e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21253 results · page 190 of 709

Negative / Null Result ReportOpen accessMedicine

Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.

Hu Z, Ma R, Wen Y et al. · 2026 · Cancer medicine

Background The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0…

View details →DOI: 10.1002/cam4.71555
Negative / Null Result ReportOpen accessMedicine

Effect of diode laser biostimulation on implant stability, post-surgical inflammation, and bone healing in immediate implant in the maxillary premolars. A randomized double-blind trial.

Kassem BA, Osman SM, El-Mahallawy Y · 2026 · Clinical oral investigations

INTRODUCTION: The stimulatory effects of laser Biostimulation on immediate implant clinical wound healing and radiographic bone quality analysis is with insufficient evidence. AIM: To evaluate the effect of low-level diode laser as a…

View details →DOI: 10.1007/s00784-026-06847-2
Negative / Null Result ReportOpen accessMedicine

Clinical characteristics and prognostic differences between elderly-onset and adult-onset ulcerative colitis: a two-center retrospective cohort study.

Li H, Ding S, Li J et al. · 2026 · Frontiers in medicine

Background The incidence of elderly-onset ulcerative colitis (EO-UC) has been gradually increasing. The unique characteristics of clinical manifestations, therapeutic strategies, and prognosis in EO-UC patients compared with adult-onset…

View details →DOI: 10.3389/fmed.2026.1847513
Negative / Null Result ReportMedicine

[Mechanism of vitamin K2 in modulating matrix Gla protein to inhibit tumor growth in inflammation-associated colorectal cancer model mice].

Zhang HM, Wu MX, Wang HY et al. · 2026 · Zhonghua yi xue za zhi

Objective: To explore the mechanism of vitamin K2 (VitK2) regulating matrix Gla protein (MGP) in inhibiting tumor growth in inflammation-associated colorectal cancer (CAC) model mice. Methods: Twenty-six C57BL/6 male mice, 6-8 weeks old…

View details →DOI: 10.3760/cma.j.cn112137-20250708-01661
Negative / Null Result ReportOpen accessMedicine

Effectiveness of prophylactic single-dose IV antibiotic versus postoperative multi-dose oral antibiotic regimen for preventing surgical site infections: A prospective comparative study.

Pusdekar VP, Dare G, Bhojwani P et al. · 2026 · Turkish journal of surgery

Objective Surgical site infections (SSIs) are among the most common postoperative complications, contributing to morbidity, prolonged hospital stays, and healthcare costs. Prophylactic antibiotics are widely used, but the optimal regimen…

View details →DOI: 10.47717/turkjsurg.2026.2025-9-30
Negative / Null Result ReportMedicine

The effects of repetitive transcranial magnetic stimulation over the lateral parietal region on episodic future thinking and episodic memory.

Toufexis C, Grant JB, van Boxtel JJA et al. · 2026 · Consciousness and cognition

The left angular gyrus (AG) has been implicated in the level of detail elicited during both episodic memory (EM) and episodic future thinking (EFT). This study aimed to investigate whether repetitive transcranial magnetic stimulation…

View details →DOI: 10.1016/j.concog.2026.104070
Negative / Null Result ReportOpen accessMedicine

Radiation Countermeasure Gamma-Tocotrienol Inhibits Accumulation of Lipid Peroxidation Products in the Serum of Nonhuman Primates Exposed to Partial- or Total-Body Radiation-A Hallmark of Inhibition of Irradiation-Induced Ferroptosis?

Brzóska K, Carpenter AD, Petrus SA et al. · 2026 · International journal of molecular sciences

Gamma-tocotrienol (GT3) is one of the constituents of vitamin E that demonstrated significant radioprotective efficacy in murine and nonhuman primate (NHP) models. Considering the antioxidant activity of GT3 and its role in terminating…

View details →DOI: 10.3390/ijms27083387
Negative / Null Result ReportMedicine

Performance of large language models and clinical decision support in perioperative management of oral anticoagulants.

Çalışkan MU, Sarıbaş H, Keskin G et al. · 2026 · International journal of medical informatics

Background Perioperative anticoagulant management is critical because of the competing risks of ischemia and bleeding. Large language models (LLMs) and clinical decision support (CDS) have shown substantial advances and are increasingly…

View details →DOI: 10.1016/j.ijmedinf.2026.106456
Negative / Null Result ReportMedicine

Comparison of 3D extraoral scanning of artex articulator scan vs scan fixator in a fully edentulous arch - in-vitro study.

Alkhallagi TS, Alshammari BK, Babeer WA et al. · 2026 · BMC oral health

Background This in vitro study compared the precision of articulator-based scanning and scan fixator-based scanning in completely edentulous arches with implant scan bodies. Materials and methods Upper and lower master casts were…

View details →DOI: 10.1186/s12903-026-08476-3
Negative / Null Result ReportOpen accessMedicine

Platelet-rich plasma versus granulocyte colony-stimulating factor in addressing recurrent implantation failure: A randomized, double-blind clinical trial.

Tehrani HG, Mostajeran E, Dehghani-Mohammadabadi R et al. · 2026 · Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Background The aim of the study is to evaluate the effect of platelet-rich plasma (PRP) versus granulocyte colony-stimulating factor in addressing recurrent implantation failure. Materials and methods Fifty patients were randomly assigned…

View details →DOI: 10.4103/jrms.jrms_736_23
Negative / Null Result ReportOpen accessMedicine

The impact of narcissistic personality traits on social media interaction and body image: individual and team athletes.

Kiliç K, Sezer BS, Aydinli İ et al. · 2026 · Frontiers in psychology

Introduction The aim of this study is to examine the effect of narcissistic personality traits on body image through social media interaction and to comparatively evaluate these relationships in the context of athletes engaged in…

View details →DOI: 10.3389/fpsyg.2026.1848790
Negative / Null Result ReportOpen accessMedicine

Outcome analysis of conservative treatment of a distal radius fracture with OPTIVOhand orthosis versus plaster cast: a randomized controlled trial.

Friederich M, Brunner J, Kirsch E et al. · 2026 · BMC musculoskeletal disorders

Background Distal radius fractures (DRF) are often immobilized using a conventional plaster cast although orthoses offer a time- and resource-saving alternative. This prospective randomized study compared the conservative DRF treatment…

View details →DOI: 10.1186/s12891-026-09585-4
Negative / Null Result ReportOpen accessMedicine

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus.

Lv N, Xiang J, Kuang J et al. · 2026 · Frontiers in endocrinology

Introduction 25-hydroxyvitamin D [25(OH)D] deficiency is highly prevalent in type 2 diabetes mellitus (T2DM) and may contribute to immune and metabolic dysfunction. This study aimed to investigate the clinical associations of serum 25(OH)D…

View details →DOI: 10.3389/fendo.2026.1867755
Failed Experiment ReportOpen accessMedicine

Is biceps augmentation effective for scope-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears? A retrospective short-term clinical comparison.

Baek CH, Elhassan BT, Lim C et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Although favorable clinical outcomes of scope-assisted lower trapezius tendon transfer (SALTT) have been reported in posterosuperior irreparable rotator cuff tears (PSIRCTs) patients, the limited restoring of static stability…

View details →DOI: 10.1007/s00402-026-06290-8
Negative / Null Result ReportOpen accessMedicine

Depression, anxiety, and mental state in patients with early-stage dementia: comparison of reminiscence therapy and cognitive stimulation therapy.

Demir ZG, Doğan IA, Keskin R et al. · 2026 · Dementia & neuropsychologia

Psychosocial interventions may differentially target affective and cognitive symptoms in mild dementia, yet comparative evidence in long-term care is limited. Objective To compare the effects of Reminiscence Therapy (RT) and Cognitive…

View details →DOI: 10.1590/1980-5764-dn-2025-0354
Negative / Null Result ReportOpen accessMedicine

Antimicrobial resistance phenotypes of E. coli from livestock and wildlife in Wyoming, U.S.A.

Bowers O, Killion HJ, Kuhlman K et al. · 2026 · BMC veterinary research

BACKGROUND: This study measured phenotypic resistance of enteric Escherichia coli (E. coli) obtained from livestock and wildlife across agricultural districts within Wyoming, U.S.A., to antimicrobials used in the cattle industry. It is the…

View details →DOI: 10.1186/s12917-026-05386-y
Negative / Null Result ReportOpen accessMedicine

KIF23 regulates cytoskeleton dynamics for cytokinesis and mitochondrial function during oocyte meiosis.

Zou YJ, Zhang KH, Lu PS et al. · 2026 · Cell communication and signaling : CCS

Cytoskeleton dynamics ensure multiple cellular progression during oocyte meiosis, which is critical for successful fertilization and early embryo development. KIF23, a member of the kinesin-6 superfamily, mediates intracellular transport…

View details →DOI: 10.1186/s12964-026-02906-z
Negative / Null Result ReportOpen accessMedicine

Effects of Ropivacaine-Based Thoracic Paravertebral Block versus Erector Spinae Plane Block on Quality of Recovery in Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial.

Shi S, Liang Y, Liu T et al. · 2026 · Drug design, development and therapy

Background Colorectal cancer remains a leading cause of cancer-related mortality worldwide. Postoperative pain can impair recovery. Thoracic paravertebral block (TPVB) and erector spinae plane block (ESPB) are regional analgesic techniques…

View details →DOI: 10.2147/dddt.s581084
Negative / Null Result ReportOpen accessMedicine

Functional data analysis of lower-limb joint kinematics during badminton lunges under fatigue.

Fang Y, Zhang X, Sun Y et al. · 2026 · Frontiers in bioengineering and biotechnology

Objective This study applied Functional Data Analysis (FDA) to investigate the effects of fatigue on lower-limb joint kinematics during badminton lunges. Methods Seventeen elite male badminton players executed both forward and 45° sideways…

View details →DOI: 10.3389/fbioe.2026.1741767
Negative / Null Result ReportMedicine

Evaluation of radiopacity in preheated fissure sealants: an in-vitro study.

Aydın Çetin EZ, Özmen B, Yılmaz B · 2026 · Oral radiology

OBJECTIVES: The use of preheated resin-containing materials is of increasing interest in contemporary dentistry. This study aimed to determine the effect of preheating on the radiopacity values of various fissure sealants. METHODS: In this…

View details →DOI: 10.1007/s11282-026-00919-5
Negative / Null Result ReportMedicine

High Abdominal Fat Deposition was Regulated by Abdominal Fatty Acid Synthesis Related Genes and Reduced Reproduction in Late Stage of Chinese Indigenous Wannan Yellow Chicken.

Yu H, Wu L, Wang H et al. · 2026 · Animal bioscience

Objective Compared with commercial laying hens, indigenous chicken breeds generally exhibit lower reproductive performance. This study aims to elucidate the impact of abdominal fat deposition on the reproductive performance of indigenous…

View details →DOI: 10.5713/ab.250869
Negative / Null Result ReportMedicine

Healing Integrity Determines Meniscal Extrusion After Isolated Medial Meniscus Posterior Root Repair in Knees With No Lower Limb Malalignment.

Kim JS, Hwang UJ, Woo CW et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purpose To investigate changes in meniscal extrusion and meniscal healing status following root repair, and the relationship between meniscal extrusion and healing conditions. Methods Patients who underwent isolated root repair between…

View details →DOI: 10.1002/arj.70337
Negative / Null Result ReportOpen accessMedicine

Evaluating the Effectiveness of Age Simulation Gloves.

Lüleci EH, Kedgley AE · 2026 · Human factors

ObjectiveThis study evaluated the effectiveness of age simulation gloves in replicating age-related declines in hand function.BackgroundCommercially available age simulation gloves are increasingly used. However, their ability to replicate…

View details →DOI: 10.1177/00187208261434691