Negative / Null Result ReportOpen accessMedicine
Timothy S. Pardee, Bayard L. Powell, Richard A. Larson et al. · 2024 · Blood Neoplasia
Acute myeloid leukemia (AML) is an aggressive cancer of the myeloid lineage. Outcomes in older patients are poor with high rates of resistant and relapsed disease. Devimistat is a lipoic acid analog that inhibits mitochondrial metabolism.…
View details →DOI: 10.1016/j.bneo.2024.100009Cited by 11 Negative / Null Result ReportOpen accessMedicine
Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas
View details →DOI: 10.1371/journal.pone.0093743Cited by 11 Negative / Null Result ReportOpen accessMedicine
Luís Alberto de Pádua Covas Lage, Rita Novello de Vita, Lucas Bassolli de Oliveira Alves et al. · 2024 · Cancers
Background: Diffuse large B-cell lymphoma (DLBCL) especially affects the older population. Old (≥60 years) and very old age (≥80 years) DLBCL patients often present high-risk molecular alterations, lower tolerability to conventional immunochemotherapy, and poor clinical outcomes. In this scenario, attenuated therapeutic strategies, such as the R-MiniCHOP and R-MiniCHOP of the elderly regimens, have emerged for this particularly fragile population. However, the responses, clinical outcomes, and toxicities of these regimens currently remain poorly understood, mainly because these individuals are
View details →DOI: 10.3390/cancers16081459Cited by 11 Negative / Null Result ReportOpen accessMedicine
Masatoshi Uchida, Toshikazu Abe, Kazuyuki Ono et al. · 2017 · Acute Medicine & Surgery
Aim Our aim was to evaluate the effect of ulinastatin on 28‐day mortality in patients who developed multiple organ failure ( MOF ) related to their acute illness and were admitted to the intensive care unit ( ICU ). Methods We carried out a retrospective observational study of MOF patients in a general ICU of a tertiary care hospital in Japan from January 2009 to December 2012. The primary outcome was 28‐day all‐cause mortality. Secondary outcomes were ventilator‐free days, ICU ‐free days, and vasopressor‐free days at day 28. We investigated the association between ulinastatin treatment and ou
View details →DOI: 10.1002/ams2.304Cited by 11 Negative / Null Result ReportMedicine
Shahid Habib, Nehali Patel, Sandeep Yarlagadda et al. · 2018 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: Infection is a leading precipitant of acute-on-chronic liver failure. This study aims to determine the safety and efficacy of antibiotics within acute-on-chronic liver failure. METHODS: Retrospective study of 457…
View details →DOI: 10.1111/jgh.14267Cited by 11 Negative / Null Result ReportOpen accessMedicine
Mathilde Ruggiu, Bruno Cassinat, Jean‐Jacques Kiladjian et al. · 2020 · Biology of Blood and Marrow Transplantation
BCR-ABL-negative myeloproliferative neoplasms (MPNs) in transformation have a dismal prognosis, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the sole curative therapeutic option. We retrospectively…
View details →DOI: 10.1016/j.bbmt.2020.02.019Cited by 11 Negative / Null Result Report
Vikash Agrawal, Satyan Lakshminrusimha, Praveen Chandrasekharan · 2019 · Children
The International Liaison Committee on Resuscitation (ILCOR) recommends the initiation of chest compressions (CC) during neonatal resuscitation after 30 s of effective ventilation if the infant remains bradycardic (defined as a heart rate…
View details →DOI: 10.3390/children6110119Cited by 11 Negative / Null Result ReportOpen accessMedicine
Emma Weeding, Andrea Fava, Chandra Mohan et al. · 2022 · Lupus Science & Medicine
Objective Urine proteomic approaches have shown promise in identifying biological pathways in lupus nephritis (LN) which are not captured on renal histopathology or by measurement of proteinuria alone. We investigated how the urine…
View details →DOI: 10.1136/lupus-2022-000763Cited by 11 Negative / Null Result Report
Bianca Bonato, Qiuran Wang, Silvia Guerra et al. · 2023 · AoB PLANTS
Abstract In life, it is common for almost every kind of organism to interact with one another. In the human realm, such interactions are at the basis of joint actions, when two or more agents syntonize their actions to achieve a common…
View details →DOI: 10.1093/aobpla/plad088Cited by 11 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Ali Nouri · 2022 · Scientific Reports
Abstract The study was conducted to consider the anticoccidial and immunogenic effectivities of encapsulated organic acids and anticoccidial drugs in broilers reared on a reused litter infected with Eimeria spp. for simulating in-field exposure to avian coccidiosis. 525 mixed -sex one-day-old broiler chicks (Ross 308) were used in a 2 × 3 factorial experiment as a completely randomized design with seven experimental groups and five replicates of 15 chicks. The seven experimental groups were included: negative (uninfected; T 1 ) and positive (infected; T 2 ) control groups fed a diet without ad
View details →DOI: 10.1038/s41598-022-20990-2Cited by 11 Negative / Null Result ReportOpen accessMedicine
Joël Mercier, Massimo Bani, Anny‐Odile Colson et al. · 2023 · Molecular Imaging and Biology
Abstract Purpose Minzasolmin (UCB0599) is an orally administered, small molecule inhibitor of ASYN misfolding in development as a potential disease-modifying therapy for Parkinson’s disease. Here we describe the preclinical development of a radiolabeled tracer and results from a phase 1 study using the tracer to investigate the brain distribution of minzasolmin. Procedures In the preclinical study, two radiolabeling positions were investigated on the S -enantiomer of minzasolmin (UCB2713): [ 11 C]methylamine UCB2713 ([ 11 C- N -CH 3 ]UCB2713) and [ 11 C]carbonyl UCB2713 ([ 11 C-CO]UCB2713). Ma
View details →DOI: 10.1007/s11307-023-01878-7Cited by 11 Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Takuji Okusaka, Manabu Morimoto, Yuichiro Eguchi et al. · 2023 · Drugs in R&D
BACKGROUND AND OBJECTIVE: For patients with advanced hepatocellular carcinoma (HCC), the standard of care for many years has been sorafenib. Preliminary data have suggested that the combination of the NAD(P)H:quinone oxidoreductase 1…
View details →DOI: 10.1007/s40268-023-00416-8Cited by 11 Negative / Null Result Report
JOHN LOOMIS, CATHERINE KESKE · 2011 · Contemporary Economic Policy
Outdoor recreation is a large industry that can diversify public land‐based economies that have traditionally relied upon resource extraction. However, what happens to nature‐based recreation visitor spending and benefits during times of…
View details →DOI: 10.1111/j.1465-7287.2011.00277.xCited by 11 Negative / Null Result ReportOpen accessMedicine
Allyson L. Anding, Sofia Kinton, Kaitlyn Baranowski et al. · 2023 · Journal of Pharmacology and Experimental Therapeutics
Pompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid α-glucosidase, which leads to muscle weakness, cardiac and respiratory failure, and early mortality. Alglucosidase alfa, a recombinant…
View details →DOI: 10.1124/jpet.123.001593Cited by 11 Negative / Null Result ReportOpen accessMedicine
Minesh Khatri, David M. Charytan, Sam Parnia et al. · 2021 · Kidney360
Abstract Key Points Patients with ESKD had higher crude mortality rates than those without CKD, but thiswas no longer significant after multivariate adjustment. Patients with ESKD, when directly compared with those with nondialysis CKD,…
View details →DOI: 10.34067/kid.0006852020Cited by 11 Negative / Null Result ReportOpen accessMedicine
Jing Cheng, Carl Gao, Reeta Ala‐Jaakkola et al. · 2024 · JAMA Network Open
Importance: Probiotic supplementation may improve bowel movements. However, large, properly designed studies are lacking. Objective: To evaluate the potential benefit of Bifidobacterium animalis subsp lactis HN019 on constipation,…
View details →DOI: 10.1001/jamanetworkopen.2024.36888Cited by 11 Negative / Null Result ReportOpen accessMedicine
Cecile A. Feldman, Janine Fredericks-Younger, Paul J. Desjardins et al. · 2025 · The Journal of the American Dental Association
BACKGROUND: Opioids are still being prescribed to manage acute postsurgical pain. Unnecessary opioid prescriptions can lead to addiction and death, as unused tablets are easily diverted. METHODS: To determine whether combination nonopioid analgesics are at least as good as opioid analgesics, a multisite, double-blind, randomized, stratified, noninferiority comparative effectiveness trial was conducted, which examined patient-centered outcomes after impacted mandibular third-molar extraction surgery. Participants were randomized to receive 5 mg of hydrocodone with 300 mg of acetaminophen (opioi
View details →DOI: 10.1016/j.adaj.2024.10.014Cited by 11 Negative / Null Result ReportNeuroscience
Ruth Horry, Neil Brewer, Nathan Weber · 2015 · Law and Human Behavior
When making a memorial judgment, respondents can regulate their accuracy by adjusting the precision, or grain size, of their responses. In many circumstances, coarse-grained responses are less informative, but more likely to be accurate,…
View details →DOI: 10.1037/lhb0000166Cited by 11 Negative / Null Result ReportOpen accessEngineering
Rachael Slater, Kukatharmini Tharmaratnam, Salma Belnour et al. · 2024 · Sensors
The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn's disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography-sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a
View details →DOI: 10.3390/s24155079Cited by 11 Negative / Null Result ReportOpen accessSocial Sciences
Syed Imran Ali, Morgan C. MacDonald, J. Jincy et al. · 2011 · Journal of Water Sanitation and Hygiene for Development
This study investigated the efficacy of a POU water treatment system featuring sari-cloth filtration and/or Moringa oleifera coagulation as pre-treatments for solar disinfection (SODIS). Surface water from a peri-urban slum in Chennai,…
View details →DOI: 10.2166/washdev.2011.043Cited by 11 Negative / Null Result ReportOpen accessComputer Science
Haoze Wu · 2017
In this project, we aimed to improve the runtime of Minisat, a Conflict-Driven Clause Learning (CDCL) solver that solves the Propositional Boolean Satisfiability (SAT) problem. We first used a logistic regression model to predict the…
View details →DOI: 10.1145/3017680.3022464Cited by 11 Negative / Null Result Report
Selin Ersoydan, Derya Yakar, Ömer Kasalak et al. · 2022 · European Radiology
Abstract Objective To investigate temporal changes in clinical reasoning quality of physicians who requested abdominal CT scans at a tertiary care center during on-call hours within a 15-year period. Methods This retrospective study…
View details →DOI: 10.1007/s00330-022-09121-7Cited by 11 Negative / Null Result Report
Arindam Datta, Md. Hafizur Rahman, R. Suresh · 2021 · Journal of Environmental Quality
Abstract To control the spread of COVID‐19, the government of India imposed a nationwide lockdown on all nonessential activities from 22 Mar. to 3 May 2020. Daily ambient particulate matter ≤10 μm in diameter (PM 10 ), particulate matter…
View details →DOI: 10.1002/jeq2.20192Cited by 11 Negative / Null Result ReportOpen accessHealth Professions
Pieter M. R. Herings, Adam H. Dyer, Seán Kennelly et al. · 2022 · Sensors
Type 2 Diabetes Mellitus (T2DM) in midlife is associated with a greater risk of dementia in later life. Both gait speed and spatiotemporal gait characteristics have been associated with later cognitive decline in community-dwelling older adults. Thus, the assessment of gait characteristics in uncomplicated midlife T2DM may be important in selecting-out those with T2DM at greatest risk of later cognitive decline. We assessed the relationship between Inertial Motion Unit (IMUs)-derived gait characteristics and cognitive function assessed via Montreal Cognitive Assessment (MoCA)/detailed neuropsy
View details →DOI: 10.3390/s22155710Cited by 11 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Lilian Anderson, Charlotte Brassey, Stuart Pond et al. · 2023 · The Anatomical Record
A reversion to secondary quadrupedality is exceptionally rare in nature, yet the convergent re-evolution of this locomotor style occurred at least four separate times within Dinosauria. Facultative quadrupedality, an intermediate state between obligate bipedality and obligate quadrupedality, may have been an important transitional step in this locomotor shift, and is proposed for a range of basal ornithischians and sauropodomorphs. Advances in virtual biomechanical modeling and simulation have allowed for the investigation of limb anatomy and function in a range of extinct dinosaurian species,
View details →DOI: 10.1002/ar.25189Cited by 11 Negative / Null Result ReportComputer Science
Suhe Ji, Ke Li, Linfeng Zou · 2019 · 2019 International Joint Conference on Information, Media and Engineering (IJCIME)
Although the increased use of authentic materials in listening comprehension teaching has become general practice, it is crucial to find out whether or not the new technology-supported authentic material could be beneficial to English as a…
View details →DOI: 10.1109/ijcime49369.2019.00065Cited by 11 Negative / Null Result Report
Eunkyung Choi, Minjoo Ryu, Haeri Lee et al. · 2017 · Dalton Transactions
The steric hindrance of reactants and trace water effects on transesterification catalysis using the cage coordination network have been scrutinized.
View details →DOI: 10.1039/c7dt00217cCited by 11 Negative / Null Result ReportMedicine
Jennifer Chun-Li Wu, Tung‐liang Chiang · 2015 · Early Child Development and Care
Low birthweight (LBW) children tend to have higher risks of developmental problems. According to differential susceptibility hypothesis, these putatively vulnerable children may also disproportionately benefit from positive environmental…
View details →DOI: 10.1080/03004430.2015.1085862Cited by 11 Negative / Null Result ReportOpen accessMedicine
Joon Lee, Sapna Govindan, Leo Anthony Celi et al. · 2013 · World Journal of Cardiovascular Surgery
OBJECTIVE: To develop a customized short LOS (<6 days) prediction model for geriatric patients receiving cardiac surgery, using local data and a computational feature selection algorithm. DESIGN: Utilization of a machine learning algorithm in a prospectively collected STS database consisting of patients who received cardiac surgery between January 2002 and June 2011. SETTING: Urban tertiary-care center. PARTICIPANTS: Geriatric patients aged 70 years or older at the time of cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Predefined morbidity and mortality events were collec
View details →DOI: 10.4236/wjcs.2013.35034Cited by 11 Negative / Null Result Report
Daniel D. De Haan · 2016 · Arabic Sciences and Philosophy
Abstract This study examines a number of different answers to the question: where does Avicenna demonstrate the existence of God within the Metaphysics of the Healing ? Many interpreters have contended that there is an argument for God's…
View details →DOI: 10.1017/s0957423915000132Cited by 11 