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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19820 results in Negative / Null Result Report · page 183 of 661

Negative / Null Result ReportMedicine

Impaction Injury of the Femoral Head After Traumatic Posterior Hip Dislocation: A Literature Review and Case Study.

Puppala, Chodavarapu, Sami et al. · 2026 · Indian journal of orthopaedics

Femoral head impaction injuries, sometimes referred to as the "Hill-Sachs lesion" of the femoral head, are an uncommon yet significant consequence of posterior hip dislocations. These occur due to compressive forces on the femoral head,…

View details →DOI: 10.1007/s43465-025-01572-6
Negative / Null Result ReportMedicine

Complement C5 inhibitors as add-on rescue treatment in severe AQP4-antibody neuromyelitis optica spectrum disorder attacks: a case series and literature review.

Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders

Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…

View details →DOI: 10.1177/17562864261449515
Negative / Null Result ReportMedicine

Posterior circulation stroke secondary to atlantoaxial instability-induced vertebral artery dissection and pseudoaneurysm in a paediatric patient.

Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports

A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…

View details →DOI: 10.1136/bcr-2026-272989
Negative / Null Result ReportMedicine

[The health insurers' perspective on defining and managing healthcare needs].

Malzahn, Höft Budde, Kneißl et al. · 2026 · Innere Medizin (Heidelberg, Germany)

The German healthcare system, despite its high performance, fails to achieve the goal of needs-based service provision. Supply-induced demand, regional disparities and misaligned financial incentives lead to overuse, underuse and misuse of…

View details →DOI: 10.1007/s00108-026-02117-1
Negative / Null Result ReportMedicine

CHIKV-Infected Human Dermal Fibroblasts Mount an IFNβ Transcriptional Response Independent of TBK1/IKKε Signaling That Fails to Prevent Lethal Infection.

Taylor, Roberts, Rayner · 2026 · Viruses

Chikungunya virus (CHIKV) is an alphavirus that infects dermal fibroblasts as a primary target cell during natural mosquito-borne transmission. While primary human dermal fibroblasts (hDFs) have been implicated as a key source of type I…

View details →DOI: 10.3390/v18050503
Negative / Null Result ReportMedicine

Pharmacokinetic and Pharmacodynamic Assessments of the Ivermectin and Levamisole Combination to Control Resistant Nematodes in Cattle.

Canton, Ceballos, Canton et al. · 2026 · Pharmaceutics

Background/Objectives: Combination of antiparasitic drugs with different mechanisms of action has been suggested as an effective strategy to delay the development of parasite resistance. Considering the need to understand the…

View details →DOI: 10.3390/pharmaceutics18050630
Negative / Null Result ReportMedicine

Beyond Reperfusion: Early Molecular Drivers and Therapeutic Opportunities in Acute Post-Infarction Cardiac Fibrosis.

Tan, Lye, Patel et al. · 2026 · International journal of molecular sciences

Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this…

View details →DOI: 10.3390/ijms27104409
Negative / Null Result ReportMedicine

Diagnosis and management of mixed Chlamydia abortus and psittaci pneumonia guided by metagenomic next-generation sequencing: a case report.

Liu, Su, Gong et al. · 2026 · BMC infectious diseases

Chlamydia abortus primarily causes abortion and stillbirth in animals and is associated with pregnancy-related complications in humans. However, it is an extremely rare cause of pneumonia in humans. While Chlamydia psittaci is a…

View details →DOI: 10.1186/s12879-026-13691-y
Negative / Null Result ReportMedicine

Multimodal digital phenotyping of bipolar disorder subtypes: Differences between bipolar disorder I and II based on passive and active behavioral features from smartphones.

Faurholt-Jepsen, Hammershøi, Bruun et al. · 2026 · Journal of affective disorders

Distinguishing between bipolar disorder type I and II constitutes a significant clinical challenge that relies on retrospective patient recall. Misclassification carries risks of inappropriate pharmacological management. Digital…

View details →DOI: 10.1016/j.jad.2026.122027
Negative / Null Result ReportMedicine

Risk stratification in early-stage Cardiovascular-Kidney-Metabolic Syndrome: The Potency of visceral adiposity and insulin resistance surrogate indices.

He, Lin, Zhang et al. · 2026 · Diabetes research and clinical practice

Cardiovascular-kidney-metabolic (CKM) syndrome defines a pathophysiological continuum linking obesity, metabolic dysfunction, chronic kidney disease, and cardiovascular disease. Stages 0-3 represent a critical subclinical window for…

View details →DOI: 10.1016/j.diabres.2026.113336
Negative / Null Result ReportMedicine

Neurotoxic effects of representative pharmaceutical mixtures from Mediterranean rivers impacted by waste water treated effluents.

Romero-Alfano, Prats, Raldúa et al. · 2026 · The Science of the total environment

Mixture toxicity studies on neuroactive chemicals remain scarce and often rely on simplified combinations of compounds with known modes of action (MoA), despite the frequent non-monotonicity of neuroactive responses. Furthermore, real…

View details →DOI: 10.1016/j.scitotenv.2026.181901
Negative / Null Result ReportMedicine

Atypical gunshot wounds resulting in fetal death: two rare case reports.

Oduncu, Zor, Çimen et al. · 2026 · Forensic science, medicine, and pathology

Gunshot wounds (GSW) pose serious risks to both mother and fetus. Determining the trajectory and cause of death in the fetus in GSW is of forensic importance. This study aims to contribute to the literature with two rare GSW cases leading…

View details →DOI: 10.1007/s12024-026-01271-0
Negative / Null Result ReportMedicine

No Additional Effects of Block- Compared to Even-Periodization of Low-Intensity Training in Junior Cross-Country Skiers.

Walther, Hänel, Krohn et al. · 2026 · International journal of sports physiology and performance

To compare effects of block periodization against evenly distributed low-intensity training on endurance performance in well-trained junior cross-country (XC) skiers. Twenty junior cross-country skiers participated in a crossover design…

View details →DOI: 10.1123/ijspp.2025-0552
Negative / Null Result ReportMedicine

Development of a mobile application for screening the risk of premarital sex among adolescents in Northern Thailand.

Songthap, Wanaratwichit, Mekrungrongwong · 2026 · BMC public health

Despite existing efforts, premarital sex among Thai adolescents remains a critical public health concern, exacerbated by nearly universal smartphone access and prolonged daily digital exposure. Traditional surveillance often fails to…

View details →DOI: 10.1186/s12889-026-27807-1
Negative / Null Result ReportMedicine

Sequential treatment strategies following methotrexate inadequate response in rheumatoid arthritis: a real-world retrospective cohort study.

Cruciani, Cafaro, Perricone et al. · 2026 · Clinical and experimental rheumatology

This study aimed to compare different treatment strategies for rheumatoid arthritis (RA) patients following inadequate response to initial methotrexate (MTX) therapy, evaluating clinical outcomes, tolerability profiles, and factors…

View details →DOI: 10.55563/clinexprheumatol/zssu99
Negative / Null Result ReportMedicine

LC3B Mediated SETDB1-Accounted Alcoholic Steatohepatitis via Lipidation-Dependent LAP and Lipidation-Independent Nuclear Stabilization.

Zhang, Wei, Wu et al. · 2026 · Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Alcohol-associated liver disease (ALD) progresses from steatosis to steatohepatitis, but the underlying mechanisms remain unclear. Here, we investigated SETDB1's role in ALD progression involving LC3B-mediated LC3-associated phagocytosis…

View details →DOI: 10.1002/advs.202513189
Negative / Null Result ReportMedicine

Quality Improvement Analysis of Operative Regimen on Urinary Tract Infections.

Bonglack, Carrel-Lammert, Hoehn et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Acute urinary tract infections (UTIs) are common after prolapse and anti-incontinence surgery, with incidence rates varying from 14% to 64%. The objective was to decrease rates of symptomatic urinary tract infections in patients undergoing…

View details →DOI: 10.1097/spv.0000000000001742
Negative / Null Result ReportMedicine

Vonoprazan is associated with a phenotype-specific increase in cholangitis reporting in immune checkpoint inhibitor-treated patients: a VigiBase pharmacovigilance study.

Mizuno, Chretien, Nishida et al. · 2026 · Journal of gastroenterology

Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), including cholangitis, a rare but clinically severe hepatobiliary phenotype. Whether potassium-competitive acid blockers (PCABs) such as vonoprazan are…

View details →DOI: 10.1007/s00535-026-02469-3