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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 199 of 661

Negative / Null Result ReportOpen accessMedicine

Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.

Tayebi SM, Mirzaei M, Stout JR · 2026 · Journal of the International Society of Sports Nutrition

Purpose High-intensity judo bouts induce oxidative stress and muscle damage, impairing recovery. This randomized, double-blind, placebo-controlled pilot trial examined whether acute β -hydroxy- β -methylbutyrate free acid (HMB-FA)…

View details →DOI: 10.1080/15502783.2026.2665962
Negative / Null Result ReportOpen accessMedicine

CO<sub>2</sub>-Extract-Based Phytopreparation from <i>Arctium tomentosum</i> Mill. Root Exhibits No Acute and Subacute Toxicity and Suppresses Xylene-Induced Ear Edema and LPS-Induced Acute Inflammation in Mice.

Aitynova A, Dyusebaeva M, Issayeva D et al. · 2026 · Molecules (Basel, Switzerland)

A phytopreparation based on the CO 2 extract of Arctium tomentosum Mill. root (AT) was evaluated for its safety and anti-inflammatory potential in Swiss albino mice. Acute and 28-day subacute oral toxicity studies demonstrated that AT, at…

View details →DOI: 10.3390/molecules31111900
Negative / Null Result ReportMedicine

Parameter Specific Modulation of Neuronal Firing and Extracellular Action Potential Dynamics by Transcranial Focused Ultrasound Stimulation in Rat Motor Cortex.

Huang H, Smets C, Chen L et al. · 2026 · Brain stimulation

Background Transcranial focused ultrasound stimulation (TUS) has emerged as a promising tool for noninvasive neuromodulation. However, the specific effects of stimulation parameters on neural activity remain incompletely understood.…

View details →DOI: 10.1016/j.brs.2026.103145
Negative / Null Result ReportMedicine

Exploring the Association of Religion and Religiosity on Mammography Screening Among White and Black Women: Results from the Brazilian Longitudinal Study of Aging (Elsi-Brazil).

Dias CS Jr, Verona AP, Leocádio V · 2026 · Journal of religion and health

This study examines the relationship between religious denomination, religious attendance, and mammography screening among White and Black women in Brazil, using baseline data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil,…

View details →DOI: 10.1007/s10943-026-02694-3
Negative / Null Result ReportMedicine

Effect of a 3.5 mm Tibial Plateau Leveling Osteotomy Locking Compression Plate on Serial Postoperative Tibial Plateau Angle Maintenance, Short-Term Osteotomy Healing, and Complication Rates in 45 to 70 kg Dogs.

Acuña J, Barnhart MD, Kennedy SC et al. · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T

To evaluate the effect of a 3.5 mm tibial plateau leveling osteotomy (TPLO) locking compression plate on serial postoperative tibial plateau angle (TPA) maintenance, short-term osteotomy healing, and complication rates in dogs weighing 45…

View details →DOI: 10.1055/a-2865-3650
Negative / Null Result ReportOpen accessMedicine

Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague-Dawley rats.

Sztechman D, Zera T, Czarzasta K et al. · 2025 · Physiological reports

In the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates…

View details →DOI: 10.14814/phy2.70549
Negative / Null Result Report

Innovation and Productivity as Engines of Economic Growth in Ghana

Xuhua H, Bakpa EK, Yeboah JA · 2026 · Preprint

This paper examines the dynamic relationship between innovation, total factor productivity (TFP), and economic growth in Ghana using annual data for the period 1965–2021. Although Ghana has recorded relatively strong economic growth,…

View details →DOI: 10.20944/preprints202604.1738.v1
Negative / Null Result ReportMedicine

Investigation of Metabolites and Mineral Content in Blood Serum of Dairy Cows of the Simmental Breed in Samsun Province During the Transition Period.

Ormancı N, Bölükbaş B, Waqas M et al. · 2026 · Biological trace element research

This study evaluated the metabolic and mineral profiles in the blood serum of Simmental dairy cows during the transition period to assess their energy, protein, and mineral status. A total of 78 cows from 10 farms in Samsun Province were…

View details →DOI: 10.1007/s12011-026-04984-z
Negative / Null Result ReportOpen accessMedicine

Effect of Orthodontic Tube Base Area and Enamel Sandblasting on Bonding Strength to Enamel: An In Vitro Study.

Osipovė K, Maldonytė L, Lukšys D et al. · 2026 · Journal of clinical medicine

Background : The bond strength of orthodontic tubes to the enamel surface is essential for maintaining appliance stability, especially due to high masticatory forces on molars. Strong adhesion reduces the need for rebonding, shortening…

View details →DOI: 10.3390/jcm15020579
Negative / Null Result ReportMedicine

How does organizational sacralization affect healthcare professionals' work engagement and turnover intentions through perceived organizational support?

Şengüllendi MF · 2026 · Journal of health organization and management

Purpose In recent years, the migration of healthcare professionals from developing countries to developed countries has accelerated. Türkiye is one of the countries negatively affected by the migration of healthcare professionals. This…

View details →DOI: 10.1108/jhom-08-2024-0352
Negative / Null Result ReportMedicine

Studying with Friends in Introductory Biology Is Associated with Low Impact Study Strategies and No Improvement of Exam Scores.

Williams AE, Denaro K · 2026 · CBE life sciences education

Students often choose to study for exams with friends. Since active learning in class boosts success, instructors might expect studying with peers to also help. However, research offers little support for this. We investigated whether…

View details →DOI: 10.1187/cbe.25-04-0074
Negative / Null Result ReportMedicine

<i>Aronia melanocarpa</i> extract modulates gut microbiota and induces dose-dependent metabolic shifts in broiler chickens.

Can MB, Kara A, Adigüzel MC et al. · 2026 · British poultry science

1. Following the ban on prophylactic antibiotic use in feed for poultry, interest in natural alternatives has increased, particularly plant-derived extracts. In this study, the effects of Aronia melanocarpa fruit extract (AMF) on growth…

View details →DOI: 10.1080/00071668.2026.2673525
Negative / Null Result ReportOpen accessMedicine

Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells.

Marinello WP, Zylka MJ · 2026 · Frontiers in toxicology

Introduction Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA), are persistent environmental contaminants known for bioaccumulation and adverse health effects, including neurodevelopmental toxicity.…

View details →DOI: 10.3389/ftox.2026.1814052
Negative / Null Result Report

Imatinib Reduces Right Ventricular Systolic Pressure Independent of Arterial or Venous Remodeling in an Inflammatory Murine Model of Pulmonary Hypertension

McGlynn M, Steffes LC, Shah A et al. · 2026 · Preprint

Pulmonary arterial hypertension is a progressive, fatal disease driven by pathologic vascular remodeling including arterial medial hypertrophy, occlusive neointimal lesion formation, and venous muscularization. Current vasodilatory…

View details →DOI: 10.64898/2026.05.05.723006
Negative / Null Result Report

Effect of CCW OTR Kinematic on Instrumentation Time and Apical Debris Extrusion in Mildly and Severely Curved Root Canals: An In Vitro Study

Albanna RH, El-Farraj H, Awawdeh S et al. · 2026 · Preprint

Abstract Apical debris extrusion is an unavoidable phenomenon; however, evidence remains limited regarding the effect of newer motion kinematics, specifically counterclockwise optimum torque reverse (CCW OTR). Sixty-six mandibular molars…

View details →DOI: 10.21203/rs.3.rs-9615788/v1
Negative / Null Result ReportMedicine

Distinct Pause Patterns in Autism: Effects of Sex and Conversational Context in French-Speaking (Pre)adolescents.

Belenger M, Dumont C, Geelhand P et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose We investigated sex differences in the production of pauses in autistic (pre-)adolescents in two conversational contexts: a monologue and an interactive discussion. Method This study included 107 French-speaking participants ( M…

View details →DOI: 10.1044/2026_jslhr-25-00565
Negative / Null Result ReportMedicine

Efficacy analysis of CAR-T cells against CD123-positive malignant tumors and exploration of the feasibility of combination therapy with venetoclax.

Zhang M, Chai X, Zhang X et al. · 2026 · Annals of hematology

Chimeric antigen receptor T cells (CAR-T cells) have been widely applied in hematologic malignancies. It has shown limited efficacy in the treatment of myeloid neoplasms. We retrospectively analyzed the safety and efficacy of CD123 CAR-T…

View details →DOI: 10.1007/s00277-026-07097-8
Negative / Null Result ReportMedicine

Effect of hydrogen peroxide disinfectant on the flexural strength of different custom impression tray materials fabricated using conventional and digital methods.

Lengerli Efe A, Özen Sütüven E, Uçar Y et al. · 2026 · International journal of computerized dentistry

Aim The aim was to evaluate the effect of hydrogen peroxide disinfectant exposure for 60 minutes -representing the longest exposure time recommended for achieving the widest antimicrobial spectrum- on the flexural strength (FS) of…

View details →DOI: 10.3290/j.ijcd.b7003304