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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 202 of 675

Negative / Null Result ReportMedicine

Quantitative assessment of tumor burden in multiple myeloma using MY-RADS from whole-body MRI: comparison with established prognostic biomarkers.

Xiong X, Yan Z, Wang J et al. · 2026 · Cancer imaging : the official publication of the International Cancer Imaging Society

Background To explore the value of MY-RADS from whole-body MRI in assessing tumor burden in MM with reference to established prognostic biomarkers. Methods 108 consecutive newly diagnosed MM patients were retrospectively enrolled. Bone…

View details →DOI: 10.1186/s40644-026-01076-y
Negative / Null Result ReportMedicine

Feasibility and signal quality of the Minder® implantable continuous EEG monitoring® system compared to 10-20 scalp electrodes over extended monitoring periods.

Ganguly TM, Lai A, Niemiec A et al. · 2026 · Epilepsia

Objective To evaluate the signal quality of the Minder implantable continuous EEG monitoring (iCEM) system compared to traditional scalp EEG in the context of long-term, continuous monitoring in individuals with epilepsy. Methods…

View details →DOI: 10.1002/epi.70290
Negative / Null Result ReportOpen accessMedicine

Enhancing wheat bran deconstruction with enzyme cocktails from Penicillium spp. and Trichoderma harzianum: the impact of β-glucosidase supplementation.

Hamann PRV, Martins HS, da Costa PHC et al. · 2026 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Forests and natural environments are valuable sources of organisms capable of degrading plant cell wall carbohydrates. In the present study, two isolates, Penicillium polonicum and Penicillium chrysogenum, obtained from Brazilian Cerrado…

View details →DOI: 10.1007/s42770-026-01974-0
Negative / Null Result ReportMedicine

Comparison of 2% lidocaine with epinephrine and 4% articaine with epinephrine in local anesthesia of maxillary molars affected by molar incisor hypomineralization: a randomized controlled trial.

Haidar M, Raslan N · 2026 · Scientific reports

The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…

View details →DOI: 10.1038/s41598-026-54698-4
Negative / Null Result ReportOpen accessMedicine

Protective role of lycopene against salinity-induced oxidative stress in Medicago sativa L. seedlings.

de Araujo Monteiro AA, da Silva Teles BR, Kamdem JP et al. · 2026 · Scientific reports

Soil salinization is one of the major challenges to agriculture, reducing productivity and directly affecting plant growth, germination, and physiology, especially in economically important crops such as Medicago sativa. Conventional soil…

View details →DOI: 10.1038/s41598-026-42699-2
Negative / Null Result Report

Influence of Minor Print Parameter Variations on the Mechanical Properties of Additively Manufactured Ti-6Al-4V Parts Using Laser Powder Bed Fusion

Hall J, Radtke MP, Waterman J et al. · 2026 · Preprint

Abstract Minor variations in print parameters are an inherent aspect of modern additive manufacturing (AM) processes. This study investigated the impact of 3 distinct print parameter variations in 21 combinations on the mechanical…

View details →DOI: 10.21203/rs.3.rs-9620697/v1
Negative / Null Result ReportOpen accessMedicine

Synergistic effect and resistance prevention activity of antimicrobial peptide MPX with Tulathromycin against <i>Actinobacillus pleuropneumoniae</i>.

Wang H, Wang L, Zhang W et al. · 2026 · Frontiers in microbiology

Introduction The emergence and dissemination of multidrug-resistant Actinobacillus pleuropneumoniae (APP) have significantly hindered the advancement of the swine industry. The combination of antimicrobial peptides (AMPs) with conventional…

View details →DOI: 10.3389/fmicb.2026.1802629
Negative / Null Result ReportMedicine

[Application of the "2+3" pancreaticojejunostomy in 110 cases of pancreaticoduodenectomy].

Guo SL, Chen SH, Liu H et al. · 2026 · Zhonghua wai ke za zhi [Chinese journal of surgery]

Objective: To report the outcomes and evaluate the safety of the "2+3"pancreaticojejunostomy in pancreaticoduodenectomy. Methods: This retrospective case series analyzed clinical data from 110 consecutive pancreaticoduodenectomy patients…

View details →DOI: 10.3760/cma.j.cn112139-20251116-00534
Negative / Null Result ReportOpen accessMedicine

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ-Subunit of the Epithelial Sodium Channel During Sodium Restriction.

Essigke D, Kalo MZ, Wörn M et al. · 2026 · Acta physiologica (Oxford, England)

Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186 RKRK mediating proteolytic ENaC…

View details →DOI: 10.1111/apha.70228
Negative / Null Result ReportOpen accessMedicine

Polymerizable inhibitor can reduce shrinkage stress of resin composite.

He J, Garoushi S, Lassila L et al. · 2026 · Clinical oral investigations

Objective The purpose of this study was to prepare dental resin composites (DRCs) with low shrinkage stress and limited leachable inhibitor content by incorporating a synthesized polymerizable inhibitor PBHT…

View details →DOI: 10.1007/s00784-026-06901-z
Negative / Null Result ReportOpen accessMedicine

Three-dimensional analysis of maxillary asymmetry in patients with mandibular prognathism.

Atarashi C, Osawa K, Saito D et al. · 2026 · Maxillofacial plastic and reconstructive surgery

Background Jaw deviation is a common feature of skeletal mandibular prognathism and often extends to the maxilla, complicating diagnosis and treatment planning in surgical orthodontic treatment. Since occlusion and maxillary morphology…

View details →DOI: 10.1186/s40902-026-00506-y
Negative / Null Result ReportOpen accessMedicine

Development of engineered magnetic liposome/exosome hybrid as a novel caffeine nanocarrier for restraining liver fibrosis induced in rats.

Elakkad YE, Refai H, Ahmed HH et al. · 2026 · Scientific reports

Liver fibrosis, a severe health issue linked to liver injury, inflammation, and cell death, often progresses to liver cancer without effective treatments. In this study, an exosome-nanoliposome hybrid loaded with caffeine (Caff) was…

View details →DOI: 10.1038/s41598-025-31169-w
Negative / Null Result ReportOpen accessMedicine

Determining the Optimal Volume of Ropivacaine Combined with Dexmedetomidine for Programmed Intermittent Epidural Bolus in Labor Analgesia: A Randomized Dose-Response Study.

Song C, Ni J, Liu C et al. · 2026 · Drug design, development and therapy

Background The programmed intermittent epidural bolus (PIEB) technique is effective for labor analgesia. Although ropivacaine combined with dexmedetomidine is used for epidural labor analgesia, the optimal PIEB volume for this regimen…

View details →DOI: 10.2147/dddt.s598405
Negative / Null Result ReportMedicine

Intermittent hemodialysis with regional citrate anticoagulation vs. priming heparin and pre-dilution HDF in patients at Risk Of Bleeding in Nephrology (the ROBIN randomized control trial).

Moranne O, Gerbal M, Chkair S et al. · 2026 · Blood purification

Introduction This single center randomized controlled trial (NCT03562754) compared pre-diluted IHDF (PIHDF) without systemic anticoagulation and the Prometheus system with regional citrate anticoagulation (IHD-RCA) in high-bleeding-risk…

View details →DOI: 10.1159/000552412
Negative / Null Result ReportOpen accessMedicine

The effect of spreader graft use on voice in rhinoplasty cases: a prospective randomized controlled study.

Ulkumen B, Mutlu S, Celik O · 2026 · Brazilian journal of otorhinolaryngology

Objective This study aimed to evaluate the impact of spreader graft placement during cosmetic rhinoplasty on both objective acoustic measures and subjective voice quality. Methods In this prospective, double-blind, controlled study,…

View details →DOI: 10.1016/j.bjorl.2026.101847
Negative / Null Result ReportMedicine

Association between short (≤ 30-day) dual antiplatelet therapy and 1-year major adverse cardiac events after drug-coated balloon-based non-stent percutaneous coronary intervention following optimal lesion preparation: a propensity score-based cohort study.

Kuroda S, Sawada T, Yui R et al. · 2026 · Cardiovascular intervention and therapeutics

Drug-coated balloon (DCB)-based non-stent percutaneous coronary intervention (PCI) may allow shorter dual antiplatelet therapy (DAPT), but whether a ≤ 30-day regimen is associated with worse outcomes remains unclear, particularly in…

View details →DOI: 10.1007/s12928-026-01312-z
Negative / Null Result ReportOpen accessMedicine

The influence of different skeletal patterns on TMJ anatomy: a comprehensive CBCT study across various sagittal and vertical skeletal patterns in adults.

Eslami S, Sayahpour B, Tashakor A et al. · 2026 · Clinical oral investigations

Objective This study aimed to evaluate the impact of sagittal and vertical skeletal patterns as well as gender on temporomandibular joint (TMJ) morphology using Cone Beam Computed Tomography (CBCT). Methods A cross-sectional analysis was…

View details →DOI: 10.1007/s00784-026-06916-6
Negative / Null Result ReportMedicine

Phacoemulsification Combined With 360° Gonioscopy-Assisted Transluminal Trabeculotomy: Prospective 12-Month Outcomes in Primary Open-Angle and Primary Angle-Closure Glaucoma.

Maheshwari D, Nagdev NG, Pillai MR et al. · 2026 · Journal of glaucoma

Precis This study concludes that combined gonioscopy assisted transluminal trabeculotomy-phacoemulsification have similar efficacy in terms of intraocular pressure and antiglaucoma medication reduction in primary open angle and primary…

View details →DOI: 10.1097/ijg.0000000000002753
Negative / Null Result Report

A Randomized, Controlled, Double Blind Clinical Study to Evaluate Use of Hydron Alkaline Ionised Water (HAIW) in Healthy Participants

Malhotra VK, Tamoli S, Kalbhor R et al. · 2026 · Preprint

Background and Objectives Alkaline Ionized Water (AIW) is considered among the highest quality healthy drinking water worldwide and is widely discussed for its various health benefits. Hydron Alkaline Ionized Water (HAIW) is produced…

View details →DOI: 10.64898/2026.06.17.26355908
Negative / Null Result ReportMedicine

The Effect of Smoking History on Inflammatory Biomarkers in Synovial Fluid of Patients Undergoing Arthroscopic Knee Surgery for Meniscal Injury.

Kurtz JL, Ehlers M, Montgomery SR Jr et al. · 2026 · The American journal of sports medicine

Background Smoking has been linked to alterations in cellular inflammatory pathways and adverse outcomes in orthopaedic procedures. It is unclear how patient smoking affects the intra-articular microenvironment in the setting of…

View details →DOI: 10.1177/03635465261459231
Negative / Null Result ReportMedicine

The Effect of a Web-Based Diabetes Education Program on Care Outcomes of Individuals With Type 2 Diabetes.

Elyeli K, Esmaeilzadeh S, Esmaeilzadeh S · 2026 · Computers, informatics, nursing : CIN

Diabetes is characterized as the "pandemic of the age" due to its increasing prevalence. Since it is a disease that affects all areas of life, it causes negative effects on the quality of life and self-care activities. This study aimed to…

View details →DOI: 10.1097/cin.0000000000001334
Negative / Null Result ReportOpen accessMedicine

Denture trueness and subjective retention analysis of digital monolithic dentures.

Ibrahim EA, Hanno KIH, Alrafah E et al. · 2026 · The journal of advanced prosthodontics

Purpose The aim is to evaluate the trueness and displacement of tooth position as well as subjective retention of the monolithic complete denture (CD). Materials and methods Twenty-two completely edentulous patients received (n = 22)…

View details →DOI: 10.4047/jap.2026.18.2.80
Negative / Null Result ReportOpen accessMedicine

Nano-magnolol enhances the modulatory effects of magnolol on cognitive performance and BACE1-related biochemical changes in an STZ-induced rat model of Alzheimer's disease.

Youssef B, Ibrahim EA, Moselhy SS et al. · 2026 · Discover nano

Background The Late-onset Alzheimer's disease (LOAD) is progressive cognitive deficits associated with different abnormalities as cholinergic dysfunction, amyloid accumulation, inflammation, and oxidative stress. Magnolol is a polyphenolic…

View details →DOI: 10.1186/s11671-026-04506-9