A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19820 results in Negative / Null Result Report · page 174 of 661
Çalışkan, Karpuzoğlu, Karpuzoğlu et al. · 2026 · Genes
Objective: To evaluate the efficacy of NADPH oxidase 4 and miR-146a-5p in current treatment planning for ascending aortic aneurysms, independent of aortic diameter, and to develop protocols that will ensure the treatment of ascending…
Shi, Zhou, Li et al. · 2026 · Animals : an open access journal from MDPI
As a precious indigenous goose resource in China, the Zhedong white goose occupies an essential position in the domestic goose industry. However, this breed spontaneously enters a prolonged non-laying period of over two months per year,…
Ma, Hu, Ma et al. · 2026 · Animals : an open access journal from MDPI
The Taiwanese loach ( Paramisgurnus dabryanus ssp. Taiwan, Dabry de Thiersant, 1872.) is an economically important aquaculture species in East Asia, and its body color directly affects its ornamental and market value. Our research group…
Sun, Sun, Liu et al. · 2026 · Animals : an open access journal from MDPI
This study aimed to elucidate the effects of different fattening stages on slaughtering performance, meat quality, muscle fiber characteristics, connective tissue properties, and intramuscular fat deposition in Yanbian cattle. A total of…
Chooseangjaew, Tanyaros, Thaochan et al. · 2026 · International journal of molecular sciences
Oyster health is important for aquaculture productivity and sustainability. In Thailand, the white scar oyster, Crassostrea belcheri , is being promoted for cultivation, yet its health status has not been compared between research breeding…
Lu, Cheng, Fang et al. · 2026 · Bioengineering (Basel, Switzerland)
High-resolution thin-slice computed tomography (CT) images are often compressed into lower-quality thick-slice images for long-term storage, necessitating synthesis for medical diagnosis. In this paper, we propose a novel 3D adversarial…
Alshaye, Alharbi, Khalil · 2026 · Biomedicines
Background: Persistent intraradicular infection and biofilm survival remain major challenges in endodontic treatment, particularly because residual microorganisms may remain within dentinal tubules despite chemomechanical preparation. The…
Nemes, Halcsik, Kormányos et al. · 2026 · Biomedicines
Introduction : Gestational physiology is characterized by an expansion of plasma volume and an elevation in cardiac output. Given the scarcity of existing data on pregnancy-related left atrial (LA) volumetric and functional features, this…
Ma, Zhang, Kong et al. · 2026 · Diagnostics (Basel, Switzerland)
Objective : To evaluate the association of routine complete blood count (CBC)-derived inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and…
Sun, Ye, Zhou et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives: Given the limited evidence on multi-distance visual function assessment in presbyopia, this study aimed to compare dynamic binocular visual function between presbyopic and non-presbyopic (NP) participants at…
Gâta, Ilieș, Mureșan-Bădescu et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives : Nowadays, lymph node assessment represents a key component in the surgical staging of endometrial cancer, as sentinel lymph node (SLN) mapping increased in adoption as an alternative to lymphadenectomy. This study…
Findik, Kaim, Uzun et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives: Although vascular mechanisms are increasingly implicated in the etiology of sudden sensorineural hearing loss (SSNHL), the inability to directly visualize the labyrinthine artery remains a diagnostic obstacle.…
Moore, Joniak, Ladan et al. · 2026 · Journal of strength and conditioning research
Moore, SR, Joniak, KE, Ladan, AN, Britton, ME, Cantu, EI, Hirsch, KR, Hackney, AC, and Smith-Ryan, AE. Does hormonal phase affect acute high-intensity interval training exercise? An evaluation of performance and fatigue. J Strength Cond…
Grzech-Leśniak, Pyrkosz, Szwajkowski et al. · 2026 · Lasers in medical science
This in vitro study aimed to evaluate the antimicrobial effects of a 1064 nm Nd:YAG laser delivered through a novel handpiece designed to provide a flat-top, homogeneous energy distribution profile (MarcoM handpiece) against key oral…
Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology
Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…
Siegmund, Delker, Widjaja et al. · 2026 · European journal of nuclear medicine and molecular imaging
Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy (RPT) is an established treatment for advanced prostate cancer, but renal radiation exposure remains a major safety concern, as no clinically established…
Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)
Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…
Momii, Hata, Fudaba et al. · 2026 · Scientific reports
Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…
Xu, Wei, Zhang et al. · 2026 · Ultrasound in medicine & biology
To develop and validate a deep learning (DL) model based on feature fusion with B-mode ultrasound (BMUS) and contrast enhanced ultrasound (CEUS) images for non-invasive diagnosis of benign and malignant focal liver lesions (FLLs),…
Liu, Zheng, Ding et al. · 2026 · Lupus science & medicine
To identify the predictors of renal relapse in patients with lupus nephritis (LN) and develop a predictive model. The patients with LN who received renal biopsies from 2005 to 2024 in Xijing Hospital were enrolled. This study was designed…
Al-Maghrabi, Müllertz, Rades · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Salmon calcitonin (sCT) is a peptide with poor enzymatic stability and permeability, limiting its oral delivery. This study investigated how hydrophobic ion pair (HIP) type and self-nanoemulsifying drug delivery systems (SNEDDS)…
Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy
Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…
Mello, Horliana, Bezerra et al. · 2026 · Journal of dentistry
Postoperative pain, swelling, and functional limitations are common after mandibular third molar surgery, affecting recovery and quality of life. This randomized, double-blind clinical trial evaluated the effects of preemptive…
Nathani, Swaminathan, Kasmirski et al. · 2026 · The Journal of surgical research
In patients undergoing surgery for hyperparathyroidism (HPT), ectopic parathyroid glands can often make the operation challenging. Understanding the most common locations of ectopic parathyroids may provide guidance if an abnormal gland…
Lamarca, Palmer, Wasan et al. · 2026 · ESMO open
The ABC-06 trial established FOLFOX as the reference second-line regimen for patients diagnosed with advanced biliary tract cancer (ABC). Here we analysed the prognostic role of tumour markers carbohydrate antigen 19-9 (CA19-9),…
Leruste, Ley, Gottrand et al. · 2026 · Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
Although recommendations for structured transition programs in adolescents with Inflammatory Bowel Diseases (IBD) have been published, few studies have addressed the implementation of transition in real-life settings at a national level.…
Hernandez, Walia, Coady et al. · 2026 · The journal of sexual medicine
Peyronie's disease (PD) is an acquired connective tissue disorder characterized by fibrous plaque formation within the penile tunica albuginea that may be influenced by androgen status. To evaluate whether baseline testosterone levels and…
Villalón López, Escaffi-Schwarz · 2026 · Journal of medical Internet research
Parental burnout is an underrecognized syndrome characterized by emotional exhaustion, detachment from children, and reduced parental efficacy. It is associated with sleep disturbance, addictive behaviors, suicidal ideation, and increased…
Zhang, Xie, Zhang et al. · 2026 · Shock (Augusta, Ga.)
Sepsis-associated encephalopathy (SAE) is a diffuse neurological injury that results from severe sepsis, and its underlying pathophysiological mechanisms remain largely unknown. This study aimed to elucidate the pathological basis of SAE…
Eitzel, Ulle, Meyer et al. · 2026 · PloS one
Measuring human interactions with protected areas is a key need in conservation social science, both to assess the potential for continuing negative impacts on sensitive resources and to support positive relationships with important…