A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20227 results in Negative / Null Result Report · page 188 of 675
Wong AJ, Donnell CC · 2026 · European journal of pediatrics
This study aims to synthesise and interpret evidence relating to fluoride-free toothpaste alternatives for caries prevention, examining how these products have been studied, the outcomes used to evaluate them, and how this evidence may…
Osei F · 2026 · Preprint
Abstract Drug repurposing and indication expansion remain important in pharmaceutical development, but the evidence supporting candidate drug--disease hypotheses is often fragmented across clinical trial registries, biomedical literature,…
Yu J, Eyles JP, Moreti Cabral Silveira A et al. · 2026 · BMC health services research
Background Evidence based medicine is a critical cornerstone in contemporary medicine, yet uptake and adoption of evidence remain suboptimal. This is prominent in many fields of healthcare, including musculoskeletal health and surgery.…
Parisien C, Ho-El Abidi N, Khalaf E et al. · 2026 · Preprint
Addiction is a chronic, relapsing disorder comprising three stages: binge, withdrawal, and preoccupation. Preclinical evidence suggests that the habenula, a small epithalamic region, is involved across these stages and may contribute to…
Scurich N, Albright TD · 2026 · Proceedings of the National Academy of Sciences of the United States of America
Proficiency testing is widely used to assess expertise in medicine, engineering, and other high-stakes fields. In forensic science, such tests are often cited in court as evidence that pattern-comparison methods are accurate and reliable.…
Mahon P, Körtner G · 2026 · Preprint
Abstract Measuring the effectiveness of management programmes for alien invasive predators can be difficult not least because the densities of these species are often hard to estimate. We estimated the proportion of nights ( incursion rate…
Stewart JJ, Allen BS, Polutchko SK et al. · 2026 · Journal of experimental botany
Refilling of xylem embolism during recovery from drought has been studied for decades, although the legitimacy of supporting evidence has been debated in recent years due to potentially widespread methodological artifacts associated with…
van der Steege AE, Humuza J, Shyirambere C et al. · 2026 · BMJ global health
Introduction The WHO Model Lists of Essential Medicines (MLEM and MLEMc) guide national medicine selection, particularly in low-income and lower middle-income countries (LMICs). Concerns exist about the adequacy and transferability of…
Ganguly A, Bhowmik S, Hajra A · 2026 · Therapeutic hypothermia and temperature management
Shivering is a common complication of targeted temperature management (TTM), which could undermine its neuroprotective benefits by increasing cerebral oxygen consumption and metabolic demand. Buspirone, a 5-HT1A receptor partial agonist,…
Simone J, Cooke C, Lee S et al. · 2026 · Sexually transmitted infections
Congenital syphilis (CS) has been rapidly re-emerging as a public health crisis across North America. The present standard of care treatment for CS involves a 10-day hospitalisation for intravenous penicillin G, which is costly for…
Jin X, Shen T, Wang Y et al. · 2026 · JBI evidence implementation
Introduction Auditory hallucinations, persistent and distressing symptoms in patients with schizophrenia, are often poorly controlled by antipsychotics. Structured non-pharmacological interventions remain limited in routine clinical…
Black CFD, Phillips C, Sanders IA et al. · 2026 · Child maltreatment
It is unclear whether research has generated causal evidence about the impact of mandatory reporting (MR) policies on reporting outcomes. This scoping review applied concepts from the NIH Stage Model to map and organize five decades of…
Gao Y, Liu M, Li L et al. · 2026 · The Cochrane database of systematic reviews
Background Triple-negative breast cancer (TNBC), an aggressive subtype lacking oestrogen and progesterone receptors and amplification of HER2 receptors, accounts for 12% to 17% of breast cancers. Adjuvant and neoadjuvant chemotherapy…
Brock AS · 2026 · American journal of speech-language pathology
Purpose The objective of this review article is to examine and describe the literature on training speech-language pathology students on the principles of evidence-based practice (EBP). Method A scoping literature review was undertaken in…
Yao S, Xu L · 2026 · Frontiers in medicine
Background Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease characterized by a prolonged clinical course with recurrent episodes, and the optimal treatment remains controversial. Multiple systematic…
Riestra-Ayora J, Fernández-Navarro C, Martín-Sanz E et al. · 2026 · Diving and hyperbaric medicine
Introduction Fitness-to-dive after otologic surgery is often approached conservatively, with some procedures historically labelled as absolute contraindications despite limited empirical evidence. The available literature is heterogeneous…
De Santis KK, Matthias K, Nikoyan K et al. · 2026 · Journal of prevention (2022)
Cochrane reviews provide high-quality evidence syntheses. To guide the production and dissemination of new Cochrane reviews, an evidence map based on the characteristics of existing reviews is necessary. This study is a scoping review that…
Yang M, Lovrenert K, Thirumavalavan N et al. · 2026 · Basic and clinical andrology
Background Male infertility affects approximately 10% of men globally, yet approximately 70% of cases lack a definitive genetic diagnosis. Next-generation sequencing has identified numerous monogenic causes, many of which are linked to…
CHANCA MJP · 2026 · Preprint
Abstract Background Phenomenon-Based Learning (PhBL), introduced through Finland's 2014–2016 national curriculum reform, replaces subject-based silos with multidisciplinary, student-centred investigation of real-world phenomena. Its…
Hu JX, Wen Q, Zhou H et al. · 2026 · Geriatric nursing (New York, N.Y.)
Objective To systematically synthesize the best available evidence on nonpharmacological interventions in traditional Chinese medicine (TCM) for cognitive impairment in patients with Alzheimer's disease (AD). Methods Guided by the "6S"…
Belančić A, Rogoznica Pavlović M, Fajkić A et al. · 2026 · Rheumatology international
Obstructive sleep apnoea (OSA) and spondyloarthritis (SpA) are chronic inflammatory disorders associated with substantial cardiometabolic morbidity and impaired quality of life. Increasing evidence suggests that these conditions frequently…
Gopinath D, On CY, Veettil SK et al. · 2026 · Oral diseases
Background The cumulative evidence from meta-analyses on interventions for oral submucous fibrosis (OSF) remains uncertain in terms of strength, precision, and quality. This umbrella review synthesizes the current evidence on available…
Qiu F, Ling C, Wang S et al. · 2026 · Molecules (Basel, Switzerland)
Mulberrofuran A (MFA), a natural product originally isolated from the root bark of Morus alba L. (Sang-Bai-Pi), is a structurally distinctive mulberry-derived 2-arylbenzofuran bearing a prenyl-related side chain. Although MFA has attracted…
Baltrak YA, Deliaga H · 2026 · Preprint
Background: /Objectives: Vesicoureteral reflux (VUR) is an important pediatric urologic condition in which accurate grading on voiding cystourethrography (VCUG) may influence counseling, surveillance, antimicrobial prophylaxis, and…
Chauhan V, Goyal D, Thakur S et al. · 2026 · The western journal of emergency medicine
Introduction Organophosphate (OP) poisoning is a significant global health issue, particularly in tropical regions. Despite established treatments such as atropine and oximes, the effectiveness of other interventions remains uncertain.…
La Vignera S, Condorelli RA · 2026 · International journal of molecular sciences
Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), have emerged as potentially promising therapeutic agents for improving ovarian function, especially in women with polycystic ovary syndrome…
Luo X, Wang B, Liu H et al. · 2026 · Integrative medicine research
Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder with substantial global burden. In some regions, Chinese medicine (CM) and integrated Chinese-Western medicine (ICWM) are widely used, but the overall…
Henriques JP, Weckwerth AVB, Santana ACP et al. · 2026 · Annales pharmaceutiques francaises
Objectives Diabetes mellitus and periodontal disease are highly prevalent chronic disorders linked by bidirectional inflammatory and oxidative pathways. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are emerging pharmacologic agents…
Shukkoor AA, Turgeon RD, De Vera MA et al. · 2026 · BMJ open
Objectives This study aimed to investigate the association and potential causal relationship between ischaemic stroke/transient ischaemic attack (TIA) and oral anticoagulant (OAC) adherence using Bradford Hill's criteria and to determine…
Mohamed D, Ramadan AA, Mabrok HB et al. · 2026 · World journal of biological chemistry
Phytosterols are plant-derived sterols structurally similar to cholesterol and present in vegetable oils, seeds, legumes, and whole grains. Their best-established health effect is lowering circulating low-density lipoprotein cholesterol,…