A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19821 results in Negative / Null Result Report · page 206 of 661
Saeed, Jalal · 2026 · Pulmonary medicine
The COVID-19 pandemic, caused by SARS-CoV-2, has led to significant global mortality and morbidity. Angiotensin-converting Enzyme 2 (ACE2) has been identified as the primary receptor for viral entry into host cells and is believed to play…
Mohammed, Naser, Abozaid · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Composite resin placement technique may influence marginal integrity, polymerization stress distribution, and long-term clinical performance of posterior restorations. This randomized controlled clinical trial evaluated the 24-month…
Niu, Bao, Zhao · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
This study aimed to systematically evaluate the efficacy and safety of different doses of domperidone (DOM) combined with esomeprazole (ESM) in the treatment of reflux esophagitis, providing a basis for precise clinical medication. This…
Shi, Yuan, Gao et al. · 2026 · Journal of neuroengineering and rehabilitation
Transcranial magnetic stimulation (TMS), as a non-invasive neurostimulation technique, modulates neural activity by applying electromagnetic fields to specific areas of the brain. It is clinically used for several approved indications,…
Yakıt Yeşilyurt, Birinci Olgun, Dağ et al. · 2026 · BMC women's health
Breathing exercises may modulate dysmenorrhea by enhancing relaxation and eliciting analgesic effects. This study investigated the effects of Pelvic Floor Muscle Training (PFMT) with or without Dynamic Neuromuscular Stabilization…
Chen, Song, Zang et al. · 2026 · BMC anesthesiology
Right lateral thoracotomy cardiac surgery induces postoperative atelectasis due to cardiopulmonary bypass (CPB), patient positioning, and mechanical ventilation. Fixed positive end-expiratory pressure (PEEP) may fail to meet pediatric…
Yıldız, Çalış, Dokuz et al. · 2026 · Psychiatry research
This study examined differences in choroidal structural parameters, including the choroidal vascularity index, among patients with schizophrenia, bipolar disorder, and healthy controls. This cross-sectional study included 40 patients with…
Chen, Yi, Cao et al. · 2026 · Neurology
The efficacy of endovascular treatment for acute large vessel occlusion strokes has been demonstrated, but whether it can improve functional outcomes in patients with acute ischemic stroke (AIS) who only present with severe large vessel…
Bejarano, Hull, Young et al. · 2026 · PloS one
We exploit state-level policy changes for physical therapy direct access to estimate the effect of enacting direct access physical therapy policy on per-capita opioid pill volume (PCPV) and opioid-related deaths (ORD) compared to states…
Wonglhow, Wetwittayakhlang, Sunpaweravong et al. · 2026 · Cancer management and research
Ampullary adenocarcinoma is a rare malignancy with limited evidence on the efficacy of systemic chemotherapy for advanced disease. This study aimed to evaluate the treatment outcomes of gemcitabine- and fluoropyrimidine-based regimens and…
Acar, Özdemir, Yalinay Dikmen · 2026 · Frontiers in neurology
Emerging evidence suggests that circadian rhythms may influence migraine pathophysiology through interactions between sleep-wake regulation and pain modulation pathways. This study aimed to investigate the association between chronotype…
Yanaoka, Tyler, Hasegawa · 2026 · Frontiers in physiology
This study investigated the effect of body mass (BM) on the efficacy of mixed-method cooling (ice slurry ingestion + cooling vest) applied between exercise bouts. Sixteen males completed two experimental trials in the heat (35°C, 50%…
Hogmark, Westermark, Envall et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Intrauterine devices (IUDs) effectively prevent unwanted pregnancies. Little is known about long-term outcomes of women choosing an IUD after second-trimester medical abortion. We performed a 12-month follow-up of a multicenter randomized…
Zhou, Bian, Yang et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery
The micropapillary pattern is a high-risk factor for postoperative recurrence in lung adenocarcinoma (LUAD), but the role of adjuvant chemotherapy (ACT) in stage IA LUAD with micropapillary pattern (LUADmp) after resection remains unclear.…
Kerr, Walker, Hinton et al. · 2026 · The American surgeon
BackgroundBarrier-coated meshes were developed to minimize adhesion formation between the PM and adjacent viscera. However, prior data has shown an increased infectious risk associated with rapidly absorbable coated PM vs uncoated PM in…
Rao, Bayliss, Wagnild et al. · 2026 · Journal of cardiothoracic surgery
Mitral valve repair (MVr) promotes left ventricular (LV) reverse remodelling, and subsequent reduction in LV diameters and volumes. The effectiveness of different MVr techniques, Resect (leaflet resection) and Respect (leaflet…
Kargar, Zareian, Rafiei et al. · 2026 · Journal of bodywork and movement therapies
Constipation is one of the most prevalent gastrointestinal issues faced by diabetic patients. An emerging therapeutic approach for addressing gastrointestinal disorders is visceral manipulation (VM). In this clinical trial, we evaluated…
Grain, Ozsancak, Bonnal et al. · 2026 · The European journal of neuroscience
The aim of this study was to examine the effects of four attentional walking conditions on dorsolateral prefrontal cortex (DLPFC) activation, an approach that has not previously been investigated. We hypothesized that DLPFC activation and…
Chesly, Patrick, Bedrich et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
To evaluate the diagnostic performance of the Sysmex XN-31 haematology analyser for malaria detection in a sentinel site. A prospective diagnostic assessment study was conducted among febrile children under 15 years of age, attending a…
Çınar, Uysal, Gürbüz et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
This study aimed to investigate morphological features on magnetic resonance cholangiopancreatography (MRCP) that may help distinguish benign from malignant causes of isolated main pancreatic duct (MPD) dilation detected without a visible…
Li, Hu, Sun et al. · 2026 · The Journal of organic chemistry
Boron neutron capture therapy (BNCT) is a promising radiotherapeutic strategy for cancer treatment that selectively eradicates tumor cells while minimizing damage to surrounding healthy cells. 4-Borono-2-[ 18 F]fluoro-l-phenylalanine ([ 18…
Tang, Mi, Xue et al. · 2026 · Annals of medicine
The impact of prior SARS-CoV-2 infection on the clinical course of recurrent pulmonary tuberculosis (TB) remains poorly defined. This study aimed to compare clinical features, radiographic evolution, and outcomes in recurrent TB patients…
Wang, Guo · 2026 · The Journal of craniofacial surgery
To investigate the growth and developmental characteristics of the temporomandibular joint (TMJ) in adolescents with facial asymmetry and its relationship with mandibular morphological changes. A total of 20 patients aged 8 to 20 years…
Stewart, Yeo · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)
To compare the refractive prediction accuracy of two modern toric intraocular lens power formulas, using predicted or measured posterior corneal astigmatism, in eyes with a history of previous myopic laser vision correction (LVC). This…
Boben, Vangala, Maraka et al. · 2026 · Cureus
Introduction Accurate assessment of interarch tooth-size relationships is essential for orthodontic diagnosis, space analysis, and treatment planning. Bolton's analysis and regression-based methods such as Tonn's and Abhi's formulas are…
Zhang, Chen, Chen et al. · 2026 · Chinese medical journal
This is a multicenter, randomized, double-blind, placebo-controlled interventional clinical study to evaluate the efficacy and safety of pronase in improving visibility in colonoscopy and to evaluate whether pronase can increase the…
Liu, Liu, Zhang et al. · 2026 · Journal of cardiothoracic surgery
To observe the effect of hemoadsorption, an emerging therapy potentially valuable in blood purification, inflammation inhibition and toxic removal, to patients with Stanford Type A Aortic Dissection. The clinical data of 100 patients with…
Liu, Lv, Li et al. · 2026 · BMC oral health
Clear aligner fit accuracy significantly influences treatment efficacy. Micro-computed tomography (micro-CT) enables precise three-dimensional quantification of aligner-tooth adaptation, but manual measurement is time-intensive and…
Kotanlı, Yılmaz, Dogan · 2026 · BMC oral health
The aim of this retrospective study is to evaluate the volumetric and histogram-based characteristics of the parotid and submandibular salivary glands in patients with hypertension compared with healthy controls. Magnetic Resonance images…
Yan, Zhang, Sha et al. · 2026 · BMC cardiovascular disorders
The single transradial guiding catheter (STGC) technique has emerged as a promising approach to minimize catheter exchanges and optimize reperfusion timelines in ST-elevation myocardial infarction (STEMI) patients undergoing primary…