Negative / Null Result ReportOpen accessMedicine
Maria Dalamaga, Rodopi Emfietzoglou, Dimitra Petropoulou et al. · 2026 · Current Nutrition Reports
PURPOSE OF REVIEW: Vitamin D is a pleiotropic hormone with an established role in skeletal integrity and broader actions in immune regulation, inflammation, cellular proliferation, and energy homeostasis. Despite decades of research, its extra-skeletal effects remain controversial, largely due to discordant findings across observational studies, Mendelian randomization studies (MRS), and randomized controlled trials (RCTs). Unlike many prior reviews, this state-of-the-art review synthesizes triangulated evidence across these study designs to clarify outcome-specific causal relationships and on
View details →DOI: 10.1007/s13668-026-00748-2Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Oxana Kirichok, Yuliia Orlovska, G.S. Zhanseitova et al. · 2025 · Environmental Economics
Type of the article: Research ArticleAbstract Global progress toward universal access to affordable, reliable, and clean energy has stalled, with over two billion people still lacking access to clean cooking, and affordability pressures are rising. AI is emerging as an energy-intensive technology and a potential enabler of more equitable energy systems. This paper assesses whether AI vibrancy contributes to advancing energy equity across countries while accounting for differences in economic capacity. The study employs a balanced panel of 36 countries from 2017 to 2023 (252 observations), draw
View details →DOI: 10.21511/ee.16(4).2025.11Cited by 9 Negative / Null Result ReportOpen accessPsychology
Ryan K. McBain, Jonathan Cantor, J. Breslau et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: The rapid expansion of artificial intelligence (AI) chatbots has coincided with a persistent youth mental health crisis in the US, raising a question about the extent to which young people are turning to this technology for…
View details →DOI: 10.1001/jamapediatrics.2026.2015Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Gonzalo Olmedo‐Saura, E Bernardi, Lidia Bojtos et al. · 2025 · International Journal of Molecular Sciences
Huntington's disease (HD) is the most common autosomal dominant neurodegenerative disorder, characterized by a triad of motor dysfunction, cognitive decline, and psychiatric disturbances. While recent efforts have focused on developing disease-modifying therapies, no treatment has yet demonstrated clinical efficacy. As a result, symptomatic treatment remains the cornerstone of care. However, high-quality evidence from large randomized trials is limited, and therapeutic decisions must rely on clinical expertise and extrapolation from other neurological or psychiatric conditions. This narrative
View details →DOI: 10.3390/ijms26136220Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
Tim Linden, Thong T. Q. Nguyen, Tim M. P. Tait · 2026 · Journal of Cosmology and Astroparticle Physics
Abstract We model and constrain the unique indirect detection signature produced by dark matter particles that annihilate through a U(1) gauge symmetry into dark photons that subsequently decay into three-photon final states. We focus on scenarios where the dark photon is long-lived, and show that γ-ray probes of celestial objects can set strong constraints on the dark matter/baryon scattering cross section that in many cases surpass the power of current direct detection constraints, and in some cases even peer into the neutrino fog.
View details →DOI: 10.1088/1475-7516/2026/08/056Cited by 9 Negative / Null Result ReportOpen accessChemistry
Josep Esteve Guasch, Debasis Pal, Marcos G. Suero · 2025 · Journal of the American Chemical Society
High Resolution Image Download MS PowerPoint Slide Herein, we disclose the first catalytic generation of alkyl–I (III) Rh (II) -carbynoids via oxidative ligand transfer between alkyl iodides and aryl–I (III) Rh (II) -carbynoids. When homoallylic iodides were used, alkyl–I (III) Rh (II) -carbynoids evolved through a diastereoselective cyclopropanation that led to highly electrophilic bicyclic alkyl–I (III) species. We observed that the latter species reacted with a plethora of nucleophiles, enabling access to a valuable class of cyclopropanes that were converted to housanes.
View details →DOI: 10.1021/jacs.5c09559Cited by 9 Negative / Null Result ReportOpen accessSocial Sciences
Ninggui Duan, Lina Li, Guangbo Lin et al. · 2026 · Scientific Reports
The rapid advancement of artificial intelligence (AI) has reshaped the employment market, triggering widespread anxiety among college students about their future careers and posing a potential threat to their career decisions. Grounded in…
View details →DOI: 10.1038/s41598-026-37648-yCited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Yunpeng Qiu, Yunfeng Zhao, Bianbian Wang et al. · 2026 · Nature Communications
Plant roots and arbuscular mycorrhizal fungi (AMF) form a ubiquitous symbiosis in terrestrial ecosystems and critically affect soil organic carbon (SOC) dynamics. However, how roots and AMF mediate the impact of reactive nitrogen (Nr) and…
View details →DOI: 10.1038/s41467-026-69301-7Cited by 9 Negative / Null Result ReportMedicine
Jean-Pierre Frat, J. Quenot, Christophe Guitton et al. · 2026 · New England Journal of Medicine
BACKGROUND: Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. METHODS: In this…
View details →DOI: 10.1056/nejmoa2516087Cited by 9 Negative / Null Result ReportOpen accessMedicine
Shanshan Zhang, Tingyu Wang, Ye Peng et al. · 2026 · Molecular Biomedicine
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairments such as bradykinesia, tremor, and rigidity. Its neuropathological hallmarks include the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the aggregation of α-synuclein (α-syn) into Lewy bodies (LBs), which gradually spread to other central nervous system regions and peripheral tissues. The etiology of PD is multifactorial, involving a complex interplay of genetic predisposition, aging, environmental exposures, and lifestyle factors. Disease pathogenesis
View details →DOI: 10.1186/s43556-026-00445-0Cited by 9 Negative / Null Result ReportOpen accessPhysics and Astronomy
A. M. Farah, A. Vijaykumar, M. Fishbach · 2026 · The Astrophysical Journal Letters
Abstract There is growing evidence from gravitational-wave (GW) observations that some merging black holes (BHs) are created from previous mergers. Using the prediction that these hierarchically merged BHs have dimensionless spin magnitudes of χ ≈ 0.69, we identify a subpopulation in the GW data consistent with a hierarchical-merger origin in dense star clusters. This subpopulation’s primary mass distribution peaks at 17 . 0 − 4.4 + 18.3 M ⊙ , which is approximately twice as large as its secondary mass distribution’s mode ( 10 . 5 − 4.7 + 29.7 M ⊙ ), and its spin tilt distribution is consisten
View details →DOI: 10.3847/2041-8213/ae4e19Cited by 9 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Fereshteh Bakhshalipoor, Marzieh Bolandi, Fariborz Nahidi et al. · 2026 · Scientific Reports
This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…
View details →DOI: 10.1038/s41598-026-52693-3Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Nurcan Kilinc‐Ata, Alia Al-Fori · 2026 · Journal of risk and financial management
The intersection of financial innovation and environmental sustainability offers important opportunities for low- and middle-income (LMI) countries. This study examines the association between FinTech investment, geopolitical-economic uncertainty, urbanization, economic development, and carbon dioxide (CO2) emissions in LMI countries. CO2 emissions per capita are used as an environmental outcome indicator rather than as a direct measure of green finance. Using a panel dataset covering 2010–2021, the study applies fixed-effects panel regressions as the main empirical approach and reports one-st
View details →DOI: 10.3390/jrfm19050362Cited by 9 Negative / Null Result ReportOpen accessComputer Science
Mohammadreza Kamsari, Soroush Sadeghi, Gabriel Gomes de Oliveira et al. · 2025 · Scientific Reports
This study conducts a comprehensive analysis of various configurations of the UNet + ConvNeXt Tiny architecture for breast tumor segmentation. We assess the influence of data augmentation, skip connections, attention mechanisms, and…
View details →DOI: 10.1038/s41598-025-29841-2Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anagha Krishna, Alison Meynert, Karamjit Singh Dolt et al. · 2026 · Nature Genetics
CTNNB1, the gene encoding β-catenin, is a frequent target for oncogenic mutations activating the canonical Wnt signaling pathway, typically through missense mutations within a degron hotspot motif in exon 3. Here, we combine saturation genome editing with a fluorescent reporter assay to quantify signaling phenotypes for all 342 possible missense mutations in the mutation hotspot. Our data define the genetic requirements for β-catenin degron function, refine the consensus motif for substrate recognition by β-TRCP and reveal diverse levels of signal activation among known driver mutations. Tumor
View details →DOI: 10.1038/s41588-025-02496-5Cited by 9 Negative / Null Result ReportOpen accessMedicine
Dinh Van Trung, Bui Thi Huong Giang, Đang Quoc Tuan et al. · 2025 · Scientific Reports
Electrical impedance tomography (EIT)-guided positive end-expiratory pressure (PEEP) titration may optimize ventilation and reduce ventilator-induced lung injury in acute respiratory distress syndrome (ARDS). We compared EIT-guided PEEP…
View details →DOI: 10.1038/s41598-025-29787-5Cited by 9 Negative / Null Result ReportOpen accessMedicine
Eleanor Quek, Neve Horn, Salman Siddiqui · 2025 · ImmunoTargets and Therapy
Asthma represents a profoundly heterogeneous syndrome underpinned by multiple, distinct and overlapping immunopathological mechanisms. Nevertheless, prevailing management algorithms continue to adopt a largely uniform, stepwise approach in…
View details →DOI: 10.2147/itt.s532291Cited by 9 Negative / Null Result ReportOpen accessMedicine
T. Nguyen, Tam Dao, Ha Thu Nguyen et al. · 2026 · Endocrinology and Metabolism
Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function, which increases the risk of falls, frailty, and loss of independence. Despite growing recognition and its…
View details →DOI: 10.3803/enm.2025.2656Cited by 9 Negative / Null Result ReportOpen accessMedicine
Ismail Gögenür, Tobias Freyberg Justesen, Line Schmidt Tarpgaard et al. · 2026 · Journal of Clinical Oncology
PURPOSE: Neoadjuvant immune checkpoint inhibition has shown promise in localized deficient mismatch repair (dMMR) colorectal cancer, yet the optimal treatment duration, regimen, and methods for response evaluation remain undefined. This trial aimed to investigate the efficacy and safety of neoadjuvant pembrolizumab for patients with localized dMMR colon cancer. METHODS: Participants received a single cycle of pembrolizumab (4 mg/kg, max 400 mg, every-6-weeks dosing regimen), followed by a preoperative endoscopy with biopsies and surgery 3-5 weeks later. The primary end point was pathologic com
View details →DOI: 10.1200/jco-25-02274Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mohammad Fayyad‐Kazan, Sarah Ayad Al-Tameemi, Allal Ouhtit · 2026 · Cells
Cancer immunotherapy has transformed modern oncology, yet durable responses remain limited for many patients due to immune exclusion, adaptive resistance, and tumor heterogeneity. Oncolytic viruses (OVs) have emerged as a novel class of immunotherapeutics that unify direct tumor cytolysis with stimulation of antitumor immunity. By inducing immunogenic cell death (ICD) and releasing tumor-associated antigens (TAAs), OVs remodel the tumor microenvironment (TME) into an inflamed and immune-permissive niche capable of enabling systemic immune activation. Rapid advances in viral engineering have st
View details →DOI: 10.3390/cells15050393Cited by 9 Negative / Null Result ReportOpen accessHealth Professions
Ghassan M. Khairallah, Samar Al‐Hajj, Hani O. Mowafi et al. · 2025 · BMC Public Health
BACKGROUND: Healthcare workers (HCWs) are exposed to a multitude of hazards in the hospital environment, increasing their risks of sustaining injuries at a higher rate compared to workers in other sectors and resulting in substantial level…
View details →DOI: 10.1186/s12889-025-22727-yCited by 9 Negative / Null Result ReportOpen accessEngineering
Yufan Zhu, Huifan Liu, Zhiqiang Yang et al. · 2026 · Theranostics
Background: Excessive inflammation and exacerbated oxidative stress are significant hallmarks of the diabetic bone microenvironment, which give rise to dysregulated immune reactions and impaired bone homeostasis, thereby hindering bone defect healing and increasing the incidence of bone nonunion.Methods: A biodegradable photothermal hybrid (SC/MTZ) was developed through the in situ self-assembly of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles on tannic acid (TA)-functionalized Ti3C2Tx MXene nanosheets, which were then integrated into a methacrylated silk fibroin/carboxymethyl chitosa
View details →DOI: 10.7150/thno.130240Cited by 9 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Goran Lalić, Dragana Trifunović · 2026 · Social Sciences
This paper examines income convergence in Europe by jointly analyzing European Union member states and Western Balkan economies over the period 2004–2023. While classical growth theory predicts that poorer economies should grow faster than richer ones, empirical evidence for Europe remains mixed, particularly when institutional and structural heterogeneity is taken into account. Using panel data techniques, the study tests for absolute and conditional β-convergence and complements this analysis with an assessment of σ-convergence. The results provide strong evidence of absolute income converge
View details →DOI: 10.3390/socsci15030180Cited by 9 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sourav Goswami, Alisha Ansari, Chetan Saraf et al. · 2026 · Nature Communications
Bifidobacteria are key health-associated members of the human gut microbiome and are widely used as probiotics, but their colonization success varies substantially between individuals, partly due to baseline microbiome composition. We…
View details →DOI: 10.1038/s41467-026-72289-9Cited by 9 Negative / Null Result ReportOpen accessMedicine
Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath et al. · 2026 · Bone Research
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-assoc
View details →DOI: 10.1038/s41413-026-00526-4Cited by 9 Negative / Null Result ReportPsychology
Gorn Huvanandana, Peerayuth Charoensukmongkol · 2026 · International Journal of Workplace Health Management
Purpose Grounded in conservation of resources theory, this study investigates how digital leadership influences AI-related job insecurity, AI use anxiety, technostress, and emotional exhaustion. Innovative climate is proposed as the work…
View details →DOI: 10.1108/ijwhm-09-2025-0252Cited by 9 Negative / Null Result ReportOpen accessMedicine
Danielle J Sisnett, Katherine B Zutautas, Dan Hoang Nguyet Vo et al. · 2026 · Frontiers in Immunology
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and survival. In particular, T cell subsets are predominant effector immune cells within the complex endometriosis lesion microenvironment. T cell biology encompasses a highly regulated and diverse network of cellular differentiation, antigen recognition, and immune regulation, all of which play critical roles in immune homeostasis. This complexity becomes particularly
View details →DOI: 10.3389/fimmu.2026.1712360Cited by 9 Negative / Null Result ReportOpen accessEnvironmental Science
Forest ISBELL, A. Mori, Michel Loreau et al. · 2026 · Nature
Stability can be desirable for many natural and social systems. Temporal stability, the invariability of a system over time, can be enhanced by resisting displacement during perturbations, accelerating recovery after them, or both1–4.…
View details →DOI: 10.1038/s41586-026-10498-4Cited by 9 Negative / Null Result ReportOpen accessNeuroscience
Louis Roberts, Juho Äijälä, Florian Bürger et al. · 2026 · Nature Communications
The cortex generates diverse neural dynamics, ranging from broadband fluctuations to narrowband oscillations at specific frequencies. Here, we investigated whether broadband and oscillatory dynamics play different roles in the encoding and transmission of visual information. We used information-theoretical measures to dissociate neural signals sharing common information (i.e., redundancy) from signals encoding complementary information (i.e., synergy). We analyzed electrocorticography (ECoG) and local field potentials (LFP) in the visual cortex of human and non-human primates (macaque) to inve
View details →DOI: 10.1038/s41467-026-72444-2Cited by 9 Negative / Null Result Report
Rolando A. Rebolledo, Bo Liu, Mohammed Z. Akhtar et al. · 2015 · BioMed Research International
Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney…
View details →DOI: 10.1155/2015/207534Cited by 9 