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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 205 of 661

Negative / Null Result ReportMedicine

Diverging paths: Modeling the relation between adverse effects, attitudes, perceived adherence, and treatment effect in an internet-based cognitive-behavioral intervention for obsessive-compulsive disorder.

Baumeister A, Schuurmans L, Schultz J et al. · 2025 · Behaviour research and therapy

Background and aim The efficacy of internet-based interventions (IBI) for various psychiatric disorders is widely established, but little is known about the mechanisms or possible influencing factors. One of the most prominent problems in…

View details →DOI: 10.1016/j.brat.2024.104673
Negative / Null Result ReportMedicine

Efficacy of Molding Helmet Therapy following Suturectomy for Craniosynostosis: A Single-center, Retrospective Analysis in Japan.

Kurimoto M, Nawashiro T, Nagakura M et al. · 2025 · The Journal of craniofacial surgery

Craniosynostosis limits normal cranial growth, significantly affecting the growth and development of children. This increase in intracranial pressure results in significant cosmetic and functional losses. This study investigated the…

View details →DOI: 10.1097/scs.0000000000010799
Negative / Null Result ReportOpen accessMedicine

A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus.

Mao J, Gan Y, Tan X et al. · 2025 · International journal of women's health

Objective High basophil count levels are associated with an increased risk of gestational diabetes mellitus (GDM). We used two-sample Mendelian randomisation (MR) to explore a potential causal relationship. It also aims to offer genetic…

View details →DOI: 10.2147/ijwh.s500632
Negative / Null Result ReportOpen accessMedicine

Reassessment of the Collaborative Normal-Tension Glaucoma Study: Statistical Evidence and Implications for Current Management.

Killer HE, Pircher A, Stekhoven DJ · 2026 · Ophthalmology and therapy

Introduction The Collaborative Normal-Tension Glaucoma Study (CNTGS) is frequently cited as evidence that a 30% reduction in intraocular pressure (IOP) slows progression in normal-tension glaucoma (NTG). This study re-examines the…

View details →DOI: 10.1007/s40123-025-01300-1
Negative / Null Result ReportMedicine

Developing Solutions to the Waitlist Problem for Eating Disorder Treatments.

Wade TD, Jabs M, Keegan E et al. · 2024 · The International journal of eating disorders

Objective We examine the small amount of research to date that describes and/or evaluates waitlist interventions as a precursor to treatment for an eating disorder (ED) with the intent to provide recommendations for future research that…

View details →DOI: 10.1002/eat.24310
Negative / Null Result ReportOpen accessMedicine

Are KLIC and CRIME-80 scores useful to assist decision-making initially or at the moment of repeat DAIR? - a retrospective study.

Contente J, Ferreira C, Silva M et al. · 2025 · Journal of bone and joint infection

Introduction : Debridement, antibiotics, and implant retention (DAIR) is recommended for early acute postoperative and late acute periprosthetic joint infections (PJIs). The KLIC and CRIME-80 scores have been proposed to predict DAIR…

View details →DOI: 10.5194/jbji-10-403-2025
Negative / Null Result ReportMedicine

Elevational pattern of species range size of vascular plants in Changbai Mountain, China:A test of Rapo-port's rule.

Li MS, Wu XQ, Zhou YJ et al. · 2024 · Ying yong sheng tai xue bao = The journal of applied ecology

Species range size is closely related to its ability to migrate and adapt to environmental change. Rapoport's rule predicts that species range size would become larger with increasing latitude or elevation. Empirical evidence for…

View details →DOI: 10.13287/j.1001-9332.202412.001
Negative / Null Result ReportMedicine

Self-Reported Inner Speech Reflects Improvement From Language Therapy.

Stark BC, Alexander JM, Stockrahm E et al. · 2026 · American journal of speech-language pathology

Purpose This study examined the role of inner speech-defined here as the subjective experience of covert lexical access-in naming recovery following semantic feature analysis (SFA) treatment in individuals with aphasia. Specifically, it…

View details →DOI: 10.1044/2026_ajslp-25-00363
Negative / Null Result ReportMedicine

Focus on renal morphology, chronic kidney disease, and urinary system malignancies in acromegaly: report on data collected over a 40-year period.

Ercan P, Firlatan Yazgan B, Sendur SN et al. · 2026 · Pituitary

Purpose Long-term renal consequences of acromegaly remain poorly characterized. We assessed prevalence and independent predictors of renal cysts, chronic kidney disease (CKD), and the frequency of urinary-system malignancies, in a large…

View details →DOI: 10.1007/s11102-026-01712-7
Negative / Null Result ReportMedicine

Rapid diagnosis and therapeutic mitigation in inflammatory bowel disease: utilizing the window of opportunity-findings from the UAE Epi-IBD study.

Swaid TK, Hamzeh LR, Bukasa LL et al. · 2026 · Intestinal research

Background/aims To determine time to diagnosis (TTD) and its impact on surgery and advanced therapy (AT) burden in inflammatory bowel disease (IBD) in a multi-ethnic United Arab Emirates (UAE) cohort, a region in the acceleration phase of…

View details →DOI: 10.5217/ir.2026.00032
Negative / Null Result ReportOpen accessMedicine

Psoas muscle variables and adjuvant chemotherapy-related and survival outcomes following pancreaticoduodenectomy for periampullary malignancy.

Hajibandeh S, Hajibandeh S, Mckittrick H et al. · 2026 · World journal of gastrointestinal surgery

Background Early skeletal muscle wasting has been demonstrated to be associated with chemotherapy-related toxicity in patients with cancer. Hounsfield unit average calculation (HUAC) or psoas muscle index (PMI) can be used to diagnose…

View details →DOI: 10.4240/wjgs.v18.i2.114743
Negative / Null Result ReportMedicine

Variation in song structure does not predict associative learning performance in zebra finches (Taeniopygia castanotis) raised under controlled cultural conditions.

Derégnaucourt S, Le Maguer L, Geberzahn N · 2026 · Animal cognition

Vocal learning in songbirds requires the integration of auditory perception, sensorimotor learning, and performance monitoring, yet its relationship to general cognitive abilities remains unclear. We tested whether interindividual…

View details →DOI: 10.1007/s10071-026-02077-x
Negative / Null Result ReportMedicine

Predictors and Outcomes of Online Health Information Avoidance in the Context of COVID-19: Application and Extension of the PRIA Model.

Guan M, Yang Q, Carey P et al. · 2026 · Health communication

Despite its significant implications for public health and individual decision-making, research on information avoidance remains limited. In this study, we applied and extended the model of planned risk information avoidance (PRIA) to…

View details →DOI: 10.1080/10410236.2026.2678930
Negative / Null Result ReportMedicine

Prenatal and adolescent exposure to metals/metalloids and telomere dynamics at 14 years: Evidence from the Chitwan birth cohort.

Wai KM, Parajuli RP, Umezaki M · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Telomeres are repetitive non-coding DNA sequences at chromosome ends that progressively shorten with each cell division, serving as markers of cellular aging. Recent studies have suggested that prenatal and postnatal exposure to…

View details →DOI: 10.1016/j.jtemb.2026.127856
Negative / Null Result ReportMedicine

Posttraumatic cognitions and PTSD symptom change in massed prolonged exposure: The impact of treatment delivery on mechanisms of change.

Burton M, Haft S, Fiskeaux M et al. · 2026 · Journal of anxiety disorders

Background Prolonged Exposure (PE) is an effective treatment for PTSD and clarification of mechanisms of change can inform training and continued improvements. Posttraumatic cognitions have been shown to predict subsequent symptom change…

View details →DOI: 10.1016/j.janxdis.2026.103186
Negative / Null Result ReportMedicine

Thalamic Volume Asymmetry as a Potential Predictor of Vagus Nerve Stimulation Outcomes in Refractory Epilepsy.

Ujihara M, Kawabori M, Nakajima M et al. · 2026 · Neurologia medico-chirurgica

Vagus nerve stimulation is an established treatment for refractory epilepsy, but predictors of treatment response remain unclear. Given that left-sided vagus nerve stimulation preferentially modulates the left thalamus and that epileptic…

View details →DOI: 10.2176/jns-nmc.2025-0409
Negative / Null Result ReportMedicine

Longitudinal profiles of parental self- and child-focused emotion regulation.

Jordan G, Stockinger K, Schiltz C et al. · 2026 · Communications psychology

Parenting is an emotion-eliciting experience that requires parents to navigate the dual demands of regulating their own and their children's emotions, drawing on regulatory strategies such as reappraisal and rumination. However, patterns…

View details →DOI: 10.1038/s44271-026-00469-w
Negative / Null Result ReportMedicine

Assessing Knowledge About Living Kidney Donation Among Transplant Candidates and Relationship to Seeking a Living Donor.

Werenski H, Stratta R, McCracken E et al. · 2026 · Clinical transplantation

Introduction Despite well-established advantages of living-donor kidney transplantation (LDKT), LDKT growth has stagnated. Barriers to seeking a living donor include insufficient knowledge among candidates and discomfort discussing LDKT.…

View details →DOI: 10.1111/ctr.70591