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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 191 of 675

Negative / Null Result ReportMedicine

Endoscopic and Histological Features of Esophagitis in Children With Duodenogastric Reflux.

Teke, Ergen, Basaran et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

Duodenogastric reflux (DGR), the backward flow of duodenal contents into the stomach, is often overlooked in children. This study aimed to evaluate the endoscopic and histopathological changes in the esophagus associated with DGR in…

View details →DOI: 10.1111/ped.70449
Negative / Null Result ReportMedicine

Quantitative Analysis of the Intracellular Efficacy of Conventional Antileishmanial Drugs Against Leishmania tropica : A Translational Approach Using the THP-1 Macrophage-Amastigote Model.

Yıldırım, Aksoy, Özbilgin · 2026 · Turkiye parazitolojii dergisi

This study aimed to quantitatively assess the intracellular susceptibility of Leishmania tropica ( L. tropica ) to conventional antileishmanial drugs using the parasite rescue and transformation assay (PRTA), which involves controlled…

View details →DOI: 10.4274/tpd.galenos.2026.82474
Negative / Null Result ReportMedicine

A Comparative Analysis of the Hinotori and da Vinci Robotic Systems in Total Hysterectomy for Benign Uterine Gynecological Diseases Using Propensity Score Matching.

Torii, Oshima, Aoki et al. · 2026 · Asian journal of endoscopic surgery

The hinotori surgical robot system, the first Japanese-made robotic-assisted surgical system to receive Japanese regulatory approval in 2020, is now being applied clinically in gynecology. This study aimed to comprehensively compare the…

View details →DOI: 10.1111/ases.70327
Negative / Null Result ReportMedicine

Clinical and radiological outcomes of unilateral biportal endoscopy and percutaneous endoscopic interlaminar discectomy for highly downward-migrated lumbar disc herniation: a retrospective study.

Liu, Zhang, Zhang et al. · 2026 · BMC surgery

To compare the clinical efficacy and safety of unilateral biportal endoscopy (UBE) versus percutaneous endoscopic interlaminar discectomy (PEID) in the treatment of highly downward-migrated lumbar disc herniation (HDM-LDH). A retrospective…

View details →DOI: 10.1186/s12893-026-03933-w
Negative / Null Result ReportMedicine

Accuracy of palatal orthodontic miniscrew placement: Static vs dynamic computer-guided techniques in a randomized clinical trial.

Brilli, Giansanti, Altieri et al. · 2026 · Clinical oral investigations

This randomized clinical trial compared the accuracy of palatal paramedian miniscrew placement using static computer-assisted surgery (s-CAS) and dynamic computer-assisted surgery (d-CAS). Forty subjects (11-17 years) requiring palatal…

View details →DOI: 10.1007/s00784-026-06975-9
Negative / Null Result ReportMedicine

Identification of broadly expressed nervous system-related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys.

Panda, Koch, Amineni · 2026 · Pest management science

The brown marmorated stink bug, Halyomorpha halys (BMSB), is an invasive polyphagous pest causing major losses in fruit and field crops in Europe and the Americas. With insecticide options increasingly limited by resistance and regulatory…

View details →DOI: 10.1002/ps.71021
Negative / Null Result ReportMedicine

Modeling the Effects of Gravity and Patient Positioning on Stone Migration During Ureteroscopy with Laser Lithotripsy in a Physics-Based Simulator.

Velasquez Ospina, Gordon, Ojalvo et al. · 2026 · Urologia internationalis

Introduction Residual lower pole fragments are a common limitation of ureteroscopy, yet the optimal patient positioning to minimize stone migration remains undefined. This study aimed to evaluate the impact of Trendelenburg (HeadTilt) and…

View details →DOI: 10.1159/000552687
Negative / Null Result ReportMedicine

No differential effects among cooling strategies on post-exercise core temperature recovery in male athletes.

Caballero, Navarro, Vanos et al. · 2026 · Temperature (Austin, Tex.)

Personal cooling strategies are used to lower body core temperature. This controlled cross-over trial evaluates the efficacy of cooling strategies following exercise-induced heat exposure resulting in increased body temperature. Ten…

View details →DOI: 10.1080/23328940.2026.2631850
Negative / Null Result ReportMedicine

Proton FLASH preserves neurocognition across delivery techniques: implications for clinical translation in pediatric brain tumors.

Miles, Sforza, Tan et al. · 2026 · bioRxiv : the preprint server for biology

Radiation therapy is integral to the curative treatment of childhood brain tumors but contributes to late neurocognitive impairment in survivors. FLASH (ultra-high dose rate, >40Gy/s) reduces normal-tissue toxicity in preclinical models,…

View details →DOI: 10.64898/2026.05.29.728901
Negative / Null Result ReportMedicine

Middle Eastern male ACL-deficient patients exhibit steeper posterior tibial slope than European counterparts: A cross-cultural matched cohort study.

Romandini, AlKhelaifi, Macchiarola et al. · 2026 · Journal of experimental orthopaedics

The posterior tibial slope (PTS) is a key anatomical factor influencing anterior cruciate ligament (ACL) stability. Steeper slopes have been associated with increased anterior tibial translation (ATT) and a higher risk of graft failure…

View details →DOI: 10.1002/jeo2.70790
Negative / Null Result ReportMedicine

Prognostic value of hematological ratios in sepsis: A prospective observational study of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and monocyte-to-lymphocyte ratios.

Deokate, Acharya, Patil et al. · 2026 · International journal of critical illness and injury science

Early identification of high-risk sepsis patients remains a clinical priority. Hematological ratios such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) have emerged as…

View details →DOI: 10.4103/ijciis.ijciis_94_25
Negative / Null Result ReportMedicine

Effect of Meibomian Gland Expression on Meibomian Gland Regeneration and Function: A Randomized Controlled Trial.

Le, Chotikkakamthorn, Kasetsuwan et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

This study aims to compare the effect of meibomian gland expression (MGX) combined with lid hygiene versus lid hygiene alone on the meibomian gland's morphology and function for obstructive meibomian gland dysfunction (oMGD). In this…

View details →DOI: 10.2147/opth.s607078
Negative / Null Result ReportMedicine

Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.

de Mello, Castelletto, Seitsonen et al. · 2026 · Journal of peptide science : an official publication of the European Peptide Society

The self-assembly in aqueous solutions, cytocompatibility, and collagen production of lipopeptide C 16 -KTTKS and a variant with arginine substitution for lysine, C 16 -RTTRS, are investigated. C 16 -KTTKS is known commercially as Matrixyl…

View details →DOI: 10.1002/psc.70111
Negative / Null Result ReportMedicine

Production of Instant Linden Tea ( Tilia spp.) Powder: Integrating Compound-Level Infusion Kinetics With Response Surface-Optimized Spray Drying.

Altiok, Kasapoglu · 2026 · Food science & nutrition

Producing instant herbal teas with consistent bioactive composition requires both efficient extraction and controlled drying to prevent compound degradation. This study developed instant linden tea ( Tilia spp.) by integrating…

View details →DOI: 10.1002/fsn3.72018
Negative / Null Result ReportMedicine

Effect of Medicaid Audio-Only Telehealth Coverage Policy on Mental Health Visits in Federally Qualified Health Centers.

Gadag, Arora, Kaskie et al. · 2026 · Health services research

We examined how the expansion of Medicaid audio-only coverage (MAOC) was associated with changes in mental health visit rates at Federally Qualified Health Centers (FQHCs). We used publicly available FQHC-level Uniform Data Systems (UDS)…

View details →DOI: 10.1111/1475-6773.70107
Negative / Null Result ReportMedicine

Investigating the Association between the Presence of Pulp Stone and Anesthesia Failure in Upper and Lower Molar Teeth.

Parirokh, Manochehrifar, Nakahee et al. · 2026 · Iranian endodontic journal

The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on…

View details →DOI: 10.22037/iej.v21i1.46586
Negative / Null Result ReportMedicine

Efficacy of Nurse-Led WIKAP Intervention on Hypoglycemia Coping Confidence and Outcomes in Adolescents with Type 1 Diabetes Mellitus: A Quasi-Experimental Study in Zhijiang, China.

Xiao, Zheng, Guo et al. · 2026 · Patient preference and adherence

Hypoglycemia is a frequent and burdensome complication in adolescents with type 1 diabetes mellitus (T1DM). Despite its high prevalence, structured interventions targeting hypoglycemia coping confidence remain scarce, especially in China.…

View details →DOI: 10.2147/ppa.s596598
Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

View details →DOI: 10.1007/s41999-026-01519-6
Negative / Null Result ReportMedicine

Occurrence of acrylamide and 4-methylimidazole in roasted and ground coffee and the effect of L-asparaginase treatment of green coffee on their levels.

da Costa, Ramirez, de Carvalho et al. · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Acrylamide and 4-methylimidazole (4-MEI) are heat-induced contaminants formed during coffee roasting, raising concerns due to their potential toxicological effects. Considering the limited information about the occurrence of these…

View details →DOI: 10.1080/19440049.2026.2683670
Negative / Null Result ReportMedicine

Effects of nitrogen and phosphorus fertilization on soil respiration and its temperature sensitivity in grassland alfalfa soil in Northwest China.

Hu, El-Sappah, Chen et al. · 2026 · Frontiers in plant science

Understanding the temperature sensitivity ( Q 10 ) of soil respiration (RS) and its response to nitrogen (N) and phosphorus (P) fertilization is essential for predicting soil carbon dynamics under climate change. However, seasonal…

View details →DOI: 10.3389/fpls.2026.1795072
Negative / Null Result ReportMedicine

The cortisol awakening response (CAR) of elite athletes is elevated before a competition, but no interaction with sport type.

Jiménez, Lopez-Lluch, Barón-López et al. · 2026 · Psychoneuroendocrinology

The cortisol awakening response (CAR) is thought to represent an anticipatory mechanism to prepare for upcoming demands. In sport, competition increases in the CAR have been reported, although findings remain inconsistent. A study on…

View details →DOI: 10.1016/j.psyneuen.2026.107905
Negative / Null Result ReportMedicine

Effects of low-magnitude high-frequency vibration on proliferation and cartilage phenotype of chondrocytes in the rat mandibular condyle.

Hou, Yu, Shen et al. · 2026 · Archives of oral biology

This study explored low-magnitude high-frequency (LMHF) mechanical vibration as a strategy to expand mandibular condylar chondrocyte (MCC) populations with enhanced chondrogenic phenotypes, providing high-quality cellular resources for…

View details →DOI: 10.1016/j.archoralbio.2026.106627