A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21245 results · page 110 of 709
Muna Canales, Terri Blackwell, Areef Ishani et al. · 2016 · American Journal of Nephrology
<b><i>Background:</i></b> Recently, the first estimated glomerular filtration rate (eGFR) formula specifically developed for community-dwelling older adults, the Berlin Initiative Study Equation 2 (BIS2), was…
Xinyang Zhang, Alexander Palevski, Aharon Kapitulnik · 2022 · Proceedings of the National Academy of Sciences
Resistivity saturation is found on both superconducting and insulating sides of an “avoided” magnetic-field-tuned superconductor-to-insulator transition (H-SIT) in a two-dimensional In/InO x composite, where the anomalous metallic behavior…
Thomas L. Delworth, William F. Cooke, Vaishali Naik et al. · 2022 · Proceedings of the National Academy of Sciences
The Mediterranean region has been identified as a climate hot spot, with models projecting a robust warming and rainfall decline in response to increasing greenhouse gases. The projected rainfall decline would have impacts on agriculture…
Michael Hoppe, Alastair B. Ross, Cecilia Svelander et al. · 2018 · European Journal of Nutrition
Abstract Purpose To investigate the effects of eating wholegrain rye bread with high or low amounts of phytate on iron status in women under free-living conditions. Methods In this 12-week, randomized, parallel-design intervention study,…
Jianghui Zheng, Guoliang Wang, Leiping Duan et al. · 2025 · Nature Nanotechnology
Abstract Triple‐junction solar cells theoretically outperform their double-junction and single‐junction counterparts in power conversion efficiency, yet practical perovskite–perovskite–silicon devices have fallen short of both theoretical limits and commercial targets. To address surface defects in the top perovskite junction, we introduce a piperazine-1,4-diium chloride treatment, which replaces less stable lithium fluoride. For interfacing the top and middle perovskite junctions, we optimize the size of gold nanoparticles deposited on atomic layer-deposited tin oxide for best ohmic contactin
Ahmet Jeyhunov, Jong Dae Kim, Seong Mi Bae · 2025 · Sustainability
This paper explores the effect of board diversity on environmental, social, and governance (ESG) performance in Korean-listed firms using regression analysis. Our findings reveal that an increased board size significantly correlates with higher ESG scores when combined with other board diversity dimensions. The presence of female directors on boards was found to have a significant effect on environmental and social components of ESG performance. Age diversity exhibits a negative association with ESG scores, emphasizing potential disruptions from intergenerational differences. Foreign directors
Emma Croxford, Yanjun Gao, Elliot First et al. · 2025 · npj Digital Medicine
Electronic Health Records (EHRs) contain vast clinical data that are difficult for providers to synthesize. Generative AI with Large Language Models (LLMs) can summarize records to reduce cognitive burden, but ensuring accuracy requires…
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
Lloyd Christopher Smith · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper forms part of Mirror Programme, Volume I: Observerhood. Mirror Mathematics II develops the formal threshold layer of the Mirror Mathematics arc. Building on Mirror Mathematics I, it asks when a self-model becomes observer-relevant rather than merely predictive, self-referential or descriptive. The paper introduces a minimal Mirror observer predicate grounded in self-model reliability, action-guidance, cost-sensitive repair and positive viability coupling under perturbation. The central condition is expressed through a salience functional measuring whether the expected viability bene
A. Cazor, A. Schmidt, J. Shatrov et al. · 2022 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to evaluate the clinical outcomes and survivorship at minimum 10‐year follow‐up of patients undergoing primary valgisation high tibial osteotomy (HTO) for medial osteoarthritis (OA), treated…
Triin Kikas, Kristiina Rull, Robin N. Beaumont et al. · 2019 · Frontiers in Genetics
= 6830) did not replicate these findings. In summary, the study emphasizes the role of genetic variation in driving the transcriptome profile of the human placenta and the importance to explore further its functional implications.
Vladimir Nikitović, Vesna Lukić · 2010 · International Migration
Abstract Serbia still hosts the largest number of forced migrants in Europe. The paper examines the impact of the refugee influx from newly formed states on the territory of the Socialist Federal Republic of Yugoslavia (SFRY) into Serbia…
Shiekh Marifatul Haq, Muhammad Waheed, Riyaz Ahmad et al. · 2023 · Biology
The distribution of large ungulates is more often negatively impacted by the changing climate, especially global warming and species with limited distributional zones. While developing conservation action plans for the threatened species…
Hunter Warwick, Carolyn Hutyra, Cary Politzer et al. · 2019 · Clinical Orthopaedics & Related Research
Abstract Background The generalizability of data derived from patient-reported outcome measures (PROMs) depends largely on the proportion of the relevant population that completes PROM surveys. However, PROM survey responses remain low,…
Robert E. Coleman, Ying Zhou, Danielle Jandial et al. · 2021 · Advances in Therapy
INTRODUCTION: D-CARE, an international, phase 3, randomized, double-blind, placebo-controlled study in women with early-stage breast cancer at high risk of disease recurrence, failed to meet its primary endpoint-improvement in bone…
Osama Sobhi Moaket, Sarah Eyad Obaid, Fawaz Eyad Obaid et al. · 2025 · International Journal of Molecular Sciences
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive neuronal dysfunction and loss, yet current treatments remain largely symptomatic with limited disease-modifying efficacy. Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. Its receptor, GLP-1R, is expressed in key brain regions implicated in cognition, emotion, and motor control, including the hippocampus, frontal cortex, and substantia nigra. GLP-1R a
Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology
Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen
Simon Bowman, Raphaèle Séror, Raphaël Porcher et al. · 2025 · Annals of the Rheumatic Diseases
Primary Sjögren's disease (pSjD) is an autoimmune rheumatic disease involving exocrine glands and associated with high symptom burden (dryness, fatigue, pain), systemic features and salivary gland dysfunction. B-cell hyperactivity is common, with an increased risk of mucosa-associated lymphoid tissue lymphoma. This review describes the unmet need, scientific validity of outcome measures, optimisation of clinical trial design, therapeutic advances and how clinical improvement relates to health-related quality of life, additional quality-adjusted life years and economic benefit in pSjD. It deriv
Catherine Gutierrez, Anthony S. Stein, Amir T. Fathi et al. · 2025 · American Journal of Hematology
Acute myeloid leukemia is a molecularly heterogenous disease caused by the rapid expansion and impaired differentiation of malignant myeloid progenitors. Overall, outcomes remain poor, and more than half of patients develop relapsed or…
Alejandro Borrego-Ruiz, Juan J. Borrego · 2024 · Nutrients
BACKGROUND/OBJECTIVES: Diet is one of the major determinants of the composition and function of the gut microbiome, and diverse studies have established directional connections between gut microbiome dysbiosis and skin dyshomeostasis. Furthermore, a significant link between the gut and certain skin-related disorders has been reported. This work reviews the mechanisms underlying the relationship between nutritional factors, gut microbiome, and certain skin diseases such as acne vulgaris, alopecia, and atopic dermatitis. In addition, it explores how the modulation of the gut microbiome and human
W. Roether, J. E. Lupton · 2011 · Ocean Science
Abstract. Observations of tritium and 3He in the Tyrrhenian Sea, 1987–2009, confirm the enhanced vertical mixing of intermediate waters into the deep waters that has been noted and associated with the Eastern Mediterranean Transient in…
Remco van Dijk, Sem J. Aronson, Dirk R. de Waart et al. · 2017 · Scientific Reports
Abstract We aimed to identify potent biliverdin reductase (BVRA) inhibitors as a novel concept for the treatment of severe unconjugated hyperbilirubinemia. 1280 FDA-approved compounds were screened in vitro for their ability to inhibit…
Rezzy Eko Caraka, Yusra Yusra, Toni Toharudin et al. · 2021 · Sustainability
Background and objectives: The impacts of COVID-19 are like two sides of one coin. During 2020, there were many research papers that proved our environmental and climate conditions were improving due to lockdown or large-scale restriction…
R. Chris Fraley, Jia Y. Chong, Kyle A. Baacke et al. · 2022 · Advances in Methods and Practices in Psychological Science
Scholars and institutions commonly use impact factors to evaluate the quality of empirical research. However, a number of findings published in journals with high impact factors have failed to replicate, suggesting that impact alone may…
Kyle Lesinger, Di Tian · 2025 · Nature Communications
Deep neural networks that learn from climate reanalysis data have produced skillful weather forecasts within ten days. However, it is still a great challenge for dynamic models to predict soil moisture, droughts, and other extreme events…
Harriet Lampe, Laura Tam, Aaron R. Hansen · 2024 · Frontiers in Pharmacology
Metastatic castrate resistant prostate cancer (mCRPC) continues to have poor survival rates due to limited treatment options. Bi-specific T cell engagers (BiTEs) are a promising class of novel immunotherapies with demonstrated success in haematological malignancies and melanoma. BiTEs developed for tumour associated antigens in prostate cancer have entered clinical testing. These trials have been hampered by high rates of treatment related adverse events, minimal or transient anti-tumour efficacy and generation of high titres of anti-drug antibodies. This paper aims to analyse the challenges f
David Curtis · 2014 · The Psychiatric Bulletin
Summary In the Oxford Community Treatment Order Evaluation Trial (OCTET), patients were randomised either to be made subject to a community treatment order (CTO) or to be managed with Section 17 leave and discharge. No differences in…
Falko Dahm, Hassan Syed, Sebastian Tomescu et al. · 2022 · Arthroscopy
Purpose The purpose of this study was to investigate biomechanical differences of medial patellofemoral ligament (MPFL) reconstruction, medial quadriceps tendon femoral ligament (MQTFL) reconstruction, and a combination of these techniques…
Tom Burns · 2010 · The Psychiatrist
Summary UK mental healh services have been distinguished by their continuity of care but recently there has been a move to separating consultant responsibility for in-patient and out-patient care. Local examples of the success of this…
Rachael Storo, Cole Easson, Mahmood Shivji et al. · 2021 · Frontiers in Microbiology
Profiles of symbiotic microbial communities (“microbiomes”) can provide insight into the natural history and ecology of their hosts. Using high throughput DNA sequencing of the 16S rRNA V4 region, microbiomes of five shark species in South…