A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19820 results in Negative / Null Result Report · page 181 of 661
Wu, Li, Zhu et al. · 2026 · Microorganisms
The gut microbiome, often termed the human "second genome", profoundly influences host physiology through metabolic interactions, immune modulation, and gut-brain axis signaling. Dysbiosis is implicated in the pathogenesis of obesity,…
Mulita, Kouroupi, Verras et al. · 2026 · Diagnostics (Basel, Switzerland)
Background and Clinical Significance: Ganglioneuromas are rare benign tumors of neural crest origin, with gastrointestinal involvement being uncommon and ampullary localization exceptionally rare. Pancreatic neuroendocrine tumors (NETs)…
Mangano, Lerner, Mangano · 2026 · Journal of dentistry
To evaluate the 2-year clinical, radiographic, and prosthetic outcomes of 3D printed porous titanium implants supporting single crowns. This retrospective study included 70 patients (31 males, 39 females; mean age 58.4 ± 12.1 years)…
Van Rompay, Tabury, Rehnberg et al. · 2026 · Cells
Three-dimensional (3D) cardiac models, including spheroids, organoids, and organ-on-chips, are advanced systems for studying human physiology, disease, and drug responses with greater biological relevance than 2D models. As their use…
Ashok, Stanicki, Thompson et al. · 2026 · The Physician and sportsmedicine
Meniscus injuries are one of the most common orthopedic pathologies. Arthroscopic partial meniscectomy can be performed if the injury has failed nonoperative management or is irreparable. Socioeconomic disparities within health insurance…
Shalamov, Cromwell, Guha · 2026 · AJP reports
Background: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder that causes alveolar hypoventilation because of impaired chemoreceptor response to hypercapnia and hypoxia occurring due to a dysfunctional central…
Fujimura, Hagio, Kouzaki · 2026 · Frontiers in sports and active living
Whole-body movements in everyday tasks challenge the neuromuscular system. Prior studies have shown that appropriate postural control supports both task success and postural balance during quiet standing or under modest postural demands.…
Yding Andersen, Poulsen, Wissing et al. · 2026 · Frontiers in endocrinology
The luteinizing hormone receptor (LHR) plays a pivotal role in regulating human follicular development and steroidogenesis through temporal and cell-specific expression on theca (TCs) and granulosa cells (GCs). Although LH-like activity…
Singh, Patel, Tripathi et al. · 2026 · Frontiers in genome editing
Myostatin ( MSTN ) gene knockout has attracted considerable interest for enhancing meat production in livestock species due to its well-established role as a negative regulator of skeletal muscle growth. In this study, we report the…
Ganjee, Bandos, Hossain et al. · 2026 · Journal of imaging informatics in medicine
Breast density is a breast cancer risk factor. The accurate quantification of breast density requires reliable segmentation of dense tissue in mammograms, but it is a challenging task due to large variations in tissue appearance across…
Li, Lai, Zou et al. · 2026 · Cellular & molecular immunology
Systemic lupus erythematosus (SLE) pathogenesis involves the dysregulated production of mutated, high-affinity autoantibodies, a process primarily orchestrated within germinal centers (GCs). However, the precise regulatory mechanisms…
Lu, Liu, Guo et al. · 2026 · Scientific reports
The prognosis of heart failure is highly dependent on patient self-management, and short-video platforms have become a key channel for the public to access information about heart failure (HF). This cross-sectional study systematically…
Gosavi, Sritharan, Bell et al. · 2026 · Annals of hepato-biliary-pancreatic surgery
Perioperative chemotherapy is frequently used for resectable colorectal liver metastases (CRLM), despite persistent uncertainty regarding the extent of its survival benefit. This perspective revisits the evidence supporting this practice…
Matsumiya, Ding, Ikegami et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity,…
Zhang, Zhang, Kwan et al. · 2026 · Social science & medicine (1982)
Urban noise pollution has become a critical environmental issue affecting residents' quality of life. Existing research struggles to capture heterogeneity in noise sensitivity across different populations and cannot precisely quantify the…
Yang, Yang, Du et al. · 2026 · BMC cancer
Accurate prognostic assessment remains challenging in patients with hepatocellular carcinoma (HCC). Although the fibrosis-4 (FIB-4) index is widely used for non-invasive evaluation of liver fibrosis, its prognostic value in HCC remains…
Sun, Wang, Lai et al. · 2026 · Neural regeneration research
The regulatory network of the spleen, a densely innervated immune hub, undergoes pathological remodeling following spinal cord injury. Whether targeted electrical stimulation of the spleen at specific frequencies can reverse peripheral…
Chen, Hu, Peng et al. · 2026 · Journal of immunology research
This multicenter study aimed to analytically compare the performance of automated quantitative assays-chemiluminescence immunoassay (CLIA) and multiplexed bead immunoassay (MBI)-for detecting anti-Ro/La antibodies in Chinese patients with…
Tishchenko, De Boeck, Van Waesberghe et al. · 2026 · Journal of virology
Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We…
Li, Feng · 2026 · Infection and drug resistance
Tropheryma whipplei (TW) , a Gram-positive bacterium, is the etiologic agent of Whipple's disease, a chronic and systemic condition that primarily involves the gastrointestinal tract. Chlamydia psittaci (C. psittaci) is a zoonotic pathogen…
Lin, Lin, Chen · 2026 · Frontiers in medicine
Postoperative chylothorax is an uncommon but challenging complication after thoracic surgery. Low-dose external beam radiotherapy (RT) has been proposed as an adjunct treatment when conservative management or surgical intervention fails,…
Kashyap, Chang, Lu et al. · 2026 · Affective science
Social expectations are a ubiquitous part of human experience, yet little is known about the emotions associated with failing to fulfill others' social expectations. In two studies, we examined the effects of failing to fulfill others'…
Chi, Zheng, Guo et al. · 2026 · Drug design, development and therapy
Ischemia-percussion (I/R) injury describes a paradoxical phenomenon in which blood flow restoration following ischemia not only fails to salvage the tissue but also exacerbates tissue injury. Due to the unique physiological functions, cell…
He, Shen, Hu et al. · 2026 · The New phytologist
Interploidy hybridization in plants is constrained by a postzygotic barrier. Triploid production via 2x × 4x interploidy hybridization is an important strategy for obtaining seedless cultivar in some fruit tree crops…
Mol, van Munster, Weersma et al. · 2026 · Journal of gastroenterology
Although ursodeoxycholic acid (UDCA) is commonly prescribed for primary sclerosing cholangitis (PSC), a beneficial long-term effect on solid clinical endpoints has not yet been established. This study evaluated the efficacy of UDCA on…
Kobayashi, Naito, Tone et al. · 2026 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
This study aimed to compare the accuracy of acetabular cup placement in total hip arthroplasty (THA) using a computed tomography (CT)-based augmented reality (AR) navigation system and a CT-based portable navigation system, both employed…
Helmy, Mahmoud Desouki, Mohamed Zayed et al. · 2026 · Medicina intensiva
To evaluate whether temporal changes in parasternal intercostal muscle thickening fraction during spontaneous breathing trials provide superior diagnostic accuracy for predicting outcomes of ventilator weaning compared to single…
Ferro, Thomas, Khattak et al. · 2026 · Clinical kidney journal
Cardiovascular disease (CVD) accounts for most of the increased morbidity and mortality associated with in chronic kidney disease (CKD). Cardiovascular risk emerges early in CKD, initially driven by atherosclerotic events but later…
Ng, Yeo, Neo · 2026 · Palliative care and social practice
This study aimed to identify how contextual, dispositional, and relational factors intersect to shape the participant experience of serious illness conversations (SICs) while exploring the nuances of appraisal across different clinical…
Kang, Zhou, Li et al. · 2026 · Frontiers in pharmacology
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by relentless cognitive decline. Despite decades of research dominated by the amyloid and tau hypotheses, clinical interventions targeting these classical…