Negative / Null Result ReportOpen accessMedicine
Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)
With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…
View details →DOI: 10.1002/trc2.12485 Negative / Null Result ReportMedicine
Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry
Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…
View details →DOI: 10.1016/j.jaac.2021.11.034 Negative / Null Result ReportOpen accessMedicine
Bremhorst A, Mills DS, Würbel H et al. · 2022 · Animal cognition
Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System…
View details →DOI: 10.1007/s10071-021-01532-1 Negative / Null Result ReportOpen accessMedicine
Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…
View details →DOI: 10.1002/acr.25658 Negative / Null Result ReportMedicine
Bedlack R, Barkhaus P, Carter G et al. · 2022 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit.…
View details →DOI: 10.1080/21678421.2021.1946088 Negative / Null Result ReportOpen accessMedicine
Aouad K, El-Zorkany B · 2022 · Mediterranean journal of rheumatology
The Treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) stipulates that treatment should reach a predefined target and if not reached, intensification of therapy is implemented aiming at best future outcomes. Clinical…
View details →DOI: 10.31138/mjr.33.1.137 Negative / Null Result ReportOpen accessMedicine
Turvill J, Haritakis M, Pygall S et al. · 2026 · Endoscopy international open
Background and study aims During the COVID-19 pandemic the National Health Service introduced colon capsule endoscopy (CCE) as an alternative to colonoscopy in patients awaiting 3-year post-polypectomy surveillance. We determined the…
View details →DOI: 10.1055/a-2779-1774 Negative / Null Result ReportOpen accessMedicine
Pepine CJ, Handberg E, Cooper-DeHoff R et al. · 2026 · Open heart
Importance Women with angina due to suspected ischaemia referred for coronary angiography often have no obstructive coronary artery disease (ANOCA/INOCA). Objective To determine if intensive medical treatment (IMT) reduces major ischaemic…
View details →DOI: 10.1136/openhrt-2026-004115 Negative / Null Result ReportMedicine
Chalak LF, Kang S, Kota S et al. · 2023 · Early human development
Background There is a critical need for development of physiological biomarkers in infants with birth asphyxia to identify the physiologic response to therapies in real time. This is an ancillary single site study of the High-Dose…
View details →DOI: 10.1016/j.earlhumdev.2023.105815 Negative / Null Result ReportMedicine
Mudugal D, Monteith TS · 2021 · Expert review of neurotherapeutics
Introduction : Cluster headache [CH] is a severely disabling trigeminal autonomic cephalalgia [TAC]. Approximately 1 in 1,000 adults are affected by CH. Calcitonin gene-related peptide [CGRP] is an important mediator in the pathophysiology…
View details →DOI: 10.1080/14737175.2021.1852931 Negative / Null Result ReportOpen accessMedicine
Figueroa-Parra G, Putman MS, Crowson CS et al. · 2024 · Lupus science & medicine
Objective We aimed to evaluate the robustness of phase III randomised controlled trials (RCTs) for SLE and lupus nephritis (LN) using the fragility index (FI), the reverse FI (RFI) and the fragility quotient (FQ). Methods We searched for…
View details →DOI: 10.1136/lupus-2023-001068 Negative / Null Result ReportOpen accessMedicine
Li S, Mahr C, Kataria R et al. · 2026 · JACC. Advances
Background Landmark randomized controlled trials like DanGer Shock, IABP-SHOCK II, and ECLS-SHOCK guide infarct-related cardiogenic shock (CS) management with temporary mechanical circulatory support (tMCS), but strict enrollment criteria…
View details →DOI: 10.1016/j.jacadv.2026.102723 Negative / Null Result ReportMedicine
Albers GW, Bernstein R, Brachmann J et al. · 2021 · Stroke
Occult atrial fibrillation (AF) is a leading cause of stroke of unclear cause. The optimal approach to secondary stroke prevention for these patients remains elusive. The term embolic stroke of undetermined source (ESUS) was coined to…
View details →DOI: 10.1161/strokeaha.121.035208 Negative / Null Result ReportOpen accessMedicine
Ishizuka K, Ono S · 2025 · Journal of clinical pharmacology
Despite the tremendous effort in the oncology community, the success rate of anticancer development remained low at 30% to 40% from the Phase 3 study to the regulatory approval. The factors associated with the regulatory approval for…
View details →DOI: 10.1002/jcph.6172 Negative / Null Result ReportOpen accessMedicine
Chen H, Colasurdo M, Matsukawa H et al. · 2026 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →DOI: 10.1093/esj/23969873251364973 Negative / Null Result ReportOpen accessMedicine
Cerbone L, Orecchia S, Bertino P et al. · 2023 · Cancers
Mesothelioma comprises a group of rare cancers arising from the mesothelium of the pleura, peritoneum, tunica vaginalis testis and pericardium. Mesothelioma is generally associated with asbestos exposure and has a dismal prognosis, with…
View details →DOI: 10.3390/cancers15245716 Negative / Null Result ReportOpen accessMedicine
Pellesi L, Onan D, Martelletti P · 2024 · Toxins
Post-traumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), often resembling migraine and tension-type headaches. Despite its prevalence, the optimal treatment for PTH remains unclear, with…
View details →DOI: 10.3390/toxins16100427 Negative / Null Result ReportOpen accessMedicine
Zhou Q, Gao B, Hu J et al. · 2026 · BMJ oncology
Background Many patients with non-small cell lung cancer (NSCLC) have tumours that are either refractory or develop resistance following an initial response to anti-programmed cell death protein (ligand)-1 (PD-(L)1)-based treatment,…
View details →DOI: 10.1136/bmjonc-2025-000890 Negative / Null Result ReportOpen accessMedicine
Kasperkiewicz M, van Beek N, Schmidt E · 2026 · Drugs
Autoimmune blistering diseases (AIBDs) are a heterogeneous group of at least a dozen disorders characterized by autoantibodies against structural proteins of desmosomes in the skin and surface-close epithelia in pemphigus and of the…
View details →DOI: 10.1007/s40265-026-02292-3 Negative / Null Result ReportOpen accessMedicine
Baugher B, Walter E, Hennigs E et al. · 2025 · Cureus
Freezing of gait (FoG) is a disabling symptom of Parkinson's disease (PD) characterized by involuntary cessation/reduction. While deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) effectively treats common PD symptoms…
View details →DOI: 10.7759/cureus.89437 Negative / Null Result ReportMedicine
Park L, Furey M, Nugent A et al. · 2018 · Biological psychiatry
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This conference abstract has been retracted at the request of author Maura Furey,…
View details →DOI: 10.1016/j.biopsych.2018.02.787 Negative / Null Result ReportMedicine
Autler AS, Darling AM, Skow RJ et al. · 2025 · Autonomic neuroscience : basic & clinical
Young women, who suffer from major depressive disorder (MDD) at twice the rate as young men, are particularly vulnerable to cardiovascular events triggered by emotional stress, an association that may be partially explained by excessive…
View details →DOI: 10.1016/j.autneu.2025.103257 Negative / Null Result ReportOpen accessMedicine
Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases
Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…
View details →DOI: 10.1136/annrheumdis-2020-219585 Negative / Null Result ReportOpen accessMedicine
Denton CP, Del Galdo F, Khanna D et al. · 2022 · Rheumatology (Oxford, England)
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…
View details →DOI: 10.1093/rheumatology/keac300 Negative / Null Result Report
Lahiri JB, Panwar S · 2026 · Preprint
Abstract Covariance matrices underpin multivariate signal classifiers in brain-computer interfaces, clinical neurophysiology, and condition monitoring. Characteristic Response Analysis (CRA) and its Positive-Orthant Characteristic Response…
View details →DOI: 10.21203/rs.3.rs-9286518/v1 Negative / Null Result ReportMedicine
Ferguson I, George G, Wu C et al. · 2025 · Cognitive therapy and research
Background The tendency to negatively interpret ambiguous situations (i.e., interpretation bias) is associated with the development and maintenance of emotional disorders. Reliable measures of this transdiagnostic construct are critical…
View details →DOI: 10.1007/s10608-024-10523-8 Negative / Null Result ReportOpen accessMedicine
van der Meulen C, van de Stadt LA, Kroon FPB et al. · 2025 · Rheumatology (Oxford, England)
Objective Pain in hand osteoarthritis (OA) is evaluated with repeated pain questionnaires. It is unclear whether these questionnaires adequately capture changes in pain recalled by patients. This study investigated whether changes on pain…
View details →DOI: 10.1093/rheumatology/keaf029 Negative / Null Result ReportOpen accessMedicine
Laviolle B, Locher C, Allain JS et al. · 2025 · Clinical pharmacology and therapeutics
Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We…
View details →DOI: 10.1002/cpt.3535 Negative / Null Result ReportOpen accessMedicine
Ter Bruggen FFJA, Redekop WK, Stronks DL et al. · 2021 · Journal of pain research
Objective The success of neurostimulation depends partly on the amount of coverage of the neurostimulation-induced paresthesia of the painful area. This is often achieved by asking feedback from patients intraoperatively. If sedation…
View details →DOI: 10.2147/jpr.s323961 Negative / Null Result ReportOpen accessMedicine
Agostinho M, Shani A, Canaipa R et al. · 2024 · Pain reports
Introduction Within-subject variability (WSV) of pain intensity reports has been shown to predict the placebo response. The focused analgesia selection test (FAST), which allows to experimentally assess WSV of pain reports, has been used…
View details →DOI: 10.1097/pr9.0000000000001175 