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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21253 results · page 182 of 709

Failed Experiment ReportMedicine

The effect of increased strength on ball release speed and front foot contact-phase technique in elite male cricket fast bowlers.

Felton PJ, Shine KJ, Yeadon MR et al. · 2025 · Journal of sports sciences

Research on strength in cricket fast bowling has focused on ball release speed over technique. This study investigates how increased strength affects performance and front foot contact-phase technique during fast bowling. A planar,…

View details →DOI: 10.1080/02640414.2025.2480921
Negative / Null Result ReportMedicine

Lighting Up MS2: Exploring Fluence Rates for Virus Inactivation

Pousty D, Betzalel Y, Mamane H · 2025 · AWWA Water Science

This study examined the impact of UV‐LED fluence rate (incident irradiance) and wavelengths on the inactivation of MS2 bacteriophage, determined by log reduction value (LRV). Three levels of fluence rates, each differing by an order of…

Negative / Null Result ReportOpen accessMedicine

Reciprocal cross-feeding between bacteria can limit the emergence of metabolic dependencies.

Chuang Y-C, Behringer MG, Patton GE et al. · 2026 · Applied and environmental microbiology

Cross-feeding is prevalent in microbial communities. Through time, cross-feeding is thought to enrich for loss-of-function mutations, thereby creating or reinforcing dependencies between community members. However, few studies have…

View details →DOI: 10.1128/aem.00363-26
Negative / Null Result ReportMedicine

Referral to chronic pain management and physiotherapy services in adults with severe mental illness: A matched cohort study.

Ma R, Romano E, Perera G et al. · 2025 · General hospital psychiatry

Introduction Chronic pain (CP) is common among people with severe mental illness (SMI). It remains unclear whether patients with comorbid CP and SMI receive equivalent pain management referrals compared to those with CP alone. This…

View details →DOI: 10.1016/j.genhosppsych.2025.05.013
Failed Experiment ReportMedicine

Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development.

Chalifoux M, Avdeeva M, Posfai E · 2025 · Developmental biology

During the first cell fate decision in mammalian embryos, the inner cell mass cells, which will give rise to the embryo proper and other extraembryonic tissues, segregate from the trophectoderm cells, the precursors of the placenta. Cell…

View details →DOI: 10.1016/j.ydbio.2025.05.006
Failed Experiment ReportMedicine

Population Genomics of <i>Macrophomina</i> spp. Reveals Cryptic Host Specialization and Evidence for Meiotic Recombination.

Pennerman KK, Goldman P, Dilla-Ermita CJ et al. · 2025 · Molecular plant-microbe interactions : MPMI

Knowledge of the factors structuring populations of pathogenic fungi is fundamental to disease management efforts and basic biology. However, this crucial information is missing for many important pathogens, including broad-host-range and…

View details →DOI: 10.1094/mpmi-03-25-0032-r
Negative / Null Result ReportMedicine

Disentangling the effects of environmental and anthropogenic drivers on fungal fruitbody and spore diversity in a Mediterranean coniferous forest.

Centenaro G, Ponce Á, de-Miguel S et al. · 2025 · Journal of environmental management

Wild macrofungal species are important non-wood forest products in Mediterranean forests, where their ability to release and disperse spores is crucial for completing their life cycle. However, the ecological drivers behind fruitbody…

View details →DOI: 10.1016/j.jenvman.2025.125897
Negative / Null Result ReportMedicine

Earth's record-high greenness and its attributions in 2020

Zhang Y, Mao J, Sun G et al. · 2025 · Remote Sensing of Environment

Terrestrial vegetation is a crucial component of Earth's biosphere, regulating global carbon and water cycles and contributing to human welfare. Despite an overall greening trend, terrestrial vegetation exhibits a significant inter-annual…

Negative / Null Result ReportOpen accessMedicine

Spurious effects in random-intercept cross-lagged panel models: Results from simulations and reanalyses of data on self-esteem and problematic eating behaviors used by Beckers et al. (2023).

Sorjonen K, Nilsonne G, Ghaderi A et al. · 2026 · PloS one

The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the…

View details →DOI: 10.1371/journal.pone.0351302
Negative / Null Result Report

Leaf nutrient resorption efficiency is related to leaf economic spectrum but not root economic spectrum in a tropical mangrove forest

Jiang D, Nie T, He Q et al. · 2024 · Preprint

not-yet-known not-yet-known not-yet-known unknown Leaf nutrient resorption efficiency (NuRE) serves as a metric for delineating plant strategies that range from ‘slow-fast’ performance to conservative-acquisitive resource management.…

View details →DOI: 10.22541/au.173269104.41827173/v1
Negative / Null Result ReportMedicine

Soil aggregation alterations under soil microplastic and biochar addition and aging process.

Li H, Yang L, Luo C et al. · 2025 · Environmental pollution (Barking, Essex : 1987)

Soil microplastics (MPs) are a substantial threat to soil health, particularly by disrupting soil aggregation. Additionally, MPs undergo aging processes in the soil, which may significantly alter their long-term impacts on soil structure.…

View details →DOI: 10.1016/j.envpol.2025.125655
Negative / Null Result ReportMedicine

Are horned cows in loose housing more stressed than hornless cows? a cross-sectional study in organic dairy farms.

Ebinghaus A, Thiessen G, Ivemeyer S et al. · 2025 · Animal : an international journal of animal bioscience

In commercial dairy farming, the majority of cows are dehorned or genetically hornless. It is argued that this reduces the risk of injurious and stressful social conflicts. On the other hand, in horned herds, management and housing may be…

View details →DOI: 10.1016/j.animal.2024.101405
Negative / Null Result ReportOpen accessMedicine

Sport fans' self-esteem and supporting the team that won over the favorite.

Takemura E, Matsuoka H · 2026 · Frontiers in sports and active living

Research purpose Most often, when their favorite team loses, sports fans are disappointed by the outcome and hostile to the winning team. However, in the tournaments, they also sometimes voice their support for the team that eliminated…

View details →DOI: 10.3389/fspor.2026.1810401
Negative / Null Result ReportOpen accessMedicine

Sodium zirconium cyclosilicate post hospital discharge to prevent hyperkalaemia: phase 4, randomized CONTINUITY trial.

Burton JO, Izquierdo MJ, Linde C et al. · 2026 · Clinical kidney journal

Background and hypothesis Hyperkalaemia is common and potentially life-threatening in individuals with chronic kidney disease (CKD). While sodium zirconium cyclosilicate (SZC) is used in the hospital setting for hyperkalaemia management,…

View details →DOI: 10.1093/ckj/sfag158
Negative / Null Result ReportMedicine

Darvadstrocel in Patients With Crohn's Disease With Complex Perianal Fistulas: The ADMIRE CD II Phase 3 Randomized Trial.

Colombel JF, Garcia Olmo D, Chen ST et al. · 2026 · Gastroenterology

Background & aims The ADMIRE CD trial demonstrated the efficacy and safety of darvadstrocel in patients with complex perianal fistulas from Europe and Israel. The efficacy and safety of darvadstrocel in an expanded patient population was…

View details →DOI: 10.1053/j.gastro.2025.12.033
Negative / Null Result ReportMedicine

Icotinib plus chemotherapy as neoadjuvant treatment for resectable stage II-IIIB EGFR-mutant lung adenocarcinoma: a phase II study (NEOIPOWER).

Lu F, Lv C, Yang X et al. · 2025 · Lung cancer (Amsterdam, Netherlands)

Background EGFR tyrosine kinase inhibitors (EGFR-TKIs) have shown activity in the neoadjuvant setting of EGFR-mutant (EGFRm) non-small cell lung cancer; however, data on the combination of neoadjuvant EGFR-TKIs plus chemotherapy are…

View details →DOI: 10.1016/j.lungcan.2025.108676
Negative / Null Result ReportMedicine

Efficacy and safety of intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable symptomatic monotherapy (PADOVA): a phase 2b, multicentre, randomised, double-blind, placebo-controlled study.

Nikolcheva T, Pagano G, Anzures-Cabrera J et al. · 2026 · Lancet (London, England)

Background Prasinezumab has previously shown potential for reducing the progression of motor signs (Movement Disorder Society-sponsored Revision of the Unified Parkinson's Disease Rating Scale [MDS-UPDRS] Part III) in patients with…

View details →DOI: 10.1016/s0140-6736(26)00865-2
Negative / Null Result ReportMedicine

Safety and efficacy of the anti-α-synuclein monoclonal antibody amlenetug for the treatment of patients with multiple system atrophy (AMULET): a phase 2, randomised, double-blind, multicentre trial.

Kjærsgaard L, Wiedemann J, Singer W et al. · 2026 · The Lancet. Neurology

Background Pathological aggregation and propagation of α-synuclein species drive disease progression in multiple system atrophy (MSA). We assessed the efficacy and safety of amlenetug, a monoclonal antibody targeting aggregated…

View details →DOI: 10.1016/s1474-4422(26)00100-6
Negative / Null Result ReportMedicine

Hepatectomy Plus Chemotherapy or Chemotherapy Alone for Resectable Liver and Unresectable Lung Metastases from Colorectal Adenocarcinoma (LUNA): A Randomized Phase II Trial.

Folkert IW, Mehran R, Sun R et al. · 2026 · Annals of surgical oncology

Background Hepatectomy for isolated colorectal liver metastases is associated with 5 year overall survival (OS) of 58% and is accepted as standard of care. However, the role of liver resection with unresectable low-volume lung metastases…

View details →DOI: 10.1245/s10434-025-18854-w