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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20217 results in Negative / Null Result Report · page 186 of 674

Negative / Null Result ReportOpen accessMedicine

Stewardship Behaviour Among Residents of the Great Barrier Reef Region and the Role of Self-Efficacy.

Dousset J, Curnock MI, Wang JZ et al. · 2026 · Environmental management

As the Great Barrier Reef (GBR, the Reef) faces unprecedented threats, reducing anthropogenic pressures and fostering stewardship within coastal communities are among the strategic priorities identified in the Australian and Queensland…

View details →DOI: 10.1007/s00267-026-02525-x
Negative / Null Result ReportOpen accessMedicine

Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma.

Hecht S, Rojas-Ruiz A, Boucher M et al. · 2025 · Lung

Introduction A recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily…

View details →DOI: 10.1007/s00408-025-00840-4
Negative / Null Result ReportOpen accessMedicine

Association of immune checkpoint inhibitor-induced bullous pemphigoid with underlying cancer type: A lack of association with cancer tissue <i>COL17A1</i> mutations and dysregulation.

Chang RC, Olbrich H, Wang YF et al. · 2026 · JID innovations : skin science from molecules to population health

Bullous pemphigoid (BP) is an autoimmune blistering disease caused by autoantibodies to collagen type 17 ( COL17A1 ) and is a recognized immune-related adverse event in patients receiving immune checkpoint inhibitors (ICIs). We…

View details →DOI: 10.1016/j.xjidi.2026.100450
Negative / Null Result Report

Does missing medication acutely change seizure risk? A prospective study

Goldenholz DM, Cheng JC, Chang C et al. · 2025 · Preprint

ABSTRACT Importance Medication adherence is widely emphasized in epilepsy management, with a belief that missing even single doses can trigger seizures. However, scientific evidence supporting this specific claim is limited, particularly…

View details →DOI: 10.1101/2025.06.06.25329144
Negative / Null Result ReportOpen accessMedicine

Associations of cord blood biomarkers with infant colic and excessive crying.

Simonin EM, Switkowski KM, Rifas-Shiman SL et al. · 2026 · Frontiers in pediatrics

Introduction There are currently no known biomarkers associated with the diagnosis of infant colic, a common early disorder of gut brain interaction (DGBI) that has been found to predict adverse health outcomes, including atopy, migraines…

View details →DOI: 10.3389/fped.2026.1767660
Negative / Null Result ReportOpen accessMedicine

Elevated serum apelin levels in breast cancer patients: A potential biomarker with limited histopathological correlations.

Soltanizadeh A, Tirgar A, Zamanian Y et al. · 2025 · Frontiers in oncology

Background Apelin, a peptide implicated in various physiological processes, has been shown to be involved in cancer development and progression. However, its role in breast cancer remains unclear. This study aimed to investigate serum…

View details →DOI: 10.3389/fonc.2025.1513693
Negative / Null Result ReportOpen accessMedicine

Lack of association between revision ACL reconstruction and preoperative, intraoperative and post-operative factors at primary ACL reconstruction in children and adolescents.

Cristiani R, Hansson F, Senorski EH et al. · 2025 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose To evaluate factors associated with revision anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR in children and adolescents. Methods Children and adolescents (age Results A total of 1888 patients (mean…

View details →DOI: 10.1002/ksa.12568
Negative / Null Result ReportOpen accessMedicine

Analyses of haplotypes of <i>TLR2</i> and <i>TLR3</i> genes for COVID-19 prognosis in a cohort of professionals who worked in the first pandemic wave in Belém-PA, Brazil.

Silva MJA, Figueira LRT, Sardinha DM et al. · 2025 · Frontiers in genetics

Coronavirus disease 2019 (COVID-19) is a multisystemic disease caused by SARS-CoV-2 that can lead to several pulmonary illnesses according to the immunological contexts of the individual. Haplotypes consist of single-nucleotide…

View details →DOI: 10.3389/fgene.2025.1659269
Negative / Null Result ReportOpen accessMedicine

VGLUT1 and PSD-95 Expression Remains Stable in the Prefrontal and Cerebellar Cortices of the VPA Autism Rat Model.

Reveley M, Owen GR, Tumba N et al. · 2026 · Developmental neurobiology

Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation-inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms…

View details →DOI: 10.1002/dneu.70018
Negative / Null Result ReportMedicine

Impact of blinatumomab and inotuzumab exposure on apheresis composition for CAR T in patients with B-cell acute lymphoblastic leukemia.

Cantilena A, Han KL, Cai Y et al. · 2026 · Cytotherapy

Children with B-cell acute lymphoblastic leukemia (B-ALL) are increasingly treated with immunotherapeutic agents such as blinatumomab and inotuzumab. Thus, those who present in relapse for chimeric antigen receptor (CAR) T-cell therapy are…

View details →DOI: 10.1016/j.jcyt.2026.102788
Negative / Null Result ReportOpen accessMedicine

The effect of serum lipase levels on clinical severity scores and mortality in acute pancreatitis: a retrospective cohort study.

Kilicaslan MB, Dikme O, Girgin MC et al. · 2026 · BMC gastroenterology

Aims This study aimed to investigate the relationship between admission serum lipase levels, prognostic clinical scoring systems, and in-hospital mortality in patients presenting to the emergency department with acute pancreatitis. Methods…

View details →DOI: 10.1186/s12876-026-04897-0
Negative / Null Result ReportOpen accessMedicine

A Comprehensive Analysis of Predictors of Marginal Ulcers After Roux-en-Y Gastric Bypass: A Cohort Review of 2106 Patients.

Abedalqader T, Migliorini A, Cerecedo LG et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives: Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed metabolic and bariatric surgeries worldwide. Marginal ulcers (MU) are a common complication following RYGB, yet their pathophysiology and the…

View details →DOI: 10.3390/medicina62050838
Negative / Null Result ReportMedicine

Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates.

Antunes RA, Souza MDCB, Souza MM et al. · 2024 · Fertility and sterility

Objective To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates. Design A retrospective cohort study. Setting A private…

View details →DOI: 10.1016/j.fertnstert.2024.06.023
Negative / Null Result ReportOpen accessMedicine

Lack of Association of Serum MMP-9 Concentration and rs17576 Single Nucleotide Variant <i>MMP-9</i> Gene With the Degree of Coronary Atherosclerosis and Other Risk Factors in Ukrainian Patients With Coronary Artery Disease.

Pogorielova OS, Korniienko VV, Chumachenko YD et al. · 2025 · Cardiology research and practice

This study probes the relationship between serum matrix metalloproteinase-9 (MMP-9) levels, the genetic variant rs17576 in the MMP-9 gene, and the extent of coronary atherosclerosis among Ukrainian patients diagnosed with coronary artery…

View details →DOI: 10.1155/crp/6610742
Negative / Null Result ReportOpen accessMedicine

Are high residual chlorhexidine skin concentrations associated with improved clinical outcomes? Lessons from the CLEAR trial.

Khoja R, Catuna TD, Gussin GM et al. · 2026 · Infection control and hospital epidemiology

Residual chlorhexidine gluconate (CHG) skin concentrations are thought to improve disease prevention. In the Changing Lives by Eradicating Antibiotic Resistance (CLEAR) trial, posthospitalization decolonization of MRSA carriers reduced…

View details →DOI: 10.1017/ice.2026.10424
Negative / Null Result ReportOpen accessMedicine

Cognitive Impairment and Quality of Life in AQP4-IgG Seropositive Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study in Iranian Patients.

Ramazanzadeh S, Ashtari F · 2026 · Neurology research international

Background Cognitive impairment (CI) has been reported with wide variability in neuromyelitis optica spectrum disorder (NMOSD), but its impact on patients' quality of life (QoL) is not well understood. The aim of this study was to describe…

View details →DOI: 10.1155/nri/5624714
Negative / Null Result ReportOpen accessMedicine

Plasmid diversity, antibiotic resistance and virulence genes associated with Staphylococcus aureus isolates from private hospitals in Gauteng, South Africa.

Ngoie K, Kingsburgh C, Hamiwe T et al. · 2026 · World journal of microbiology & biotechnology

This study investigated the association between plasmid diversity, antibiotic resistance and virulence genes of Staphylococcus aureus (S. aureus) isolates from private hospitals in Gauteng, South Africa. Automated antibiotic susceptibility…

View details →DOI: 10.1007/s11274-026-04956-4
Negative / Null Result ReportOpen accessMedicine

Application of the SF-BARI Score for Evaluating long-term Metabolic and Clinical Outcomes after Bariatric Surgery.

Mendes C, Carvalho M, Gregório J et al. · 2026 · Obesity surgery

BACKGROUND: Bariatric surgery is an effective treatment for severe obesity, resulting in significant weight loss and remission of obesity-related diseases. However, weight gain remains a challenge, potentially impacting long-term outcomes.…

View details →DOI: 10.1007/s11695-026-08541-4
Negative / Null Result ReportMedicine

Understanding Platelet Activation in the Aeson Bioprosthetic Total Artificial Heart: Insights From Aspirin Treatment and Outcomes.

Smadja DM, Roux de Bezieux J, Peronino C et al. · 2025 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

This study aimed to assess platelet activation following implantation of the Aeson bioprosthetic total artificial heart (A-TAH). We monitored plasma levels of platelet activation markers in patients receiving A-TAH support (n = 16)…

View details →DOI: 10.1097/mat.0000000000002403
Negative / Null Result ReportOpen accessMedicine

Feasibility of Using Dynamic Appraisal of Situational Aggression to Reduce Agitation in an Inpatient Psychiatric Unit.

Mathew DE, Mathews DP, Wang D et al. · 2025 · Cureus

Agitation in inpatient psychiatric units is common and is an important area for research given its impact on staff and patients. This study explores the feasibility and utility of the Dynamic Appraisal of Situational Aggression (DASA) risk…

View details →DOI: 10.7759/cureus.96243
Negative / Null Result ReportMedicine

Lack of association between Lp(a) and retinal vein occlusion in a single institution and US national database.

Russell MW, Maatouk CM, Kim S et al. · 2024 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Objective This study examines associations between lipoprotein(a) (Lp[a]), a low-density-like lipoprotein, and renal vein occlusion (RVO) in US cohorts to characterize its prognostic role in the setting of RVO. Design A two-phase…

View details →DOI: 10.1016/j.jcjo.2023.10.007
Negative / Null Result ReportMedicine

Participation among young people in the child protection system and how it relates to subsequent educational and employment outcomes.

Bolvig I, Kloppenborg H, Lausten M · 2025 · Child abuse & neglect

Background Previous research has shown that young people in the child protection system experience different levels of participation in decision-making on important issues. Nonetheless, researchers agree that children's participation in…

View details →DOI: 10.1016/j.chiabu.2024.107001
Negative / Null Result ReportOpen accessMedicine

Single-arm Cohort Study on the Effects of the COVID-19 Pandemic on the Radiation Treatment of Cancer Patients Referred to the Radiation Oncology Division of a Tertiary Hospital.

de Guzman SPC, Chavez LL, Abrilla AA · 2024 · Acta medica Philippina

Objective This study aimed to identify the effects of COVID-19 pandemic on radiation treatment delays, interruptions, and cancer outcomes if any, in a Philippine tertiary hospital. Methods A retrospective observational cohort study was…

View details →DOI: 10.47895/amp.vi0.7867