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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20217 results in Negative / Null Result Report · page 167 of 674

Negative / Null Result Report

Do Bilinguals Outperform Monolinguals in Switching Tasks? Contrary Evidence for Nonlinguistic and Linguistic Switching Tasks

Ernest Mas-Herrero, Daniel Adrover-Roig, María Ruz et al. · 2021 · Neurobiology of Language

Abstract The benefits of bilingualism in executive functions are highly debated. Even so, in switching tasks, these effects seem robust, although smaller than initially thought (Gunnerud et al., 2020; Ware et al., 2020). By handling two…

View details →DOI: 10.1162/nol_a_00059Cited by 6
Negative / Null Result Report

Supplementing 2 g per day bovine lactoferrin from late gestation until weaning did not improve lactation performance of mixed parity sows

Fan Liu, Jordon Hogg, Susie Kracht et al. · 2019 · Animal Production Science

Context Lactoferrin is a non-haem binding protein that possesses antimicrobial, antioxidant and anti-inflammatory properties. A previous study showed lactoferrin supplementation from early gestation to weaning improved lactation…

View details →DOI: 10.1071/an18286Cited by 6
Negative / Null Result Report

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI

Patrick Albers, Jacob Bennett, Moira Evans et al. · 2024 · Canadian Urological Association Journal

Introduction: Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging…

View details →DOI: 10.5489/cuaj.8626Cited by 6
Negative / Null Result Report

The most significant change for Colombian medical trainees going transformative learning on cultural safety: qualitative results from a randomised controlled trial

Juan Pimentel, Paola López, Anne Cockcroft et al. · 2022 · BMC Medical Education

Abstract Background Cultural safety training is not yet standard in Colombian medical education. If incorporated, it could address currently adversarial interactions between health professionals and the 40% of people who use traditional…

View details →DOI: 10.1186/s12909-022-03711-1Cited by 6
Negative / Null Result Report

Another Brick to Confirm the Efficacy of Rigosertib as Anticancer Agent

Alessio Malacrida, Marie Deschamps-Wright, Roberta Rigolio et al. · 2023 · International Journal of Molecular Sciences

Rigosertib is a small molecule in preclinical development that, due to its characteristics as a dual PLK1 and PI3K inhibitor, is particularly effective in counteracting the advance of different types of tumors. In this work, we evaluated…

View details →DOI: 10.3390/ijms24021721Cited by 6
Negative / Null Result Report

Association between Intraoperative Blood Pressure Drop and Clinically Significant Hypoperfusion in Abdominal Surgery: A Cohort Study

Zbigniew Putowski, Szymon Czajka, Łukasz J. Krzych · 2021 · Journal of Clinical Medicine

The recent consensus by the Perioperative Quality Initiative (POQI) on intraoperative hypotension (IOH) stated that mean arterial pressure (MAP) below 60–70 mmHg is associated with myocardial infarction (MI), acute kidney injury (AKI),…

View details →DOI: 10.3390/jcm10215010Cited by 6
Negative / Null Result Report

Significant liver histological change is common in HBeAg-positive chronic hepatitis B with normal ALT

Menghui Duan, Huanming Xiao, Meijie Shi et al. · 2024 · BMC Infectious Diseases

Abstract Background and aims Numerous HBeAg-positive chronic hepatitis B (CHB) patients with persistently normal ALT have significant liver histopathology. It is imperative to identify true “immune tolerant” patients. We aimed to evaluate…

View details →DOI: 10.1186/s12879-024-09617-1Cited by 6
Negative / Null Result Report

50 Years of Cumulative Open-Source Data Confirm Stable and Robust Biodiversity Distribution Patterns for Macrofungi

Haili Yu, Tiejun Wang, Andrew Skidmore et al. · 2022 · Journal of Fungi

Fungi are a hyper-diverse kingdom that contributes significantly to the regulation of the global carbon and nutrient cycle. However, our understanding of the distribution of fungal diversity is often hindered by a lack of data, especially…

View details →DOI: 10.3390/jof8090981Cited by 6
Negative / Null Result Report

Calcium and magnesium supplementation of ewes grazing pasture did not improve lamb survival

Susan M. Robertson, Shawn R. McGrath, Samuel Scarlett et al. · 2022 · Animal Production Science

Context Clinical deficiencies of calcium and magnesium may result in the metabolic disorders hypocalcaemia and hypomagnesaemia, resulting in ewe and lamb mortality. However, the contribution of subclinical deficiencies to perinatal lamb…

View details →DOI: 10.1071/an22113Cited by 6
Negative / Null Result Report

An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change

Marlene M. Moretti, Sebastian P. Dys, Stephanie G. Craig et al. · 2024 · JCPP Advances

Abstract Background Given the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in…

View details →DOI: 10.1002/jcv2.12248Cited by 6
Negative / Null Result Report

Significant association of nicotine reinforcement and cue reactivity: a translational study in humans and rats

Kevin Butler, Benoît Forget, Stephen J. Heishman et al. · 2021 · Behavioural Pharmacology

Relapse is common amongst smokers attempting to quit and tobacco cue-induced craving is an important relapse mechanism. Preclinical studies commonly use cue-induced reinstatement of nicotine seeking to investigate relapse neurobiology.…

View details →DOI: 10.1097/fbp.0000000000000607Cited by 6
Negative / Null Result Report

Incidence and time trends of herpes zoster among patients with head and neck cancer who did and did not undergo radiotherapy: A population-based cohort study

Peng-Yi Lee, Jung-Nien Lai, Lu-Ting Chiu et al. · 2021 · PLOS ONE

Purpose This study aimed to determine the risk and time trends of herpes zoster among patients with head and neck cancer, with or without radiotherapy. Methods A total of 2160 patients with head and neck cancer were enrolled. The…

View details →DOI: 10.1371/journal.pone.0250724Cited by 6
Negative / Null Result Report

MWPoW: Multiple Winners Proof of Work Protocol, a Decentralisation Strengthened Fast-Confirm Blockchain Protocol

Yibin Xu, Yangyu Huang · 2019 · Security and Communication Networks

Blockchain mining should not be a game among power oligarchs. In this paper, we present the Multiple Winners Proof of Work Protocol (MWPoW), a mining-pool-like decentralised blockchain consensus protocol. MWPoW enables disadvantaged nodes…

View details →DOI: 10.1155/2019/3674274Cited by 6
Negative / Null Result Report

Shared miRNA landscapes of COVID-19 and neurodegeneration confirm neuroinflammation as an important overlapping feature

Sara Redenšek Trampuž, David Vogrinc, Katja Goričar et al. · 2023 · Frontiers in Molecular Neuroscience

Introduction Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with…

View details →DOI: 10.3389/fnmol.2023.1123955Cited by 6
Negative / Null Result Report

Does SLOPE outperform bridge regression?

Shuaiwen Wang, Haolei Weng, Arian Maleki · 2021 · Information and Inference: A Journal of the IMA

Abstract A recently proposed SLOPE estimator [6] has been shown to adaptively achieve the minimax $\ell _2$ estimation rate under high-dimensional sparse linear regression models [25]. Such minimax optimality holds in the regime where the…

View details →DOI: 10.1093/imaiai/iaab025Cited by 6
Negative / Null Result Report

Education Finance Reform and the Great Recession: Did State Policy and Fiscal Federalism Improve Education Spending, School Resources, and Student Achievement in Pennsylvania?

Matthew P. Steinberg, Rand Quinn, J. Cameron Anglum · 2020 · Journal of Education Finance

abstract: We estimate the impact of school finance reform on adequate and equitable district spending, school resources and student achievement in Pennsylvania. From the 2008-09 to the 2010-11 school years, amid the Great Recession,…

View details →DOI: 10.1353/jef.2020.a760723Cited by 6
Negative / Null Result Report

ReplicOpter: A replicate optimizer for flexible docking

Omar N. A. Demerdash, Amanda Buyan, Julie C Mitchell · 2010 · Proteins: Structure, Function, and Bioinformatics

Abstract We present a computationally efficient method for flexible refinement of docking predictions that reflects observed motions within a protein's structural class. Using structural homologs, we derive deformation models that capture…

View details →DOI: 10.1002/prot.22811Cited by 6
Negative / Null Result Report

Can masked synonym priming replicate masked translation priming?

Naoko Witzel · 2019 · Quarterly Journal of Experimental Psychology

This study examines whether synonyms are represented similarly to translation equivalents in the bilingual mind. In particular, this study investigated whether there is masked synonym priming such that it will simulate masked translation…

View details →DOI: 10.1177/1747021819848683Cited by 6
Negative / Null Result Report

Who did what to whom, and what did we already know?

Tania Ionin, Maria Goldshtein, Tatiana Luchkina et al. · 2021 · Linguistic Approaches to Bilingualism

Abstract This paper reports on an experimental investigation of what second language (L2) learners and heritage speakers of Russian know about the relationship between word order and information structure in Russian. The participants…

View details →DOI: 10.1075/lab.20045.ionCited by 6
Negative / Null Result Report

Did expanded access to denture services improve chewing ability in the Korean older population? Results of a regression discontinuity analysis

Nam-Hee Kim, Ichiro Kawachi · 2020 · Scientific Reports

Abstract The Korean National Health Insurance expanded the dental insurance in 2012 to cover denture services for older adults. We analyzed whether the new policy improved of chewing ability in the eligible population. We used regression…

View details →DOI: 10.1038/s41598-020-68189-7Cited by 6
Negative / Null Result Report

The significant role of educational status in PKU patients: the beneficial effect of psychological support in depression

Kostas Iakovou, Kleopatra Schulpis · 2019 · International Journal of Adolescent Medicine and Health

Abstract Introduction Classical Phenylketonuria (PKU) is a metabolic disease characterized by high phenylalanine (phe) levels in blood and brain. PKU patients are commonly treated with low phe diet supplemented with amino acid free…

View details →DOI: 10.1515/ijamh-2018-0233Cited by 6
Negative / Null Result Report

Cover crops did not improve soil health but hydroclimatology may guide decisions preventing cash crop yield loss

Debankur Sanyal, Avik Mukherjee, Amin Rahhal et al. · 2023 · Frontiers in Soil Science

Introduction Cover crop (CC) is an essential tool to improve or maintain soil health, potentially improving cash crop productivity. Several recent reports of cash crop yield reduction following cover cropping necessitated this research to…

View details →DOI: 10.3389/fsoil.2023.1111821Cited by 6
Negative / Null Result Report

Did School Meal Programs and SNAP Participation Improve Diet Quality of US Children from Low-Income Households: Evidence from NHANES 2013–2014?

Tzuan A. Chen, Lorraine R. Reitzel, Ezemenari M. Obasi et al. · 2021 · Nutrients

Nutrition assistance programs such as school meals and the Supplemental Nutrition Assistance Program (SNAP) are designed to provide a safety net for the dietary intake of children from low-income families. However, compared with eligible…

View details →DOI: 10.3390/nu13103574Cited by 6
Negative / Null Result Report

Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites

Emily E. Fay, Lindsay C. Czuba, Jennifer E. Sager et al. · 2021 · Therapeutic Drug Monitoring

Background: Bupropion (BUP) is a chiral antidepressant and smoking cessation aide with benefits and side effects correlated with parent and active metabolite concentrations. BUP is metabolized by CYP2B6, CYP2C19, and CYP3A4 to hydroxy-BUP…

View details →DOI: 10.1097/ftd.0000000000000885Cited by 6
Negative / Null Result Report

Diversity, equity and inclusion work: a difference that makes a difference … ?

Ann Armstrong · 2024 · Equality, Diversity and Inclusion: An International Journal

Purpose I examine if current diversity, equity and inclusion (DEI) initiatives can actually accomplish what they aim and claim to do. I argue that perforce they cannot, as they remain instruments of capitalist corporations and other…

View details →DOI: 10.1108/edi-10-2023-0325Cited by 6