Failed Experiment ReportMedicine
Wittek T, Riepl A, Hildebrand A et al. · 2025 · Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Pregnancy diagnosis in South American camelids (SAC) is commonly performed in early pregnancy about 30 to 45 days after mating. Due to embryonic mortality, it is advisable to confirm the pregnancy later. A laboratory analysis would be…
View details →DOI: 10.1055/a-2563-3236 Failed Experiment ReportOpen accessMedicine
Lucchetti D, Di Leone A, Sabbatinelli G et al. · 2026 · Frontiers in immunology
Background Triple-negative breast cancer (TNBC) is a heterogeneous disease lacking approved targeted therapies and standardized treatment regimens. Among its molecular subtypes, luminal androgen receptor-positive (LAR+) TNBC is…
View details →DOI: 10.3389/fimmu.2026.1810096 Failed Experiment Report
Bhat YA, Mocavini I, O’Donnell E et al. · 2026 · Preprint
The Bre1 ubiquitin conjugating enzyme catalyzes the monoubiquitylation of histone H2B-K120/K123 at promoter proximal nucleosomes, contributing to transcriptional regulation. These same nucleosomes are targeted by the yeast SWR1C chromatin…
View details →DOI: 10.64898/2026.04.22.720199 Failed Experiment ReportMedicine
Yerraguntla S, Bakshi B, Chandran K et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration
N-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical…
View details →DOI: 10.1080/21678421.2026.2638590 Failed Experiment ReportMedicine
Guin S, Alden KM, Harshbarger E et al. · 2026 · European journal of medicinal chemistry
With millions of cases reported annually, fungal infections represent a growing public health concern. The effectiveness of current treatment options is hindered by the availability of only three antifungal drug classes, rising resistance,…
View details →DOI: 10.1016/j.ejmech.2025.118373 Failed Experiment ReportOpen accessMedicine
Orozco Loaiza G, Alfaro Guerra MJ, Murillo Sotela A et al. · 2026 · Cureus
Geographic atrophy (GA) represents the advanced form of non-neovascular age-related macular degeneration (AMD) and is associated with progressive and irreversible vision loss. Evidence has implicated the dysregulation of the complement…
View details →DOI: 10.7759/cureus.109282 Failed Experiment ReportMedicine
Holden A, Burns P, Devenny A et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Improved survival in cystic fibrosis (CF) has shifted clinical focus toward late complications, including altered body composition, bone health and cardiopulmonary fitness. The effects of Elexacaftor/Tezacaftor/Ivacaftor (ETI)…
View details →DOI: 10.1016/j.jcf.2026.05.013 Failed Experiment ReportOpen accessMedicine
Kinnard KR, Khalid E · 2026 · Case reports in neurological medicine
Myasthenia gravis is an autoimmune disorder characterized by muscle weakness due to impaired neuromuscular transmission. While antibodies against the acetylcholine receptor and muscle-specific kinase are commonly used for diagnosis, a…
View details →DOI: 10.1155/crnm/3092521 Failed Experiment ReportOpen accessMedicine
Harbi E, Byrne YY, Bozbey HU et al. · 2026 · Apoptosis : an international journal on programmed cell death
Glioblastoma is the most aggressive and most common grade 4 tumor of the central nervous system (CNS). Despite standard treatments such as surgical resection and chemoradiotherapy, overall survival (OS) usually does not exceed 14-16 months…
View details →DOI: 10.1007/s10495-026-02275-5 Failed Experiment ReportOpen accessMedicine
Zamalloa N, Rose J, Lap CJ et al. · 2026 · Current oncology (Toronto, Ont.)
Human epidermal growth factor receptor 2 (HER2) is a molecular target of interest in prostate cancer due to its association with poor prognosis and its potential role in androgen receptor signaling. However, earlier clinical trials…
View details →DOI: 10.3390/curroncol33020091 Failed Experiment Report
Matthew Boyea, null null, null null et al. · 2022 · John Heinrichs Scholarly & Creative Activities Day
Modern manufacturing processes increasingly demand machine driven solutions When developing robot applications in industry, programmers must be able to safely write code which is reusable, expandable, and well documented This case study…
View details →DOI: 10.58809/ptsh7036 Failed Experiment ReportMedicine
Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology
Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…
View details →DOI: 10.1093/jjco/hyaf171 Failed Experiment ReportOpen accessMedicine
Pollard J, Parry J, Wilkinson T et al. · 2026 · Case reports in oncology
Introduction Leptomeningeal disease is a rare and devastating complication of ovarian cancer which typically occurs in patients with advanced relapsed disease. It is challenging to treat and associated with a very poor prognosis. Case…
View details →DOI: 10.1159/000550838 Failed Experiment ReportMedicine
Shimizu K · 2025 · Biological & pharmaceutical bulletin
Multiple sclerosis (MS) develops due to an abnormal T-cell immune response to autoantigens and control of T-cell activation is a mainstream approach for its treatment. In the present study, neogenin, a key molecule for T-cell activation,…
View details →DOI: 10.1248/bpb.b25-00229 Failed Experiment ReportOpen accessMedicine
Whitaker R · 2025 · Health and human rights
The discourse around health as a human rights issue usually focuses on access to medical treatment. However, the "right to health" begins with the right to informed consent about the merits of a treatment, which has been lacking as a…
Failed Experiment ReportMedicine
Tilanus AM, Shields RK, Lodise TP et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…
View details →DOI: 10.1093/cid/ciaf038 Failed Experiment Report
Talapatra A, Mathew S, Kanakalakshmi ST et al. · 2024 · Preprint
Background Post-operative sore throat (POST) is one of the most common complaints post-endotracheal intubation and can be decreased through various interventions. This study aimed to determine the effect of fluticasone-impregnated versus…
View details →DOI: 10.12688/f1000research.139742.2 Failed Experiment ReportOpen accessMedicine
Cardani S, Janes TA, Asif R et al. · 2026 · Acta physiologica (Oxford, England)
Aim Rhythmic breathing movements driven by the brainstem rely on chemosensory inputs to homeostatically adjust motor output to the prevailing metabolic demand. The central CO 2 chemoreflex is a critical component of this neural circuitry,…
View details →DOI: 10.1111/apha.70194 Failed Experiment Report
Seojoon Park, Paul Adams, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day
Every person would have thought of this idea of launching aballoon high up in the sky in their youth, and that is exactlywhat we did. We filled a large elastic balloon filled withhelium and flew it high up into the sky until it popped…
View details →DOI: 10.58809/kqgl3096 Failed Experiment ReportOpen accessMedicine
Maeda Y, Akino S, Kondo N · 2026 · Microbes and environments
Fusarium crown and root rot (FCRR), caused by the fungus Fusarium oxysporum f. sp. asparagi, is one of the most destructive diseases affecting asparagus worldwide. Despite evidence of the suppression of FCRR by several nonpathogenic F.…
View details →DOI: 10.1264/jsme2.me25063 Failed Experiment ReportMedicine
Ariizumi T, Oike N, Murayama Y et al. · 2026 · Discover oncology
Background Giant cell tumor of bone (GCTB) is a locally aggressive tumor that rarely metastasizes, although a small subset undergoes malignant transformation. H3F3A driver mutations have been recognized as characteristic molecular features…
View details →DOI: 10.1007/s12672-026-05196-6 Failed Experiment ReportOpen accessMedicine
El Gazar SM, El Backly RN, Lotfy WA et al. · 2026 · BMC oral health
Aim To evaluate the antimicrobial effects of Nd: YAG laser irradiation, antimicrobial photodynamic therapy (aPDT), and passive ultrasonic irrigation (PUI) in comparison with conventional irrigation with Sodium hypochlorite (NaOCl) in root…
View details →DOI: 10.1186/s12903-026-08651-6 Failed Experiment ReportMedicine
Bagińska M, Morawska-Tota M, Pałka T et al. · 2026 · Journal of clinical medicine
Background/Objectives : Bone tissue undergoes continuous remodelling processes that are closely controlled by mechanical stimuli and metabolic as well as inflammatory factors. Although the beneficial effects of regular physical activity on…
View details →DOI: 10.3390/jcm15124662 Failed Experiment ReportOpen accessMedicine
Ma H, Yan Z, Gu R et al. · 2024 · Cancer immunology, immunotherapy : CII
Background Immunotherapy, such as chimeric antigen receptor T (CAR-T) cells targeting CD33 or CD123, has been well developed over the past decade for the treatment of acute myeloid leukemia (AML). However, the inability to sustain…
View details →DOI: 10.1007/s00262-024-03847-7 Failed Experiment Report
Kelso ZS, Snyder MC, Gershman SJ · 2026 · Preprint
Planarian flatworms represent one of the most evolutionarily informative nervous systems for an account of ancient bilaterian brains. Likewise, the unparalleled regenerative ability of planarians makes possible certain investigations of…
View details →DOI: 10.64898/2026.04.18.719399 Failed Experiment ReportMedicine
Liu ZL, Zhou YY, Xu QX et al. · 2025 · Insect science
The clustered regularly interspaced small palindromic repeats (CRISPR) / CRISPR-associated nuclease 9 (Cas9)-mediated gene editing technology has revolutionized the study of fundamental biological questions in various insects. Diverse…
View details →DOI: 10.1111/1744-7917.13447 Failed Experiment ReportMedicine
Nishimura T, Kodama T, Chiba K et al. · 2026 · Physical chemistry chemical physics : PCCP
To identify factors that enhance thermochemical redox reaction efficiency, we have investigated the thermochemical properties of transition-metal-doped cerium oxide. This study examines thermodynamic parameters using vibrational entropy…
View details →DOI: 10.1039/d5cp04695e Failed Experiment ReportMedicine
Liu C, Lyu Y, Jiang Y et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To carry out genetic analysis for a fetus with confined placental mosaicism (CPM) for trisomy 2 (T2) in conjunct with fetal uniparental disomy (UPD). Methods Amniocentesis and chromosomal karyotyping was carried out for a…
View details →DOI: 10.3760/cma.j.cn511374-20220524-00348 Failed Experiment Report
Zahl-Olsen R, Gausel N, Tellefsen Håland Å et al. · 2022 · Preprint
Background: Routine Outcome Monitoring (ROM) systems have been used to monitor how a client’s life changes over the course of therapy. However, if a ROM system is to be used, the system should have sufficient construct validity to warrant…
View details →DOI: 10.12688/f1000research.125176.1 Failed Experiment ReportMedicine
Sung K, Park M, Kweon O et al. · 2026 · Food Microbiology.
Campylobacter jejuni is a foodborne pathogen with limited ability to thrive at low temperatures. This study investigated the survival and proteomic responses of C. jejuni NCTC 11168 during prolonged storage at 4 °C, with specific focus on…
