Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Alina Marculetiu, Çiğdem Ataseven, Injazz J. Chen · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT This study investigates the effectiveness of institutional pressures in motivating two contrasting sustainability strategies, symbolic and substantive, and their subsequent impact on the triple bottom line (TBL). Using data from…
View details →DOI: 10.1111/beer.12827Cited by 9 Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →DOI: 10.7150/thno.99562Cited by 9 Negative / Null Result ReportOpen accessEngineering
M. A. Huque, Leon M. Tolbert, Benjamin J. Blalock et al. · 2026 · IMAPSource Proceedings
High-temperature power conversion modules (DC-DC converters, inverters, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. Power-to-volume and…
View details →DOI: 10.4071/001c.161842Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna Barton, Maciej Jaśkiewicz, Anna Więch -Walów et al. · 2025 · Cell Communication and Signaling
Abstract The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to the low oxygen tension. Cellular studies of hypoxia have used the low oxygen model by using hypoxia chambers to monitor the gene expression changes, while others have utilized hypoxia mimetics in normoxic conditions. Here, we provide a comparison of the utility and limitations of two hypoxia mimetics by studying the changes in the miRNA and mRNA expre
View details →DOI: 10.1186/s12964-025-02459-7Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
S. H. Suyu, Ana Acebrón, C. Grillo et al. · 2026 · Astronomy and Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs, including parametric and free-form approaches. By conducting a blind analysis where all the mass-modeling teams constructed their models independently without exchanging results, we quantified uncertainties arising from modeling software and assumptions. MACS J0138−2155 is unique as the only cluster found to strongly lens two supernovae (SNe), R
View details →DOI: 10.1051/0004-6361/202557235Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
R. Abbasi, M. Ackermann, J. Adams et al. · 2026 · The Astrophysical Journal Letters
Abstract Recently, IceCube reported neutrino emission from the Seyfert galaxy NGC 1068. Using 13.1 yr of IceCube data, we present a follow-up search for neutrino sources in the northern sky. NGC 1068 remains the most significant neutrino source among 110 preselected gamma-ray emitters while also being spatially compatible with the most significant location in the northern sky. Its energy spectrum is characterized by an unbroken power-law with spectral index γ = 3.4 ± 0.2. Consistent with previous results, the observed neutrino flux exceeds its gamma-ray counterpart by at least 2 orders of magn
View details →DOI: 10.3847/2041-8213/ae4aadCited by 9 Negative / Null Result ReportOpen accessEngineering
Lihua Liang, Xiaodong Li, Shutong Liu et al. · 2026 · Buildings
This study develops and applies an integrated methodology that combines deep learning-based computer vision and spatial statistics to automate the large-scale identification and analysis of morphological features in vernacular courtyard dwellings. Focusing on Liangshuaixiu dwellings in Wu’an, southern Hebei, we trained an HRNetV2 semantic segmentation model on high-resolution satellite imagery to identify and extract contours for 134,280 courtyard spaces. Core morphological parameters (area, orientation) were calculated and analyzed using GIS spatial statistics and the geographic detector mode
View details →DOI: 10.3390/buildings16061118Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Wenying Huo, Yingying Qiao, Xiangru He et al. · 2025 · Toxins
Mycotoxins are toxic secondary metabolites produced by filamentous fungi that contaminate agricultural commodities, posing risks to food safety, animal productivity, and human health. The gastrointestinal tract is the first and most critical site of exposure, where the intestinal epithelium functions as both a physical and immunological barrier against luminal toxins and pathogens. While extensive research has demonstrated that mycotoxins disrupt epithelial integrity through tight junction impairment, oxidative stress, apoptosis, and inflammation, their effects on the intestinal stem cell (ISC
View details →DOI: 10.3390/toxins17110534Cited by 9 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Bálint Soczó, Ildikó Pethes · 2025 · Journal of Molecular Liquids
Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations . Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction potential model for water. In various studies, the models have been evaluated based on their ability to reproduce different properties of water. This work focuses on the atomic-scale structure in the liquid phase of water. Forty-four classical water potential models are compared to identify those that can accurately describe the structure in alignment with experim
View details →DOI: 10.1016/j.molliq.2025.127975Cited by 9 Negative / Null Result ReportOpen accessPsychology
Marielle Demarais, Melissa Fisher, Anne Williams-Wengerd et al. · 2024 · BMC Psychiatry
BACKGROUND: Coordinated specialty care (CSC) programs for first episodes of psychosis are increasingly offered in the United States. A component of CSC programs is active family engagement in treatment, though research on the impact of…
View details →DOI: 10.1186/s12888-024-06126-yCited by 9 Negative / Null Result ReportOpen accessNursing
Clara Barnés-Calle, P. Gou, E. Fulladosa et al. · 2026 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Fourier transform infrared spectroscopy (FTIR) combined with Amide I band deconvolution has been used to investigate protein structural changes occurring during high moisture extrusion processing (HMEP). However, it is a sensitive,…
View details →DOI: 10.1016/j.saa.2026.127509Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Korenjak, Nuri A. Temiz, Stéphane Keïta et al. · 2026 · Genome Medicine
BACKGROUND: Tobacco use is linked to multiple cancer types and a quarter of cancer deaths. Tobacco smoke contains numerous mutagenic chemicals such as polycyclic aromatic hydrocarbons (PAH), however, the mutagenicity of many chemicals in…
View details →DOI: 10.1186/s13073-026-01685-zCited by 9 Negative / Null Result ReportOpen accessEngineering
Kaituo Li, Lin Zhu, Fei Xiong et al. · 2026 · Processes
Enhanced geothermal systems (EGS) are a key technology for developing deep geothermal resources, yet they face significant challenges in constructing efficient thermal reservoirs within high-stress, high-strength, and low-permeability crystalline rock formations. Traditional hydraulic fracturing (HF) techniques encounter deep challenges in these environments, including excessively high fracturing pressures, limited fracture network patterns, and the risk of induced seismicity. This paper reviews the multi-scale thermal-mechanical mechanisms, fracture evolution patterns, and control strategies
View details →DOI: 10.3390/pr14081199Cited by 9 Negative / Null Result ReportOpen accessEngineering
Zhenlin Zhang, Lang Yan, Weiwei Li et al. · 2026 · Nature Communications
In the development of clinically translatable triplet photosensitizers for hypoxia regulated photodynamic therapy (PDT), there is an unmet need for engineering sensitizers as near-infrared (NIR)-responsive, type I/type Ⅱ dual…
View details →DOI: 10.1038/s41467-026-71476-yCited by 9 Negative / Null Result ReportOpen accessMedicine
Niklas Mattsson-Carlgren, Sebastian Palmqvist, Kanta Horie et al. · 2026 · The Lancet Neurology
BACKGROUND: Alzheimer's disease pathology can be accurately identified with blood biomarkers (core 1 biomarkers), including plasma p-tau217 tests. Biomarkers that change longitudinally after diagnosis (core 2 biomarkers) can increase confidence that Alzheimer's disease pathology is contributing to cognitive symptoms. Plasma eMTBR-tau243 reflects tau tangle pathology and is a promising core 2 biomarker. We aimed to examine whether, among patients positive for plasma p-tau217, plasma eMTBR-tau243 improves classification of established Alzheimer's disease and predicts cognitive decline and tau ta
View details →DOI: 10.1016/s1474-4422(26)00029-3Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Sami Saeed Binyamin · 2026 · Edinburgh Napier Research Repository (Edinburgh Napier University)
Learning management systems (LMS), which allow education at the student’s choice of place and time, have been widely adopted in higher education worldwide. In the case of Saudi Arabia, LMS have been recently introduced in Saudi…
View details →DOI: 10.17869/enu.2026.2376896Cited by 9 Negative / Null Result ReportOpen accessMedicine
Jenny Bouchard, Nicola Gasparre, Thomas Netticadan et al. · 2025 · Journal of Functional Foods
The integration of resveratrol, a naturally occurring, health promoting polyphenolic stilbene, into food systems poses a challenge due to its low water solubility, chemical instability, poor bioavailability, and bitter taste. To address…
View details →DOI: 10.1016/j.jff.2025.107127Cited by 9 Negative / Null Result ReportOpen accessMathematics
Ezequiel Mauro, Tiago de Castro, Marcus Zeitlhoefler et al. · 2025 · Journal of Hepatology
BACKGROUND & AIMS: Non-proportional hazards (NPH) can lead to discrepancies between interim (IA) and final analyses (FA) in randomized controlled trials (RCTs) of hepatocellular carcinoma (HCC). We assessed the impact of NPH in pivotal HCC…
View details →DOI: 10.1016/j.jhep.2025.08.042Cited by 9 Negative / Null Result ReportOpen accessMathematics
Joe V. Selby, Carolien C. H. M. Maas, Bruce Fireman et al. · 2025 · JAMA Network Open
Importance: The Predictive Approaches to Treatment Effect Heterogeneity (PATH) Statement of 2020 proposed predictive modeling for identifying heterogeneity in treatment effects (HTE) in randomized clinical trials (RCTs). It described 2 approaches: risk modeling, which develops a multivariable model predicting individual baseline risk of study outcomes and then examines treatment effects across strata of predicted risk, and effect modeling, which develops a model that directly predicts individual treatment effects using a variety of regression and machine learning methods. Objective: To identif
View details →DOI: 10.1001/jamanetworkopen.2025.22390Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Erlei Zhi, Haowei Bai, Chuan Ren et al. · 2025 · Nature Communications
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its role in sperm function has remained unclear. Through whole-exome sequencing (WES) of 800 patients with asthenozoospermia, we…
View details →DOI: 10.1038/s41467-025-63280-xCited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Wolfgang Wüster · 2025 · Vertebrate Zoology
The advent of molecular methods has revolutionised the field of species delimitation and description, one of the key tasks of systematic biology. In animal taxonomy, one marker, the mitochondrial DNA (mtDNA) molecule, has acquired and retained disproportionate influence. This is despite its uniparental, clonal mode of inheritance, as a result of which the entire molecule acts as a single locus, and that precludes its use as a test for admixture between putative lineages, a key consideration in species delimitation. To establish the extent to which the limitations of mtDNA affect present-day ta
View details →DOI: 10.3897/vz.75.e161536Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Alfonz Kedves, Máté Balogh, Jamsheed Abbas Dar et al. · 2026 · Bioresource Technology
The increasing occurrence of microplastics and antibiotics in wastewater poses emerging challenges for biological treatment processes. Microalgal-bacterial granular sludge (MBGS) has emerged as an efficient algae-based biotechnology for wastewater treatment; however, its response to simultaneous exposure to these contaminants remains largely unexplored. Here, the effects of degradable polycaprolactone microplastics (PCL MPs) and sulfamethoxazole (SMX) were evaluated at 1 mg/L during granulation and long-term operation. PCL alone caused only minor changes, whereas SMX impaired granule stability
View details →DOI: 10.1016/j.biortech.2026.134820Cited by 9 Negative / Null Result ReportOpen accessImmunology and Microbiology
Weiye Chen, Yige Zeng, Jinxin Zheng et al. · 2026 · Nature Medicine
Antimicrobial resistance (AMR) poses a major global health threat, yet the effectiveness of national action plans (NAPs) remains uncertain. Here we developed a multidimensional One Health governance index through a structured Delphi expert…
View details →DOI: 10.1038/s41591-026-04257-1Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Muhammad Dawood, Kim Branson, Sabine Tejpar et al. · 2026 · Nature Biomedical Engineering
Deep learning models that infer clinically relevant biomarker status from tissue images are being explored as rapid and low-cost alternatives to molecular testing. Here we show, through statistical analysis across multiple cancer types, datasets and modelling approaches, that the datasets used to train these models contain strong dependencies between biomarkers and clinicopathological features, which prevent models from isolating the effect of a single biomarker and lead them to learn confounded signals. Consequently, their prediction accuracy varies substantially with the status of codependen
View details →DOI: 10.1038/s41551-026-01616-8Cited by 9 Negative / Null Result ReportMedicine
Toni K. Choueiri, R Motzer, Jose A. Karam et al. · 2026 · Journal of Clinical Oncology
LBA418 Background: Adjuvant pembrolizumab is a standard of care for patients with ccRCC at increased risk of recurrence following nephrectomy based on the phase 3 KEYNOTE-564 study (N Engl J Med 385:683; N Engl J Med 390:1359). Combination…
View details →DOI: 10.1200/jco.2026.44.7_suppl.lba418Cited by 9 Negative / Null Result ReportOpen accessImmunology and Microbiology
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →DOI: 10.1172/jci189570Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
John M. Carey, Brian J. Fogarty, Marília Gehrke et al. · 2025 · Science Advances
We investigate how to counter misinformation about voter and election fraud using data from the US and Brazil. Our study first compares two types of messages countering claims of widespread fraud: (i) retrospective corrections from…
View details →DOI: 10.1126/sciadv.adv3758Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Davide Faccialà, M. Bonanomi, Bruno Nunes Cabral Tenorio et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide We report a study of the electronic and nuclear relaxation dynamics of the photoexcited RNA base uracil in the gas phase using time-resolved core-level photoelectron spectroscopy together with high-level calculations. The dynamics was investigated by trajectory surface hopping calculations, and the core ionization energies were calculated for geometries sampled from these. The molecule was excited by a UV laser and dynamics probed on the oxygen, nitrogen, and carbon sites by core electron spectroscopy. We find that the main de-excitation chann
View details →DOI: 10.1021/jacs.5c04874Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Jonas Schmidinger, Viacheslav Barkov, Sebastian Vogel et al. · 2025 · Computers and Electronics in Agriculture
Machine learning and geostatistics are two fundamentally different frameworks for the prediction and spatial mapping of soil properties. Geostatistics leverages the spatial structure of soil properties, whereas machine learning models capture the relationship between available environmental features and soil properties. We propose a hybrid framework that augments machine learning with spatial context through the engineering of ‘spatial lag’ features derived from ordinary kriging. We call this approach ‘kriging prior regression’ (KpR), as it reverses the logic of regression kriging by incorpera
View details →DOI: 10.1016/j.compag.2025.111352Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Sabine Willems, Vasily Morozov, Julian A. Marschner et al. · 2025 · Journal of Medicinal Chemistry
The ligand-activated transcription factors of the NR4A family are implicated as promising drug targets with neuroprotective and anticancer potential and attract strong attention in drug discovery. Several NR4A modulators have been…
View details →DOI: 10.1021/acs.jmedchem.5c00459Cited by 9 