A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19820 results in Negative / Null Result Report · page 179 of 661
Aouimeur, Sagnial, Travers et al. · 2026 · Scientific reports
Primary human corneal endothelial cell (CEC) culture is a key step toward developing cell-based therapies for corneal endothelial diseases, yet its success remains highly variable, particularly when using tissues from older donors. This…
Le Jan, Gourmelon, Destrumelle et al. · 2026 · Microvascular research
Endothelial dysfunction (ED) is a hallmark of metabolic disturbances such as Metabolic Syndrome (MetS), where oxidative stress and reduced nitric oxide (NO) bioavailability play key roles. High glucose (HG), a major metabolic alteration in…
Li, Megaw, Shenker et al. · 2026 · Journal of applied microbiology
Molecular methods have shown bacteriophage diversity in human milk, but this does not reflect viability, particularly within donor human milk which has been subjected to multiple freeze-thaw cycles and heat treatment. Our aim was to…
Tchum, Koto, Kanyoke et al. · 2026 · medRxiv : the preprint server for health sciences
Affecting 40% of infants and young children worldwide, anaemia in sub-Saharan Africa hampers cognitive and physical development, often in ways that cannot be reversed. Iron-based micronutrient powders (MNPs) are recommended to combat…
Wu, Jiang, Wei · 2026 · The New phytologist
Spring phenology is closely linked to plant growth and reproduction and is highly sensitive to environmental changes. For dioecious species, the temporal overlap between female and male flowering is critical for their successful…
Wang, Chao, Chen et al. · 2026 · Scientific reports
Smart home appliances are pivotal for advancing energy efficiency and environmental sustainability; however, their widespread adoption faces complex psychological and functional barriers. This study investigates the key determinants of…
Erdoğan, Ayaz-Alkaya · 2026 · Nurse education in practice
To evaluate the effect of crossword puzzle activities on nursing students' willingness to work with older adults and their competence in gerontological nursing. Although crossword puzzles are widely used learning tools, their effects in…
Ramay, Bundur, Riaz et al. · 2026 · Veterinary medicine and science
Optimizing ruminant diets and mitigating methane emissions using feed additives like yeast cell wall is of growing significance in animal nutrition. The present study aimed to evaluate the effects of varying roughage-to-concentrate (R:C)…
Zhou, Vo, Morelli et al. · 2026 · Journal of clinical pharmacology
Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan-genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1…
Yan, Liang, Zhou et al. · 2026 · Frontiers in aging neuroscience
The relationship between plasma chaperone-related autophagy proteins and white matter hyperintensity (WMH) in Alzheimer's disease (AD) remains unclear. We employed 4D-DIA proteomics to identify plasma protein changes, and evaluated the…
Suzuki, Kandar, Ting et al. · 2026 · Cancer immunology research
Loss-of-function STK11 mutations occur in 15-20% of lung adenocarcinomas (LUAD) and correlate with immunotherapy failure and worse survival. By integrating analysis of human tumor samples, a human LUAD cell line panel, and CCLE and TCGA…
Andersen, Sloth, Bøgestad et al. · 2026 · MicrobiologyOpen
IMP-1700 was developed as a compound designed to target bacterial DNA repair-associated pathways, including homologous recombination mediated by the AddAB/RecBCD system. While its antibacterial properties are well established, the…
Kang, Lee, Choi et al. · 2026 · Frontiers in public health
Despite the rapid rise in adolescent poly-tobacco use, evidence on what drives quit attempts in this high-risk group remains limited compared to single-product users. This study identifies these differential predictors using a…
Mohammadian, Ghiasi, Soleimani · 2025 · Galen medical journal
This study assessed the effects of 0.05% cetylpyridinium chloride (CPC) and 1% povidone iodine (PI) on flexural strength of nickel-titanium (NiTi) orthodontic wires. In this in vitro, experimental study, 27 pieces of NiTi orthodontic wires…
Jia, Han, Macreadie et al. · 2026 · Global change biology
Coastal wetlands represent one of the most intensive carbon sinks, and the stability of their soil carbon reserves is critical to the global carbon balance. While existing studies have predominantly focused on the effects of changes in…
Eminoğlu · 2026 · Food science & nutrition
In this study, yogurt formulations with paraprobiotic (heat inactivated Lactobacillus acidophilus ) and postbiotic (autolyzed and dried Saccharomyces cerevisiae ) additions were developed to improve the techno-functional properties of…
Lim, Chin, Chee et al. · 2026 · The American journal of cardiology
Patients' length of stay (LOS) during admission for myocardial infarction (MI) represents a closely tracked outcome metric for Cardiology services, which has declined over time. Charlson Comorbidity Index (CCI) is a validated tool for…
Yoshida, Fukuoka, Kawahara et al. · 2026 · Biochimica et biophysica acta. General subjects
Vasculogenic mimicry (VM) is a phenomenon in which tumor cells form capillary-like networks without endothelial cells and is associated with tumor progression and poor prognosis. Understanding mechanisms of VM and identifying its reliable…
Kim, Shin, Kim et al. · 2026 · The journal of adhesive dentistry
Self-adhesive flowable giomer (SAG) has been used in dental practice recently to simplify clinical procedures and shorten chair times. However, there are only few studies evaluating its bond strength to enamel and dentin, resulting in a…
Sternberg, Podolsky, Yu et al. · 2026 · The journal of prevention of Alzheimer's disease
High cholesterol contributes to the development and progression of dementia due to both Alzheimer's disease (A.D.) and vascular pathology. However, the effects of lipid-lowering regimen (LLR) on cognitive dysfunction and brain…
Lau, Fok, Lee et al. · 2026 · PloS one
Ankle joint quasi-stiffness is a measure representing the control of quiet standing. Here we investigated three methods for determining parameters associated with ankle joint quasi-stiffness. Eleven healthy, young males were asked to stand…
Kizuki, Kaneko, Taniguchi et al. · 2026 · Sleep and biological rhythms
We previously found that seasonal changes in sleep duration were affected by sex, residential area, and age in Japanese community residents. This study aimed to determine whether these factors also affect the seasonality of…
Yang, Jang, Park et al. · 2026 · Veterinary ophthalmology
To evaluate the clinical efficacy of a newly developed adhesive tissue sealant, gelatinized cornea-derived decellularized extracellular matrix (Cod-ECM) for the treatment of stromal ulcers in dogs. This study included 60 eyes of 56 dogs…
Campbell, Wilson, Du Plessis et al. · 2026 · Journal of neurotrauma
Following a mild traumatic brain injury (mTBI), up to 30% of individuals will experience persisting symptoms beyond 3 months. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique that has shown…
Antoniou, Yang, Juurlink et al. · 2026 · Clinical pharmacology and therapeutics
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co-administration with CYP3A4-inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the…
Huggins, Martinez, Baird et al. · 2026 · Journal of neurotrauma
Mild traumatic brain injury (mTBI), a common health burden among combat veterans, has been associated with alterations in brain structure. Moreover, post-traumatic stress disorder (PTSD), frequently comorbid with mTBI, is linked to smaller…
Abdolahi, Li, Zou et al. · 2026 · Translational vision science & technology
To assess the performance of an artificial intelligence deep learning (DL) model compared with neuro-ophthalmologists for the classification of subjects with elevated intracranial pressure (ICP) and papilledema versus control subjects,…
Gozen, Sezgin, Yavuzer et al. · 2026 · Frontiers in pharmacology
Propofol is a short-acting intravenous hypnotic anesthetic widely used for sedation and the induction and maintenance of general anesthesia. Although it reliably produces unconsciousness, its intrinsic analgesic efficacy remains a subject…
Schmeisk-Rosa, Andersen, Cordeiro et al. · 2026 · Plant and soil
In highly weathered soils of central Amazonia, where nutrients such as phosphorus (P) and base cations are scarce, fertilization experiments have demonstrated above- and belowground effects on total net primary productivity (NPP). This…
Yigitbay, Kural, Tanrıverdi et al. · 2026 · Foot & ankle specialist
ObjectiveThis study aimed to identify the possible risk factors for the development of partial bridging and synostosis in the distal tibiofibular joint following surgically treated ankle fracture-dislocations and to examine the effects of…