A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19727 results in Negative / Null Result Report · page 2 of 658
Vivek Y. Reddy, Shephal K. Doshi, Saibal Kar et al. · 2017 · Journal of the American College of Cardiology
BACKGROUND: The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, St.…
Broido, Anna D, Clauset, Aaron · 2019 · CU Scholar (University of Colorado Boulder)
Real-world networks are often claimed to be scale free, meaning that the fraction of nodes with degree k follows a power law k-α, a pattern with broad implications for the structure and dynamics of complex systems. However, the universality of scale-free networks remains controversial. Here, we organize different definitions of scale-free networks and construct a severe test of their empirical prevalence using state-of-the-art statistical tools applied to nearly 1000 social, biological, technological, transportation, and information networks. Across these networks, we find robust evidence that
Robert Gottlieb, Ajay Nirula, Peter Chen et al. · 2021 · JAMA
Importance: Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19. Objective: To determine the effect of bamlanivimab monotherapy and combination therapy…
P.J. Devereaux, Marko Mrkobrada, Daniel I. Sessler et al. · 2014 · New England Journal of Medicine
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a…
The ORIGIN Trial Investigators · 2012 · New England Journal of Medicine
BACKGROUND: The use of n-3 fatty acids may prevent cardiovascular events in patients with recent myocardial infarction or heart failure. Their effects in patients with (or at risk for) type 2 diabetes mellitus are unknown. METHODS: In this…
Paulina Salminen, Mika Helmiö, Jari Ovaska et al. · 2018 · JAMA
Importance: Laparoscopic sleeve gastrectomy for treatment of morbid obesity has increased substantially despite the lack of long-term results compared with laparoscopic Roux-en-Y gastric bypass. Objective: To determine whether laparoscopic…
Anna D. Broido, Aaron Clauset · 2019 · Nature Communications
, a pattern with broad implications for the structure and dynamics of complex systems. However, the universality of scale-free networks remains controversial. Here, we organize different definitions of scale-free networks and construct a severe test of their empirical prevalence using state-of-the-art statistical tools applied to nearly 1000 social, biological, technological, transportation, and information networks. Across these networks, we find robust evidence that strongly scale-free structure is empirically rare, while for most networks, log-normal distributions fit the data as well or be
Hedy L. Kindler, Donna Niedzwiecki, Donna Hollis et al. · 2010 · Journal of Clinical Oncology
PURPOSE: The combination of gemcitabine plus bevacizumab produced a 21% response rate and a median survival of 8.8 months in a multicenter phase II trial in patients with metastatic pancreatic cancer. These encouraging data led Cancer and…
The CDMS II Collaboration · 2010 · Science
Astrophysical observations indicate that dark matter constitutes most of the mass in our universe, but its nature remains unknown. Over the past decade, the Cryogenic Dark Matter Search (CDMS II) experiment has provided world-leading…
Antoni Ribas, Richard Kefford, Margaret Marshall et al. · 2013 · Journal of Clinical Oncology
PURPOSE: In phase I/II trials, the cytotoxic T lymphocyte-associated antigen-4-blocking monoclonal antibody tremelimumab induced durable responses in a subset of patients with advanced melanoma. This phase III study evaluated overall…
Mark R. Thursz, Paul Richardson, Michael Allison et al. · 2015 · New England Journal of Medicine
BACKGROUND: Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease…
Anis Eliyana, Syamsul Maarif, Muzakki Muzakki · 2019 · European Research on Management and Business Economics
This research focuses on the discussion regarding antecedent variable of transformational leadership with its effect to work performance of the middle-level leaders at the organization of Pelabuhan Indonesia III Inc. The samples used in…
Katrina L. Salazar, Haijun Zhou, Jiaqiong Xu et al. · 2015 · Acta Cytologica
OBJECTIVE: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in the development of cervical disease is not well established. This study aimed to…
Michael Young, Stephen T. Slota, Andrew B. Cutter et al. · 2012 · Review of Educational Research
Do video games show demonstrable relationships to academic achievement gains when used to support the K-12 curriculum? In a review of literature, we identified 300+ articles whose descriptions related to video games and academic…
Friedrich Koehler, Sebastian Winkler, Michael Schieber et al. · 2011 · Circulation
BACKGROUND: This study was designed to determine whether physician-led remote telemedical management (RTM) compared with usual care would result in reduced mortality in ambulatory patients with chronic heart failure (HF). METHODS AND…
Thomas G. Brott, George Howard, Gary S. Roubin et al. · 2016 · New England Journal of Medicine
BACKGROUND: In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke,…
Philipp Stiefel, Sabrina Schmidt-Emrich, Katharina Maniura‐Weber et al. · 2015 · BMC Microbiology
BACKGROUND: Viability staining with SYTO9 and propidium iodide (PI) is a frequently used tool in microbiological studies. However, data generated by such routinely used method are often not critically evaluated for their accuracy. In this study we aim to investigate the critical aspects of this staining method using Staphylococcus aureus and Pseudomonas aeruginosa as the model microorganisms for high throughput studies in microtiter plates. SYTO9 or PI was added alone or consecutively together to cells and the fluorescence intensities were measured using microplate reader and confocal laser sc
Russell Fulmer, Angela Joerin, Breanna Gentile et al. · 2018 · JMIR Mental Health
BACKGROUND: Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less-intensive and more cost-effective alternative for treating depression and anxiety. Although CBT is one of the most effective treatment methods, applying an integrative approach has been linked to equally effective posttreatment improvement. Integrative psychological artificial intelligence (AI) offers a scalable solution as the demand for affor
Marco Valgimigli, Gianluca Campo, Monia Monti et al. · 2012 · Circulation
BACKGROUND: The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of…
Xiuchan Guo, Cheryl A. Winkler, Ji Li et al. · 2014 · BioMed Research International
UNLABELLED: Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic ro
Bart L. Scott, Marcelo C. Pasquini, Brent R. Logan et al. · 2017 · Journal of Clinical Oncology
Purpose The optimal regimen intensity before allogeneic hematopoietic cell transplantation (HCT) is unknown. We hypothesized that lower treatment-related mortality (TRM) with reduced-intensity conditioning (RIC) would result in improved…
Duncan Young, Sarah E Lamb, Sanjoy Shah et al. · 2013 · New England Journal of Medicine
BACKGROUND: Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV)…
Nereo Segnan, Paola Armaroli, L Bonelli et al. · 2011 · JNCI Journal of the National Cancer Institute
BACKGROUND: A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening. METHODS: We conducted a randomized controlled trial to evaluate the effect of…
Aneesh B. Singhal · 2011 · Archives of Neurology
OBJECTIVES: To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects. DESIGN:…
Matthew Cole, Tamara S. Galloway · 2015 · Environmental Science & Technology
Plastic debris is a prolific contaminant effecting freshwater and marine ecosystems across the globe. Of growing environmental concern are "microplastics"and "nanoplastics" encompassing tiny particles of plastic derived from manufacturing and macroplastic fragmentation. Pelagic zooplankton are susceptible to consuming microplastics, however the threat posed to larvae of commercially important bivalves is currently unknown. We exposed Pacific oyster (Crassostrea gigas) larvae (3-24 d.p.f.) to polystyrene particles spanning 70 nm-20 μm in size, including plastics with differing surface propertie
Troels F. Rønnow, Zhihui Wang, Joshua Job et al. · 2014 · Science
The development of small-scale quantum devices raises the question of how to fairly assess and detect quantum speedup. Here, we show how to define and measure quantum speedup and how to avoid pitfalls that might mask or fake such a…
Alwyn Young · 2018 · The Quarterly Journal of Economics
I follow R. A. Fisher's The Design of Experiments (1935), using randomization statistical inference to test the null hypothesis of no treatment effects in a comprehensive sample of 53 experimental papers drawn from the journals of the…
Francis Kim, Graham Nichol, Charles Maynard et al. · 2013 · JAMA
IMPORTANCE: Hospital cooling improves outcome after cardiac arrest, but prehospital cooling immediately after return of spontaneous circulation may result in better outcomes. OBJECTIVE: To determine whether prehospital cooling improves…
Fabrice André, Eva Ciruelos, Dejan Juric et al. · 2020 · Annals of Oncology
•In SOLAR-1, the key secondary endpoint of OS was evaluated in patients with HR+, HER2−, PIK3CA-mutated ABC.•Adding alpelisib to fulvestrant numerically improved mOS by 7.9 months, though the result was not statistically significant.•OS…
Leonard L. Gunderson, Kathryn Winter, Jaffer A. Ajani et al. · 2012 · Journal of Clinical Oncology
PURPOSE: On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study of 5-Fluorouracil (5-FU), Mitomycin, and Radiotherapy Versus 5-Fluorouracil, Cisplatin and Radiotherapy in…