Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Adriano Gravina, P. Gargiulo, Michelino De Laurentiis et al. · 2025 · ESMO Open
BACKGROUND: The Hormonal Bone Effects (HOBOE) study tested whether adjuvant triptorelin plus either letrozole (L) or zoledronic acid (Z) plus L (ZL) was more effective than tamoxifen (T) in premenopausal patients with hormone…
View details →DOI: 10.1016/j.esmoop.2024.104085Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Joss Bland‐Hawthorn, Thor Tepper-García, Oscar Agertz et al. · 2025 · The Astrophysical Journal
Abstract In response to recent observations from JWST and Atacama Large Millimeter Array, we explore a new class of dynamically self-consistent models that mimics a plausible progenitor of the Milky Way over a wide range of disk gas fractions, f gas . The high gas surface densities encourage vigorous star formation, which in turn couples with the gas to drive turbulence. We show that this coupling through momentum recoil drives a random walk of the baryonic potential minimum with respect to total gravitational potential, Φ tot ( R , ϕ , z ). The amplitude of the bulk motion depends on the feed
View details →DOI: 10.3847/1538-4357/ae0931Cited by 9 Negative / Null Result ReportOpen accessMedicine
Hyunmin Yu, Jacqueline Margo Brooks Carthon, Linda H. Aiken et al. · 2026 · Research in Nursing & Health
The Pathway to Excellence (Pathway) program administered by the American Nurses Credentialing Center, recognizes organizations that foster positive nursing practice environments. However, evidence linking Pathway designation to nurse-reported outcomes remains limited. This cross-sectional study integrated data from the Penn 2024 Nurses4All Study and the American Hospital Association Annual Survey. The sample included 16,979 direct care nurses from 1672 hospitals in 10 US states (866 nurses in 63 Pathway hospitals and 16,113 nurses in 1609 non-Pathway, non-Magnet hospitals). The independent var
View details →DOI: 10.1002/nur.70052Cited by 9 Negative / Null Result ReportOpen accessMedicine
Vanda Haralović, Mislav Mokos, Sanja Špoljar et al. · 2025 · Biomedicines
Background: Hypochlorous acid (HOCl) is an integral component of the human innate immune system. It possesses antimicrobial properties and is available in solution, dermal spray, and scar gel forms. Objectives/Methods: This review presents data from studies on the clinical use of HOCl in various specialties, including dermatology, surgery, dentistry, ophthalmology, and rhinology. Results: Due to its anti-inflammatory/antimicrobial/immunomodulatory and healing properties, HOCl is advantageous in treating various skin disorders: ulcus cruris (and wound care), diabetic ulcers, atopic dermatitis,
View details →DOI: 10.3390/biomedicines13122921Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sourav Goswami, Alisha Ansari, Chetan Saraf et al. · 2026 · Nature Communications
Bifidobacteria are key health-associated members of the human gut microbiome and are widely used as probiotics, but their colonization success varies substantially between individuals, partly due to baseline microbiome composition. We…
View details →DOI: 10.1038/s41467-026-72289-9Cited by 9 Negative / Null Result ReportOpen accessMedicine
Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath et al. · 2026 · Bone Research
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-assoc
View details →DOI: 10.1038/s41413-026-00526-4Cited by 9 Negative / Null Result ReportOpen accessMedicine
Danielle J Sisnett, Katherine B Zutautas, Dan Hoang Nguyet Vo et al. · 2026 · Frontiers in Immunology
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and survival. In particular, T cell subsets are predominant effector immune cells within the complex endometriosis lesion microenvironment. T cell biology encompasses a highly regulated and diverse network of cellular differentiation, antigen recognition, and immune regulation, all of which play critical roles in immune homeostasis. This complexity becomes particularly
View details →DOI: 10.3389/fimmu.2026.1712360Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Prabha M. Kumarage, Mirka Saarela · 2026 · AI
Generative Artificial Intelligence (GenAI) models produce increasingly sophisticated outputs, yet their underlying mechanisms remain opaque. To clarify how explainability is conceptualized and implemented in GenAI research, this two-stage review systematically examined 261 articles retrieved from six major databases. After removing duplicates and applying predefined inclusion criteria, 63 articles were retained for full analysis. In the first stage, an umbrella review synthesized insights from 18 review papers to identify prevailing frameworks, strategies, and conceptual challenges surrounding
View details →DOI: 10.3390/ai7010031Cited by 9 Negative / Null Result ReportOpen accessMathematics
Joe V. Selby, Carolien C. H. M. Maas, Bruce Fireman et al. · 2025 · JAMA Network Open
Importance: The Predictive Approaches to Treatment Effect Heterogeneity (PATH) Statement of 2020 proposed predictive modeling for identifying heterogeneity in treatment effects (HTE) in randomized clinical trials (RCTs). It described 2 approaches: risk modeling, which develops a multivariable model predicting individual baseline risk of study outcomes and then examines treatment effects across strata of predicted risk, and effect modeling, which develops a model that directly predicts individual treatment effects using a variety of regression and machine learning methods. Objective: To identif
View details →DOI: 10.1001/jamanetworkopen.2025.22390Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Chi-Horng Liao · 2025 · Frontiers in Psychology
This study examines how media factors influence pro-environmental behavior (PEB) through an integration of Media System Dependency Theory (MSDT) and Norm Activation Theory (NAT). Using both Fuzzy Decision-Making Trial and Evaluation Laboratory (F-DEMATEL) and Structural Equation Modeling (SEM), it evaluates the effects of media factors on NAT components-awareness of consequences and ascription of responsibility-and their role in activating personal norms that drive PEB. The study also considers the moderating impact of self-efficacy on the link between personal norms and PEB. Findings from F-D
View details →DOI: 10.3389/fpsyg.2025.1520537Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports
Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise
View details →DOI: 10.1038/s41598-025-99000-0Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Roxana-Maria Amărandi, Luminița Marin, Brînduşa Drăgoi et al. · 2024 · Molecular Pharmaceutics
High Resolution Image Download MS PowerPoint Slide Liposomes, small bilayer phospholipid-containing vesicles, are frequently used to ensure slow drug release for a prolonged and improved therapeutic effect. Nevertheless, current findings…
View details →DOI: 10.1021/acs.molpharmaceut.4c00328Cited by 9 Negative / Null Result ReportOpen accessMedicine
Mathilde Duchon, Raj Naik, Fabrice R Lecuru et al. · 2025 · Cancers
Background: The surgical and medical management of recurrent ovarian cancer is complex and requires a personalized approach based on several factors, including the timing of recurrence, the patient’s performance status, previous treatment regimens, and the tumor’s histology and molecular characteristics. Objectives: Five randomized trials—GOG-0213, DESKTOP III, SOC 1, HORSE, and CHIPOR—have been conducted and shed light on our practice. Results: Both the DESKTOP III and the SOC 1 trials support the benefit of secondary surgery. The GOG-0213 trial, however, did not show an overall survival bene
View details →DOI: 10.3390/cancers17040646Cited by 9 Negative / Null Result ReportOpen accessMedicine
Carmella Evans‐Molina, Yasminye D. Pettway, Diane C. Saunders et al. · 2026 · Nature Communications
Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers…
View details →DOI: 10.1038/s41467-026-70689-5Cited by 9 Negative / Null Result ReportOpen accessMedicine
Cristina Gonzalez‐Robles, Oliver Bandmann, Anthony H.V. Schapira · 2025 · Neurology and Therapy
Parkinson disease (PD) is a progressive neurodegenerative condition characterised by tremor, bradykinesia and rigidity, as well as other motor and non-motor symptoms, for which no effective disease-modifying treatments have been…
View details →DOI: 10.1007/s40120-025-00793-zCited by 9 Negative / Null Result ReportOpen accessMedicine
Emmanouil Karampinis, Christina-Marina Zoumpourli, Aimilios Lallas et al. · 2026 · Medicina
Background and Objectives: Artificial intelligence (AI) has transitioned to an integral part of dermatology in only few years, yet perceptions of its use vary widely, reflecting diverse hopes, concerns, and perceived clinical utility. Materials and Methods: In this study, 300 dermatologists from 13 countries, representing a range of experience levels and AI usage statuses, were surveyed regarding the characteristics and applications of AI in dermatology. Results: Among respondents, 61.33% reported having used AI tools in clinical practice. Adoption of AI was observed across all age groups, cou
View details →DOI: 10.3390/medicina62040759Cited by 9 Negative / Null Result ReportOpen accessMedicine
Xiaofeng Dai, Chongxiang Wang, Ping Jiang et al. · 2026 · MedComm
Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic, each with distinct biopsychosocial mechanisms. Chronic pain was historically viewed as a monolithic symptom and managed with opioid-centric models, causing widespread therapeutic failure. While recognition of its heterogeneity has driven a paradigm shift toward precision medicine, tailoring multimodal strategies to the dominant pain mechanism, critical challenges persist. These include difficulty in identifying treatable root causes, limited long-
View details →DOI: 10.1002/mco2.70685Cited by 9 Negative / Null Result ReportOpen accessPsychology
Kağan Kırcaburun, Pınar Özdemir · 2026 · Behavioral Sciences
The rapid integration of generative artificial intelligence (GAI) tools into academic and professional contexts has raised concerns regarding unethical use and the potential development of problematic usage patterns. Drawing on personality and moral psychology frameworks, the present study examined the associations between antagonistic personality traits (narcissism, Machiavellianism, and psychopathy) and problematic (i.e., addictive) GAI use (PGAIU), as well as the chain mediating effect of moral disengagement and unethical GAI use (UGAIU). Data were collected from an adult sample (N = 491; 5
View details →DOI: 10.3390/bs16040500Cited by 9 Negative / Null Result ReportOpen accessMedicine
Wenjing Chen, Heng Tian, Ran Wei et al. · 2026 · International Journal of Molecular Medicine
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, are characterized by progressive loss of neurons. Although the precise pathogenesis of such diseases is complex and…
View details →DOI: 10.3892/ijmm.2026.5790Cited by 9 Negative / Null Result ReportOpen accessArts and Humanities
Mehdi Solhi, Majid Elahi Shirvan, Tahereh Taherian · 2026 · Asian-Pacific Journal of Second and Foreign Language Education
Abstract The dynamic and reciprocal nature of boredom and motivation in L2 classrooms remains underexplored and little is known about how L2 teachers’ perceived boredom (PTB), foreign language learning boredom (FLB), and L2 writing motivation (WM) evolve within and across individuals over time, particularly from a dynamic systems perspective. A total of 264 English as a foreign language (EFL) learners and 21 teachers participated, and data were collected using a 10-day experience sampling approach. We specifically examined three feedback loops—PTB-FLB, FLB-WM, and PTB-WM. Dynamic structural eq
View details →DOI: 10.1186/s40862-026-00388-7Cited by 9 Negative / Null Result ReportOpen accessMaterials Science
Jingyi Xu, Zhanming Wu, Yunan Tan et al. · 2026 · Journal of Advanced Ceramics
Abstract The escalating complexity of the electromagnetic environment calls for advanced electromagnetic wave (EMW) absorption materials capable of efficient multi-frequency attenuation. Silicon carbide (SiC) is a promising dielectric candidate but is hindered by intrinsic impedance mismatch and limited polarization loss. Herein, we report a novel ternary heterostructure absorber consisting of SiC nanowires synergistically coupled with dual rare-earth silicides (Ce5Si4 and Pr5Si4) fabricated via a combined magnesiothermic and carbothermal reduction process using an MFI-type zeolite precursor.
View details →DOI: 10.26599/jac.2026.9221325Cited by 9 Negative / Null Result ReportOpen accessMedicine
Daniel R. Richardson, Ying Wang, Marie Anne Flannery et al. · 2026 · JAMA Oncology
Importance: Health care systems should strive to achieve outcomes that matter to patients. Limited data exist on the outcomes achieved by patients with cancer with different treatment outcome preferences. Objective: To describe treatment…
View details →DOI: 10.1001/jamaoncol.2026.0072Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Shukun Luo, Joshua Bulos, Ricky Uroza et al. · 2025 · Pharmaceutics
Background: Photostability assessment is a critical component in the development of drug products, particularly for antibody–drug conjugates (ADCs) containing light-sensitive small molecules such as camptothecin (CPT) and its derivatives. ADCs conjugated with CPT derivative payloads often require extensive formulation and drug product development to ensure product stability due to their unique light-induced degradation pathways. In this study, we assessed the photostability of two ADC molecules with a CPT derivative payload (deruxtecan, DXd). Methods: Following light exposure, the stability of
View details →DOI: 10.3390/pharmaceutics17111397Cited by 9 Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →DOI: 10.7150/thno.99562Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Michael Vaccaro, Mikayla Friday, Arash E. Zaghi · 2025 · Applied Sciences
Multi-agent large language models promise flexible, modular architectures for delivering personalized educational content. Drawing on a pilot randomized controlled trial with middle school students (n = 23), we introduce a two-agent GPT-4 framework in which a Profiler agent infers learner-specific preferences and a Rewrite agent dynamically adapts science passages via an explicit message-passing protocol. We implement structured system and user prompts as inter-agent communication schemas to enable real-time content adaptation. The results of an ordinal logistic regression analysis hinted that
View details →DOI: 10.3390/app15137579Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
W. V. Jacobson-Galán, Luc Dessart, Kyle W. Davis et al. · 2025 · The Astrophysical Journal
Abstract We present analysis of the plateau and late-time phase properties of a sample of 39 Type II supernovae (SNe II) that show narrow, transient, high-ionization emission lines (i.e., “IIn-like”) in their early-time spectra from interaction with confined, dense circumstellar material (CSM). Originally presented by W. V. Jacobson-Galán et al., this sample also includes multicolor light curves and spectra extending to late-time phases of 35 SNe with no evidence for IIn-like features at <2 days after first light. We measure photospheric phase light-curve properties for the distance-correct
View details →DOI: 10.3847/1538-4357/adfa23Cited by 9 Negative / Null Result ReportOpen accessChemistry
Weida Wang, Chunqi Wang, Baocheng Zhao et al. · 2026 · Foods
Soybean protein content is a key indicator of nutritional value and quality grade, and its determination is important for quality evaluation and cultivar selection. To overcome the time-consuming and costly limitations of conventional chemical assays, this study proposed a multiple linear learner ensemble importance-score wavelength selection (MLLEISWS) method to identify informative wavelengths from soybean near-infrared spectra and establish a partial least squares (PLS) model. MLLEISWS was compared with competitive adaptive reweighted sampling, successive projections algorithm, and uninform
View details →DOI: 10.3390/foods15101755Cited by 9 Negative / Null Result ReportOpen accessImmunology and Microbiology
Nina Martino, Erin Sanders, Ramon Bossardi Ramos et al. · 2025 · Journal of Clinical Investigation
Severe systemic inflammatory reactions, including sepsis, often lead to shock, organ failure, and death, in part through an acute release of cytokines that promote vascular dysfunction. However, little is known about the vascular endothelial signaling pathways regulating the transcriptional profile in failing organs. Our work focused on signaling downstream of IL-6, due to its clinical importance as a biomarker for disease severity and predictor of mortality. Here, we show that loss of endothelial expression of the IL-6 pathway inhibitor SOCS3 promoted a type I IFN-like (IFNI-like) gene signat
View details →DOI: 10.1172/jci189570Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
John M. Carey, Brian J. Fogarty, Marília Gehrke et al. · 2025 · Science Advances
We investigate how to counter misinformation about voter and election fraud using data from the US and Brazil. Our study first compares two types of messages countering claims of widespread fraud: (i) retrospective corrections from…
View details →DOI: 10.1126/sciadv.adv3758Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Davide Faccialà, M. Bonanomi, Bruno Nunes Cabral Tenorio et al. · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide We report a study of the electronic and nuclear relaxation dynamics of the photoexcited RNA base uracil in the gas phase using time-resolved core-level photoelectron spectroscopy together with high-level calculations. The dynamics was investigated by trajectory surface hopping calculations, and the core ionization energies were calculated for geometries sampled from these. The molecule was excited by a UV laser and dynamics probed on the oxygen, nitrogen, and carbon sites by core electron spectroscopy. We find that the main de-excitation chann
View details →DOI: 10.1021/jacs.5c04874Cited by 9 