A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1757 results in Negative / Null Result Report for "Mpro" · page 2 of 59
Mark van den Boogaard, Arjen J. C. Slooter, Roger J. M. Brüggemann et al. · 2018 · JAMA
Importance: Results of studies on use of prophylactic haloperidol in critically ill adults are inconclusive, especially in patients at high risk of delirium. Objective: To determine whether prophylactic use of haloperidol improves survival…
Marianna Fontana, Steve K White, Sanjay M Banypersad et al. · 2012 · Journal of Cardiovascular Magnetic Resonance
BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated. METHODS: Multibreathhold T1 quantification with heart rate correction and single breath-hold T1 mapping using
Patrick D. McGorry, Barnaby Nelson, Connie Markulev et al. · 2016 · JAMA Psychiatry
IMPORTANCE: A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated fatty acids (PUFAs). OBJECTIVE: To determine whether…
Ryan Hidayat Rafiola, Punaji Setyosarı, Carolina Ligya Radjah et al. · 2020 · International Journal of Emerging Technologies in Learning (iJET)
This study aims to analyze the effect of learning motivation, self-efficacy, and blended learning on students’ achievement in the industrial revolution 4.0. This is done to follow the development of the world of education to improve the quality of service, Human Resources and the quality of graduates. The research object was Public High School in Padang Sampling using Slovin formula. To analyze the research data used Partial Least Square (PLS) Version 3.0. The results showed that (1) Learning Motivation had a positive and significant effect on student achievement of Public High School in Padan
Kim de Jong, Patricia van Sluis, Annet Nugter et al. · 2012 · Psychotherapy Research
Providing outcome monitoring feedback to therapists seems to be a promising approach to improve outcomes in clinical practice. This study aims to examine the effect of feedback and investigate whether it is moderated by therapist…
Chris Blake, I. K. Baldry, Joss Bland‐Hawthorn et al. · 2013 · Monthly Notices of the Royal Astronomical Society
We present the first application of a ‘multiple-tracer’ redshift-space distortion (RSD) analysis to an observational galaxy sample, using data from the Galaxy and Mass Assembly (GAMA) survey. Our data set is an r < 19.8 magnitude-limited…
Godfrey Tan, John V. Guttag · 2026 · arXiv (Cornell University)
The performance seen by individual clients on a wireless local area network (WLAN) is heavily influenced by the manner in which wireless channel capacity is allocated. The popular MAC protocol DCF (Distributed Coordination Function) used…
Judith T. Moskowitz, Adam W. Carrico, Larissa G. Duncan et al. · 2017 · Journal of Consulting and Clinical Psychology
OBJECTIVE: We conducted a randomized controlled trial to determine whether IRISS (Intervention for those Recently Informed of their Seropositive Status), a positive affect skills intervention, improved positive emotion, psychological…
Thamaraiselvan Murugan, Sugumari Elavarasu, Thangakumaran Suthanthiran et al. · 2014 · Journal of Indian Society of Periodontology
AIM: The aim of this study was to determine whether the addition of an autologous platelet rich fibrin (PRF) membrane to a coronally advanced flap (CAF) would improve the clinical outcome in terms of root coverage, in the treatment of…
Nicholas Bloom, Ruobing Han, James Liang · 2024 · Nature
Abstract Working from home has become standard for employees with a university degree. The most common scheme, which has been adopted by around 100 million employees in Europe and North America, is a hybrid schedule, in which individuals spend a mix of days at home and at work each week 1,2 . However, the effects of hybrid working on employees and firms have been debated, and some executives argue that it damages productivity, innovation and career development 3–5 . Here we ran a six-month randomized control trial investigating the effects of hybrid working from home on 1,612 employees in a Ch
Davy Vancampfort, Joseph Firth, Christoph U. Correll et al. · 2019 · World Psychiatry
We summarized and compared meta-analyses of pharmacological and non-pharmacological interventions targeting physical health outcomes among people with schizophrenia spectrum disorders. Major databases were searched until June 1, 2018. Of…
MaryAnn P. Noonan, Nika Adamian, Alexandra C. Pike et al. · 2016 · Journal of Neuroscience
It is well established that preparatory attention improves processing of task-relevant stimuli. Although it is often more important to ignore task-irrelevant stimuli, comparatively little is known about preparatory attentional mechanisms…
Carlos Ferrando, Ricard Mellado Artigas, Alfredo Gea et al. · 2020 · Critical Care
BACKGROUND: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone. METHODS: Prospective, multicenter, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June 2020. Patients were cla
Lydiane Agier, Lützen Portengen, Marc Chadeau‐Hyam et al. · 2016 · Environmental Health Perspectives
BACKGROUND: The exposome constitutes a promising framework to improve understanding of the effects of environmental exposures on health by explicitly considering multiple testing and avoiding selective reporting. However, exposome studies…
Aaron T. Piepmeier, Jennifer L. Etnier · 2014 · Journal of sport and health science/Journal of Sport and Health Science
The literature shows that improvements in cognitive performance may be observed following an acute bout of exercise. However, evidence in support of the biological mechanisms of this effect is still limited. Findings from both rodent and…
James J. McNamee, Michael Gillies, Nicholas Barrett et al. · 2021 · JAMA
Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes. Objective: To determine…
US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2018 · JAMA
Importance: Cardiovascular disease (CVD) is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by the Framingham Risk Score, the Pooled Cohort Equations, or similar CVD risk assessment models. If current CVD risk assessment models could be improved by adding more risk factors, treatment might be better targeted, thereby maximizing the benefits and minimizing the harms. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on using nontraditional risk factors in coron
C. Abel, N. J. Ayres, Ban, Giles et al. · 2017 · Repository for Publications and Research Data (ETH Zurich)
We report on a search for ultralow-mass axionlike dark matter by analyzing the ratio of the spin-precession frequencies of stored ultracold neutrons and 199Hg atoms for an axion-induced oscillating electric dipole moment of the neutron and an axion-wind spin-precession effect. No signal consistent with dark matter is observed for the axion mass range 10â24â¤maâ¤10â17 eV. Our null result sets the first laboratory constraints on the coupling of axion dark matter to gluons, which improve on astrophysical limits by up to 3 orders of magnitude, and also improves on previous laboratory constra
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt et al. · 2017 · European Heart Journal - Cardiovascular Imaging
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size:…
Lee Fong Ling, Thomas H. Marwick, Demetrio Roland Flores et al. · 2013 · Circulation Cardiovascular Imaging
BACKGROUND: Although the recent surgical treatment of ischemic heart failure substudy reported that revascularization of viable myocardium did not improve survival, these results were limited by the viability imaging technique used and the…
F. Perry Wilson, Melissa Martin, Yu Yamamoto et al. · 2021 · BMJ
Abstract Objective To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injury. Design Double blinded, multicenter, parallel,…
Sean Lewis-Faupel, Yusuf Neggers, Benjamin Olken et al. · 2016 · American Economic Journal Economic Policy
This paper examines whether electronic procurement (e-procurement), which increases access to information and reduces personal interactions with potentially corrupt officials, improves procurement outcomes. We develop unique datasets from…
Nina Johnston, Johan Bodegård, Susanna Jerström et al. · 2016 · American Heart Journal
BACKGROUND: Patients with myocardial infarction (MI) seldom reach recommended targets for secondary prevention. This study evaluated a smartphone application ("app") aimed at improving treatment adherence and cardiovascular lifestyle in MI…
Ranjani R. Starr · 2015 · American Journal of Public Health
Millions of people in the United States consume dietary supplements hoping to maintain or improve their health; however, extensive research has failed to demonstrate the efficacy of numerous supplements in disease prevention. In addition,…
Robert H. Squires, Anil Dhawan, Estella M. Alonso et al. · 2012 · Hepatology
UNLABELLED: N-acetylcysteine (NAC) was found to improve transplantation-free survival in only those adults with nonacetaminophen (non-APAP) acute liver failure (ALF) and grade 1-2 hepatic encephalopathy (HE). Because non-APAP ALF differs…
Seema A. Khan, Fengmin Zhao, Lori J. Goldstein et al. · 2022 · Journal of Clinical Oncology
PURPOSE Distant metastases are present in 6% or more of patients with newly diagnosed breast cancer. In this context, locoregional therapy for the intact primary tumor has been hypothesized to improve overall survival (OS), but clinical…
Eva van het Reve, Patrícia Silveira, Florian Daniel et al. · 2014 · Journal of Medical Internet Research
BACKGROUND: Home-based exercise programs can improve physical functioning and health status of elderly people. Successful implementation of exercise interventions for older people presents major challenges and supporting elderly people properly while doing their home-based exercises is essential for training success. We developed a tablet-based system-ActiveLifestyle-that offers older adults a home-based strength-balance training program with incorporated motivation strategies and support features. OBJECTIVE: The goal was to compare 3 different home-based training programs with respect to thei
David C. Mohr, Jenna Duffecy, Joyce Ho et al. · 2013 · PLoS ONE
BACKGROUND: Web-based interventions for depression that are supported by coaching have generally produced larger effect-sizes, relative to standalone web-based interventions. This is likely due to the effect of coaching on adherence. We evaluated the efficacy of a manualized telephone coaching intervention (TeleCoach) aimed at improving adherence to a web-based intervention (moodManager), as well as the relationship between adherence and depressive symptom outcomes. METHODS: 101 patients with MDD, recruited from primary care, were randomized to 12 weeks moodManager+TeleCoach, 12 weeks of self-
Sarah J. Marzi, Karen Sugden, Louise Arseneault et al. · 2018 · American Journal of Psychiatry
OBJECTIVE: DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether…
Stefan Hagel, Friedhelm Bach, Thorsten Brenner et al. · 2022 · Intensive Care Medicine
PURPOSE: Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. METHODS: Randomized, multicenter, controlled…