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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19820 results in Negative / Null Result Report · page 187 of 661

Negative / Null Result Report

P5264There is no significant effect of ischemic time and elapse time since cardiac allograft transplant on myocardial T1 relaxation time

J Vietheer, C Unbehaun, K Classen et al. · 2019 · European Heart Journal

Abstract Background Graft failure caused by allograft rejection and vasculopathy is the most common cause of mortality after heart transplantation. To detect an early allograft rejection, endomyocardial biopsy is still needed. Tissue…

View details →DOI: 10.1093/eurheartj/ehz746.0235
Negative / Null Result Report

The Pandemic Effect: Secondary Impact on the Diagnosis of Clinically Significant Congenital Heart Disease and Role of Deprivation Index

Cassandra Campbell, Kristin Wyckoff, Ronak Naik et al. · 2025 · Pediatric Cardiology

Abstract We sought to determine the impact of the COVID-19 on prenatal diagnosis (PND) of clinically significant congenital heart disease (CHD) and the role of socioeconomic status (SES), complexity of diagnosis, and proximity to advance…

View details →DOI: 10.1007/s00246-025-03844-2
Negative / Null Result Report

Non-significant Effect of El Niño on the Nest Occupancy and Breeding Success of Markham’s Storm Petrel <i>Hydrobates markhami</i>

Fernando Medrano, Benjamín Gallardo, Pablo Gutiérrez et al. · 2024 · Marine Ornithology

The impact of the El Niño varies across seabirds, usually altering the distribution and causing population declines. Understanding El Niño’s effects is thus critical for conservation. We monitored 296 nests of the little-known Hydrobates…

View details →DOI: 10.5038/2074-1235.52.2.1603
Negative / Null Result ReportOpen access

Correlation of c-erbb2 Expression in Undifferentiated Nasopharyngeal Carcinoma and Tumor Size (T-Stage) (Dyah Fauziah et al.) 290 CORRELATION OF C-ERBB2 EXPRESSION IN UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA AND TUMOR SIZE (T-STAGE), REGIONAL LYMPHNODES

Willy Sandhika, Faroek Hoesin, Dyah Fauziah · 2020

No significant correlation was found between c-erbB2 expression and tumor size (T-stage). c-erbB2 expression in various N-stages were as follows: N0 (80%), N1 (33,3%), N2 (50%), N3 (42,9%). No significant correlation was found between…

Negative / Null Result ReportOpen access

Forest plot diagram showing the effect of low-dose tamsulosin on total International Prostate Symptom Score (IPSS) (a), storage IPSS (b), quality of life (QoL) (c), maximal urinary flow rate (Qmax) (d), and post-voided residual volume (PVR) (e).

Seung Whan Doo (703584), Young Myoung Ko (703588), Hwa Yeon Sun (3628463) et al. · 2017

Total IPSS and Qmax showed no significant improvement. Storage IPSS and QoL showed significant improvement and PVR showed significant increase. The black diamond signifies that the mean difference is in favor of IPSS. The size of each…

View details →DOI: 10.1371/journal.pone.0169248.g002
Negative / Null Result ReportOpen access

有酸素運動 (Aerobics) を中心にした一般教養体育実技の有効性と限界について-第一報:血液組成と体組成におよぼす影響-

田原, 靖昭, 西澤, 昭, 管原, 正志 et al. · 1991

Aerobic exercise class was opened and blood and physical composition were examined. Results indicated that no significant improvement on measured items was observed. Frequency of participation is suggested to be increased or class goal…

Negative / Null Result ReportOpen access

Performance of Perforated Heat Exchanger Surfaces

J. R. Mondt, D. C. Siegla · 1974

Heat transfer and flow friction behavior have been measured for plain and perforated plate-fin and 10-deg herringbone surfaces. For the range of geometries and Reynolds numbers studied, the perforations produced no significant improvement…

View details →DOI: 10.1115/1.3445766
Negative / Null Result ReportOpen access

The SOS Pilot Study: a RCT of routine oxygen supplementation early after acute stroke—effect on recovery of neurological function at one week

Khalid Mustafa Ali (4461853), Christine Roffe (220471), Anushka Warusevitane (220475) et al. · 2011

Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…

Negative / Null Result ReportOpen access

Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer

Akerley, Wallace, Herndon, James E. 2nd, Vokes, Everett E. et al. · 2017

BACKGROUND: In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…

View details →DOI: 10.1097/jto.0b013e3181b27b33.
Negative / Null Result ReportOpen access

Treatment Outcomes of Different Prognostic Groups of Patients on Cancer and Leukemia Group B Trial 39801: Induction Chemotherapy Followed by Chemoradiotherapy Compared with Chemoradiotherapy Alone for Unresectable Stage III Non-small Cell Lung Cancer

Akerley, Wallace, Vokes, Everett E., Cicchetti, M Giulia et al. · 2009

BackgroundIn Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…

View details →DOI: 10.1097/jto.0b013e3181b27b33
Negative / Null Result ReportOpen access

IL-24 regulated CXCR4 at post-transcriptional level.

Jiankang Jin (703171), Stephen J. Archibald (703175), Janani Panneerselvam (703170) et al. · 2015

A , RT-PCR analysis showed IL-24 reduced CXCR4 mRNA levels at 6 h and 24 h ( P B , CXCR4 promoter activity was determined using a luciferase reporter vector. Induction of IL-24 showed no significant reduction in luciferase activity…

View details →DOI: 10.1371/journal.pone.0122439.g004
Negative / Null Result ReportOpen access

Effects of α-MSH treatment on Caspase 3 activity.

Andrew W. Taylor (451751) · 2013

The macrophages lysates were assayed for protein concentration and Caspase 3 activity. There was no significant change of Caspase 3 activity in cells treated with α-MSH compared to SFM cells. The graft is the mean ± SD of Caspase 3…

View details →DOI: 10.1371/journal.pone.0074488.g004
Negative / Null Result ReportOpen access

Supplementary Table S1 from Radiation-induced Adaptive Response: New Potential for Cancer Treatment

Sandra Demaria (15026216), Shannon Martello (11246282), Molykutty J. Aryankalayil (5544962) et al. · 2020

Metabolic data from PC3 cells 6h, 24h, and 48h after SD or MF radiation. Samples were sent to Metabolon for processing. Results indicate decrease in glycolysis intermediates in SD sample at 6h. No significant changes to TCA cycle…

View details →DOI: 10.1158/1078-0432.22477403.v1
Negative / Null Result ReportOpen access

Water radial arm maze performance.

Tristan G. Pesaresi (6751925), Grayson Breneman Ashby (6751931), Min-Ken Liao (6751934) et al. · 2019

Working memory correct (A), working memory incorrect (B) and reference memory (C) errors over the 12 days of testing are shown between low fat and high fat-fed rats. There were no significant differences between dietary group for any of…

View details →DOI: 10.1371/journal.pone.0217553.g002
Negative / Null Result ReportOpen access

Birth Order and past-Orientation

Christopher D. Green, Gladys M. Batten, Anton F. De Man et al. · 1983

Three studies examined Adler's suggestion that firstborns are past-oriented. The first study of the relationship between birthorder and temporal relatedness and dominance in 37 female undergraduates yielded no significant differences. The…

View details →DOI: 10.2466/pr0.1983.53.2.425
Negative / Null Result ReportOpen access

A. Box plot of the maximum decrease of temperatures from the baseline.

Ayako Asakura (711890), Takahisa Goto (711892), Takahiro Mihara (789554) · 2015

No significant differences were detected among the groups, but the maximum decreases tended to be smaller in the CHO and ORS groups than in the control group. B. Box plot of the final temperature changes at the end of surgery. No…

View details →DOI: 10.1371/journal.pone.0133309.g003
Negative / Null Result ReportOpen access

Conflict duration on the flanker task (i.e., reaction time for each incongruent trial–reaction time for each congruent trial) pre- (white bar) and post-treatment (black bar) with OT or placebo.

Yuko Yoshimura (283970), Hirotoshi Hiraishi (283977), Mitsuru Kikuchi (140272) et al. · 2015

Two-way ANOVA (treatment × drug) failed to demonstrate any drug or treatment effects, and no significant interaction between these two factors was detected. Therefore, we failed to demonstrate any OT-related effect on…

View details →DOI: 10.1371/journal.pone.0116918.g004