A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19820 results in Negative / Null Result Report · page 175 of 661
Benson, Cohen, Peskin et al. · 2026 · Digestive diseases (Basel, Switzerland)
Introduction Familial Dysautonomia (FD) is characterized by abnormal function of autonomic and sensory nervous systems. Gastrointestinal (GI) symptoms are extremely prevalent in FD patients, but the impact of FD on the pancreas is less…
Çakıcı, Akkoç · 2026 · Caries research
Caries risk assessment (CRA) is essential for individualized caries management in early childhood, but existing tools are difficult to standardize in routine practice. The ability of large language model (LLM)-based artificial intelligence…
Bahdi, Bachu, Aldzhyan et al. · 2026 · Journal of clinical gastroenterology
While glucagon-like peptide 1 receptor agonists (GLP1-RAs) increase the risk of gastric food retention (GFR) and inadequate bowel preparation (IBP), the confounding role of diabetes mellitus is still questioned. Here, we compare the…
Baskar, Patel, Rose et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
The incidence of neuroendocrine neoplasms (NENs) is rising, particularly among younger patients, but data comparing early-onset (EO-NENs) and average-onset (AO-NENs) remain limited. Using the National Inpatient Sample (2016-2020), we…
Curtis, McCrary, Daud et al. · 2026 · Cardiovascular journal of Africa
Epstein-Barr virus (EBV) affects greater than 95% of the global population, and when acquired at an early age, results in poor control of viral replication and increased risk to subsequent chronic illnesses. To analye the association…
Goda El-Hamalawy, Abdelmoneim, Al-Sayed et al. · 2026 · Archives of orthopaedic and trauma surgery
Management of unstable anterior pelvic ring fractures has shifted toward minimally invasive fixation techniques. This prospective randomized cohort study compares anterior subcutaneous internal fixator with percutaneous retrograde pubic…
Şibar, Biçici, Şibar et al. · 2026 · Orthopedics
Periprosthetic joint infection (PJI) is one of the most serious complications following total knee arthroplasty (TKA). Vancomycin powder has been proposed as a low-cost adjunct to reduce infection by providing high local antibiotic…
Fussey, Manzie, Nanayakkara et al. · 2026 · ANZ journal of surgery
It is unknown whether the method of application of povidone iodine solution for skin antisepsis affects its efficacy. The primary aim of this study was to compare the efficacy of spray-on aqueous povidone iodine solution in preventing…
Sakamoto · 2026 · Traffic injury prevention
While previous research suggests that e-scooter riders and pedestrians may exhibit similar injury patterns due to a shared standing posture, direct comparisons using unified datasets are lacking. This study aims to identify the distinctive…
Wang, Wang, Zhang et al. · 2026 · Journal of agricultural and food chemistry
Reactive carbonyl species (RCS) are highly reactive molecules linked to chronic diseases. Dihydromyricetin (DMY), a high-activity RCS scavenger, exhibited MGO- and ACR-scavenging rates of 70.1% (0.5 h) and 70.3% (2 h) at 37 °C,…
Yu, Zhao, Duan et al. · 2026 · Cancer medicine
The adoption of robotic partial nephrectomy has grown significantly over the past decade, prompting a debate on the merits of transperitoneal versus retroperitoneal surgical access. This study evaluated the association between surgical…
Yin, Bae, Ni · 2026 · Journal of anthropological sciences = Rivista di antropologia : JASS
Since its appearance at the terminal Pleistocene, intentional cranial modification ("ICM") and its implications have generated considerable scientific debate regarding how or why such a tradition arose. Here, we report on newly discovered…
Sun, Chen, Yang et al. · 2026 · Journal of animal science and biotechnology
Sow anemia has been reported to be associated with reduced reproductive performance. Additionally, anemia may alter gut microbiota composition. However, the gut microbiota and metabolic signatures specifically linked to sow anemia status…
Eldabe, Adel-Khattab, Beshay et al. · 2026 · BMC oral health
This clinical trial was conducted to compare the four types of static fully guided surgical guides (bilateral tooth-supported guides, unilateral tooth-supported guides, mucosa-supported complete arch guides, and stackable bony-supported…
Aprina, Rahayu, Prihartono et al. · 2026 · Korean journal of ophthalmology : KJO
To investigate the effect of higher cylindrical power and axis misalignment of toric SCL in mild and moderate astigmatism on visual acuity, contrast sensitivity, visual satisfaction, and vision acceptability. 20 astigmatic participants…
Yu, Yu, Sun et al. · 2026 · Frontiers in bioengineering and biotechnology
Proprioceptive deficits following anterior cruciate ligament (ACL) injury increase reliance on visual input in athletes after ACL reconstruction (ACLR). Visual disruption may therefore alter movement patterns and increase re-injury risk.…
El-Tallawy, Pergolizzi, Alsubaie et al. · 2026 · Cureus
Background  Postoperative pain management in children remains a significant challenge due to developmental differences in pain perception, reporting, and communication. However, limited evidence exists regarding age-specific…
Sykes, Brindle, Kazmi et al. · 2026 · ERJ open research
Azithromycin is beneficial in a multitude of respiratory diseases; however, its effects on both subjective and objective measures of cough have been less extensively studied. Traditional 24-h cough counting assessments are highly variable,…
Tsai, Huang, Wang et al. · 2026 · Integrative cancer therapies
BackgroundTraditional, complementary, and integrative medicine (TCIM) is an evolving field in oncology focused on managing cancer symptoms. Hydrogen water (HW) has gained attention for its antioxidant and anti-inflammatory properties, yet…
McComish, Brewster, Brizard et al. · 2026 · Transplant immunology
Human Leucocyte Antigen (HLA) sensitisation following red cell transfusion can disrupt planned transplantation and impair outcomes. We conducted a prospective, randomised controlled, double blinded, parallel arm study to evaluate the…
Ribeiro, Stuginski, do Amaral E Luna et al. · 2026 · Toxicon : official journal of the International Society on Toxinology
Snakebites represent a significant public health concern in tropical and subtropical countries. In 2025, approximately 21,000 incidents of snakebites were reported in Brazil, with 1.7% attributed to coral snakes. Although the incidence of…
Ferrari, Saracutu, Pontoriero et al. · 2026 · Journal of dentistry
To compare the outcome of short fiber reinforced composites, as a core material, with respect to conventional fiber post, for the reconstruction of anterior endodontically treated teeth (ETT), covered by a lithium disilicate crown.…
Chen, Han, Guo et al. · 2026 · International dental journal
To compare the accuracy, instrumentation time, and success rate of three dynamic navigation systems (DNSs)-infrared-active (IA), infrared-passive (IP), and visible light-passive (VP)-with freehand (FH) operation in locating root canals of…
Vastardis, Tolia, Pallazola et al. · 2026 · The Journal of surgical research
Preoperative handgrip strength (HGS) is a noninvasive estimate of muscle strength, and reduced HGS is associated with increased frailty and postoperative complications. However, best practices for preoperative HGS collection remain…
Ghimire, Sohrabi, Zhou et al. · 2026 · Microbial ecology
Over 90% of the mixotrophic algae surveyed require vitamin B 12 (B 12 ), a micronutrient synthesized exclusively by certain prokaryotes. Bacteria-mediated B 12 supply presents an important but poorly understood control on physiology and…
Park, Kim, Kim et al. · 2026 · Annals of hepato-biliary-pancreatic surgery
The optimal surgical approach for middle-third extrahepatic cholangiocarcinoma (MCC)-bile duct segmental resection (BDSR) or pancreaticoduodenectomy (PD)-remains controversial. This study aimed to compare the short- and long-term outcomes…
Shao, Feng, Yang et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
This study compared the incidence of adverse reactions following single versus simultaneous administration of the domestic diphtheria, tetanus and acellular pertussis combined vaccine (DTaP) after the immunization schedule adjustment in…
Du, Wu, Yang et al. · 2026 · Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Dust mites (DM) are important allergens for allergic rhinitis (AR) and allergic asthma (AA). This study aims to analyze the component characteristics of dust mite-sensitized patients in Shenzhen and to explore the association between…
Liu, Hong, Yang et al. · 2026 · International dental journal
Traditional dental composite resins faced persistent challenges regarding biofilm accumulation and hydrolytic degradation. This study aimed to develop a novel resin monomer fluorinated polyurethane dimethacrylate (FPUDMA) and…
Li, Liu, Sun et al. · 2026 · American journal of translational research
To investigate the seroprevalence and risk factors of Toxoplasma gondii ( T. gondii ) infection in females with breast tumors in eastern China. This case-control study enrolled 610 breast tumor patients and 610 healthy controls. Serum…