Negative / Null Result ReportMedicine
Delgado CA, Poletto E, Vera LNP et al. · 2024 · Cell biochemistry and function
Mucopolysaccharidosis type II (MPS II) is an inborn error of the metabolism resulting from several possible mutations in the gene coding for iduronate-2-sulfatase (IDS), which leads to a great clinical heterogeneity presented by these…
View details →DOI: 10.1002/cbf.3932 Negative / Null Result ReportOpen accessMedicine
Adegboye HA, Sun Y, Zhang P et al. · 2026 · Journal of the American Heart Association
Background Von Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests apolipoprotein E ( APOE )-ε4 alters VWF release. This…
View details →DOI: 10.1161/jaha.125.043186 Negative / Null Result ReportOpen accessMedicine
Goldsmith BE, Horiuchi Y, Matush K et al. · 2025 · PNAS nexus
US democracy appears to have weakened during the 21st century. Scholars have raised concerns that this democratic backsliding will reduce favorable views of the United States among foreign citizens in other democracies. In turn, observers…
View details →DOI: 10.1093/pnasnexus/pgaf104 Negative / Null Result Report
Weissman DG, Baum G, Sanders A et al. · 2023 · Preprint
Growing evidence indicates that brain development varies as a function of family socioeconomic status (SES). Numerous studies have demonstrated that children from low-SES backgrounds have thinner cortex than children from higher-SES…
View details →DOI: 10.31234/osf.io/7hwnb Negative / Null Result ReportMedicine
Luchetti M, Terracciano A, Karakose S et al. · 2026 · Journal of the International Neuropsychological Society : JINS
Objective This study examines how multiple dimensions of socio-emotional well-being relate to cognitive functioning in older adults, and whether the associations vary by cognitive status, depression, and socio-demographic factors. Methods…
View details →DOI: 10.1017/s1355617726101933 Negative / Null Result ReportOpen accessMedicine
Roth TS, Samara I, Perea-Garcia JO et al. · 2024 · Scientific reports
Primate faces provide information about a range of variant and invariant traits, including some that are relevant for mate choice. For example, faces of males may convey information about their health or genetic quality through symmetry or…
View details →DOI: 10.1038/s41598-024-62187-9 Negative / Null Result ReportOpen accessMedicine
Lee GJ, Morrell HER, Adams M et al. · 2026 · The journal of nutrition, health & aging
Background With the rising incidence of neurodegenerative diseases and aging of the global population, it is important to investigate foods that may preserve cognitive function with advancing years. Avocados are rich in fiber, carotenoids,…
View details →DOI: 10.1016/j.jnha.2026.100847 Negative / Null Result ReportOpen accessMedicine
Hu L, Gao Z, Gao Q et al. · 2024 · Scientific reports
Holding and processing actions in visual working memory (VWM) is crucial for daily functioning, but it is capacity-limited. The vestibular system, which is activated by both vestibular signals and visual gravitational motion, may be…
View details →DOI: 10.1038/s41598-024-80678-7 Negative / Null Result ReportOpen accessMedicine
Meyer JH, Wang Z, Santhirakumar A et al. · 2024 · EClinicalMedicine
Background Postpartum blues (PPB) is a frequent syndrome of sad mood, crying spells, anxiety, restlessness, reduced appetite, and irritability, typically peaking day 5 postpartum. When severe, it greatly increases risk for later postpartum…
View details →DOI: 10.1016/j.eclinm.2024.102593 Negative / Null Result ReportOpen accessMedicine
Ruiz Hispán E, Pedregal M, Cristobal I et al. · 2021 · Journal of clinical medicine
Peritoneal metastases from gastric cancer play a key role in the fatal prognosis of the disease. The lack of efficacy of actual therapeutic approaches together with the outcomes achieved with checkpoint inhibitors in gastric cancer compel…
View details →DOI: 10.3390/jcm10204649 Negative / Null Result ReportOpen accessMedicine
Rabbia M, Guridi Ormazabal M, Staunton H et al. · 2024 · Journal of neuromuscular diseases
Background Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne…
View details →DOI: 10.3233/jnd-230188 Negative / Null Result ReportOpen accessMedicine
Chase DM, Huang HQ, Deng W et al. · 2025 · Gynecologic oncology
Objective To prospectively evaluate the impact of adjuvant chemoradiation (RT + CIS) versus radiation (RT) on quality of life (QOL) and patient-reported outcomes (PROs) among patients with intermediate-risk, stage I-IIA cervical cancer…
View details →DOI: 10.1016/j.ygyno.2025.09.014 Negative / Null Result ReportOpen accessMedicine
Floreani ED, Orlandi S, Chau T · 2022 · Frontiers in human neuroscience
Brain-computer interfaces (BCIs) are being investigated as an access pathway to communication for individuals with physical disabilities, as the technology obviates the need for voluntary motor control. However, to date, minimal research…
View details →DOI: 10.3389/fnhum.2022.938708 Negative / Null Result ReportOpen accessMedicine
Corpening B, Bürgler A, Tamási B et al. · 2025 · Environmental epidemiology (Philadelphia, Pa.)
Background Prior research suggests pollen allergies may be associated with cognitive function, although the effect sizes and specific cognitive outcomes varied across studies. With pollen seasons starting earlier and intensifying due to…
View details →DOI: 10.1097/ee9.0000000000000374 Negative / Null Result ReportOpen accessMedicine
Shkreli L, Woud ML, Bergunde L et al. · 2025 · European journal of psychotraumatology
Background: Steroid hormone dysregulations have frequently been implicated in posttraumatic stress disorder (PTSD) pathogenesis. However, the translation into naturalistic clinical settings as markers of symptomatology and treatment…
View details →DOI: 10.1080/20008066.2025.2457295 Negative / Null Result ReportOpen accessMedicine
Nicolaou L, Reuland CJ, Yang M et al. · 2026 · Lancet regional health. Americas
Background Household air pollution (HAP) is a major global health risk. Observational studies link HAP exposure to impaired child growth, but randomized controlled trial (RCT) evidence is inconsistent. Methods We followed children born…
View details →DOI: 10.1016/j.lana.2026.101382 Negative / Null Result ReportOpen accessMedicine
Willems YE, Raffington L, Ligthart L et al. · 2024 · Frontiers in psychiatry
Background Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding,…
View details →DOI: 10.3389/fpsyt.2024.1388264 Negative / Null Result ReportOpen accessMedicine
Madrigano J, Yan D, Liu T et al. · 2024 · GeoHealth
Indonesia faces significant air quality issues due to multiple emissions sources, including rapid urbanization and peatland fires associated with agricultural land management. Limited prior research has estimated the episodic shock of…
View details →DOI: 10.1029/2024gh001014 Negative / Null Result ReportOpen accessMedicine
Wachowicz A, Galbarczyk A, Marcinkowska UM et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council
Objectives Duration and quality of sleep are influenced by many factors, including hormonal changes. The aim of this study was to investigate the differences between the phases of the menstrual cycle in total sleep duration and sleep stage…
View details →DOI: 10.1002/ajhb.70247 Negative / Null Result ReportOpen accessMedicine
Jennings EA, Roberts-Toler C, Harriman NW et al. · 2026 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Social isolation is a concern among aging populations, and household composition may play an important role in its impact on mental health. We use data from an aging cohort in rural South Africa to investigate the moderating…
View details →DOI: 10.1093/geronb/gbag076 Negative / Null Result ReportOpen accessMedicine
Abdul Jafar NK, Tham EKH, Fok D et al. · 2026 · Nutrients
Background: Maternal chronotype, maternal sleep, and breastfeeding practices are separately associated with maternal mood. However, it is not known if maternal mood mediates the associations between maternal chronotype or maternal sleep…
View details →DOI: 10.3390/nu18030405 Negative / Null Result ReportOpen accessMedicine
Barendse MEA, Bilder RM, Snijders AL et al. · 2026 · Biological psychiatry global open science
Background Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these…
View details →DOI: 10.1016/j.bpsgos.2026.100692 Negative / Null Result Report
Mifune N · 2021 · Preprint
Whether intergroup conflict is a necessary condition for the evolution of human prosociality has been a matter of debate. At the center of the debate is the coevolutionary model of parochial altruism—that human cooperation with in-group…
View details →DOI: 10.21203/rs.3.rs-936427/v1 Negative / Null Result ReportMedicine
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
View details →DOI: 10.1016/j.semradonc.2025.07.002 Negative / Null Result ReportOpen accessMedicine
Tebib N, Liaudet L, Ltaief Z · 2026 · Journal of intensive care
Background In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilitate ECMO weaning…
View details →DOI: 10.1186/s40560-026-00884-5 Negative / Null Result ReportOpen accessMedicine
Xu H, Yan Y, Niu J et al. · 2026 · BMC cancer
BACKGROUND: Metastatic colorectal cancer (mCRC) patients who progress following the standard chemotherapy have maintained a favourable performance status. Nevertheless, there are limited effective treatment options, particularly for a…
View details →DOI: 10.1186/s12885-026-15705-z Negative / Null Result ReportMedicine
Koonrungsesomboon N, Teeyakasem P, Dukaew N et al. · 2025 · International journal of clinical oncology
Background Osteosarcoma is a prevalent and aggressive bone malignancy primarily affecting young adults. Despite advances in standard treatment, the 5-year survival rate remains low, highlighting the need for new chemotherapy options.…
View details →DOI: 10.1007/s10147-025-02877-0 Negative / Null Result ReportMedicine
Liu J, Moura DS, Jones RL et al. · 2024 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This exploratory analysis evaluated the tumor samples of the patients treated with doxorubicin (with or without olaratumab) in a negative phase III ANNOUNCE trial to better understand the complexity of advanced soft tissue sarcomas…
View details →DOI: 10.1158/1078-0432.ccr-23-3936 Negative / Null Result ReportMedicine
Bendetowicz D, Fabbri M, Sirna F et al. · 2024 · Current neurology and neuroscience reports
Purpose of review This review summarizes previous and ongoing neuroprotection trials in multiple system atrophy (MSA), a rare and fatal neurodegenerative disease characterized by parkinsonism, cerebellar, and autonomic dysfunction. It also…
View details →DOI: 10.1007/s11910-024-01335-0 Negative / Null Result ReportOpen accessMedicine
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
View details →DOI: 10.1016/j.jbspin.2023.105543 