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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,218Computer Science 744Biochemistry, Genetics and Molecular Biology 414Social Sciences 302Psychology 299Physics 280Neuroscience 244Economics, Econometrics and Finance 196Environmental Science 172Mathematics 155Agricultural and Biological Sciences 138Engineering 135

750 results in Failed Experiment Report · page 19 of 25

Failed Experiment ReportMedicine

Population Genomics of <i>Macrophomina</i> spp. Reveals Cryptic Host Specialization and Evidence for Meiotic Recombination.

Pennerman KK, Goldman P, Dilla-Ermita CJ et al. · 2025 · Molecular plant-microbe interactions : MPMI

Knowledge of the factors structuring populations of pathogenic fungi is fundamental to disease management efforts and basic biology. However, this crucial information is missing for many important pathogens, including broad-host-range and…

View details →DOI: 10.1094/mpmi-03-25-0032-r
Failed Experiment ReportMedicine

Optimizing Genome Editing in Mollusks (<i>Crassostrea gigas</i>) <i>in Vitro</i> Validation of sgRNA and Identifying Key Factors Influencing Efficiency.

Li Q, Yu H, Du S et al. · 2025 · The CRISPR journal

CRISPR-Cas9 genome editing holds tremendous potential for accelerating genetic improvements in aquaculture. The success of the CRISPR-Cas9 system relies on the specificity and efficiency of engineered single-guide RNAs (sgRNAs). In this…

View details →DOI: 10.1089/crispr.2024.0086
Failed Experiment ReportOpen accessMedicine

Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Studies to Assess the Safety and Efficacy of Elezanumab when Added to Standard of Care in Relapsing and Progressive Forms of Multiple Sclerosis.

Cree BAC, Freedman MS, Gold M et al. · 2025 · Annals of neurology

Objective Elezanumab is a monoclonal antibody that binds repulsive guidance molecule a (RGMa), an inhibitor of central nervous system regeneration after inflammation or injury. The aim was to assess the safety and efficacy of elezanumab in…

View details →DOI: 10.1002/ana.27262
Failed Experiment ReportMedicine

Comparing Durvalumab, Olaparib, and Cediranib Monotherapy, Combination Therapy, or Chemotherapy in Patients with Platinum-Resistant Ovarian Cancer with Prior Bevacizumab: The Phase II NRG-GY023 Trial.

Lee JM, Miller A, Rose PG et al. · 2025 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose We assessed the efficacy of anti-PD-L1 durvalumab in combination with olaparib and cediranib (DOC), compared with the standard-of-care chemotherapy (SOC) in patients with platinum-resistant ovarian cancer (PROC), who had prior…

View details →DOI: 10.1158/1078-0432.ccr-24-3877
Failed Experiment ReportMedicine

Basket study of oral progesterone antagonist onapristone extended release in progesterone receptor-positive recurrent granulosa cell, low-grade serous ovarian cancer, or endometrioid endometrial cancer.

Andres S, Finch L, Iasonos A et al. · 2024 · Gynecologic oncology

Objective To determine the safety and efficacy of the oral progesterone antagonist onapristone extended release (onapristone-XR) in patients with recurrent progesterone receptor (PR)-positive adult-type granulosa cell tumor (aGCT),…

View details →DOI: 10.1016/j.ygyno.2024.06.026
Failed Experiment ReportOpen accessMedicine

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19.

Da Cruz RS, Teague HL, Ramos-Benitez MJ et al. · 2026 · Critical care explorations

Objectives Understanding the mechanistic impact of fostamatinib, a spleen tyrosine kinase inhibitor, in severe COVID-19 using biomarkers associated with disease severity is crucial for the development of host-directed therapeutics. We…

View details →DOI: 10.1097/cce.0000000000001405
Failed Experiment ReportMedicine

A randomized phase II/III trial of conventional paclitaxel and carboplatin with or without bevacizumab versus dose-dense paclitaxel and carboplatin with or without bevacizumab, in stage IVB, recurrent, or persistent cervical carcinoma (JCOG1311): Primary analysis.

Ishikawa M, Shibata T, Iwata T et al. · 2021 · Gynecologic oncology

Objective To assess the efficacy and safety of dose-dense weekly paclitaxel plus carboplatin (ddTC) with or without bevacizumab compared to conventional, tri-weekly paclitaxel plus carboplatin (cTC) with or without bevacizumab, in…

View details →DOI: 10.1016/j.ygyno.2021.05.007
Failed Experiment ReportOpen accessMedicine

Early identification of difficult-to-manage axial spondyloarthritis using machine-learning decision trees.

Juárez-García M, Plasencia-Rodríguez C, Benavent D et al. · 2026 · Therapeutic advances in musculoskeletal disease

Background Axial spondyloarthritis (axSpA) is an inflammatory disease in which, despite expanding therapeutic options, a substantial proportion of patients do not achieve the desired treatment target, highlighting the emerging concept of…

View details →DOI: 10.1177/1759720x261456162
Failed Experiment ReportMedicine

Immunotherapy-Based Strategies for Treatment of Type 1 Diabetes.

Jacobsen LM, Schatz D · 2025 · Hormone research in paediatrics

Background Type 1 diabetes (T1D) is more than an insulin-deficiency disease - it is an autoimmune disease, and the field is moving toward adopting disease-modifying immunotherapy as part of clinical care during T1D development. Summary…

View details →DOI: 10.1159/000542002
Failed Experiment ReportOpen accessMedicine

Antibiotic treatment of bacterial lung infections in cystic fibrosis.

Taccetti G, Terlizzi V, Campana S et al. · 2024 · European journal of pediatrics

Bacterial infections of the lower airways are the main cause of mortality and morbidity in cystic fibrosis. The most frequently isolated pathogens are S. aureus and P. aeruginosa; bacterial co-infections are frequently observed. The aim of…

View details →DOI: 10.1007/s00431-024-05905-9
Failed Experiment ReportOpen accessMedicine

Emerging Concepts in Therapeutic Interventions for Idiopathic Pulmonary Fibrosis.

Schott CA, Mohning MP, Cooley JC · 2025 · Seminars in respiratory and critical care medicine

Idiopathic pulmonary fibrosis (IPF) is a rare but devastating diagnosis for patients with only two approved drug therapies. Extensive preclinical studies have identified and characterized novel pathways driving IPF pathogenesis, and…

View details →DOI: 10.1055/a-2651-1937
Failed Experiment ReportOpen accessMedicine

Deucravacitinib, an oral, selective, allosteric, tyrosine kinase 2 inhibitor, in patients with active SLE: efficacy on patient-reported outcomes in a phase II randomised trial.

Mosca M, Arnaud L, Askanase A et al. · 2025 · Lupus science & medicine

Objective In PAISLEY, a 48-week, phase II, randomised controlled trial that assessed deucravacitinib in patients with active SLE, all primary and secondary endpoints were met with the deucravacitinib 3 mg two times per day dose. Changes in…

View details →DOI: 10.1136/lupus-2025-001517
Failed Experiment ReportMedicine

Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306).

Pettengell R, Długosz-Danecka M, Andorsky D et al. · 2020 · British journal of haematology

PIX306 was a phase 3, randomised, single-blind, multicentre trial conducted in adult patients with diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL) grade 3 who relapsed after ≥1 rituximab-containing regimen and were not…

View details →DOI: 10.1111/bjh.16255
Failed Experiment ReportMedicine

A Phase II Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor-Positive Breast Cancer.

Tolaney SM, Sahebjam S, Le Rhun E et al. · 2020 · Clinical cancer research : an official journal of the American Association for Cancer Research

Purpose The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary to hormone receptor-positive (HR + ) metastatic breast…

View details →DOI: 10.1158/1078-0432.ccr-20-1764
Failed Experiment ReportOpen accessMedicine

Increasing adverse event reports coincide with declining Medicare billings for interspinous devices.

McAnena AP, McClennen T, Gala RJ · 2026 · North American Spine Society journal

Background ISDs treat spinal stenosis via a minimally invasive approach, but limited studies assess their efficacy and durability. The objective of this study was to characterize the incidence of adverse event reports (AERs) compared to…

View details →DOI: 10.1016/j.xnsj.2026.100875
Failed Experiment ReportOpen accessMedicine

Tasting pain-relief through tongue stimulation: results from a feasibility study looking into the use of cranial nerve non-invasive neuromodulation in healthy individuals and chronic poststroke patients.

Ahiatsi M, Milot MH, Flaive A et al. · 2026 · BMC neurology

Purpose Chronic pain is a common consequence of stroke, often impairing survivors' quality of life. By targeting cranial nerves and brainstem regions involved in pain modulation, cranial nerve non-invasive neuromodulation (CN-NINM) offers…

View details →DOI: 10.1186/s12883-025-04498-6
Failed Experiment ReportOpen accessMedicine

A Pilot Study on the Influence of Self-Paced Auditory Cues and Preferred Music on Gait in Persons with Parkinson's Disease.

Brant M, Barrick C, Muno L et al. · 2025 · Brain sciences

Background : Gait disturbance in Parkinson's Disease (PD) significantly impacts quality of life and is not completely mitigated by dopaminergic treatment. Auditory cueing has been shown to help improve certain aspects of gait, but its…

View details →DOI: 10.3390/brainsci15050528
Failed Experiment ReportOpen accessMedicine

Effects of early treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) on the bronchoalveolar lavage proteome and oxylipids during bovine respiratory syncytial virus (BRSV) infection.

Hägglund S, Laloy E, Alvarez I et al. · 2024 · PloS one

Non-steroidal anti-inflammatory drugs (NSAID) are not recommended for use against pneumonia in humans, but are commonly utilised against bovine respiratory disease. This study aimed to determine if the use of NSAIDs in the early phase of…

View details →DOI: 10.1371/journal.pone.0309609
Failed Experiment ReportMedicine

Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels.

Gallegos-Reyes MA, Antaño-Martínez AR, Alcaraz-Contreras Y et al. · 2023 · The Journal of toxicological sciences

Lead (Pb) exposure induces testicular damage and infertility. The aim of this study was to analyze and compare the therapeutic effects of antioxidants or vitamin D and calcium, which have previously been shown to reduce the toxic effects…

View details →DOI: 10.2131/jts.48.481
Failed Experiment ReportOpen accessMedicine

Efficacy and Safety of Sakurajima Radish in Patients with Metabolic Syndrome: A Phase IIb Randomized, Three-Period Crossover Trial.

Tokushige A, Akasaki Y, Shibata K et al. · 2026 · Nutrients

Background/objectives We aimed to evaluate the efficacy and safety of a short-term dietary intervention using trigonelline-rich Sakurajima radish on vascular endothelial function in patients with metabolic syndrome (MetS). Methods In this…

View details →DOI: 10.3390/nu18111801
Failed Experiment ReportOpen accessMedicine

The Inflammatory Response in the Murine Ovalbumin-Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences.

Henriksen IW, Bartholdy C, Koch J et al. · 2026 · Clinical and translational science

Valid pre-clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low-to-moderate inflammatory responses with significant variability, undermining…

View details →DOI: 10.1111/cts.70593
Failed Experiment ReportOpen accessMedicine

Mechanical Preservation and Delayed Graft Function and Hospital Length of Stay as Deployed in the United States: Analysis of the Last Decade.

Keith DS, Lessmann E · 2024 · Annals of transplantation

BACKGROUND Mechanical preservation (MP) of deceased donor kidney transplants showed a 30% to 50% reduction in delayed graft function (DGF) as defined by dialysis in the first week, when compared with cold storage. DGF is associated with…

View details →DOI: 10.12659/aot.944338
Failed Experiment ReportMedicine

Beneficial Effect of Follicle-Stimulating Hormone Priming on OPU-IVF in Prepubertal Calves of Japanese Black Cattle (Wagyu).

Liu Z, Zhao H, Chen X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

Hormonal stimulation was performed on Japanese black prepubertal calves (8- and 12-month-old) and heifers (2-3-year-old), followed by oocyte retrieval by ovum pick-up (OPU) and in vitro fertilization (IVF). Both calves and heifers…

View details →DOI: 10.1111/rda.70242
Failed Experiment ReportMedicine

Placebo-controlled three-armed pilot trial of Escitalopram or Nortriptyline for depressive symptoms in Parkinson's disease (ADepT-PD).

Schrag A, Embleton-Thirsk A, Carroll C et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)

Pilot randomised-controlled trial of nortriptyline and escitalopram compared to placebo for depressive symptoms in people with Parkinson's disease (PD). Participants with PD and depressive symptoms received either nortriptyline,…

View details →DOI: 10.1007/s00702-026-03170-8