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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 201 of 661

Negative / Null Result Report

Association between global longitudinal strain and coronary artery calcium in the diagnosis of significant coronary artery disease

M Shvydka, M Lutay, I Golikova · 2026 · European Heart Journal - Cardiovascular Imaging

Abstract Introduction Non-invasive diagnostic methods for coronary artery disease (CAD) are gaining increasing importance due to their accessibility, diagnostic value, safety, and cost-effectiveness. Both global longitudinal strain (GLS)…

View details →DOI: 10.1093/ehjci/jeaf367.070
Negative / Null Result Report

Significant Association between Sleep Deprivation and Somato Testicular Index: an experimental study on Albino Rats

Ameera Al-Humidi, Mohammed Abdulsalam · 2025 · Yemeni Journal for Medical Sciences

Background: Sleep deprivation is total or partial absence of sleep. It is a risk factor for many diseases including disorders of reproductive system. Objective: This study aimed to investigate the correlation between sleep deprivation and…

View details →DOI: 10.20428/yjms.v19i4.2793
Negative / Null Result Report

Prognostically significant peripheral retinal degenerations: Association with axial length, refraction, and age

A. V. Myagkov, A. S. Stoyukhina, E. V. Shibalko et al. · 2025 · The EYE GLAZ

Background. Peripheral retinal degeneration (PRD) is among the key risk factors for rhegmatogenous retinal detachment (RRD), particularly in patients with myopia. Despite the accumulated data, the threshold values of axial length and…

View details →DOI: 10.33791/2222-4408-2025-4-288-296
Negative / Null Result Report

Comparative analysis of dietary patterns and depression risk: significant inverse association with HEI-2015 and mediating role of BMI

Zicheng Wang, Lei Fang, Fachao Shi et al. · 2025 · Frontiers in Nutrition

Objective Depression is a severe global mental disorder closely associated with dietary habits. This study aimed to evaluate associations between four dietary patterns [assessed by Dietary Inflammatory Index (DII), Healthy Eating…

View details →DOI: 10.3389/fnut.2025.1680741
Negative / Null Result Report

Evaluation of the departmental inter-rater reliability when scoring thyroid nodules according to the British Thyroid Association Ultrasound-classification model: Is there significant disagreement?

Nabil Rtam · 2023 · Ultrasound

Introduction: The British Thyroid Association Ultrasound-classification is a risk stratification model which grades thyroid nodules in U2–5 based on their sonographic appearance. Existence of variability between the ultrasound operators…

View details →DOI: 10.1177/1742271x231215500
Negative / Null Result Report

Investigation of Chromosomal Abnormalities and AZF Microdeletions in Iranian Infertile Men and Their Significant Association

Narges Taheri, Mahzad Nasir Shalal, Mahdi Mazloom et al. · 2025 · Andrologia

Objective Chromosomal abnormalities participate in male infertility by affecting a variety of physiological functions including spermatogenesis, hormonal homoeostasis, and semen quality. The long arm of the Y chromosome has an important…

View details →DOI: 10.1155/and/6689096
Negative / Null Result Report

The Association between a Recorded Diagnosis of Obesity and Clinically Significant Weight Loss in the Primary Care Setting: A Nationwide Registry

Michal Kasher Meron, Nira Koren-Morag, Dan Oieru · 2024 · Obesity Facts

Introduction: Overweight and obesity (OW/OB) are underdiagnosed. The primary aim was to assess whether a diagnosis of OW/OB recorded by a primary care physician (PCP) is associated with clinically significant weight loss, compared to a…

View details →DOI: 10.1159/000542080
Negative / Null Result Report

A Study on the Job Training Support Experience of Job Coach for the Vocational Rehabilitation Support Project for the People with a Significant Disability

Min-Sik Kim, Young-Ran Kim · 2024 · The K Association of Education Research

This study focuses on experience of Job Coach in Occupational Rehabilitation Support Projects that is offered by the field at the Field-Centric Occupational Rehabilitation Centers. The purpose of the study is to present better support to…

View details →DOI: 10.48033/jss.9.1.3
Negative / Null Result Report

Abstract 4364710: Association Between Pre-Operative History of Significant Bleeding and Post-Operative Cardiovascular Events Following Lower Extremity Revascularization

David Bresnahan, Yuhe Xia, Elliot Luttrell-Williams et al. · 2025 · Circulation

Background and Hypothesis: Patients with symptomatic peripheral artery disease (PAD) frequently undergo lower extremity revascularization (LER) but remain at increased risk of major adverse cardiovascular and limb events following the…

View details →DOI: 10.1161/circ.152.suppl_3.4364710
Negative / Null Result Report

Is There a Significant Association Between Body Image and Psychological Health in Moroccan Postmenopausal Women? A Cross-Sectional Study

Sara Esseffar, Said Bellahcen, Ghizlane Azizi et al. · 2025 · The Open Public Health Journal

Background Menopause and its consequences, sometimes complex, can generate discomfort in well-being and consequently affect the quality of women’s lives. Objective The present study was carried out to examine the quality of life of…

View details →DOI: 10.2174/0118749445384009250422052548
Negative / Null Result Report

AI in Portfolio Management: Can Algorithms Outperform Human Fund Managers?

Shantanu Chakravarti · 2026 · International Journal on Science and Technology

This study explores whether AI-driven portfolio management systems can outperform traditional human fund managers in terms of returns and risk-adjusted performance. Drawing on secondary research from global studies between 2020 and 2024,…

View details →DOI: 10.71097/ijsat.v17.i1.9900
Negative / Null Result Report

Significant Association Between Snapping Scapula Syndrome and Anterior Angulation of the Superomedial Scapular Angle

Peter J. Millett, Sean Smith, Charles Ho et al. · 2014 · Orthopaedic Journal of Sports Medicine

Objectives: Significant Association Between Snapping Scapula Syndrome and Anterior Angulation of the Superomedial Scapular Angle. Methods: In this Institutional Review Board approved study, bony morphologies of the scapula were evaluated…

View details →DOI: 10.1177/2325967114s00063
Negative / Null Result Report

Abstract 10858: Significant Association Between Washout Ratio of Renal 123i-metaiodobenzylguanidine and Muscle Sympathetic Nerve Activity in Patients With Hypertension

Yoshitaka Okabe, Hisayosi Murai, souichiro usui et al. · 2015 · Circulation

Background: Simplicity HTN-3 trial showed the negative result for renal denervation (RDN) in patient with resistant hypertension. One of limitations was that no appreciate evaluation of renal sympathetic nerve activity (RSNA) was applied…

View details →DOI: 10.1161/circ.132.suppl_3.10858
Negative / Null Result Report

P–212 Mitochondrial DNA content shows a significant association with timing of human embryo development and fertility diagnosis in euploid embryos

C Hur, V Nanavaty, A Chehab et al. · 2021 · Human Reproduction

Abstract Study question Does mitochondrial DNA content (mtDNA) correlate with clinical parameters and embryo morphokinetics using advanced time-lapse technology? Summary answer mtDNA correlated with embryo morphokinetics and the growth…

View details →DOI: 10.1093/humrep/deab130.211
Negative / Null Result Report

Linkage Disequilibrium between LDLR rs688 and AvaII Genes and its Significant Association with Ischemic Stroke

Yabin Chen, Hehui Cai, Jianming Zhang et al. · 2023 · Journal of Integrative Neuroscience

Background: To analyze the polymorphism distribution of low density lipoprotein receptor rs688, AvaII, NcoI gene in ischemic stroke, and explore the linkage disequilibrium among them. The correlation between the linkage disequilibrium and…

View details →DOI: 10.31083/j.jin2204094
Negative / Null Result Report

Use of Direct‐Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Significant Tricuspid Regurgitation

Yujin Yang, Mijin Kim, Jun Kim et al. · 2024 · Journal of the American Heart Association

Background There are limited data on the efficacy and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation with significant tricuspid regurgitation (TR), which can lead to hepatic dysfunction and intestinal…

View details →DOI: 10.1161/jaha.123.032272
Negative / Null Result Report

LACK OF SIGNIFICANT ASSOCIATION BETWEEN COMPONENT ALIGNMENT AND FUNCTIONAL OUTCOME IN TOTAL HIP ARTHROPLASTY

Ismail Hadisoebroto Dilogo, Wildan Latief, Muh Trimugroho Fahrudhin · 2018 · Journal of Southeast Asian Medical Research

Background : Total hip replacement (THR) failure isinfluenced bythe prosthesis component orientation. The debate is still ongoing to determine the best angles for acetabular or femoral components. Objective :To evaluate the functional…

View details →DOI: 10.55374/jseamed.v2i1.21
Negative / Null Result Report

No significant association between 40bp ins/del promoter polymorphism of MDM2 and breast cancer susceptibility in Pakistani women

Sania Gull, Nabeela Tariq, Hamida Ali et al. · 2025 · LIAQUAT MEDICAL RESEARCH JOURNAL

Breast cancer remains the most prevalent malignancy among women, and is the second leading cause of mortality worldwide. Genetic heterogeneity in the MDM2 promoter region has been associated with increased cancer susceptibility. The study…

View details →DOI: 10.38106/lmrj.2025.7.4-06
Negative / Null Result Report

No significant association between term premature rupture of membranes and neonatal APGAR score: A cross-sectional study

Shelvy Era Chintia, Henidekasari, Veronica Ela Rimawati et al. · 2025 · Jurnal Ilmiah Kesehatan Sandi Husada

Introduction: Premature rupture of membranes (PROM) is defined as the rupture of the amniotic sac before the onset of labor, potentially increasing the risk of infection, hypoxia, and a low APGAR score in newborns. The APGAR score assesses…

View details →DOI: 10.35816/jiksh.v14i2.269
Negative / Null Result Report

No significant association between term premature rupture of membranes and neonatal APGAR score: A cross-sectional study

Shelvy Era Chintia, Henidekasari Henidekasari, Veronica Ela Rimawati et al. · 2025 · Jurnal Ilmiah Kesehatan Sandi Husada

Introduction: Premature rupture of membranes (PROM) is defined as the rupture of the amniotic sac before the onset of labor, potentially increasing the risk of infection, hypoxia, and a low APGAR score in newborns. The APGAR score assesses…

View details →DOI: 10.35816/jiskh.v14i2.1293
Negative / Null Result Report

Non-invasive right ventricular myocardial work in patients with significant tricuspid regurgitation: association with etiology and outcome

Y Obayashi, S C Butcher, X Galloo et al. · 2026 · European Heart Journal - Cardiovascular Imaging

Abstract Background/Introduction Right ventricular (RV) function is a key factor in risk stratification of patients with tricuspid regurgitation (TR). Right ventricular myocardial work (RVMW) has been proposed as a novel echocardiographic…

View details →DOI: 10.1093/ehjci/jeaf367.232
Negative / Null Result Report

No significant association between quadriceps tendon alignment and 1‐year patient‐reported outcomes following physiological total knee arthroplasty without patellar resurfacing

Manabu Akagawa, Roberto Berebichez‐Fridman, Loic Villet et al. · 2026 · Knee Surgery, Sports Traumatology, Arthroscopy

Abstract Purpose This study aimed to clarify the clinical relevance of quadriceps tendon alignment (QTA), focusing on the quadriceps tendon axial angle (QTAx), in patients undergoing ‘physiological total knee arthroplasty (TKA)’. This…

View details →DOI: 10.1002/ksa.70310
Negative / Null Result Report

Significant Association Between Arctic Oscillation and Winter Wildfires in Southern China

Meng Meng, Daoyi Gong, Yunfei Lan et al. · 2024 · International Journal of Disaster Risk Science

Abstract The recent increase of regional wildfire occurrences has been associated with climate change. In this study, we investigated the association between the February to March wildfire points and burned area in the southern region of…

View details →DOI: 10.1007/s13753-024-00589-z
Negative / Null Result Report

Association between postdischarge antibiotic use and C. difficile testing as a surrogate for clinically significant diarrhea

Daniel J. Livorsi, James Merchant, Hyunkeun Cho et al. · 2025 · Antimicrobial Stewardship & Healthcare Epidemiology

Abstract Objective: Postdischarge antibiotics are often sub-optimal or unnecessary. This study sought to measure the risk of diarrhea in recently hospitalized patients treated with postdischarge antibiotics Design: Retrospective cohort…

View details →DOI: 10.1017/ash.2025.10162
Negative / Null Result Report

A174 TESTING FOR AND INCIDENCE OF CELIAC DISEASE AUTOIMMUNITY SAW SIGNIFICANT BUT TEMPORARY DECLINES DURING COVID-19 PANDEMIC

J A King, S Coward, G G Kaplan et al. · 2024 · Journal of the Canadian Association of Gastroenterology

Abstract Background Celiac disease (CD) is an autoimmune disorder with various complications and long-term health risks. The COVID-19 pandemic affected the entire healthcare system—including screening for and diagnosing non-infectious…

View details →DOI: 10.1093/jcag/gwad061.174
Negative / Null Result Report

Lack of Association between Cholelithiasis and Significant Coronary Artery Disease: An Autopsy Study from Greece

Christos Soutis, Chara Spiliopoulou, Nikolaos Goutas et al. · 2022 · Journal of Advances in Medicine and Medical Research

Aims: Cholelithiasis or Gallstone disease and coronary artery disease have been reported to share several common risk factors. The aim of this study was to examine if there is an association between coronary artery disease (CAD) and…

View details →DOI: 10.9734/jammr/2022/v34i2031472
Negative / Null Result Report

Significant association of specific DRB1 & DQB1 sequence feature variant types with systemic sclerosis autoantibodies types and racial groups (159.20)

Richard Scheuermann, Nishanth Marthandan, Paula Guidry et al. · 2012 · The Journal of Immunology

Abstract The sequence feature variant type (SFVT) approach to genetic association analysis has previously identified parts of HLA proteins that are associated with development of a variety of autoimmune diseases. Using the SFVT approach,…

View details →DOI: 10.4049/jimmunol.188.supp.159.20
Negative / Null Result Report

A200 HIGH-DEFINITION CHROMOENDOSCOPY RESULTS IN MORE SIGNIFICANT DYSPLASIA DETECTION THAN WHITE LIGHT ENDOSCOPY WITH RANDOM BIOPSIES IN ULCERATIVE COLITIS PATIENTS

T T Hoang, Y Leung, G Rosenfeld et al. · 2023 · Journal of the Canadian Association of Gastroenterology

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease that results in inflammation of the colonic mucosa, leading to abdominal pain, rectal bleeding, weight loss, and diarrhea. This chronic inflammation results in a…

View details →DOI: 10.1093/jcag/gwac036.200
Negative / Null Result Report

Significant Factors Affecting the Outcome in Emergency Open Surgery for Perforated Peptic Ulcer

Md Shahidul Islam, Md Sohel Aktar, Md Nur Islam Dewan et al. · 2026 · TAJ: Journal of Teachers Association

Background: Perforated peptic ulcer remains a life-threatening surgical emergency, with outcomes strongly influenced by patient-related, disease-related, and perioperative factors despite advances in medical therapy. Objective: To identify…

View details →DOI: 10.70818/taj.v39i01.0578