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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20217 results in Negative / Null Result Report · page 183 of 674

Negative / Null Result Report

TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma

Erling Håland, Ingrid Nyhus Moen, Esten N. Vandsemb et al. · 2022 · BMC Research Notes

Abstract Objective Multiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of resistance and minimal residual disease remain challenging in the treatment of…

View details →DOI: 10.1186/s13104-022-06237-3Cited by 1
Negative / Null Result Report

Repeated Annual Health Risk Assessments With Intervention Did Not Reduce 10-year Cardiovascular Disease Risk

Nceba Hene, Paola Wood, Martin Schwellnus et al. · 2021 · Journal of Occupational & Environmental Medicine

Objective: To determine if repeat annual health risk assessments (RAHRAs) with intervention reduce 10-year cardiovascular disease (CVD) risk in financial sector employees. Methods: Retrospective analysis from RAHRAs in 13,737 employees…

View details →DOI: 10.1097/jom.0000000000002251Cited by 1
Negative / Null Result Report

Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double‐blinded, placebo‐controlled trial

Mikkel Andreas Holm, Anders Gram‐Hanssen, Bennedikte Kollerup Madsen et al. · 2022 · Acta Anaesthesiologica Scandinavica

Abstract Background Preoperative anxiety is a common issue in surgery. Preoperative anxiety may lead to increased mortality, pain and dissatisfaction with surgery. Melatonin is a drug with only mild adverse effects and has previously been…

View details →DOI: 10.1111/aas.14128Cited by 1
Negative / Null Result Report

Preliminary study does not demonstrate SARS-CoV-2 infection in bats from Oaxaca, México during the Covid-19 pandemic

Itandehui Hernández-Aguilar, Luis Román Ramírez-Palacios, Consuelo Lorenzo et al. · 2024 · Therya Notes

The SARS-CoV-2 virus is the etiological agent of the 2019 coronavirus disease that caused the COVID-19 pandemic. This virus has achieved sustained transmission across human populations; however, since 2020, reverse zoonotic contagion…

View details →DOI: 10.12933/therya_notes-24-155Cited by 1
Negative / Null Result Report

A Mismatched Group of Items That I Would Not Find Particularly Interesting: Challenges and Opportunities with Digital Exhibits and Collections Labels

Mikala Narlock, Anna Michelle Martinez-Montavon, Melissa Harden · 2022 · Evidence Based Library and Information Practice

Objective – The authors sought to identify link language that is user-friendly and sufficiently disambiguates between a digital collection and digital exhibit platform for users from a R1 institution, or a university with high research…

View details →DOI: 10.18438/eblip30194Cited by 1
Negative / Null Result Report

Can Collective Action Institutions Outperform the State?

Max Harleman, Jeremy G. Weber · 2025 · Policy Studies Journal

ABSTRACT A core literature in the field of public policy seeks to understand whether decentralized collective action institutions will emerge to provide public goods. While some studies examine how they perform relative to public…

View details →DOI: 10.1111/psj.70065Cited by 1
Negative / Null Result Report

Two Familial Cases of Hb Tyne Confirm Instability as Cause of Low Expression

Beverley M. Pullon, Stephen O. Brennan · 2017 · Thalassemia Reports

We report a second occurrence of hemoglobin (Hb) Tyne, [β5 (A2) Pro>Ser] HBB:c.16C>T(p.Pro6Ser), which like the first case was associated with normal hematology. We verified the variant was mildly unstable by showing it was greatly…

View details →DOI: 10.4081/thal.2017.6504Cited by 1
Negative / Null Result Report

Minding Spatial Allocation Entropy: Sentinel-2 Dense Time Series Spectral Features Outperform Vegetation Indices to Map Desert Plant Assemblages

Frederick N. Numbisi · 2025 · Remote Sensing

The spatial distribution of ephemeral and perennial dryland plant species is increasingly modified and restricted by ever-changing climates and development expansion. At the interface of biodiversity conservation and developmental planning…

View details →DOI: 10.3390/rs17152553Cited by 1
Negative / Null Result Report

Performance of sustainable investments: do green-labeled bonds outperform green-unlabeled bonds?

Linh Tu Ho, Christopher Gan, Wei Yang et al. · 2025 · Studies in Economics and Finance

Purpose The increase in demand for sustainable investments globally raises the question of benefits of investing in green bonds. A green label attracts investors because it represents less information asymmetry on green bonds with lower…

View details →DOI: 10.1108/sef-08-2024-0536Cited by 1
Negative / Null Result Report

Antibacterial Activity of Moringa Oleifera Leaf Extract Against Clinically Significant Bacteria

Sagar Kandel, Anup Muni Bajracharya, Laxmi Shrestha et al. · 2025 · Journal of Nepal Biotechnology Association

The global rise of multidrug-resistant (MDR) bacteria calls for different alternative antimicrobial strategies. Moringa oleifera, which is found to be rich in secondary metabolites compounds, has shown some antibacterial potential. This…

View details →DOI: 10.3126/jnba.v6i1.76915Cited by 1
Negative / Null Result Report

Impact of Significant Hemoglobin Drop Without Bleeding in Patients Undergoing Transcatheter Aortic Valve Replacement

Pavan Reddy, Ilan Merdler, Cheng Zhang et al. · 2024 · Journal of the American Heart Association

Background Hemoglobin (Hgb) drop without bleeding is common among patients undergoing transcatheter aortic valve replacement; however, the clinical implications of significant Hgb drop have not been fully evaluated. Methods and Results…

View details →DOI: 10.1161/jaha.123.032291Cited by 1
Negative / Null Result Report

Aerosol–Climate Interaction in the South Asian Region: A Focused Exploration of the Impacts of Ozone, Black Carbon, Optical Properties and Radiative Forcing in a Region of Significant Climate Change Dynamics

Kazi Rakib Uddin, Shahid Uz Zaman, Krishnakant B. Budhavant et al. · 2025 · International Journal of Climatology

ABSTRACT In South Asia, our understanding of atmospheric aerosols and their optical properties is limited, posing a challenge to comprehending climate change dynamics. This study characterises aerosol optical properties, radiative…

View details →DOI: 10.1002/joc.8800Cited by 1
Negative / Null Result Report

Do Female Fund Managers outperform their Male Counterparts? A Quantitative Analysis of UK Retail Funds

Jacob H Schmidt, Bianca Hutton Chimes · 2023 · Journal of Applied Finance & Banking

Abstract Why are there so few women in finance and even fewer managing funds? There is a major discrepancy between the number of female and male fund managers worldwide. The aim of this paper is to ascertain if gender is a contributing…

View details →DOI: 10.47260/jafb/1352Cited by 1
Negative / Null Result Report

Type III collagen formation is significantly associated with risk of outcome in HFpEF patients but loses its significant association with underlying AF

E Angeli, A Reese-Petersen, A Gonzalez et al. · 2022 · European Heart Journal

Abstract Introduction Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, associated with high morbidity and mortality. Atrial fibrillation (AF) has been associated with structural remodelling…

View details →DOI: 10.1093/eurheartj/ehac544.792Cited by 1
Negative / Null Result Report

On the most significant change of teachers’ evaluation: A descriptive-narrative research

Carina Seron, Betarmos Jr. Vicente, Melbert Hungo et al. · 2024 · Journal of Research, Policy & Practice of Teachers & Teacher Education

This study aimed to explore transformative shifts resulting from teacher evaluations. Employing a descriptive-narrative research design, sixteen teachers in Bontoc I and II districts, Southern Leyte, Philippines were purposively sampled…

View details →DOI: 10.37134/jrpptte.vol14.2.4.2024Cited by 1
Negative / Null Result Report

Perioperative Echocardiography to Confirm Correct Central Venous Catheter Placement: A Case Report

Parag Gharde, Sourangshu Sarkar, Kalpana Irpachi et al. · 2020 · A&A Practice

Central venous catheterization is widely regarded as a safe procedure by anesthesiologists and intensivists, but insertion complications and catheter malposition remain challenges for the clinicians performing central venous catheter (CVC)…

View details →DOI: 10.1213/xaa.0000000000001291Cited by 1
Negative / Null Result Report

Scaling transformers for time series forecasting: do pretrained large models outperform small-scale alternatives?

Sanjay Chakraborty, Ibrahim Delibasoglu, Fredrik Heintz · 2026 · Artificial Intelligence Review

Abstract Large pre-trained models have demonstrated remarkable capabilities across domains, but their comparative effectiveness in time series forecasting, especially against smaller, efficient models, remains underexplored. This work…

View details →DOI: 10.1007/s10462-025-11481-7Cited by 1
Negative / Null Result Report

Granuloma Annulare, Autoimmune Thyroiditis, and Lichen Sclerosus in a Woman: Randomness or Significant Association?

Mariele De Paola, Anastasia Batsikosta, Luca Feci et al. · 2013 · Case Reports in Dermatological Medicine

We report a 60-year-old Caucasian female with a 2-year history of diffused granuloma annulare (GA), who presented for the simultaneous occurrence of genital lichen sclerosus (LS) and autoimmune thyroiditis (AT). In our opinion this…

View details →DOI: 10.1155/2013/289084Cited by 1
Negative / Null Result Report

192 Abundance of rumen methanogens did not differ in cattle that differed in residual feed intake

Harvey C Freetly, Amanda K Lindholm-Perry, Andrew P Foote et al. · 2020 · Journal of Animal Science

Abstract Methane represents an energetic loss, and it has been proposed that its reduction may be associated with improved feed efficiency. Rumen methanogens produce most of the methane. Forty-nine crossbred heifers were individually fed a…

View details →DOI: 10.1093/jas/skaa278.274Cited by 1
Negative / Null Result Report

The influence of pre-university education resources on school dropout and the unemployment rate in Romania is significant?

Marian Zaharia · 2024 · Journal of Research and Innovation for Sustainable Society

In Romania, especially at county level, school dropout rate in primary and secondary education, school dropout rate in high school and professional education, as well as unemployment rate, differ significantly from one county to another,…

View details →DOI: 10.33727/jriss.2024.2.22:202-214Cited by 1
Negative / Null Result Report

No Significant Association Between Herpes Zoster and Breast Cancer: A German Outpatient Study with over 120,000 Participants

Vedanth D. Krishnan, Niklas Gremke, André Hajek et al. · 2024 · Clinics and Practice

Purpose: The purpose of this study was to investigate a possible association between Herpes Zoster (HZ) and the subsequent diagnosis of breast cancer (BC). Methods: Utilizing the Disease Analyzer database, anonymized medical records from…

View details →DOI: 10.3390/clinpract14060218Cited by 1
Negative / Null Result Report

Persistent Nanophosphors: Poised to Outperform Bulk Counterparts?

Victor Castaing, Simon Delacroix, Thierry Gacoin et al. · 2026 · Advanced Optical Materials

Abstract The design of advanced materials often reveals how apparent imperfections, such as structural defects or impurities, can be transformed into functional advantages. In insulating oxide matrices, the controlled introduction of…

View details →DOI: 10.1002/adom.202503356Cited by 1
Negative / Null Result Report

A novel approach to off-clamp partial nephrectomy demonstrates significant improvements in renal injury in an experimental porcine model

Daniel Olvera-Posada, Shouzhe Lin, Ghaleb Aboalsamh et al. · 2017 · Canadian Urological Association Journal

Introduction: We sought to design a partial nephrectomy (PN) with contralateral total nephrectomy porcine model and assess the underlying mechanisms of ischemia reperfusion injury (IRI) after PN using a novel, clinically approved resection…

View details →DOI: 10.5489/cuaj.4305Cited by 1
Negative / Null Result Report

Burden of Significant Anxiety and Stress Symptoms in Persons with Visual Impairment in a Nigerian Hospital

Suhanyah Okeke, Justus Uchenna Onu, Ifeoma Nwabuogo Asimadu et al. · 2023 · Journal of the Nigerian Academy of Medicine

Background: Visual impairment (VI) presents a unique situation for adaptation with diverse socio-cultural and psychological consequences. However, the treatment of patients with visual impairment (PVI) in Nigeria is yet to embrace the…

View details →DOI: 10.4103/jnam.jnam_2_23Cited by 1
Negative / Null Result Report

Time as a marker of quality in diagnostic upper endoscopy: a retrospective study of its association with clinically significant findings

Micheal Tadros, Dharma Ayer, Caesar Ferrari et al. · 2026 · Clinical Endoscopy

Background/Aims: Procedural duration has been proposed as a marker of esophagogastroduodenoscopy (EGD) quality; however, formal benchmarks remain undefined. This study examined the association between EGD duration and clinically…

View details →DOI: 10.5946/ce.2025.342Cited by 1
Negative / Null Result Report

Humans Outperform Machines at the Bilingual Shannon Game

Marjan Ghazvininejad, Kevin Knight · 2016 · Entropy

We provide an upper bound for the amount of information a human translator adds to an original text, i.e., how many bits of information we need to store a translation, given the original. We do this by creating a Bilingual Shannon Game…

View details →DOI: 10.3390/e19010015Cited by 1