A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20211 results in Negative / Null Result Report · page 119 of 674
Johan P. Mackenbach, Marina Karanikolos, Jamie Lopez Bernal et al. · 2015 · Scandinavian Journal of Public Health
Background: The upturn of life expectancy in Central and Eastern Europe in the 1990s, after a period of stagnation or even decline, is one of the main events in European population history of the late 20th century, but has not been…
Winston A. Haynes, Kathy Kamath, Rebecca Waitz et al. · 2021 · Frontiers in Immunology
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer. Discovering antigens at a proteome scale could enable broader identification of…
Melissa A. Snyder, Kieran McCann, Maryline J. Lalande et al. · 2016 · Journal of Neurochemistry
Abstract The sigma‐1 receptor (σ‐1R) is a chaperone protein located at the endoplasmic reticulum ( ER ) mitochondrial interface with roles in neuroprotection and cognition. Increasing evidence suggests that loss of σ‐1R function could…
Lauren N. Forrest, Ross C. Jacobucci, Carlos M. Grilo · 2020 · Psychological Medicine
Abstract Background Eating-disorder severity indicators should theoretically index symptom intensity, impairment, and level of needed treatment. Two severity indicators for binge-eating disorder (BED) have been proposed (categories of…
Hao Huang, Wei Song, Xue‐Yan Liu · 2021 · Global Change Biology
Abstract Anthropogenic nitrogen (N) emissions and deposition have been increasing over past decades. However, spatiotemporal variations of N deposition levels and major sources remain unclear in many regions, which hinders making…
Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo et al. · 2021 · PLOS ONE
Background and purpose The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases ( MMPs ) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia. Methods The 781…
Anne M Rowat, Catriona Graham, Martin Dennis · 2018 · BMJ Open Gastroenterology
Objective To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement. Methods This prospective observational study included a convenience sample of adult…
Aydin Demircioğlu · 2023 · Diagnostics
In radiomics, utilizing features extracted from pretrained deep networks could result in models with a higher predictive performance than those relying on hand-crafted features. This study compared the predictive performance of models…
Veeral Ajmera, Na Wang, Hanfei Xu et al. · 2023 · Alimentary Pharmacology & Therapeutics
Summary Background Adiposity amplifies the genetic risk of non‐alcoholic fatty liver disease (NAFLD). Aim We evaluated the association between overweight‐years, a cumulative exposure based on the product of the duration and severity of…
Kata Gellén, David Buttelmann · 2017 · Child Development Research
Rather than reenacting every action they observe, preverbal infants adapt their imitative behavior. Although previous studies have revealed the capability of preverbal infants to imitate selectively, the question about the adaptability of this behavior on an individual level did not attract considerable scientific attention until now. In the current study, we investigated whether 14-month-old infants flexibly alternate their imitative response in accordance with a model’s changing physical constraints in a body-part imitation paradigm. Participants were presented with two novel actions whereby
Sanaa R. Elsegeny, Fatima S. Radwan, Yomna M. Elshamy et al. · 2025 · Annals of Microbiology
Abstract Background Aquaculture is an essential sector for global food security, providing protein-rich food, reducing pressure on wild stocks, creating jobs, and contributing to national economies. However, it faces major sustainability challenges, including disease outbreaks, inefficient feed utilization, and environmental impact. Main body The significance of probiotics in mitigating these issues is highlighted in this review. The current review underscores and highlights important considerations while developing or using probiotics in the aquaculture field: how strains are selected as cand
Andrew T. Rajczewski, J. Alfredo Blakeley‐Ruiz, Annaliese Meyer et al. · 2025 · PROTEOMICS
Mass spectrometry (MS)-based metaproteomics is used to identify and quantify proteins in microbiome samples, with the frequently used methodology being data-dependent acquisition mass spectrometry (DDA-MS). However, DDA-MS is limited in…
Tingting Bai, Dong Xu, Muhammad Ali Nasir · 2026 · Technological Forecasting and Social Change
With the accelerating growth of the digital economy, digital technology—as a type of general-purpose technology—creates a more inclusive and open environment for innovation, thereby facilitating the shift toward a low-carbon economy by promoting green innovation. However, we know little about whether there are differences in the roles of various types of green innovation. Therefore, this study evaluates the impact of DE on low-carbon development (LCD) through heterogeneous green innovation. The results show that DE has a significant nonlinear effect on LCD, with an initial suppressing effect t
Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang et al. · 2026 · Nature Neuroscience
ABSTRACT Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety, post-traumatic stress disorder,…
Yuqi Ren, Miao Cheng, Hongbin He et al. · 2025 · Nature Communications
CO2-to-hydrocarbon fuel conversion via artificial photosynthesis is limited by catalyst poisoning under high O2 partial pressures and sluggish C2-product formation. Herein, Ru0.6Cu1(Cu0–Cu1+)/CeO2 catalysts with adaptive O2 tolerance are…
Gabriel Jiménez, DMITRY KUVSHINOV, José‐Luis Peydró et al. · 2026 · The Journal of Finance
ABSTRACT We show that a U‐shaped monetary rate path increases banking crisis risk, via credit and asset price cycles, analyzing 17 countries over 150 years. Rate hikes (raw or instrumented) increase crisis risk, but only if preceded by prolonged cuts. These patterns are unique to banking crises, unlike noncrisis recessions. Regarding the mechanism, prolonged cuts raise the likelihood of large credit and asset price booms, consistent with higher credit supply and risk‐taking. Subsequent hikes strongly reduce credit and asset prices, and increase banks' realized credit risk, rather than interest
Jiacheng Ma, Shengrui Liu, Yuting Pei · 2025 · Scientific Reports
Sports injury prediction is crucial for university football player health, yet existing research predominantly focuses on professional athletes and lacks interpretability. Using the Kaggle "University Football Injury Prediction Dataset"…
Kevin J. Mitchell, Darren Dahly, Dorothy Bishop · 2025 · Neuron
The idea that the gut microbiome causally contributes to autism has gained currency in the scientific literature and popular press. Support for this hypothesis comes from three lines of evidence: human observational studies, preclinical experiments in mice, and human clinical trials. We critically assessed this literature and found that it is beset by conceptual and methodological flaws and limitations that undermine claims that the gut microbiome is causally involved in the etiology or pathophysiology of autism.
Zhiyu Yang, Fanny‐Dhelia Pajuste, Kristina Zguro et al. · 2025 · Nature Genetics
Abstract Understanding disease progression is of high biological and clinical interest. Unlike disease susceptibility, whose genetic basis has been abundantly studied, less is known about the genetics of disease progression and its overlap with disease susceptibility. Considering nine common diseases ( n cases ranging from 11,980 to 124,682) across seven biobanks, we systematically compared genetic architectures of susceptibility and progression, defined as disease-specific mortality. We identified only one locus substantially associated with disease-specific mortality and showed that, at a si
Ashish Sriram Mishra, Bhavna Ghosh, Sivakumar Ponnurengam Malliappan et al. · 2026 · RSC Advances
The development of colon-targeted drug delivery systems (CDDS) has gained increasing attention due to their potential to improve therapeutic outcomes for diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, and other colonic disorders. Targeted delivery to the colon offers the advantages of site-specific action, reduced systemic side effects, and improved patient compliance. However, several physiological barriers, such as variable pH, microbial metabolism, enzymatic degradation, and transit time, pose significant formulation challenges. This re
Federica Canfora · 2025 · Journal of Oral & Facial Pain and Headache
Burning Mouth Syndrome (BMS) is a complex, chronic neuropathic orofacial pain disorder characterized by a persistent burning or dysesthetic sensation in the oral cavity without an identifiable organic cause. Accurate diagnosis and…
Yu Zhang, Yuxi Liu, Yanping Li et al. · 2026 · JAMA
Importance: Evidence linking coffee and tea to cognitive health remains inconclusive, and most studies fail to differentiate caffeinated from decaffeinated coffee. Objective: To investigate associations of coffee and tea intake with…
Claudia Monaco, Coleen A. McNamara, Bram Slütter et al. · 2025 · Physiological Reviews
Cardiovascular disease is the global number one cause of mortality and morbidity. The majority of cardiovascular diseases are caused by atherosclerosis, a lipid-driven, inflammatory disease of the middle- and large-sized arteries. The…
Roohi Chaudhary, Ralf Weiskirchen, Marcelo Ehrlich et al. · 2025 · Frontiers in Pharmacology
The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors (GDFs). These cytokines play critical roles in liver function and disease progression. Here, we discuss Smad-dependent (canonical) and non-Smad pathways activated by these cytokines in a hepatocellular context. We highlight the connection between the deregulation of these pathways or the balance between them and key hepatocellular processes (e.g., proliferation, apoptosis, and epithelial-mesenchym
Nicholas Forelli, Trace Thome, Deborah Eaton et al. · 2026 · Science
Abstract Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i…
Jonne Kotta, Helen Orav‐Kotta, Kristjan Herkül et al. · 2024 · Työväentutkimus Vuosikirja
Following the establishment of the invasive gammarid amphipod Gammarus tigrinus the native gammarids almost disappeared from some habitats of the northeastern Baltic Sea.The aims of the current work were to experimentally study whether the habitat choice of G. tigrinus and G. salinus was similar and whether G. tigrinus modified the habitat selection of G. salinus, providing thus evidence that competition for space between the two species might explain the disappearance of the native gammarids from the study area.In general, the gammarid amphipods had a significant overlap in habitat selection.
Xinchi Luan, Xuezhe Wang, Ying Shi et al. · 2025 · Frontiers in Psychiatry
Depression represents a global health challenge with complex etiology and significant societal impact. Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders. This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression). On this basis, we have summarized that abnormal lipid metabolism may serve as a diagnostic and therapeu
Aras Fahrettin Korkmaz, Fatih Ekinci, Şehmus Altaş et al. · 2025 · Biology
This study presents a novel approach for classifying Discomycetes species using deep learning and explainable artificial intelligence (XAI) techniques. The EfficientNet-B0 model achieved the highest performance, reaching 97% accuracy, a 97% F1-score, and a 99% AUC, making it the most effective model. MobileNetV3-L followed closely, with 96% accuracy, a 96% F1-score, and a 99% AUC, while ShuffleNet also showed strong results, reaching 95% accuracy and a 95% F1-score. In contrast, the EfficientNet-B4 model exhibited lower performance, achieving 89% accuracy, an 89% F1-score, and a 93% AUC. These
Yimao Wu, Kaiyu Zhang, 夏新亚 et al. · 2026 · BMC Medicine
BACKGROUND: Breast cancer is the most commonly diagnosed malignancy in women worldwide, and its marked heterogeneity together with the complexity of the tumor microenvironment contributes to substantial variability in therapeutic…
Liangsuo Ma, Larry Keen, Joel L. Steinberg et al. · 2024 · NeuroImage
• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs…