, Lau GA et al. · 2026 · JAMA pediatrics

Importance People with spina bifida historically have worse survival. Despite health care improvements, survival improvement data are mixed. Objectives To compare survival for people with spina bifida to an unaffected cohort and to…

View details →DOI: 10.1001/jamapediatrics.2026.2241