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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19810 results in Negative / Null Result Report · page 119 of 661

Negative / Null Result Report

Physical activity and prenatal depression: going beyond statistical significance by assessing the impact of reliable and clinical significant change

Marina Vargas-Terrones, Taniya S. Nagpal, Maria Perales et al. · 2020 · Psychological Medicine

Abstract Background Previous literature supports exercise as a preventative agent for prenatal depression; however, treatment effects for women at risk for prenatal depression remain unexplored. The purpose of the study was to examine…

View details →DOI: 10.1017/s0033291719003714Cited by 15
Negative / Null Result Report

Nomograms confirm serum IL-6 and CRP as predictors of immune checkpoint inhibitor efficacy in unresectable hepatocellular carcinoma

Jiajia Du, Zhiyong Huang, Erlei Zhang · 2024 · Frontiers in Immunology

Background Immunotherapy based on immune checkpoint inhibitors (ICIs) has become the first-line treatment for unresectable hepatocellular carcinoma (uHCC). However, only a small portion of patients are responsive to ICIs. It is important…

View details →DOI: 10.3389/fimmu.2024.1329634Cited by 15
Negative / Null Result Report

“The more you did, the more it made sense”: Problem‐based learning to improve early evidence‐based practice in an undergraduate physiotherapy professional programme

Olive Lennon, Deirdre Phelan, Deborah Wallace et al. · 2019 · Physiotherapy Research International

Abstract Background and Purpose Evidence‐based practice (EBP), which integrates clinical reasoning skills, research evidence, and patient preference, has become standard in curricula for health care professional programs. Students however…

View details →DOI: 10.1002/pri.1774Cited by 15
Negative / Null Result Report

The Development of a Charcot Foot after Significant Weight Loss in People with Diabetes

Rachel Murchison, Catherine Gooday, Ketan Dhatariya · 2014 · Journal of the American Podiatric Medical Association

Medication to aid weight loss and weight loss surgery are becoming more commonly available for people with diabetes. As a result of profound weight loss, diabetes may go into remission and many biochemical and physical parameters improve.…

View details →DOI: 10.7547/0003-0538-104.5.522Cited by 15
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing

Mohamad Saad, Ayman El‐Menyar, Khalid Kunji et al. · 2022 · Circulation Genomic and Precision Medicine

Background: Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about their portability to diverse ancestry groups, thus motivating genome-wide association studies in non-European ancestry…

View details →DOI: 10.1161/circgen.122.003712Cited by 15
Negative / Null Result ReportMedicine

Replication of a predictive model for youth ADHD in an independent sample from a developing country

Cezar H. Lorenzi, Douglas Teixeira Leffa, Rodrigo A. Bressan et al. · 2022 · Journal of Child Psychology and Psychiatry

BACKGROUND: Very few predictive models in Psychiatry had their performance validated in independent external samples. A previously developed multivariable demographic model for attention-deficit/hyperactivity disorder (ADHD) accurately…

View details →DOI: 10.1111/jcpp.13682Cited by 15
Negative / Null Result ReportOpen accessMedicine

Re-Sequencing of the <b><i>APOL1</i></b>-<b><i>APOL4</i></b> and <b><i>MYH9</i></b> Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression

Gregory A. Hawkins, David J. Friedman, Lingyi Lu et al. · 2015 · American Journal of Nephrology

<b><i>Background:</i></b> In African Americans (AAs), <i>APOL1</i> G1 and G2 nephropathy risk variants are associated with non-diabetic end-stage kidney disease (ESKD) in an autosomal recessive pattern.…

View details →DOI: 10.1159/000439448Cited by 15
Negative / Null Result ReportOpen accessSocial Sciences

Challenging Empathic Deficit Models of Autism Through Responses to Serious Literature

Melissa Chapple, Philip Davis, Josie Billington et al. · 2022 · Frontiers in Psychology

Dominant theoretical models of autism and resultant research enquiries have long centered upon an assumed autism-specific empathy deficit. Associated empirical research has largely relied upon cognitive tests that lack ecological validity and associate empathic skill with heuristic-based judgments from limited snapshots of social information. This artificial separation of thought and feeling fails to replicate the complexity of real-world empathy, and places socially tentative individuals at a relative disadvantage. The present study aimed to qualitatively explore how serious literary fiction,

View details →DOI: 10.3389/fpsyg.2022.828603Cited by 15
Negative / Null Result ReportMedicine

Dyslipidemia Is a Major Factor in Stem Cell Damage Induced by Uncontrolled Long-Term Type 2 Diabetes and Obesity in the Rat, as Suggested by the Effects on Stem Cell Culture

Maryam Masouminia, R. Gelfand, Istvan Kovanecz et al. · 2018 · The Journal of Sexual Medicine

BACKGROUND: Previous work showed that muscle-derived stem cells (MDSCs) exposed long-term to the milieu of uncontrolled type 2 diabetes (UC-T2D) in male obese Zucker (OZ) rats, were unable to correct the associated erectile dysfunction and…

View details →DOI: 10.1016/j.jsxm.2018.09.019Cited by 15
Negative / Null Result ReportOpen accessMedicine

Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study

Adam Stevens, Philip Murray, Jérôme Wojcik et al. · 2016 · European Journal of Endocrinology

OBJECTIVE: Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term follow-up (LTFU) study (Nbib699855). Here, we describe the PREDICT validation (VAL) study (Nbib1419249), which aimed to confirm these genetic associations. DESIGN AND METHODS: Children with GHD (n = 293) or TS (n = 132) were recruited retrospectively from 29 sites in nine countries. All children had completed 1 year of r-hGH therapy. 48 SNPs previou

View details →DOI: 10.1530/eje-16-0357Cited by 15
Negative / Null Result ReportOpen accessSocial Sciences

A Puzzle Unsolved: Failure to Observe Different Effects of God and Religion Primes on Intergroup Attitudes

Jonathan E. Ramsay, Eddie M. W. Tong, Joyce S. Pang et al. · 2016 · PLoS ONE

Religious priming has been found to have both positive and negative consequences, and recent research suggests that the activation of God-related and community-related religious cognitions may cause outgroup prosociality and outgroup derogation respectively. The present research sought to examine whether reminders of God and religion have different effects on attitudes towards ingroup and outgroup members. Over two studies, little evidence was found for different effects of these two types of religious primes. In study 1, individuals primed with the words "religion", "God" and a neutral contro

View details →DOI: 10.1371/journal.pone.0147178Cited by 15
Negative / Null Result Report

STABILIZER

Charlie Curtsinger, Emery D. Berger · 2013 · ACM SIGARCH Computer Architecture News

Researchers and software developers require effective performance evaluation. Researchers must evaluate optimizations or measure overhead. Software developers use automatic performance regression tests to discover when changes improve or…

View details →DOI: 10.1145/2490301.2451141Cited by 15
Negative / Null Result ReportOpen accessSocial Sciences

Testing the status‐legitimacy hypothesis: Predicting system justification using objective and subjective socioeconomic status in China and the United States

Evan A. Valdes, James H. Liu, Matt N Williams · 2022 · Asian Journal Of Social Psychology

The status‐legitimacy hypothesis proposes that those who are most disadvantaged by unequal social systems are even more likely than members of more advantaged groups to provide ideological support for the very social system that is responsible for their disadvantages. Li, Yang, Wu, and Kou (2020, Personality and Social Psychology Bulletin ) sought to expand the generalizability of this hypothesis by testing it in China, addressing inconsistencies surrounding the empirical support for this hypothesis by postulating that the construct of status should be separated into an objective and subjectiv

View details →DOI: 10.1111/ajsp.12555Cited by 15
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469

Jacqueline Ramı́rez, Tae Won Kim, Wanqing Liu et al. · 2013 · Pharmacogenetics and Genomics

XK469 (NSC 697887) is a selective topoisomerase II β inhibitor eliminated mainly by aldehyde oxidase I (AOX1). We performed a candidate gene study to investigate whether AOX1 genetic variation contributes to interindividual variability in…

View details →DOI: 10.1097/fpc.0000000000000023Cited by 15
Negative / Null Result ReportOpen accessMedicine

Characterization of a Novel Tanay Virus Isolated From Anopheles sinensis Mosquitoes in Yunnan, China

Lu Zhao, Caroline Mwaliko, Evans Atoni et al. · 2019 · Frontiers in Microbiology

Globally, mosquitoes are known to be competent vectors to various arboviruses that cause serious and debilitating diseases to humans and animals. Conversely, mosquitoes harbor a wide array of insect specific viruses (ISVs) that are generally neglected. Extensive characterization of these ISVs is important in understanding their persistence infection effect on host behavior and arbovirus transmission. Herein, we report first time isolation of Tanay virus (TANAV) isolate YN15_103_01 in Anopheles sinensis mosquitoes from Yunnan Province, China. Phylogenetically, the isolate’s nucleotide identity

View details →DOI: 10.3389/fmicb.2019.01963Cited by 15
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Impact of Acquisitions on the Financial Performance of the Acquiring Companies in Kenya: A Case Study of Listed Acquiring Firms at the Nairobi Securities Exchange

George Gitonga Inoti · 2014 · Journal of Finance and Accounting

This study sought to determine whether acquisitions enhance corporate financial performance. The general objective of the study was to assess the effects of acquisitions on the financial performance of the acquiring companies in Kenya. The…

View details →DOI: 10.11648/j.jfa.20140205.12Cited by 15
Negative / Null Result ReportOpen accessSocial Sciences

Application of Bloom’s Taxonomy in Categorization of Cognitive Process Development in Colleges

Selina Banda, Florence Phiri, Jack Kaale et al. · 2023

Bloom’s Taxonomy is crucial in any teaching and learning environment because it determines direction for a course of study. This study assessed application of Bloom’s Taxonomy in courses of study offered in colleges in Lusaka District. Objectives were: Assess the application of Bloom’s Taxonomy in setting learning outcomes for the courses; Assess reflection of Bloom’s Taxonomy in activities set for course participants; Ascertain significance attached to Bloom’s Taxonomy in courses of study designed for participants. The study employed a mixed methodology, in particular employing a descriptive

View details →DOI: 10.7176/jep/14-4-02Cited by 15
Negative / Null Result ReportMedicine

In situcell–matrix mechanics in tendon fascicles and seeded collagen gels: implications for the multiscale design of biomaterials

Neil A. Duncan, Sabina B. Bruehlmann, Christopher Hunter et al. · 2012 · Computer Methods in Biomechanics & Biomedical Engineering

Designing biomaterials to mimic and function within the complex mechanobiological conditions of connective tissues requires a detailed understanding of the micromechanical environment of the cell. The objective of our study was to measure…

View details →DOI: 10.1080/10255842.2012.742075Cited by 15
Negative / Null Result ReportOpen accessMedicine

Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson’s Disease: Data from the PPMI Study

Christos Koros, Athina‐Maria Simitsi, Dimitra Papadimitriou et al. · 2020 · Journal of Parkinson s Disease

BACKGROUND: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. OBJECTIVE: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. METHODS: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers

View details →DOI: 10.3233/jpd-191860Cited by 15
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Response of broilers to supplementation of branched-chain amino acids blends with different valine contents in the starter period under summer conditions

Canan Kop Bozbay, Ahmet Akdag, Helin Atan et al. · 2020 · Animal Bioscience

OBJECTIVE: The objectives of this study were to compare the effects of normal and low protein content (PC) of starter diet supplemented or not with blends of branched-chain amino acids (BCAAs) on growth performance of broilers under summer conditions and to investigate whether these effects altered some quality traits and the characteristics of gastrointestinal tract. METHODS: A total of 768 mixed-sex broiler chicks (Ross 308, one-d-old) with an average initial body weight (BW) of 47.6±1.03 g were allocated into six treatments with four replications in 2×3 factorial arrangement. Factors were:

View details →DOI: 10.5713/ajas.19.0828Cited by 15
Negative / Null Result ReportOpen accessMedicine

Integrating large language model-based agents into a virtual patient chatbot for clinical anamnesis training

Nicolas Laverde, Christian Grévisse, Sandra Ximena Jaramillo-Rincón et al. · 2025 · Computational and Structural Biotechnology Journal

Effective communication is crucial for trust-building, accurate information gathering, and clinical decision-making in healthcare. Despite its emphasis in medical curricula, traditional training methods, such as role-playing with…

View details →DOI: 10.1016/j.csbj.2025.05.025Cited by 15
Negative / Null Result ReportOpen accessMedicine

Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort

Rachel Charlton, Anita McGrogan, Julia Snowball et al. · 2017 · Drug Safety

Electronic healthcare data have several advantages over prospective observational studies, but the sensitivity of data on neurodevelopmental outcomes and its comparability with data generated through other methodologies is unknown. The…

View details →DOI: 10.1007/s40264-017-0506-5Cited by 15
Negative / Null Result ReportAgricultural and Biological Sciences

Cortical Neurons Derived from Equine Induced Pluripotent Stem Cells Are Susceptible to Neurotropic Flavivirus Infection and Replication: An In Vitro Model for Equine Neuropathic Diseases

Patrick R.J. Fortuna, Helle Bielefeldt‐Ohmann, Dmitry A. Ovchinnikov et al. · 2018 · Stem Cells and Development

Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious…

View details →DOI: 10.1089/scd.2017.0106Cited by 15
Negative / Null Result ReportOpen accessMedicine

Microstructural White Matter Characteristics in Parkinson's Disease With Depression: A Diffusion Tensor Imaging Replication Study

Colleen Lacey, Lisa Ohlhauser, Jodie R. Gawryluk · 2019 · Frontiers in Neurology

Background Clarifying the neuropathology of depression as a symptom of Parkinson's disease (PD) has been the goal of recent neuroimaging studies; however, results have been conflicting and lack replication. The purpose of the current study was to replicate recent methods that have used diffusion tensor imaging (DTI) to compare individuals with PD with and without depression and to extend previous findings to allow for a better understanding of the results. Methods Thirty-seven participants with de novo PD were retrieved from the Parkinson's Progression Marker's Initiative (PPMI) and were separ

View details →DOI: 10.3389/fneur.2019.00884Cited by 15
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Eristalis flower flies can be mechanical vectors of the common trypanosome bee parasite, Crithidia bombi

Abby E. Davis, Kaitlin R. Deutsch, Alondra M. Torres et al. · 2021 · Scientific Reports

Flowers can be transmission platforms for parasites that impact bee health, yet bees share floral resources with other pollinator taxa, such as flies, that may be hosts or non-host vectors (i.e., mechanical vectors) of parasites. Here, we assessed whether the fecal-orally transmitted gut parasite of bees, Crithidia bombi, can infect Eristalis tenax flower flies. We also investigated the potential for two confirmed solitary bee hosts of C. bombi, Osmia lignaria and Megachile rotundata, as well as two flower fly species, Eristalis arbustorum and E. tenax, to transmit the parasite at flowers. We

View details →DOI: 10.1038/s41598-021-95323-wCited by 15