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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 205 of 675

Negative / Null Result ReportMedicine

Differences in time to treatment and impact on overall survival in adolescents and young adults with Hodgkin lymphoma.

Cruz CA, Rodriguez ER, Thawani M et al. · 2025 · Leukemia & lymphoma

Delays in time to treatment (TTT) have been shown to affect cancer survival, yet this has not been investigated in adolescent and young adult (AYA) Hodgkin lymphoma (HL) patients. This retrospective analysis included 508 patients with TTT…

View details →DOI: 10.1080/10428194.2025.2499607
Negative / Null Result ReportMedicine

Lack of Association of Pediatric Surgical Patient Outcomes With Increased Disposable Operating Room Supply Costs.

Acker SN, Prendergast C, Inge TH et al. · 2024 · Journal of pediatric surgery

Introduction There is wide variation in the cost of disposable operating room supplies between surgeons performing the same operation at the same institution. The general relationship between variation in disposable supply cost and patient…

View details →DOI: 10.1016/j.jpedsurg.2024.03.046
Negative / Null Result ReportOpen accessMedicine

Assessment of the Association Between Whole Blood Viscosity and Coronary Artery Calcium Score.

Duyuler S, Türker Duyuler P, Kalaycı S et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Whole Blood Viscosity (WBV), estimated using the De Simone formula, is a key hemodynamic parameter linked to endothelial dysfunction and atherosclerosis. Its association with significant coronary calcification,…

View details →DOI: 10.3390/medicina62010169
Negative / Null Result ReportMedicine

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

Cinkilli Aktağ E, Yalçin SS, Yіrün A et al. · 2025 · International journal of environmental health research

Bisphenol A (BPA) has negative impact on human health. This study aims to explore the association between the levels of BPA and 25(OH) vitamin D in breastmilk. BPA exposure and vitamin D sources were recorded on the study form. Breastmilk…

View details →DOI: 10.1080/09603123.2024.2412118
Negative / Null Result ReportOpen accessMedicine

Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study.

Emilsson ÖI, Malinovschi A, Johnsson Å et al. · 2025 · Thorax

Background Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known. Aim Investigate the association between nGER and pulmonary abnormalities on…

View details →DOI: 10.1136/thorax-2024-222570
Negative / Null Result ReportOpen accessMedicine

Association between neutrophil extracellular traps, the Von Willebrand factor axis, and clinical outcome in stable coronary artery disease.

Bratseth V, Kindberg KM, Warlo EMK et al. · 2026 · Frontiers in cardiovascular medicine

Introduction Coronary artery disease (CAD) is the clinical manifestation of atherosclerosis, an inflammatory disorder of the coronary arteries, characterized by endothelial dysfunction, lipid accumulation, immune activation, and formation…

View details →DOI: 10.3389/fcvm.2026.1759117
Negative / Null Result ReportMedicine

Ultrafine particles and black carbon concentrations and determinants in aircraft cabins of a French airline: Paris-aircraft study.

Laporte MC, Mullot JU, Hlal R et al. · 2025 · Environment international

People are spending increasing amounts of time on airplanes. Nevertheless, few studies have characterized the concentrations of ultrafine particles (UFP) and black carbon (BC) in aircraft cabins, which are particulate pollutants known to…

View details →DOI: 10.1016/j.envint.2025.109905
Negative / Null Result ReportMedicine

Chymotrypsin B2 (CTRB2) Deletion Variant Induces Endoplasmic Reticulum Stress but does not Increase Risk for Chronic Pancreatitis.

Demcsák A, Hegyi E, Hegyi P et al. · 2025 · Pancreas

Objectives CTRB2-del, a commonly occurring loss-of-function deletion variant in the CTRB2 gene encoding chymotrypsinogen B2 was shown to induce endoplasmic reticulum (ER) stress and increase risk for pancreatic cancer but not for chronic…

View details →DOI: 10.1097/mpa.0000000000002538
Negative / Null Result ReportMedicine

The Relationships Between Cochlear Nerve Health and AzBio Sentence Scores in Quiet and Noise in Postlingually Deafened Adult Cochlear Implant Users.

Gao Z, Yuan Y, Oleson JJ et al. · 2026 · Ear and hearing

Objectives This study investigated the relationships between the cochlear nerve (CN) health and sentence-level speech perception outcomes measured in quiet and noise in postlingually deafened adult cochlear implant (CI) users. Design Study…

View details →DOI: 10.1097/aud.0000000000001779
Negative / Null Result ReportMedicine

The association between body mass index and treatment outcomes in major depressive disorder: a CAN-BIND-1 study.

Kim HK, Jones BDM, Hahn MK et al. · 2026 · Journal of psychiatric research

Being overweight is commonly observed in patients with major depressive disorder (MDD). However, the relationship between body weight and treatment outcomes in MDD is less clear. In this context, we examined the association between BMI and…

View details →DOI: 10.1016/j.jpsychires.2026.03.036
Negative / Null Result ReportMedicine

Beyond appearance: Cultural and psychometric validation of the Thai broad conceptualization of beauty scale using bifactor ESEM.

Jinchang K, Jarunratanakul P · 2025 · Body image

Expanding conceptualizations of beauty can promote positive body image and reduce appearance-related concerns. In collectivist cultures, beauty is often perceived through both appearance and inner or social qualities. This study examined…

View details →DOI: 10.1016/j.bodyim.2025.101964
Negative / Null Result ReportMedicine

Lack of association between chronological age and fisher group and poor outcomes in older patients with severe-grade aneurysmal subarachnoid hemorrhage: a nationwide registry study in Japan.

Suzuki K, Sato H, Sorimachi T et al. · 2025 · Neurosurgical review

Older age and Fisher group scores predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, among aging societies, treatment indications and decisions in older patients with severe-grade aSAH (World…

View details →DOI: 10.1007/s10143-025-03638-3
Negative / Null Result ReportMedicine

Gestational weight gain and postpartum depressive symptoms in high-income women with low and late fertility.

Zanardo V, Polver S, Zanardo B et al. · 2025 · European journal of obstetrics, gynecology, and reproductive biology

Objective This study aimed to investigate the relationship between GWG and postpartum depressive symptoms among high income women with 'low and late fertility', combined into a single category. Methods We examined the impact of low and…

View details →DOI: 10.1016/j.ejogrb.2025.114746
Negative / Null Result ReportMedicine

The Value of Anti-Drug Antibody Detection in Discriminating Patients from Healthy Controls and Predicting the Gross Motor Functional State in Patients with Pompe Disease.

Aziz-Ahari S, Aminian M, Rahimian A et al. · 2026 · Iranian journal of allergy, asthma, and immunology

Anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection…

View details →DOI: 10.18502/ijaai.v25i2.20800
Negative / Null Result ReportMedicine

Early Markers of Systemic Inflammation are not Related to Pain Burden After Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Study.

Kardon A, Ren H, Gerard E et al. · 2026 · Neurocritical care

Background Headache is nearly ubiquitous in the immediate aftermath of nontraumatic, aneurysmal pattern subarachnoid hemorrhage (SAH); however, pain experiences vary significantly throughout the intensive care unit (ICU) course across…

View details →DOI: 10.1007/s12028-025-02396-w
Negative / Null Result ReportOpen accessMedicine

Radiolucent lines after robotic-assisted surface-matching kinematically aligned UKA: short-term incidence and lack of association with tibial alignment.

Itou J, Kuwasawa A, Nihei K et al. · 2026 · Archives of orthopaedic and trauma surgery

Purpose This study investigated the clinical outcomes of robotic-assisted unicompartmental knee arthroplasty (UKA) performed using a surface-matching kinematic technique that restores native joint morphology without alignment constraints.…

View details →DOI: 10.1007/s00402-026-06335-y
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Middle Cerebral Artery Diastolic Deceleration Area and Gestational Diabetes Mellitus: A Prospective Case-Control Study.

Emiralioglu Cakır Z, Ankara Aktaş H, Gercik Arzık I et al. · 2026 · Medicina (Kaunas, Lithuania)

Backgroud and Objectives : To evaluate conventional Doppler indices and the novel middle cerebral artery (MCA) diastolic deceleration area (DDA) in pregnancies complicated by gestational diabetes mellitus (GDM), and to explore their…

View details →DOI: 10.3390/medicina62050957
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between COL1A1 rs1800012 Polymorphism and Anterior Open Bite Malocclusion in a Turkish Case-Control Cohort.

Polat T, Yılmaz ÖÖ, Önem Özbilen E et al. · 2025 · Genes

Background/objectives Anterior open bite is a multifact orial malocclusion influenced by genetic and environmental factors. Variants in the Collagen type I, alpha 1 ( COL1A1 ) gene, particularly rs1800012, have been implicated in bone…

View details →DOI: 10.3390/genes16101122
Negative / Null Result ReportMedicine

Lack of Association of Emotional Distress With Insulin Initiation in the GRADE Randomized Diabetes Comparative Effectiveness Trial.

Presley CA, Butera NM, Krause-Steinrauf H et al. · 2025 · The science of diabetes self-management and care

PurposeThe purpose of this study is to evaluate whether higher emotional distress (depressive symptoms or diabetes distress) was associated with a lower likelihood of basal or rapid-acting insulin initiation among participants enrolled in…

View details →DOI: 10.1177/26350106251361363
Negative / Null Result ReportMedicine

Habitual Worry, Cognitive Control, and Heart Rate Variability in Adult ADHD.

Längle A, Reyes Del Paso GA, Ettinger U et al. · 2025 · Psychophysiology

Adult attention-deficit/hyperactivity disorder (ADHD) is associated with substantial impairments in well-being and quality of life. In addition to cognitive and behavioral symptoms, emotional dysregulation characterizes the disorder. This…

View details →DOI: 10.1111/psyp.70110
Negative / Null Result ReportMedicine

Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study.

Houghton JSM, Black I, Meffen A et al. · 2026 · Annals of vascular surgery

Background The wound, ischemia and foot infection (WIfI) classification system has been widely adopted in chronic limb-threatening ischemia (CLTI) management. Primary aim was to prospectively investigate the association of WIfI stage with…

View details →DOI: 10.1016/j.avsg.2025.11.008
Negative / Null Result ReportMedicine

Epigenetic alterations of serotonergic but not dopaminergic signalling in compulsive sexual behaviour disorder.

Androvičová R, Jahn K, Engel J et al. · 2026 · Behavioural brain research

Rationale The compulsive sexual behaviour disorder (CSBD) is a recent addition to the ICD-11 diagnostic manual under the chapter of impulse control disorders. Though there is a wealth of different theoretical viewpoints regarding the…

View details →DOI: 10.1016/j.bbr.2025.115872
Negative / Null Result ReportMedicine

The Characteristics of Peripheral Blood Lymphocyte Subsets in HIV-related Diffuse Large B-cell Lymphoma Patients and Their Impact on Treatment Efficacy.

Xiang H, Lin C, Chen S et al. · 2025 · Current HIV research

Introduction Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression…

View details →DOI: 10.2174/011570162x369231250818043532