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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19821 results in Negative / Null Result Report · page 190 of 661

Negative / Null Result Report

Is protrusive occlusal interference a risk factor for anterior disc displacement of the temporomandibular joint: A retrospective analysis based on the superior head of the lateral pterygoid muscle

Lin J, Chen J, Wang D et al. · 2026 · Preprint

Abstract Objective :‌ To investigate whether protrusive occlusal interference is related to anterior displacement of the temporomandibular joint disc based on clinical data, and to explore the relationship between the two and the superior…

View details →DOI: 10.21203/rs.3.rs-9425170/v1
Negative / Null Result ReportOpen accessMedicine

Effects of water and fertilizer coupling on growth and development of Chinese dwarf cherry (<i>Cerasus humilis</i>) and evaluation of water and fertilizer use efficiency.

Liu S, Li Z, Chen S et al. · 2026 · Frontiers in plant science

Introduction In recent years, the demand for high-nutrition fruits has increased. As a unique fruit tree in China, Cerasus humilis has both ecological and nutritional value. Water and fertilizer nutrition is closely related to plant growth…

View details →DOI: 10.3389/fpls.2026.1841934
Negative / Null Result ReportOpen accessMedicine

Mechanical Tuning of the Cell Microenvironment Using a Biomimetic Hydrogel System for Articular Cartilage Tissue Engineering.

van Mourik M, Spierings J, Koca P et al. · 2026 · Journal of tissue engineering and regenerative medicine

Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM…

View details →DOI: 10.1155/term/9947868
Negative / Null Result ReportOpen accessMedicine

Long-Term Outcomes of Combined Phacoemulsification and Non-Penetrating Deep Sclerectomy versus Standalone Non-Penetrating Deep Sclerectomy.

Safadi K, Gutierrez Vargas GA, Cnaany Y et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To compare the efficacy and safety of combined phacoemulsification and non-penetrating deep sclerectomy (Phaco-NPDS) with standalone NPDS in a large glaucoma cohort with long-term follow-up. Methods This retrospective cohort study…

View details →DOI: 10.2147/opth.s579848
Negative / Null Result Report

Clinical Characteristics and Disease Severity Analysis of Mycoplasma pneumoniae Pneumonia in Guangxi ChildrenCarrying Drug-Resistant Genes: A Retrospective Clinical Study

Mo R, Chen J, Liu G et al. · 2026 · Preprint

Abstract ‌ Objective: ‌ To investigate the clinical characteristics of Mycoplasma pneumoniae pneumonia (MPP) in children from Guangxi carrying drug-resistant genes and to identify risk factors for predicting severe cases. ‌ Methods: ‌ A…

View details →DOI: 10.21203/rs.3.rs-10052579/v1
Negative / Null Result ReportOpen accessMedicine

Surrounding space associations affect attentional orienting and visual discrimination in frontal field.

Soret R, Charras P, Peysakhovich V · 2026 · Scientific reports

Attentional orienting is essential for the optimal processing of sensory information. In orienting studies, the visual modality related to surrounding space is often overlooked because visual cues are not directly available to individuals…

View details →DOI: 10.1038/s41598-026-39071-9
Negative / Null Result ReportMedicine

Social Media Content, Engagement, and Reliability for Infantile Hemangiomas: A Comparison Across YouTube, Instagram, and TikTok.

Rothberg SE, Barone S, Bins G et al. · 2026 · The Journal of craniofacial surgery

Background Infantile hemangiomas are a benign vascular abnormality that presents in infancy. Parents may seek a variety of resources to gather information, including social media. This study seeks to compare information on infantile…

View details →DOI: 10.1097/scs.0000000000012916
Negative / Null Result ReportOpen accessMedicine

Vonoprazan as an adjuvant to cisplatin: enhancing antitumor efficacy while mitigating nephrotoxicity and gastrointestinal adverse effects.

Alenezi FN, Abdelmageed ME, Nader MA et al. · 2026 · Frontiers in pharmacology

Background/objective Cisplatin is a popular platinum-containing chemotherapeutic agent that has been used clinically since the 1970s to manage a wide range of hematologic and solid tumors. However, its therapeutic purpose is restricted by…

View details →DOI: 10.3389/fphar.2026.1798103
Negative / Null Result ReportOpen accessMedicine

Effects of 3',4'-dihydroxyflavonol treatment on Neu N and BDNF and ICAM levels in the striatum of rats subjected to transient bilateral carotid occlusion-induced ischemia-reperfusion.

Hoşgör M, Uzdil EK, Aladag T et al. · 2026 · Journal of bioenergetics and biomembranes

Cerebral infarction is a leading cause of severe long-term disability and functional and cognitive impairment. With the advancement of acute stroke treatment, more patients are now experiencing stroke with varying degrees of impairment.…

View details →DOI: 10.1007/s10863-026-10109-x
Negative / Null Result ReportMedicine

Comparison of fibrin glue posterior fixation and omentopexy in laparoscopic sleeve gastrectomy: a propensity score-matched analysis.

Liang JL, OuYang SR, Liu ZX et al. · 2026 · Updates in surgery

Laparoscopic sleeve gastrectomy (LSG) is currently the most commonly performed weight loss surgery. Omentopexy is believed to help reduce the risk of postoperative nausea and vomiting (PONV), bleeding, gastric leakage, and gastroesophageal…

View details →DOI: 10.1007/s13304-026-02675-x
Negative / Null Result ReportOpen accessMedicine

Hemodynamic effects of high frequency oscillatory ventilation versus conventional mechanical ventilation in term neonates with persistent pulmonary hypertension: a single-center randomized trial.

El Amrousy D, Koura H, Abdou N et al. · 2026 · Italian journal of pediatrics

Background We aimed to evaluate the hemodynamics in full-term neonates with persistent pulmonary hypertension (PPH) on high frequency oscillatory ventilation (HFOV) versus conventional mechanical ventilation (CMV). Methods This trial was…

View details →DOI: 10.1186/s13052-026-02272-z
Negative / Null Result ReportMedicine

The effect of video assisted instruction on central venous catheter application skills, anxiety and satisfaction in nursing students: a randomised controlled study.

Koç G, Yüce Başaran HD, Yavuz B et al. · 2026 · BMC medical education

Objective This study aimed to evaluate the effect of video-assisted instruction on central venous catheter (CVC)-related psychomotor skills (blood collection, drug administration, and dressing care), anxiety levels, and student…

View details →DOI: 10.1186/s12909-026-09532-w
Negative / Null Result Report

Lower urinary tract symptoms are elevated with depression in Japanese male

Yamazaki M, Ninomiya S, Hashizume A et al. · 2026 · Preprint

Abstract Background About half of both men and women have lower urinary tract symptoms, and aging is reported to have a significant impact on these symptoms. Lifestyle-related diseases such as diabetes, hypertension, and metabolic syndrome…

View details →DOI: 10.21203/rs.3.rs-9310496/v1
Negative / Null Result ReportOpen accessMedicine

Large language models perpetuate bias in palliative care: Development and analysis of the Palliative Care Adversarial Dataset (PCAD).

Akhras N, Antaki F, Mottet F et al. · 2026 · PLOS digital health

Bias and inequity in palliative care disproportionately affect marginalised groups. Large language models (LLMs), such as GPT-4o, hold potential to enhance care but risk perpetuating biases present in their training data. This study aimed…

View details →DOI: 10.1371/journal.pdig.0001451
Negative / Null Result ReportOpen accessMedicine

Enhanced efficacy of tylvalosin tartrate enteric-coated granules against <i>Mycoplasma hyopneumoniae</i> in pigs: <i>in vitro</i> activity and clinical dosage optimization.

Li J, Zhou X, Wang W et al. · 2026 · Frontiers in microbiology

Background Mycoplasma hyopneumoniae (Mhp), the etiological agent of enzootic pneumonia in pigs, poses significant challenges to swine production. This study evaluated the anti-Mhp efficacy of a novel enteric-coated granules of tylvalosin…

View details →DOI: 10.3389/fmicb.2026.1809157
Negative / Null Result ReportOpen accessMedicine

Comparison of the Effects of Local Heat and Massage Using the Flick Application on Pain Caused by Vitamin K Injection in Neonates.

Momenisoroshk J, Sadeghi T, Seyedbagheri S · 2026 · Pediatric health, medicine and therapeutics

Purpose Healthy neonates experience pain during procedures such as vitamin K injections. Pain adversely affects the neonate, so it is important to control it. This study compared the effects of local heat and massage using the flick…

View details →DOI: 10.2147/phmt.s559432
Negative / Null Result ReportOpen accessMedicine

The Effect of the combination therapy of statin and dapagliflozin, a selective inhibitor of sodium_glucose Co-transporter type 2, in the treatment of Ischemic heart disease with heart failure: A randomized controlled trial.

Abdelkader AM, Osama H, Hassan ES et al. · 2026 · European journal of clinical pharmacology

Purpose Gliflozins (SGLT2 inhibitors) and statins are key treatments commonly used in patients with ischemic heart failure. Although both are well known for diminishing cardiovascular risk and heart failure-related mortality, the possible…

View details →DOI: 10.1007/s00228-026-04050-6
Negative / Null Result ReportMedicine

PERFECT MATCH: can you fit the personality to the service? Understanding personality traits of hospital pharmacists in different clinical services-an observational study.

Brideau S, Duong T, Nacevska I et al. · 2026 · The International journal of pharmacy practice

Objectives The objective of the study was to evaluate if using a validated psychometric test, The Big Five Personality Test, would identify an association between personality traits among hospital pharmacists and certain clinical services.…

View details →DOI: 10.1093/ijpp/riaf105
Negative / Null Result ReportOpen accessMedicine

The abilities of nitrogen-fixing bacteria to produce siderophores affect their promoting effects on cucumber growth and antiphytopathogenic fungus activities.

Wang EX, Li J, Zhang YT et al. · 2026 · Frontiers in microbiology

Introduction Many nitrogen-fixing bacteria (NFB) can synthesize siderophores. However, the contribution of NFB siderophore synthesis to plant growth has not been evaluated, and its impact on NFB's antifungal activity remains unclear.…

View details →DOI: 10.3389/fmicb.2026.1756337
Negative / Null Result ReportOpen accessMedicine

Oral Health and Idiopathic Female Infertility: A Potential Association.

Kovács D, Boda K, Badó A et al. · 2026 · Oral health & preventive dentistry

Purpose To explore the possible link between periodontal and dental health and idiopathic female infertility in South East Hungary, along with identifying relevant sociodemographic factors. Methods and materials The study included women…

View details →DOI: 10.3290/j.ohpd.c_2670
Negative / Null Result ReportOpen accessMedicine

Effect of implant position on clinical outcomes of two implant overdentures: a 3-year randomized clinical trial.

Raafat MH, Mourad KE, Elsyad MA · 2026 · BMC oral health

Background Reviewing the literature, the optimal implant position for 2-implant retained mandibular overdentures, which would be associated with improved peri-implant tissues, higher retention values, and better patient satisfaction,…

View details →DOI: 10.1186/s12903-026-08441-0
Negative / Null Result ReportOpen accessMedicine

Comparison of physico-mechanical properties of 3D-printed resins used as permanent indirect restoration materials.

Arıkan M, Akarsu S · 2026 · Biomaterial investigations in dentistry

Objective To compare the physico-mechanical properties (microhardness, surface roughness, and flexural strength) of permanent 3D-printed dental resins with those of a resin nanoceramic computer-aided design and computer-aided manufacturing…

View details →DOI: 10.2340/biid.v13.46113
Negative / Null Result ReportOpen accessMedicine

Antibacterial and anti-biofilm effects of postbiotic mediator derived from <i>Jeotgal</i> isolate <i>Lactiplantibacillus plantarum</i> KMC12 against <i>Streptococcus mutans</i>.

Oh H, Kim J, Bai J · 2026 · Journal of oral microbiology

Background Dental caries, commonly known as tooth decay, is a progressive breakdown of tooth tissues caused by the biofilm-producing bacteria, Streptococcus mutans . S. mutans plays a primary role in the initiation and progression of…

View details →DOI: 10.1080/20002297.2026.2684130
Negative / Null Result ReportOpen accessMedicine

Empagliflozin enhances cisplatin activity in chemo-resistant EJ138 bladder cancer cells: The importance of anti-diabetic medications in cancer treatment.

Shariati S, Mohtadi S, Molavinia S et al. · 2026 · Scientific reports

Anti-diabetic medications have been found to reduce chemotherapy resistance. This study sought to investigate the role of Empagliflozin (Empa) as an anti-diabetic medication in reversing Cisplatin (Cis) resistance in EJ138 bladder cancer…

View details →DOI: 10.1038/s41598-026-49196-6
Negative / Null Result ReportOpen accessMedicine

Selected immunoendocrine and performance adaptations to upper-body plyometric training and β-alanine supplementation in male swimmers.

Gao H, Yu X, Guo Z · 2026 · Journal of the International Society of Sports Nutrition

Background Upper-body plyometric training (PT) enhances neuromuscular performance and power production. However, its application in swimming and its potential interaction with β-alanine (BA) supplementation remain largely unexplored.…

View details →DOI: 10.1080/15502783.2026.2679050
Negative / Null Result Report

Effects of Community-Based Nutrition Education on Maternal Knowledge, Attitudes, and Practices Regarding Childhood Nutrition in Ningi LGA, Nigeria: A Pre–Post intervention Study

Alhassan A · 2026 · Preprint

Abstract The study aims to assess the effects of community-based nutrition education program on childhood nutrition for children 6months − 5years. Finding from the study indicate that the analysis of 100% response at baseline data (N =…

View details →DOI: 10.21203/rs.3.rs-9520536/v1