A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19821 results in Negative / Null Result Report · page 204 of 661
Costa E, Vercoutere A, Alexander S et al. · 2026 · Preprint
Introduction During the COVID-19 pandemic, gestational diabetes mellitus (GDM) prevalence showed variable changes across regions, with most reporting increases and others decreases; anxiety and lifestyle modifications linked to…
Shen R, Yu Y, Ma Y et al. · 2026 · Biomolecules
Gatifloxacin (GTFX), a fourth-generation fluoroquinolone, causes metabolic disturbances in mammals, but its hepatotoxic mechanisms in aquatic vertebrates remain unclear. This study investigated whether GTFX induces liver injury in…
Yıldırım Erdal BD, Bayraktar S · 2026 · Turkish journal of ophthalmology
Objectives To investigate the effects of selective laser trabeculoplasty (SLT) on the iridocorneal angle, anterior chamber, and iris in patients with pseudoexfoliation glaucoma (PEXG) and to evaluate the relationship between these…
Streese L, Ritter ET, Schoch R et al. · 2026 · Journal of vascular research
Purpose We aimed to investigate the effect of different exercise modes on retinal microvascular endothelial function in patients with HF with preserved ejection fraction (HFpEF). Methods Twenty-eight patients were randomly allocated to…
Kumar D S, Dandekar S, Prakash GH · 2026 · BMC medical education
Background Antimicrobial resistance is a major global public health threat, necessitating improved antibiotic stewardship. India's Competency-Based Medical Education (CBME) framework requires robust methods to assess and cultivate clinical…
Hornemann A, Bosserhoff M, Coltan L et al. · 2026 · International urogynecology journal
Introduction and hypothesis This study investigates the postoperative mobility following partial semitendinosus tendon harvesting performed during pelvic organ prolapse (POP) repair using the Hornemann Tendon Transplantation (HoTT®)…
Sethi D, Prajapati S, Garg G · 2026 · Anesthesia and pain medicine
Background A few studies investigating the perioperative use of lung ultrasound (LUS) have shown loss of lung aeration with decline in diaphragmatic function after general anesthesia. We aimed to measure changes in lung aeration and…
Kume D, Horiuchi M, Nishiwaki M · 2026 · Microvascular research
Acute mental stress (MS) can impair macrovascular function, causing increased arterial stiffness and endothelial dysfunction; however, its effect on microvascular function remains largely unclear. This study examined the impact of acute MS…
Oliver CJ, Del Vecchio L, Climstein M et al. · 2026 · Clinical nutrition ESPEN
Background Accurate assessment of body composition beyond BMI is necessary in clinical care. Bioelectrical impedance analysis (BIA) and 3D scanning (3DS) are practical two-compartment (2C) methods estimating % body fat (%BF), fat mass…
Baytaroğlu HN, Yalçınsoy KÖ · 2026 · Preprint
Abstract Purpose To evaluate the effect of topical cyclosporine-A treatment on edematous punctal stenosis (PS) using anterior segment optical coherence tomography (AS-OCT). Methods Patients with edematous PS who suffered from epiphora for…
Bowman J, Cornelius JM, Schoen A et al. · 2026 · Journal of experimental zoology. Part A, Ecological and integrative physiology
The release of waterborne chemical cues is a well-documented anti-predator strategy in teleost fish, allowing individuals to detect, and respond to, predation threats. However, little is known about whether an ancient group of fishes,…
Balachandran A, Elliot JLN, Curtis S et al. · 2026 · Preprint
Abstract Background: Adolescents and young adults (AYAs) with congenital heart disease (CHD) are frequently lost to follow-up during transition to adult congenital heart disease (ACHD) care. Successful transition requires navigating…
Kikuchi M, Yoshimura Y, Tanaka S et al. · 2026 · Preprint
Abstract Facilitated drum circles may promote social bonding in children, yet endocrine responses vary widely. In a school-based pilot study (n = 11; aged 9–10 years), we examined whether the temporal structure of facilitator–child…
Booth SE, Rubins D, O'Donoghue AL et al. · 2026 · Applied clinical informatics
Intravenous (IV) and oral (PO) acetaminophen have equivalent bioavailability and effectiveness, but IV formulations are significantly more expensive. Clinical decision support (CDS) tools can encourage cost-effective prescribing. We…
Seijas R, Vázquez M, Barastegui D et al. · 2026 · International orthopaedics
Purpose To characterise recovery trajectories across nine patient-reported outcomes (PROs) during the first twelve months after hip arthroscopy for femoroacetabular impingement syndrome (FAIS), and to determine whether six-month assessment…
Aftabi S, Leslie WD · 2026 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing bone mineral density (BMD), but technical factors such as acquisition mode may affect measurement. On GE Healthcare DXA systems, Thin and Thick modes are often…
Singh PK, Kumar BS, Nandi S et al. · 2026 · Veterinary medicine international
Bisphenol A (BPA), an organic environment chemical, has extensive presence in consumer goods and food/feed items. The present study aimed to explore how BPA influenced the viability, proliferation, apoptosis, and steroidogenic activity of…
Lin YH, Teng MMH · 2026 · PloS one
Monitoring bone mineral density (BMD) changes can be challenging when both the spine and hips are included in follow-up assessments. This study aimed to evaluate BMD changes using different monitoring approaches, including comparisons…
Abd Elghany AA, Kamel Eyada MM, Maher SA et al. · 2026 · Cytokine
Background Alopecia areata (AA) is a common autoimmune disease which causes non-scarring patches of hair loss and has a 2% lifetime risk. Its chronic, recurrent nature makes treatment difficult. Potential roles of the JAK/STAT pathway,…
Butler A, Croxford R, Owusu-Bempah A et al. · 2026 · The International journal on drug policy
Background In October 2018, Canada legalized non-medical cannabis possession and use. While a stated objective of legalization was to prevent people from entering the criminal justice system for cannabis possession, we lack evidence about…
Shiraiwa K, Sueshige Y, Tanaka R et al. · 2026 · Preprint
Aims: Lenvatinib (LEN) inhibits organic anion transporting polypeptide 1B1 (OATP1B1) in vitro , raising concerns about potential risk for transporter-mediated drug–drug interactions (DDIs). This study evaluated the in vivo impact of LEN on…
Qian H, Jin H, Li S · 2026 · Clinical biochemistry
Objective To investigate the cause of markedly elevated cardiac troponin I (cTnI) levels that were inconsistent with the clinical presentation in an 18-year-old male patient with bradycardia. Methods Serial dilution analysis, heterophile…
Bellali YA, Jetté S, Delisle M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
Paraffin wax is applied to scar tissue for its proposed benefits of increasing skin pliability and relieving pain. However, limited studies have objectively assessed hypertrophic scar (HSc) response. This study examined immediate HSc…
Xu Y, Wang H, Wang N et al. · 2026 · Journal of cardiothoracic surgery
Background OBJECTIVE: To explore changes of tumor-infiltrating lymphocytes and the relationship with therapeutic effect before and after neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma(ESCC). Method This…
Çopur İ, Erbay RH, İlhan S et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : This prospective, randomized study aimed to evaluate the effects of different local anesthetic (LA) volume-dose combinations administered during supraclavicular brachial plexus block (SCBPB), a widely used…
Lu J, Shorey A, Uduba R et al. · 2026 · Clinical transplantation and research
Background Up to 23% of renal transplant recipients may develop transplant renal artery stenosis (TRAS). However, diagnosis requires angiography, and the contrast used may be nephrotoxic. We aimed to identify predictors of TRAS and clarify…
Feng J, Li S, Li X et al. · 2026 · Journal of agricultural and food chemistry
The effects of dietary supplementation with conjugated linoleic acid (CLA) on broiler duck growth performance and the quality of dry-cured products were investigated. Ten days preslaughter with the supplementation of 2 mL/d CLA was more…
To B, Prasath V, Veney D et al. · 2026 · NPJ breast cancer
Circulating tumor DNA (ctDNA) 'tumor fraction' (TF) may correlate with therapy response, but little is known regarding TF dynamics immediately after therapy initiation. Plasma samples from a single-arm clinical trial enrolling patients…
Mace C, Deighton R · 2026 · Death studies
Empirical evidence is lacking on the effectiveness of grief telephone counseling, particularly in Australia. This study addresses an important gap by evaluating the effectiveness of the Integrating Grief Program-Victoria (IGP-V), an…
Ajai S, Agnihotri R · 2026 · Journal of dental hygiene : JDH
Purpose Recently, charcoal-based oral hygiene products, such as toothpastes, have gained popularity due to their whitening and antibacterial properties. However, there is limited data on charcoal-bristle electric toothbrushes. The purpose…