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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21697 results · page 164 of 724

Negative / Null Result ReportSocial Sciences

Can Court Diversion Improve School Attendance among Elementary Students? Evidence from Five School Districts

Won Fy Lee, Clea McNeely, Janet E. Rosenbaum et al. · 2020 · Journal of Research on Educational Effectiveness

We examined the effect on attendance of a truancy court-diversion program for elementary students. Truancy court-diversion programs represent a shift from a law-and-order approach toward a public health model to address school absenteeism.…

View details →DOI: 10.1080/19345747.2020.1760976Cited by 9
Negative / Null Result ReportMedicine

Phase II Trial of Bevacizumab Monotherapy in Pancreatic Neuroendocrine Tumors

Mojun Zhu, Brian A. Costello, Jun Yin et al. · 2021 · Pancreas

OBJECTIVES: Systemic therapies for pancreatic neuroendocrine tumors (PNETs) are limited. The combination of bevacizumab and temsirolimus showed significant antitumor activity, but the single-agent activity of bevacizumab was unknown. We…

View details →DOI: 10.1097/mpa.0000000000001950Cited by 9
Negative / Null Result ReportOpen accessPsychology

Detecting the contagion effect in mass killings; a constructive example of the statistical advantages of unbinned likelihood methods

Sherry Towers, Anuj Mubayi, Carlos Castillo‐Chávez · 2018 · PLoS ONE

BACKGROUND: When attempting to statistically distinguish between a null and an alternative hypothesis, many researchers in the life and social sciences turn to binned statistical analysis methods, or methods that are simply based on the moments of a distribution (such as the mean, and variance). These methods have the advantage of simplicity of implementation, and simplicity of explanation. However, when null and alternative hypotheses manifest themselves in subtle differences in patterns in the data, binned analysis methods may be insensitive to these differences, and researchers may erroneou

View details →DOI: 10.1371/journal.pone.0196863Cited by 9
Negative / Null Result ReportOpen accessMedicine

Does gender have a significant effect on normal nerve conduction studies values?

Kawthar Al-Salmi, Farook S Wali, Ahmed Sameer Nadeem et al. · 2019 · Journal of Neurology & Stroke

Background: nerve conduction study (NCS) is a neurophysiologic medical diagnostic test used commonly to evaluate the function of the peripheral nerves. It is an extension to the clinical examination and extremely useful to diagnose and…

View details →DOI: 10.15406/jnsk.2019.09.00394Cited by 9
Negative / Null Result ReportOpen accessMedicine

Doubts over landmark heart drug trial: ticagrelor PLATO study

Peter Doshi · 2024 · BMJ

A top selling antiplatelet drug has never quite shaken off doubts about its advantage over cheaper rivals. With generic versions of ticagrelor about to launch, Peter Doshi takes a fresh look at the evidence

View details →DOI: 10.1136/bmj.q2550Cited by 9
Negative / Null Result ReportOpen accessMedicine

Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial

Pooja Advani, Kathryn J. Ruddy, Joerg Herrmann et al. · 2023 · Frontiers in Oncology

Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Methods Using the Agena Bioscience MassARRAY system, we genotyped TRPC6 rs77679196, BRINP1 rs62568637, LDB2 rs55756123, RAB22A rs707557, intergenic rs4305714, LINC01060 rs7698718, and CBR3 rs1056892 (V244M) (previously associated with either doxorubicin or trastuzumab-related cardiotoxicity in the NCCTG N9831 trial of anthracycline-based chemotherapy ± trastuzum

View details →DOI: 10.3389/fonc.2023.1139347Cited by 9
Negative / Null Result ReportOpen accessSocial Sciences

Less Than I Expected and oh so True? On the Interplay Between Expectations and Framing Effects in Judgments of Truth

Mariela E. Jaffé, Rainer Greifeneder · 2019 · Journal of Language and Social Psychology

This article investigates the negativity bias in truth judgments, which holds that negatively (vs. positively) framed statements are more likely to be judged true. Throughout four studies we find that expectations moderate the negativity…

View details →DOI: 10.1177/0261927x19869392Cited by 9
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Associations of common variants in TAAR5, OR6C70, and GBA with hyposmia in Han Chinese individuals with Parkinson’s disease

Yi-Lun Ge, Pu-Zhi Wang, Jia-Hui Yan et al. · 2022 · Advanced Neurology

Hyposmia is one of the cardinal symptoms of Parkinson’s disease (PD), with a considerably high prevalence rate in PD individuals. However, some individuals still retain normal olfactory function. Recent studies have shown that genetic factors may play a role in such a phenomenon. This study aimed to explore the potential genetic factors underlying the variation of olfactory function among PD individuals. Two hundred and three Han Chinese individuals with PD were recruited into this study. All the individuals underwent detailed clinical assessment conducted by experienced neurologists

View details →DOI: 10.36922/an.v1i2.71Cited by 9
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

When Do Low-Frequency Measures Really Measure Effective Spreads? Evidence from Equity and Foreign Exchange Markets

Mohammad R. Jahan‐Parvar, Filip Žikeš · 2023 · Review of Financial Studies

Abstract We present evidence that several popular low-frequency measures of effective spread suffer from a volatility-induced bias and that volatility is the primary driver of the variation of these liquidity proxies. Using data for U.S. equities and major foreign exchange rates, we show that the bias arises when the effective spread is small relative to volatility. We document that the bias has become more acute over time and show that volatility-biased measures fail to replicate some well-known results in empirical finance. We conclude by providing guidance on the choice of low-frequency mea

View details →DOI: 10.1093/rfs/hhad028Cited by 9
Negative / Null Result ReportPhysics and Astronomy

Detecting Statistically Significant Communities

Zengyou He, Hao Liang, Zheng Chen et al. · 2020 · IEEE Transactions on Knowledge and Data Engineering

Community detection is a key data analysis problem across different fields. During the past decades, numerous algorithms have been proposed to address this issue. However, most work on community detection does not address the issue of…

View details →DOI: 10.1109/tkde.2020.3015667Cited by 9
Negative / Null Result ReportPsychology

Loneliness and social monitoring: A conceptual replication of Knowles et al.

Kory Floyd, Nathan T. Woo · 2020 · Personal Relationships

Abstract Contrary to the claim that loneliness routinely impairs the decoding of social cues such as emotion displays, Knowles, Lucas, Baumeister, and Gardner (2015) proposed that lonely adults “choke under pressure,” experiencing…

View details →DOI: 10.1111/pere.12304Cited by 9
Negative / Null Result ReportOpen accessNeuroscience

Computational genetics analysis of grey matter density in Alzheimer’s disease

Amanda Zieselman, Jonathan Fisher, Ting Hu et al. · 2014 · BioData Mining

BACKGROUND: Alzheimer's disease is the most common form of progressive dementia and there is currently no known cure. The cause of onset is not fully understood but genetic factors are expected to play a significant role. We present here a bioinformatics approach to the genetic analysis of grey matter density as an endophenotype for late onset Alzheimer's disease. Our approach combines machine learning analysis of gene-gene interactions with large-scale functional genomics data for assessing biological relationships. RESULTS: We found a statistically significant synergistic interaction among t

View details →DOI: 10.1186/1756-0381-7-17Cited by 9
Negative / Null Result ReportOpen accessEnvironmental Science

Early COVID-19 Interventions Failed to Replicate 1918 St. Louis vs. Philadelphia Outcomes in the United States

Aliea M. Jalali, Brent M. Peterson, Thushara Galbadage · 2020 · Frontiers in Public Health

The Coronavirus disease 2019 (COVID-19) pandemic has elicited an abrupt pause in the United States in multiple sectors of commerce and social activity. As the US faces this health crisis, the magnitude and rigor of their initial public health response was unprecedented. As a response, the entire nation shutdown at the state-level for the duration of a ~1-3 months. These public health interventions, however, were not arbitrarily decided, but rather, implemented as a result of evidence-based practices. These practices were a result of lessons learned during the 1918 influenza pandemic and the ci

View details →DOI: 10.3389/fpubh.2020.579559Cited by 9
Negative / Null Result ReportOpen accessMedicine

Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice

Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma et al. · 2023 · npj Vaccines

Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. This protein in the insect stage leads to the inactivation of insect anti-parasitic peptides and parasite transformation whereas in the intracellular amastigotes it participates in generating ROS promoting the growth of parasites. We have generated a parasite mutant with depleted expression of Cyp19 by removal of 2 of 3 genes encoding this protein using doubl

View details →DOI: 10.1038/s41541-023-00647-5Cited by 9
Negative / Null Result Report

Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

Chunyuan Zhang, Xu Wu, Yanfang Xian et al. · 2019 · Evidence-Based Complementary and Alternative Medicine

Isorhynchophylline (IRN) and rhynchophylline (RN), a pair of stereoisomers, are tetracyclic oxindole alkaloids isolated from Uncaria rhynchophylla , a commonly used Chinese medicinal herb. These two compounds have drawn extensive attention…

View details →DOI: 10.1155/2019/4016323Cited by 9
Negative / Null Result ReportNeuroscience

Better memory for emotional sources? A systematic evaluation of source valence and arousal in source memory

Nikoletta Symeonidou, Beatrice G. Kuhlmann · 2021 · Cognition & Emotion

Emotion-enhanced memory (EEM) describes the robust memory advantage of emotional over non-emotional stimuli. While extensively investigated with emotional items, it is unclear whether the EEM effect extends to source memory for a neutral…

View details →DOI: 10.1080/02699931.2021.2008323Cited by 9
Negative / Null Result ReportOpen accessPsychology

Robustness of the rule‐learning effect in 7‐month‐old infants: A close, multicenter replication of Marcus et al. (1999)

Andreea Geambașu, Sybren Spit, Daan van Renswoude et al. · 2022 · Developmental Science

We conducted a close replication of the seminal work by Marcus and colleagues from 1999, which showed that after a brief auditory exposure phase, 7-month-old infants were able to learn and generalize a rule to novel syllables not previously present in the exposure phase. This work became the foundation for the theoretical framework by which we assume that infants are able to learn abstract representations and generalize linguistic rules. While some extensions on the original work have shown evidence of rule learning, the outcomes are mixed, and an exact replication of Marcus et al.'s study has

View details →DOI: 10.1111/desc.13244Cited by 9
Negative / Null Result ReportOpen accessSocial Sciences

Replication of Study 1 in “Differentiating Social and Personal Power” by Lammers, Stoker, and Stapel (2009)

Lewend Mayiwar, Linda Lai · 2019 · Social Psychology

Abstract. We performed an independent, direct, and better powered ( N = 295) replication of Study 1, an experiment ( N = 113) by Lammers, Stoker, and Stapel (2009) . Lammers and colleagues distinguished between social power (influence over…

View details →DOI: 10.1027/1864-9335/a000388Cited by 9
Negative / Null Result Report

The more we search, the more we find: discovering and expanding the biodiversity in the ring nematode genus Xenocriconemella De Grisse and Loof, 1965 (Nematoda: Criconematidae)

A. Archidona-Yuste, I. Clavero-Camacho, A. N. Ruiz-Cuenca et al. · 2024 · Zoological Letters

Abstract The ring nematode genus Xenocriconemella De Grisse and Loof, 1965 comprises only one nominal species, Xenocriconemella macrodora (Taylor, 1936) De Grisse and Loof, 1965. The initial objective of the present study was to…

View details →DOI: 10.1186/s40851-024-00230-3Cited by 9
Negative / Null Result ReportOpen accessMedicine

A genome‐wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study

Sara R. Rashkin, Mario A. Cleves, Gary M. Shaw et al. · 2022 · American Journal of Medical Genetics Part A

Abstract Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures,…

View details →DOI: 10.1002/ajmg.a.62759Cited by 9
Negative / Null Result ReportComputer Science

epEBench: True Energy Benchmark

Simon Holmbacka, Robert Müller · 2017

Current benchmark suites for evaluating energy efficiency of modern computer systems fail to replicate real-world streaming applications accurately enough because of indeterministic load pattern which depends heavily on the input data of…

View details →DOI: 10.1109/pdp.2017.21Cited by 9
Negative / Null Result ReportPsychology

Narcissism and Reactions to a Self-Esteem Insult: An Experiment Using Predictions from Self-Report and the Rorschach Task

Emanuela S. Gritti, Gregory J. Meyer, Robert F. Bornstein et al. · 2020 · Journal of Personality Assessment

We used self-reported narcissistic grandiosity and vulnerability and a component derived from 11 potential grandiosity and narcissism variables (GNVs) coded from Rorschach behavior to predict fluctuations in self-esteem and their links to…

View details →DOI: 10.1080/00223891.2020.1848854Cited by 9
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma

Breanne Cuddington, Meghan L. Verschoor, Ali A. Ashkar et al. · 2015 · Molecular Therapy — Oncolytics

Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the…

View details →DOI: 10.1038/mto.2015.4Cited by 9
Negative / Null Result Report

Did the use of open invitations in place of timed appointment invitations reduce the uptake of breast screening in the London region during the COVID-19 recovery?

Sue M Hudson, Kathie Binysh, Stephen W Duffy · 2022 · Journal of Medical Screening

Objective The Covid-19 pandemic created a backlog of women awaiting an invitation for breast screening in the UK. To recover in a timely fashion, the National Health Service programme opted to issue open invitations (OI) to women rather…

View details →DOI: 10.1177/09691413221127583Cited by 9
Negative / Null Result ReportEnvironmental Science

Influence of Hook Size and Style on Short-Term Survival of Deeply Hooked Bluegills

Justin J. Robert, Sarah M. Larocque, Steven J. Cooke · 2012 · North American Journal of Fisheries Management

Abstract Catch and release is a common practice among recreational anglers. In instances when fish are deeply hooked, the proper techniques for promoting survival are poorly understood, although evidence suggests that the fishing line…

View details →DOI: 10.1080/02755947.2012.703161Cited by 9
Negative / Null Result ReportOpen accessMedicine

An exploratory study to evaluate visual function endpoints in non-advanced age-related macular degeneration

Divya Narayanan, John David Rodriguez, Garrick Wallstrom et al. · 2020 · BMC Ophthalmology

BACKGROUND: To prevent irreversible vision loss in age-related macular degeneration (AMD), it is critical to detect retinal dysfunction before permanent structural loss occurs. In the current study we evaluated a series of visual function tests to identify potential endpoints to detect visual dysfunction in non-advanced AMD. METHODS: A series of visual function tests were performed on 23 non-advanced AMD subjects (AREDS grade 1-4 on simplified scale) and 34 age-matched normals (AREDS grade 0). Tests included some commonly used endpoints such as ETDRS visual acuity (VA), low luminance (LL) 2.0N

View details →DOI: 10.1186/s12886-020-01683-8Cited by 9
Negative / Null Result Report

Stroke Volume Variation-Guided Goal-Directed Fluid Therapy Did Not Significantly Reduce the Incidence of Early Postoperative Complications in Elderly Patients Undergoing Minimally Invasive Esophagectomy: A Randomized Controlled Trial

Wei Tang, Yuwei Qiu, Huijie Lu et al. · 2021 · Frontiers in Surgery

Study Objective: This study aimed to investigate whether stroke volume variation (SVV)-guided goal-directed therapy (GDT) can improve postoperative outcomes in elderly patients undergoing minimally invasive esophagectomy (MIE) compared…

View details →DOI: 10.3389/fsurg.2021.794272Cited by 9
Negative / Null Result ReportOpen accessMedicine

Milademetan in Advanced Solid Tumors with MDM2 Amplification and Wild-type TP53: Preclinical and Phase II Clinical Trial Results

Ecaterina E. Dumbrava, Thomas E. Stinchcombe, Mrinal M. Gounder et al. · 2025 · Clinical Cancer Research

PURPOSE: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that degrades the tumor suppressor p53. In cancers, MDM2 amplification (MDM2amp) leads to overexpression of MDM2, inducing p53 degradation and a p53-null phenotype even in the…

View details →DOI: 10.1158/1078-0432.ccr-25-0762Cited by 9
Negative / Null Result ReportOpen accessMedicine

Impact of Coronary Lesion Stability on the Benefit of Emergent Percutaneous Coronary Intervention After Sudden Cardiac Arrest

Louis Pechmajou, Éloi Marijon, Olivier Varenne et al. · 2020 · Circulation Cardiovascular Interventions

Background: Conflicting data exist regarding the benefit of urgent coronary angiogram and percutaneous coronary intervention (PCI) after sudden cardiac arrest, particularly in the absence of ST-segment elevation. We hypothesized that the…

View details →DOI: 10.1161/circinterventions.119.009181Cited by 9