Negative / Null Result ReportOpen accessMaterials Science
Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović et al. · 2025 · npj Biomedical Innovations.
3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,
View details →DOI: 10.1038/s44385-025-00041-xCited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sarah L. Addison, Zhenzhen Yan, Thomas F. Carlin et al. · 2025 · Global Change Biology
Increased aridity is emerging as a key impact of climate change in terrestrial ecosystems globally. Forest biomes are particularly vulnerable to the impacts of changing environmental conditions due to their long-lived and sessile nature.…
View details →DOI: 10.1111/gcb.70165Cited by 11 Negative / Null Result ReportOpen accessMedicine
André Zimerman, Alexander Dal Forno, Luis E. Rohde et al. · 2026 · JAMA Cardiology
Importance: Conduction system pacing (CSP) is a promising and potentially cost-effective alternative to biventricular pacing (BiVP) in patients with heart failure with reduced ejection fraction (HFrEF) and left bundle-branch block (LBBB), but its impact on heart failure (HF) outcomes remains uncertain. Objective: To compare CSP vs BiVP on an HF-related outcome in patients with HFrEF and LBBB. Design, Setting, and Participants: PhysioSync-HF (Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure) was an investigator-initiated, multicenter, noninf
View details →DOI: 10.1001/jamacardio.2026.0101Cited by 11 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Matthew MacLachlan, Michael K. Adjemian, Xiaoli Etienne et al. · 2025 · Nature Communications
The advent of COVID-19 ended an era of stable US retail food prices that followed the world food price crisis of 2010–2012. Pandemic-related disruptions, avian influenza outbreaks, and the Russia-Ukraine war drove 2022 food-at-home…
View details →DOI: 10.1038/s41467-025-61660-xCited by 11 Negative / Null Result ReportOpen accessEngineering
Claudia Del Toro Runzer, Elizabeth R. Balmayor, Martijn van Griensven · 2026 · Bone Research
Bone fractures represent a significant global healthcare burden. Although fractures typically heal on their own, some fail to regenerate properly, leading to nonunion, a condition that causes prolonged disability, morbidity, and mortality. The challenge of treating nonunion fractures is further complicated in patients with underlying bone disorders where systemic and local factors impair bone healing. Traditional treatment approaches, including autografts, allografts, xenografts, and synthetic biomaterials, face limitations such as donor site pain, immune rejection, and insufficient mechanical
View details →DOI: 10.1038/s41413-025-00487-0Cited by 11 Negative / Null Result ReportOpen accessMedicine
Xuefeng Jin, Zhaojie Su, Jian-Fa Zhong et al. · 2026 · Cardiovascular Diabetology
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic disorders, and cardiovascular disease is the leading cause of death among affected individuals. Identifying simple biomarkers…
View details →DOI: 10.1186/s12933-026-03119-xCited by 11 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Bo Yang, Fatma Ahmed Hassan, Waqar Ahmad et al. · 2026 · Frontiers in Public Health
Air pollution (AIRP) remains a critical public health and environmental challenge in developing Asia, where rapid industrialization and fossil fuel dependence continue to undermine population health and longevity. This study examines the impact of AIRP on life expectancy (LIFE) and investigates whether renewable energy adoption moderates this relationship. AIRP is proxied by carbon dioxide (CO₂) and nitrous oxide (N₂O) emissions, which capture pollution-intensive energy systems, industrial activity, and agricultural practices that jointly generate health-damaging co-pollutants, particularly in
View details →DOI: 10.3389/fpubh.2026.1724402Cited by 11 Negative / Null Result ReportOpen accessNeuroscience
Olivier Senn, Florian Hoesl, Toni Bechtold et al. · 2024 · PLoS ONE
There is a broad consensus in groove research that the experience of groove, understood as a pleasurable urge to move in response to music, is to some extent related to the complexity of the rhythm. Specifically, music with medium rhythmic complexity has been found to motivate greater urge to move compared to low or high complexity music (inverted-U hypothesis). Studies that confirmed the inverted-U hypothesis usually based their measure of complexity on the rhythmic phenomenon of syncopation, where rhythms with more and/or stronger syncopation are considered to be more complex than less synco
View details →DOI: 10.1371/journal.pone.0311877Cited by 11 Negative / Null Result ReportOpen accessNeuroscience
Evgeny A. Ermakov, Irina A. Mednova, Anastasiia S. Boiko et al. · 2025 · Journal of Integrative Neuroscience
Neuroinflammation, meaning an inflammatory process primarily occurring within the central nervous system (CNS), is thought to be associated with the pathogenesis of psychiatric disorders including schizophrenia (SC), although existing evidence is sometimes contradictory. This review critically summarizes the existing data on neuroinflammation and possible neuroinflammatory mechanisms in the pathogenesis of SC. Despite heterogeneity and inconsistency, the existing evidence indicates dysregulation of inflammatory genes and infiltration of the CNS parenchyma by immune cells, disturbances in the b
View details →DOI: 10.31083/jin27636Cited by 11 Negative / Null Result ReportOpen accessPhysics and Astronomy
Chloe E. Pugh · 2026 · Kyoto University Research Information Repository (Kyoto University)
Quasi-periodic pulsations (QPPs) are a phenomenon commonly observed in solar flares, and are also occasionally observed in stellar flares. They are time variations in the intensity of the flare emission that repeat with approximately…
View details →DOI: 10.82444/warw.33766342Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Marco Raffaele Cosenza, Alice Gaiatto, Büşra Erarslan Uysal et al. · 2025 · Nature
, the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence (MAGIC)-an autonomously operated platform that integrates live-cell imaging of micronucleated cells, machine learning on-the-fly and single-cell genomics to systematically investigate CA formation. Applying MAGIC to near-diploid, non-transformed cell lines, we track de novo CAs over successive cell cycles, highlighting the common role of dicentric chromosomes as initiating events. We determine the baseline CA mutation ra
View details →DOI: 10.1038/s41586-025-09632-5Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Theresa Abdo, Ahmad Alhalabi, Sacha Yaghi et al. · 2026 · Cancer
Minimal residual disease (MRD) refers to the presence of residual cancer cells or tumor-derived fragments that persist after treatment and remain undetectable by conventional imaging or protein-based assays. Circulating tumor DNA (ctDNA)…
View details →DOI: 10.1002/cncr.70286Cited by 11 Negative / Null Result ReportOpen accessMedicine
Andrew Wong, Danielle Currey, Megan Schwinne et al. · 2026 · JAMA Network Open
Importance: The Epic Sepsis Model version 2 (ESM v2) is a widely implemented proprietary sepsis prediction model, but no multicenter, external validation of its performance has been reported to guide adoption and use. Objective: To conduct a multicenter validation of the ESM v2 to compare performance against the original ESM v1, outline differences across heterogenous clinical sites, and compare model performance against clinician recognition of sepsis. Design, Setting, and Participants: This prognostic study included adult inpatient encounters at 4 large US health systems between August 31, 2
View details →DOI: 10.1001/jamanetworkopen.2026.0181Cited by 11 Negative / Null Result ReportOpen accessPhysics and Astronomy
Andrei Kudriashov, Xiong Zhou, Razmik A. Hovhannisyan et al. · 2025 · Science Advances
Josephson junctions (JJs) are key to superconducting quantum technologies and the search for self-conjugate quasiparticles potentially useful for fault-tolerant quantum computing. In topological insulator (TI)–based JJs, measuring the current-phase relation (CPR) can reveal unconventional effects such as Majorana bound states (MBS) and nonreciprocal transport. However, reconstructing CPR as a function of magnetic field has not been attempted. Here, we present a platform for field-dependent CPR measurements in planar JJs made of NbSe 2 and few-layer Bi 2 Se 3 . When a flux quantum Φ 0 thr
View details →DOI: 10.1126/sciadv.adw6925Cited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Nannan Li, Guoliang Li, Xiaofang Huang et al. · 2026 · Nature Plants
The rhizosphere microbiome plays a crucial role in determining plant performance and fitness. Nevertheless, regulatory mechanisms linking host genetic variation, root gene regulation and microbiome assembly-and their collective influence on plant nutritional traits-remain poorly understood. Here we generated and integrated 1,341 paired datasets, including root transcriptomes, rhizosphere bacterial 16S rRNA profiles and root ionomes, across 175 resequenced Brassica napus ecotypes grown at two contrasting field sites. We identified 203 highly heritable bacterial amplicon sequence variants (ASVs)
View details →DOI: 10.1038/s41477-025-02210-7Cited by 11 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Abdurrahman M. Fahmy, Osama Saher, Heba Attia et al. · 2026 · AAPS PharmSciTech
Abstract This study introduces and statistically optimizes novel Tetra-Synergistic Bilosomes (TSB), an advanced nano-platform for topical delivery of voriconazole (VOR) in otomycosis therapy. The term “Tetra-Synergistic” reflects the incorporation of four complementary components: Cremophor® EL, sodium deoxycholate, Brij® 58, and Brij® S2, working in synergy to enhance therapeutic efficacy. TSB was fabricated using the thin-film hydration method and optimized through a 2 3 D-optimal design. Three formulation factors were investigated: Cremophor® EL: VOR ratio, sodium deoxycholate: cholesterol
View details →DOI: 10.1208/s12249-026-03342-5Cited by 11 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Luca Henkel, Christian Zimpelmann · 2026 · Review of Financial Studies
Abstract This paper introduces a key factor influencing households’ decision to invest in the stock market: how people view stockholders. Using surveys we conducted with nearly 8,500 individuals from 11 countries, we document that a large majority hold negative views of stockholders based on identity-relevant characteristics. Linking survey and administrative data, we find that negative perceptions strongly predict households’ stock market participation. We show that negative perceptions causally influence household decision-making and provide evidence supporting identity concerns as the under
View details →DOI: 10.1093/rfs/hhag034Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hubert Krukowski, Sophie Valkenburg, A. Vich Vila et al. · 2026 · Nature Microbiology
Despite recent progress, microbial associations reported in chronic kidney disease (CKD) remain inconsistent. Here we combined quantitative faecal metagenomics (n = 130) and cross-study biomarker comparisons (ntotal = 4,420) to study…
View details →DOI: 10.1038/s41564-026-02259-wCited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhuoxu Gu, Zhonghao Wang, Xianquan Zhang et al. · 2025 · Frontiers in Pharmacology
As a modern dosage form of traditional Chinese medicine, Traditional Chinese Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as a critical material basis for elucidating its multi-target regulatory mechanisms. Recent studies have highlighted the significant potential of TCMFG in treating complex diseases, such as inflammation, tumors, metabolic disorders, fibrosis, and orthopedic conditions like osteoarthritis and osteoporosis, by modulati
View details →DOI: 10.3389/fphar.2025.1609211Cited by 11 Negative / Null Result ReportPsychology
Muhammad Ahsan Younas, Rashid Menhas, Uzma Noor · 2026 · European Journal of Education
ABSTRACT This study investigates the multifaceted role of artificial intelligence (AI) and digital transformation (DT) in reshaping smart learning environments within the education sector. Using structural equation modelling with data…
View details →DOI: 10.1111/ejed.70536Cited by 11 Negative / Null Result ReportOpen accessMedicine
Kenta Watanabe, Sho Fukuda, Dai Kubota et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: In Japan, gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) account for nearly all fatal upper gastrointestinal malignancies. A unified model that simultaneously predicts the incidence of these two…
View details →DOI: 10.1111/jgh.70409Cited by 11 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Stevo Pavićević, Thomas Keil · 2024 · Strategic Management Journal
Abstract Research Summary Why do some boards of directors dismiss the CEO when a firm performs poorly, while others do not? We argue that military directors—outside directors with military backgrounds—on the board increase the likelihood…
View details →DOI: 10.1002/smj.3675Cited by 11 Negative / Null Result ReportOpen accessEngineering
João Paulo Vieira, Victor Afonso Bauler, Rodrigo Kobashikawa Rosa et al. · 2026 · Mechanical Systems and Signal Processing
Reliable detection of bearing faults is essential for maintaining the safety and operational efficiency of rotating machinery. While recent advances in machine learning (ML), particularly deep learning, have shown strong performance in controlled settings, many studies fail to generalize to real-world applications due to methodological flaws, most notably data leakage. This paper investigates the issue of data leakage in vibration-based bearing fault diagnosis and its impact on model evaluation. We demonstrate that common dataset partitioning strategies, such as segment-wise and condition-wise
View details →DOI: 10.1016/j.ymssp.2026.114640Cited by 11 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Suelen Gauna Trindade, Fernando Bonin Okasaki, Ashley P. Williams et al. · 2025 · Journal of Colloid and Interface Science
The self-assembly of glycyrrhizic acid (GA) in aqueous solutions has significant implications for soft matter science and material design. Here, we describe the self-assembly of GA under well-defined conditions, focusing on measurements of the critical aggregation concentration (CAC) - when GA dimers start stacking into nanofibrils, and of the critical gel concentration (CGC) - when nanofibrils entangle into a viscoelastic network. We examine in detail the structure at low concentrations and its evolution into a viscoelastic hydrogel, addressing the kinetic pathway. We highlight the dependence
View details →DOI: 10.1016/j.jcis.2025.138280Cited by 11 Negative / Null Result ReportOpen accessMedicine
Arthur R. H. van Zanten, Y. G. Van Der Meer, Willem A. Venhuizen et al. · 2015 · Journal of Parenteral and Enteral Nutrition
Neurologic adverse reactions, including extrapyramidal disorders, dyskinesia, dystonia, convulsions, hypertonia, and tremors.4 The reported occurrence of tardive dyskinesia ranges from <0.01%–23%.5 High occurrence is attributed to chronic…
View details →DOI: 10.1177/0148607114567711Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Vasilios Liapis, Aneta Zysk, Mark DeNichilo et al. · 2017 · Cancer Medicine
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors. Evofosfamide is a hypoxia-activated prodrug that is created by linking the hypoxia-seeking 2-nitroimidazole moiety to the cytotoxic bromo-isophosphoramide mustard (Br-IPM). When evofosfamide is delivered to hypoxic regions of tumors, the DNA cross-linking toxin, Br-IPM, is released leading to cell death. This study assessed the anticancer efficacy of evofosfamide in
View details →DOI: 10.1002/cam4.1115Cited by 11 Negative / Null Result ReportMedicine
Xu Yang, Lina Zhao, Anhui Shi et al. · 2023 · The American Journal of Gastroenterology
INTRODUCTION: Adjuvant radiotherapy is recommended for pT1b esophageal squamous cell cancer (ESCC) after endoscopic submucosal dissection (ESD). However, it is unclear whether additional radiotherapy can improve patient survival. This…
View details →DOI: 10.14309/ajg.0000000000002257Cited by 11 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hiroki Isono, Taiju Miyagami, Kohta Katayama et al. · 2016 · Internal Medicine
Tetanus is a potentially fatal infection. Approximately 100 cases are reported in Japan each year; however, little is known about its clinical course and outcomes in the current era of treatment. We herein report three cases of tetanus in…
View details →DOI: 10.2169/internalmedicine.55.7131Cited by 11 Negative / Null Result ReportOpen accessMedicine
Timothy S. Pardee, Bayard L. Powell, Richard A. Larson et al. · 2024 · Blood Neoplasia
Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism.…
View details →DOI: 10.1016/j.bneo.2024.100009Cited by 11 Negative / Null Result ReportOpen accessMedicine
Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas
View details →DOI: 10.1371/journal.pone.0093743Cited by 11 