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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 196 of 661

Negative / Null Result ReportMedicine

Comparative Effects of Experimental Bioactive Glasses on Dentin Permeability and Tubule Occlusion In Vitro.

Destro JM, Reis BO, Chrisostomo DA et al. · 2026 · Journal of functional biomaterials

This study aimed to evaluate the effects of experimental bioactive glass solutions on dentinal fluid flow and hydraulic conductance in vitro. Dentin blocks of 50 bovine incisors were divided into 5 groups according to the desensitizing…

View details →DOI: 10.3390/jfb17060302
Negative / Null Result ReportMedicine

Current comorbid psychiatric symptoms in the statistical indirect association between childhood attention-deficit/hyperactivity disorder symptoms and functional impairment among university students.

Koyuncu Z, Evcil FY, Kilimci ÖS et al. · 2026 · BMC psychiatry

Objective This study investigated whether current comorbid psychiatric symptoms were involved in statistical indirect associations between childhood attention-deficit/hyperactivity disorder (ADHD) symptoms (CAS) and functional impairment…

View details →DOI: 10.1186/s12888-026-08299-0
Negative / Null Result Report

Development and Validation of Machine Learning Models for Predicting Initiation of Emergency Dialysis in Advanced Chronic Kidney Disease

Hirano K, Seki T, Watanabe A et al. · 2026 · Preprint

Background Initiation of emergency dialysis, often requiring temporary catheter owing to unprepared definitive vascular access, is associated with infectious and vascular complications and suggests advanced chronic kidney disease (CKD)…

View details →DOI: 10.64898/2026.06.21.26356128
Negative / Null Result ReportMedicine

In vivo Administration of Atorvastatin Does Not Impair Mitochondrial Function or Cellular Viability in the Prefrontal Cortex of Mice.

Gessler KB, Rescaroli J, Pires SM et al. · 2026 · Neurotoxicity research

Atorvastatin is a widely prescribed statin used for its cholesterol-lowering effects; however, it also exerts known pleiotropic effects, including antioxidant and anti-inflammatory properties. Atorvastatin´s impact on mitochondrial…

View details →DOI: 10.1007/s12640-026-00805-2
Negative / Null Result Report

High Concordance in Molecular Profiles Between Primary Tumors and Matched Lymph Node Metastases in Differentiated Thyroid Carcinoma: Implications for Clinical Sample Selection

Pan Y, Sun Y, Shi C et al. · 2026 · Preprint

Abstract Genetic testing guides personalized management of differentiated thyroid carcinoma (DTC). However, tumor heterogeneity, including spatial and temporal heterogeneity, has created an unresolved clinical problem. It remains unclear…

View details →DOI: 10.21203/rs.3.rs-9922971/v1
Negative / Null Result ReportMedicine

Influence of inhalation exposure to biogenic volatile organic compounds from Syringa oblata flowers on behavior, spatial working memory, and hematological parameters in mice.

Tuo Y, Yang S, Dai X et al. · 2026 · Journal of ethnopharmacology

Ethnopharmacological relevance Syringa oblata Lindl. emits a variety of biogenic volatile organic compounds (BVOCs) during full bloom, which forms the key chemical basis for its characteristic floral scent. Species of the genus Syringa…

View details →DOI: 10.1016/j.jep.2026.122022
Negative / Null Result ReportMedicine

Exploring Emotional Abuse, Physical Abuse and Mobile Phone Dependence in Left- and Non-Left-Behind Adolescents: Roles of Self-Esteem, Social Anxiety, and Loneliness.

Zhen B, Yang X, Yao B · 2026 · Scandinavian journal of psychology

Child abuse has been significantly associated with children's mobile phone dependence (MPD), particularly in left-behind children (LBC). However, whether distinct forms of child abuse (physical and emotional) are associated with MPD in LBC…

View details →DOI: 10.1111/sjop.70119
Negative / Null Result ReportMedicine

Ethosomal nanocarrier encapsulating curcumin for antimicrobial photodynamic therapy: efficacy analysis against mature Streptococcus mutans biofilm.

Partoazar A, Shahabi S, Afrasiabi S · 2026 · BMC oral health

Background Biofilms contribute to the dental calculus formation, which in turn deteriorates oral and systemic health. The use of antimicrobial photodynamic therapy (PDT) may be limited by problems with photosensitizer penetration. In…

View details →DOI: 10.1186/s12903-026-09022-x
Negative / Null Result ReportMedicine

Too Old for PESI?: Risk Stratification of Octogenarians with Pulmonary Embolism in the Emergency Department.

Lipa AJ, Janata-Schwatczek K, Sterz M et al. · 2026 · Seminars in thrombosis and hemostasis

Pulmonary embolism (PE) in octogenarians (i.e., patients > 80 years) is associated with substantial morbidity and mortality, yet this population remains underrepresented in major studies. We compared the predictive performance of the…

View details →DOI: 10.1055/a-2896-8297
Negative / Null Result ReportMedicine

Plasma protein biomarkers for early risk prediction of colorectal cancer.

Chen W, Ge X, Hu C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Prospective studies are necessary to determine the association between circulating proteins and colorectal cancer (CRC) risk, offering non-invasive biomarkers for early CRC risk prediction and interventions. The Olink Explore-3072 platform…

View details →DOI: 10.1158/1055-9965.epi-26-0341
Negative / Null Result ReportMedicine

Impact of circadian rhythm disruption on biochemical parameters in mice.

Umer H, Mumtaz T, Weiskirchen R et al. · 2026 · Chronobiology international

Disruption of circadian rhythm is common in rotating shift workers, individuals with jet lag, and people with irregular sleep schedules and contributes to metabolic diseases including obesity, type 2 diabetes, metabolic…

View details →DOI: 10.1080/07420528.2026.2681614
Negative / Null Result ReportMedicine

Preliminary investigation of T-wave peak-end interval and its ratio to QT interval in dogs with an echocardiographic phenotype of dilated cardiomyopathy and its possible correlation with left ventricular diameter and volume.

Kurogochi K, Stern JA, DeFrancesco TC et al. · 2026 · Journal of the American Veterinary Medical Association

Objective The T-wave peak-end (TpTe) interval and its ratio to the QT interval (TpTe:QT) are ECG markers of myocardial repolarization dispersion. We hypothesized that these markers are associated with echocardiographic indices reflecting…

View details →DOI: 10.2460/javma.25.12.0802
Negative / Null Result ReportOpen accessMedicine

Synthesis, Docking Profiles, and Biological Insights into Selenium-NHC Adducts and Benzimidazolium Salts with Antimicrobial Potential.

Boualia B, Sandeli A, Boulebd H et al. · 2026 · ACS omega

In this research, we present the successful synthesis of benzimidazolium salts ( 2a - e ) and their corresponding selenium-NHC adducts ( 3a - e ), achieved with satisfactory yields ranging from 75% to 88%, and characterized using…

View details →DOI: 10.1021/acsomega.5c10880
Negative / Null Result ReportOpen accessMedicine

Anticoccidial efficacy of a cinnamon-Rumex nervosus phytobiotic mixture on growth performance, carcass traits, cecal morphology, and cecal health in Eimeria tenella-challenged broilers.

Qaid MM, Al-Garadi MA, Al-Abdullatif AA et al. · 2026 · Poultry science

Coccidiosis remains a major constraint in poultry production; therefore, this study evaluated the anticoccidial efficacy of a phytogenic blend of cinnamon bark and Rumex nervosus leaf in Eimeria tenella-challenged broilers. Birds were…

View details →DOI: 10.1016/j.psj.2026.107288
Negative / Null Result ReportOpen accessMedicine

Discrepant Intracranial and Extracranial Responses to Tarlatamab in Relapsed Small-Cell Lung Cancer With Untreated Brain Metastases: A Case Report.

Hayashi E, Kano H, Nakamura K et al. · 2026 · Respirology case reports

Small-cell lung cancer (SCLC) has a poor prognosis, and the efficacy of tarlatamab for untreated brain metastases remains unclear. We report a case demonstrating a discrepant response between extracranial and intracranial lesions after…

View details →DOI: 10.1002/rcr2.70615
Negative / Null Result ReportMedicine

Pulmonary function trajectories in children with symptom-controlled asthma -a 10-year retrospective cohort study in China.

Wei X, Xue M, Fan B et al. · 2026 · BMC pulmonary medicine

Background Long-term changes in lung function in children with symptom control asthma are rare. To assess the trajectory of pulmonary function in children and analyze the influence factors. Methods The effects of gender, age, Body Mass…

View details →DOI: 10.1186/s12890-026-04442-5
Negative / Null Result ReportMedicine

Utility of ultrasensitive, US Food and Drug Administration-approved κ and λ dual in situ hybridization assay in the diagnosis of Hodgkin lymphomas.

Eltahir M, Young K, Younes S et al. · 2026 · American journal of clinical pathology

Objectives Determination of B-cell clonality in formalin-fixed, paraffin-embedded tissues is challenging, especially in cases where tumor B cells are sparse. Flow cytometry is of limited utility in Hodgkin lymphomas, at least in part due…

View details →DOI: 10.1093/ajcp/aqag043
Negative / Null Result ReportMedicine

Performance of a new bone-level tapered two-piece zirconia implant manufactured by injection moulding: A pilot preclinical study in minipig mandibles.

Hauck F, Herber V, Moecke S et al. · 2026 · International journal of oral implantology (Berlin, Germany)

Purpose The aim of this pilot preclinical study was to investigate the performance of a novel double-lead thread, conical bone-level ceramic implant manufactured by injection moulding (test group) in comparison to a well-established…

Negative / Null Result ReportMedicine

Serum Apelin-13 and Galectin-3 in COVID-19: Associations With Routine Biochemical Parameters and Diagnostic Performance in a Case-Control Study.

Uğurlu İ · 2026 · Journal of clinical laboratory analysis

Background Apelin-13 and Galectin-3 (Gal-3) are bioactive mediators linked to inflammation and cardiometabolic pathways. Their clinical utility in COVID-19 alongside routine laboratory tests remains unclear. Methods In this case-control…

View details →DOI: 10.1002/jcla.70284
Negative / Null Result ReportMedicine

Clinical and Neuroimaging Predictors of Outcome and Impact of Surgical Intervention in Cryptococcal Meningitis: An Observational Study.

Qian MY, He LY, Lan P et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia. We conducted a single-center…

View details →DOI: 10.1016/j.ijid.2026.108923
Negative / Null Result ReportMedicine

Profiles of Invalidating Family Environments and Their Associations With Borderline Personality Features, Depression, and Anxiety in Children and Adolescents.

Fang H, Feng L, Gu M et al. · 2026 · Personality and mental health

Invalidating family environments are theorized to undermine youths' emotion socialization and confer risk for psychopathology, yet heterogeneity in how invalidation is expressed within families is rarely examined. This study employed…

View details →DOI: 10.1002/pmh.70083