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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 194 of 675

Negative / Null Result ReportMedicine

Relationship of the Wound, Ischemia, and Foot Infection Stage with Frailty, Disability, Quality of Life, and One-Year Outcomes in All-Comers with Chronic Limb-Threatening Ischemia: Single-Center Prospective Cohort Study.

Houghton JSM, Black I, Meffen A et al. · 2026 · Annals of vascular surgery

Background The wound, ischemia and foot infection (WIfI) classification system has been widely adopted in chronic limb-threatening ischemia (CLTI) management. Primary aim was to prospectively investigate the association of WIfI stage with…

View details →DOI: 10.1016/j.avsg.2025.11.008
Negative / Null Result ReportMedicine

Lack of Association between Vitamin D Genetic Polymorphism and Virological Characteristics of Hepatitis B Infection.

da Silva JC, Caetano AR, Mendonça ACDF et al. · 2025 · The journal of applied laboratory medicine

Background Exploring polymorphisms in vitamin D-related genes (VDR) within the Brazilian population provides a valuable model to contribute to the influence of the host genetic variants on chronic viral hepatitis B (CHB). Methods 126 CHB…

View details →DOI: 10.1093/jalm/jfae151
Negative / Null Result ReportMedicine

Is time interval from breastfeeding cessation to frozen single euploid embryo transfer cycle associated with pregnancy outcome?

Bergin K, Leibner L, Roger S et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Prolactin (PRL) secretion during breastfeeding suppresses gonadotropin releasing hormone and ovulation. While PRL receptors are present in the endometrium, it is unknown whether transient rises in secretion during breastfeeding…

View details →DOI: 10.1002/ijgo.70418
Negative / Null Result ReportOpen accessMedicine

The relational association between multiple sexual partners and HIV testing on cervical cancer screening among women of reproductive age in Ghana: A national population-based study.

Afaya A, Awunyo W, Udeoha MA et al. · 2026 · PloS one

Background Cervical cancer screening remains vital in the early detection of precancerous lesions and promotes better treatment outcomes. Though evidence suggested multiple sexual partners and HIV infection as risk factors for cervical…

View details →DOI: 10.1371/journal.pone.0344086
Negative / Null Result Report

Carboplatin-Induced Ototoxicity in Children Treated for Retinoblastoma

Singh V, N B, Palla S et al. · 2025 · Preprint

Background: The chemotherapy regimen comprising carboplatin, vincristine, and etoposide (JOE) is commonly used to treat retinoblastoma. Carboplatin-induced ototoxicity is infrequently reported. High-frequency hearing loss may impair…

View details →DOI: 10.22541/au.174962434.47219542/v1
Negative / Null Result ReportOpen accessMedicine

Lack of Association Between Glucose Homeostasis and Immune Checkpoint Inhibitor Outcomes: A Retrospective Institutional Review.

Justice J, Burnette H, Irlmeier R et al. · 2025 · Cancers

Background/objectives Immune checkpoint inhibitors (ICIs) have revolutionized outcomes for patients with melanoma. As such, it is important to understand factors that may influence response as well as toxicity to these therapies. Impaired…

View details →DOI: 10.3390/cancers17193230
Negative / Null Result ReportMedicine

Carboplatin-Induced Ototoxicity in Children Treated for Retinoblastoma.

Singh V, Banumathy N, Palla S et al. · 2025 · Pediatric blood & cancer

Background The chemotherapy regimen comprising carboplatin, vincristine, and etoposide (JOE) is commonly used to treat retinoblastoma. Carboplatin-induced ototoxicity is infrequently reported. Extended high-frequency hearing loss may…

View details →DOI: 10.1002/pbc.31934
Negative / Null Result ReportOpen accessMedicine

Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.

Akbari T, Mach L, Hammersley DJ et al. · 2025 · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Background Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium. Objectives To…

View details →DOI: 10.1016/j.jocmr.2025.101953
Negative / Null Result ReportMedicine

High levels of the adipokines leptin and metrnl in patients with paroxysmal atrial fibrillation and obstructive sleep apnea are not associated with the severity of sleep apnea or the burden of atrial fibrillation.

Ueland T, Traaen GM, Hunt TE et al. · 2025 · Sleep medicine

Study objectives Obstructive sleep apnea (OSA) and atrial fibrillation (AF) are highly prevalent conditions sharing multiple risk factors including obesity. Adipokines secreted from adipose tissue could modify pathways affecting atrial…

View details →DOI: 10.1016/j.sleep.2025.106862
Negative / Null Result ReportMedicine

Epigenetic alterations of serotonergic but not dopaminergic signalling in compulsive sexual behaviour disorder.

Androvičová R, Jahn K, Engel J et al. · 2026 · Behavioural brain research

Rationale The compulsive sexual behaviour disorder (CSBD) is a recent addition to the ICD-11 diagnostic manual under the chapter of impulse control disorders. Though there is a wealth of different theoretical viewpoints regarding the…

View details →DOI: 10.1016/j.bbr.2025.115872
Negative / Null Result ReportMedicine

The Characteristics of Peripheral Blood Lymphocyte Subsets in HIV-related Diffuse Large B-cell Lymphoma Patients and Their Impact on Treatment Efficacy.

Xiang H, Lin C, Chen S et al. · 2025 · Current HIV research

Introduction Peripheral blood lymphocyte subsets have been shown to influence prognosis in HIV-associated Diffuse Large B-Cell Lymphoma (HIV-DLBCL), a rare and highly aggressive form of non-Hodgkin's lymphoma linked to immunosuppression…

View details →DOI: 10.2174/011570162x369231250818043532
Negative / Null Result ReportMedicine

Suicidal Communications in Adults with Borderline Personality Disorder: Clinical Correlates and Treatment Response to Dialectical Behavior Therapy.

Bitran AM, Kleiman EM, Rizvi SL · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Objective Suicidal communications (SCs)-also known as suicide threats or "gestures," whereby an individual verbally or behaviorally signals suicidal intent-present a serious challenge to clinicians and loved ones, who may struggle to…

View details →DOI: 10.1080/13811118.2025.2512455
Negative / Null Result ReportOpen accessMedicine

Comment on "Post-stroke cognitive impairment and fatigue in patients with white matter hyperintensities: A prospective cohort study".

Mehta R, Sah R · 2025 · Cerebral circulation - cognition and behavior

•SDMT drop at baseline linked to higher Fazekas (WMH) scores.•No follow-up MoCA/SDMT association after multiple correction.•Practice effects likely inflated cognitive test recovery scores.•High attrition biased against fatigue and…

View details →DOI: 10.1016/j.cccb.2025.100394
Negative / Null Result ReportMedicine

Association between exposure to pyrethroids and chlorpyrifos at age 5 years and IQ at age 7 years among children from the Odense Child Cohort, a prospective birth cohort study.

Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental research

Background Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults…

View details →DOI: 10.1016/j.envres.2025.120853
Negative / Null Result ReportMedicine

Connections matter: Exploring the relationship between belonging and psychosocial well-being in type 1 diabetes in Iran.

Razeghi M, Abdoli S, Mardanian Dehkordi L · 2024 · Applied nursing research : ANR

Aim Identify the relationship between a sense of belonging and psychosocial well-being in individuals with type 1 diabetes (T1D) in Iran. Background Understanding this relationship is vital for tailored nursing interventions to enhance…

View details →DOI: 10.1016/j.apnr.2024.151843
Negative / Null Result ReportOpen accessMedicine

Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans.

Gao Y, Hsu V, Kil A et al. · 2026 · The Journal of clinical endocrinology and metabolism

Context Previous animal studies show association between osteocalcin (OC) and type 2 diabetes-related quantitative traits (QTs), with some suggesting these effects being mediated by adipokines. Replication in humans has been inconsistent.…

View details →DOI: 10.1210/clinem/dgaf460
Negative / Null Result ReportMedicine

It is time to appreciate the value of processed foods

Fitzgerald M · 2024 · Trends in Food Science & Technology.

The messaging around processed food recently is that it is unhealthy and associated with the onset of chronic disease. However, food is processed for many reasons that range from preservation to safety, and then more recently in response…

Negative / Null Result ReportOpen accessMedicine

Stewardship Behaviour Among Residents of the Great Barrier Reef Region and the Role of Self-Efficacy.

Dousset J, Curnock MI, Wang JZ et al. · 2026 · Environmental management

As the Great Barrier Reef (GBR, the Reef) faces unprecedented threats, reducing anthropogenic pressures and fostering stewardship within coastal communities are among the strategic priorities identified in the Australian and Queensland…

View details →DOI: 10.1007/s00267-026-02525-x
Negative / Null Result ReportOpen accessMedicine

Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma.

Hecht S, Rojas-Ruiz A, Boucher M et al. · 2025 · Lung

Introduction A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily…

View details →DOI: 10.1007/s00408-025-00840-4
Negative / Null Result ReportOpen accessMedicine

Genital tract infections, antiretroviral treatment and HIV-1 viral load in early postpartum women: : implications for sexual and breastfeeding HIV transmission.

Govender V, Govender K, Moodley D · 2026 · BMC infectious diseases

BACKGROUND: Maintaining viral suppression in the postpartum period is critical for preventing HIV transmission to sexual partners and breastfed infants. Despite systemic viral suppression, genital HIV shedding may still occur in some…

View details →DOI: 10.1186/s12879-026-12621-2
Negative / Null Result ReportMedicine

Lack of Association of Chronological Age and Antithrombotic Agents With Acute Intracranial Hemorrhage in the Group of Older Adults With Traumatic Brain Injury.

Kambara M, Ikawa F, Hidaka T et al. · 2025 · Neurosurgery

Background and objectives Some reports suggest that older patients with traumatic brain injury (TBI) are more likely to experience acute intracranial hemorrhage, resulting in poor outcomes. However, the association between precise…

View details →DOI: 10.1227/neu.0000000000003240
Negative / Null Result ReportMedicine

Lack of Association Between Hemoglobin A1c and Continuous Glucose Monitor Metrics Among Individuals with Prediabetes and Normoglycemia.

Rodriguez JA, Palermo NE, Song W et al. · 2026 · Diabetes technology & therapeutics

Continuous glucose monitors (CGMs) are becoming increasingly available, yet the relationship between CGM metrics and hemoglobin A1c (HbA1c) among individuals with prediabetes and normoglycemia remains unclear. We examined associations…

View details →DOI: 10.1177/15209156251379506
Negative / Null Result ReportMedicine

Lack of association between serum apelin levels and sarcopenia in elderly malnourished subjects.

de Luis D, Primo D, Izaola O et al. · 2024 · European review for medical and pharmacological sciences

Objective Sarcopenia is a condition characterized by muscle mass loss. Skeletal muscle is capable of producing and secreting different molecules called myokines, and apelin is one of them. The literature contains contradictory data on the…

View details →DOI: 10.26355/eurrev_202406_36461
Negative / Null Result ReportOpen accessMedicine

Lack of association between genetic variations in <i>CYP3A5</i> and blood pressure or hypertension risk in the UK biobank.

Leibold P, Lteif C, Duarte JD · 2025 · Frontiers in genetics

Introduction Hypertension (HTN) is a leading risk factor for several cardiovascular diseases. While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no…

View details →DOI: 10.3389/fgene.2025.1490863