A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19735 results in Negative / Null Result Report · page 12 of 658
M. M. Aggarwal, Z. Ahammed, A. V. Alakhverdyants et al. · 2010 · Physical Review Letters
We report the first measurements of the kurtosis ($\ensuremath{\kappa}$), skewness ($S$), and variance (${\ensuremath{\sigma}}^{2}$) of net-proton multiplicity (${N}_{p}\ensuremath{-}{N}_{\overline{p}}$) distributions at midrapidity for…
Hannah Fraser, Timothy Parker, Shinichi Nakagawa et al. · 2018 · PLoS ONE
We surveyed 807 researchers (494 ecologists and 313 evolutionary biologists) about their use of Questionable Research Practices (QRPs), including cherry picking statistically significant results, p hacking, and hypothesising after the results are known (HARKing). We also asked them to estimate the proportion of their colleagues that use each of these QRPs. Several of the QRPs were prevalent within the ecology and evolution research community. Across the two groups, we found 64% of surveyed researchers reported they had at least once failed to report results because they were not statistically
Joeli Marrero, Kyu Y. Rhee, Dirk Schnappinger et al. · 2010 · Proceedings of the National Academy of Sciences
Metabolic adaptation to the host niche is a defining feature of the pathogenicity of Mycobacterium tuberculosis (Mtb). In vitro, Mtb is able to grow on a variety of carbon sources, but mounting evidence has implicated fatty acids as the…
Sebastian Cachero, Aaron D. Ostrovsky, Jai Y. Yu et al. · 2010 · Current Biology
BACKGROUND: Sex-specific behavior may originate from differences in brain structure or function. In Drosophila, the action of the male-specific isoform of fruitless in about 2000 neurons appears to be necessary and sufficient for many aspects of male courtship behavior. Initial work found limited evidence for anatomical dimorphism in these fru+ neurons. Subsequently, three discrete anatomical differences in central brain fru+ neurons have been reported, but the global organization of sex differences in wiring is unclear. RESULTS: A global search for structural differences in the Drosophila bra
Anders Gustafsson, Per Kristensson, Lars Witell · 2012 · Journal of service management
Purpose Customer co‐creation is becoming increasingly popular among companies, and intensive communication with customers is generally seen as a determinant of the success of a new service or product. The purpose of this study is to…
David Habier, Rohan L. Fernando, Dorian J. Garrick · 2013 · Genetics
Genomic best linear unbiased prediction (BLUP) is a statistical method that uses relationships between individuals calculated from single-nucleotide polymorphisms (SNPs) to capture relationships at quantitative trait loci (QTL). We show…
D. Robert Siemens, Sanoj Punnen, James M.W. Wong et al. · 2010 · BMC Medical Education
BACKGROUND: An observed decrease of physician scientists in medical practice has generated much recent interest in increasing the exposure of research programs in medical school. The aim of this study was to review the experience and attitudes regarding research by medical students in Canada. METHODS: An anonymous, cross-sectional, self-report questionnaire was administered to second and fourth year students in three medical schools in Ontario between February and May of 2005. Questions were primarily closed-ended and consisted of Likert scales. Descriptive and correlative statistics were used
Michael A. Kuhn, Lynne A. Hillenbrand, Alison Sills et al. · 2019 · The Astrophysical Journal
Abstract The Gaia mission has opened a new window into the internal kinematics of young star clusters at the sub-km s −1 level, with implications for our understanding of how star clusters form and evolve. We use a sample of 28 clusters…
Elroy Dimson, Paul Marsh, Mike Staunton · 2020 · The Journal of Portfolio Management
Responsible investors require data to underpin their stock and sector selections. Regardless of the rating agency, bond ratings for a particular issuer are broadly similar. This is not the case for ESG ratings. Companies with a high score…
Robert F. Spetzler, Cameron G. McDougall, Felipe C Albuquerque et al. · 2013 · Journal of neurosurgery
OBJECT: The authors report the 3-year results of the Barrow Ruptured Aneurysm Trial (BRAT). The objective of this ongoing randomized trial is to compare the safety and efficacy of microsurgical clip occlusion and endovascular coil…
Ronald van den Berg, Edward Awh, Wei Ji · 2014 · Psychological Review
Three questions have been prominent in the study of visual working memory limitations: (a) What is the nature of mnemonic precision (e.g., quantized or continuous)? (b) How many items are remembered? (c) To what extent do spatial binding…
Andrew Gonzalez, Bradley J. Cardinale, Ginger Allington et al. · 2016 · Ecology
Global species extinction rates are orders of magnitude above the background rate documented in the fossil record. However, recent data syntheses have found mixed evidence for patterns of net species loss at local spatial scales. For…
Joachim von Pawel, Robert M. Jotte, David R. Spigel et al. · 2014 · Journal of Clinical Oncology
PURPOSE: Amrubicin, a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials. This phase III trial compared the safety and efficacy of amrubicin…
John D. Meeker, Tiffany Yang, Xiaoyun Ye et al. · 2010 · Environmental Health Perspectives
BACKGROUND: Parabens are commonly used as antimicrobial preservatives in cosmetics, pharmaceuticals, and food and beverage processing. Widespread human exposure to parabens has been recently documented, and some parabens have demonstrated adverse effects on male reproduction in animal studies. However, human epidemiologic studies are lacking. OBJECTIVE: We investigated relationships between urinary concentrations of parabens and markers of male reproductive health in an ongoing reproductive epidemiology study. METHODS: Urine samples collected from male partners attending an infertility clinic
Julianne L. Holloway, Anthony M. Lowman, Giuseppe R. Palmese · 2012 · Soft Matter
The biocompatibility, processing ease, and mechanical properties of freeze-thawed poly(vinyl alcohol) (PVA)-based hydrogels have encouraged significant research toward developing this material for various biomedical applications.…
Stephen J. Nicholls, John J.P. Kastelein, Gregory G. Schwartz et al. · 2014 · JAMA
IMPORTANCE: Secretory phospholipase A2 (sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on…
Ji Young Bang, Udayakumar Navaneethan, Muhammad K. Hasan et al. · 2018 · Gut
OBJECTIVE: Although lumen-apposing metal stents (LAMS) are increasingly used for drainage of walled-off necrosis (WON), their advantage over plastic stents is unclear. We compared efficacy of LAMS and plastic stents for WON drainage.…
Ralph Peterli, Yves Borbély, Béatrice Kern et al. · 2013 · Annals of Surgery
In Brief Objective: Laparoscopic sleeve gastrectomy (LSG) has been proposed as an effective alternative to the current standard procedure, laparoscopic Roux-en-Y gastric bypass (LRYGB). Prospective data comparing both procedures are rare.…
Manuel R. Agosín, Roberto Álvarez, Claudio Bravo‐Ortega · 2011 · World Economy
Abstract Using a large dataset for 79 countries covering the period 1962–2000, this study analyses the main determinants of export diversification (concentration). We explore the role of several factors and we use three different…
Céline Michaud, Daniel Llerena · 2010 · Business Strategy and the Environment
Abstract Products' end‐of‐life management has recently become a critical business issue. One of the possible end‐of‐life strategies is remanufacturing, which can provide competitive advantages through material and energy savings. Beyond…
Hilal Daglar, Hasan Can Gülbalkan, Gökay Avcı et al. · 2021 · Angewandte Chemie International Edition
Abstract Development of computation‐ready metal–organic framework databases (MOF DBs) has accelerated high‐throughput computational screening (HTCS) of materials to identify the best candidates for gas storage and separation. These DBs…
Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein et al. · 2021 · Circulation
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular risk. Low HDL-C is also associated with increased risk of…
John Antoniadis, Zaven Arzoumanian, S. Babak et al. · 2021 · Monthly Notices of the Royal Astronomical Society
ABSTRACT We searched for an isotropic stochastic gravitational wave background in the second data release of the International Pulsar Timing Array, a global collaboration synthesizing decadal-length pulsar-timing campaigns in North…
Colin J. Carlson, Kevin R. Burgio, Eric R. Dougherty et al. · 2017 · Science Advances
Climate change is a well-documented driver of both wildlife extinction and disease emergence, but the negative impacts of climate change on parasite diversity are undocumented. We compiled the most comprehensive spatially explicit data set…
Margaret A. Abernethy, Jan Bouwens, Laurence van Lent · 2014 · Minerva Access (University of Melbourne)
We investigate two determinants of two choices in the control system of divisionalized firms, namely decentralization and use of performance measures. The two determinants are those identified in the literature as important to control…
Jennifer Alix‐Garcia, Elizabeth N. Shapiro, Katharine R. E. Sims · 2012 · Land Economics
We investigate a Mexican federal program that compensates landowners for forest protection. We use matched controls from the program applicant pool to establish counterfactual deforestation rates. Deforestation was reduced by 50% in…
Abel Brodeur, Nikolai Cook, Anthony Heyes · 2020 · American Economic Review
The credibility revolution in economics has promoted causal identification using randomized control trials (RCT), difference-in-differences (DID), instrumental variables (IV) and regression discontinuity design (RDD). Applying multiple…
Ahmed Mushfiq Mobarak, Puneet Dwivedi, Rob Bailis et al. · 2012 · Proceedings of the National Academy of Sciences
Biomass combustion with traditional cookstoves causes substantial environmental and health harm. Nontraditional cookstove technologies can be efficacious in reducing this adverse impact, but they are adopted and used at puzzlingly low…
Jian Fang, Li Zhang, David Sutton et al. · 2012 · Journal of Nanomaterials
Polypropylene (PP) nanofibres have been electrospun from molten PP using a needleless melt‐electrospinning setup containing a rotary metal disc spinneret. The influence of the disc spinneret (e.g., disc material and diameter), operating parameters (e.g., applied voltage, spinning distance), and a cationic surfactant on the fibre formation and average fibre diameter were examined. It was shown that the metal material used for making the disc spinneret had a significant effect on the fibre formation. Although the applied voltage had little effect on the fibre diameter, the spinning distance affe
Aung Ko Win, Joanne Young, Noralane M. Lindor et al. · 2012 · Journal of Clinical Oncology
PURPOSE: To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the general population. PATIENTS AND METHODS: We prospectively followed a…