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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1757 results in Negative / Null Result Report for "Mpro" · page 11 of 59

Negative / Null Result ReportOpen accessPhysics and Astronomy

An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 4: Impact of Fitting Functions in Estimated Absorbed Doses

Sara Kurkowska, Julia Brosch-Lenz, Yuni K. Dewaraja et al. · 2025 · Journal of Nuclear Medicine

Individualized radiopharmaceutical therapies guided by patient-specific absorbed dose (AD) assessments using nuclear medicine imaging have the potential to improve both efficacy and safety. Understanding sources of variability in AD calculations is critical for standardization. The Society of Nuclear Medicine and Molecular Imaging Dosimetry Task Force launched the 177Lu Dosimetry Challenge to evaluate variability across steps within the dosimetry workflow. This work aimed to assess the variability in ADs due to different fitting and integration methods. Methods: Anonymized datasets from 2 pati

View details →DOI: 10.2967/jnumed.124.268612Cited by 13
Negative / Null Result ReportOpen accessNeuroscience

Resolution limit of the eye — how many pixels can we see?

Maliha Ashraf, Alexandre Chapiro, Rafał Mantiuk · 2025 · Nature Communications

As large engineering efforts go towards improving the resolution of mobile, augmented reality (AR), and virtual reality (VR) displays, it is important to know the maximum resolution at which further improvements bring no noticeable benefit. This limit is often referred to as the retinal resolution, although the limiting factor may not necessarily be attributed to the retina. To determine the ultimate resolution at which an image appears sharp to our eyes with no perceivable blur, we created an experimental setup with a sliding display, which allows for continuous control of the resolution. The

View details →DOI: 10.1038/s41467-025-64679-2Cited by 13
Negative / Null Result ReportOpen accessPhysics and Astronomy

Limits on the 21 cm Power Spectrum at z = 6.5–7.0 from Murchison Widefield Array Observations

Chuneeta D. Nunhokee, Donald M. Null, Cathryn M. Trott et al. · 2025 · The Astrophysical Journal

Abstract This paper presents the spherically averaged 21 cm power spectrum derived from Epoch of Reionization (EoR) observations conducted with the Murchison Widefield Array (MWA). The analysis uses EoR0-field data, centered at (R.A. = 0 h , decl. = −27 ∘ ), collected between 2013 and 2023. Building on the improved methodology described in C. M. Trott et al. (2024), we incorporate additional data quality control techniques introduced in C. D. Nunhokee (2020). We report the lowest-power-level limits on the EoR power spectrum at redshifts z = 6.5, z = 6.8, and z = 7.0. These power levels, measur

View details →DOI: 10.3847/1538-4357/adda45Cited by 13
Negative / Null Result ReportOpen accessEnvironmental Science

Resolving a heated debate: The utility of prescribed burning as a management tool for biodiversity on lowland heath

Barbara Smith, Dan Carpenter, J. M. Holland et al. · 2023 · Journal of Applied Ecology

Abstract Lowland heath is a priority habitat for conservation, nowadays largely managed for biodiversity. Historically, prescribed burning has been the principal management tool, but there are increasing calls to substitute burning with cutting to improve biodiversity outcomes. However, poor understanding of potential impacts compromises decision making. Our study was carried out in the New Forest National Park, the largest area of lowland heath in Europe. Using a multi‐trophic approach, we compared the ecological impact of prescribed burning with two types of vegetation cutting (swiping and b

View details →DOI: 10.1111/1365-2664.14471Cited by 13
Negative / Null Result Report

Did a quality improvement intervention improve quality of maternal health care? Implementation evaluation from a cluster-randomized controlled study

Elysia Larson, Godfrey M Mbaruku, Jessica Cohen et al. · 2019 · International Journal for Quality in Health Care

Abstract Objective To test the success of a maternal healthcare quality improvement intervention in actually improving quality. Design Cluster-randomized controlled study with implementation evaluation; we randomized 12 primary care…

View details →DOI: 10.1093/intqhc/mzz126Cited by 13
Negative / Null Result Report

Human-derived Treg and MSC combination therapy may augment immunosuppressive potency in vitro, but did not improve blood brain barrier integrity in an experimental rat traumatic brain injury model

Henry W. Caplan, Karthik S. Prabhakara, Naama E. Toledano Furman et al. · 2021 · PLOS ONE

Traumatic brain injury (TBI) causes both physical disruption of the blood brain barrier (BBB) and altered immune responses that can lead to significant secondary brain injury and chronic inflammation within the central nervous system…

View details →DOI: 10.1371/journal.pone.0251601Cited by 13
Negative / Null Result Report

Air Quality Index (AQI) Did Not Improve during the COVID-19 Lockdown in Shanghai, China, in 2022, Based on Ground and TROPOMI Observations

Qihan Ma, Jianbo Wang, Ming Xiong et al. · 2023 · Remote Sensing

The lockdowns from the coronavirus disease of 2019 (COVID-19) have led to a reduction in anthropogenic activities and have hence reduced primary air pollutant emissions, which were reported to have helped air quality improvements. However,…

View details →DOI: 10.3390/rs15051295Cited by 13
Negative / Null Result ReportOpen accessMedicine

Home-Based Prehabilitation for Older Surgical Patients With Frailty

Daniel I. McIsaac, Susan M. Lee, Dean Fergusson et al. · 2025 · JAMA Surgery

Importance: Explanatory trials suggest that prehabilitation has efficacy in improving surgical outcomes. The effectiveness of offering home-based prehabilitation across multiple centers and for older adults with frailty remains unknown. Objective: To evaluate the effectiveness of offering coach-supported, home-based prehabilitation to older surgical patients with frailty. Design, Setting, and Participants: This study is a pragmatic, parallel-arm, multicenter randomized clinical trial with embedded qualitative assessment. Clinicians and assessors were fully blinded; participants were partially

View details →DOI: 10.1001/jamasurg.2025.5288Cited by 13
Negative / Null Result Report

Operational and investment efficiency of investment trust companies: Do foreign firms outperform domestic firms?

Mohammad Nourani, Qian Long Kweh, Wen-Min Lu et al. · 2022 · Financial Innovation

Abstract This study examines the efficiency of investment trust companies (ITCs) from 2011 to 2020 using a meta-frontier two-stage network data envelopment analysis (DEA) based on the directional distance function (DDF). We improved the…

View details →DOI: 10.1186/s40854-022-00382-1Cited by 13
Negative / Null Result ReportMedicine

Efficacy and safety of percutaneous cryoablation for elderly patients with small hepatocellular carcinoma: A prospective multicenter study

Jing Luo, Zheng Dong, Hui Xie et al. · 2022 · Liver International

BACKGROUND & AIMS: Management of elderly patients with hepatocellular carcinoma (HCC) has become a major concern. Some data suggest that cryoablation improves the outcomes of elderly patients with HCC, but its efficacy and safety remain…

View details →DOI: 10.1111/liv.15169Cited by 13
Negative / Null Result ReportOpen accessComputer Science

Does metaverse improve recommendations quality and customer trust? A user-centric evaluation framework based on the cognitive-affective-behavioural theory

Rabab Ali Abumalloh, Mehrbakhsh Nilashi, Osama Halabi et al. · 2024 · Journal of Innovation & Knowledge

Recommendation agents (RAs) have proven to be effective decision-making tools for customers, as they can boost trust and loyalty when customers shop online. They can analyse large amounts of data using machine learning algorithms and…

View details →DOI: 10.1016/j.jik.2024.100569Cited by 13
Negative / Null Result ReportOpen accessMaterials Science

Solar methane pyrolysis in a liquid metal bubble column reactor: Effect of medium type and gas injection configuration

Malek Msheik, Sylvain Rodat, Stéphane Abanades · 2024 · Journal of Analytical and Applied Pyrolysis

Solar methane pyrolysis in different molten media and reactor configurations was experimented to improve hydrogen production . Pure Sn, Ni 0.18 Sn 0.82 , Cu 0.45 Bi 0.55 , and KCl melts were compared at three different temperatures…

View details →DOI: 10.1016/j.jaap.2024.106756Cited by 13
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Diversity of adapted tobacco microbial community and its application in improving tobacco quality

Jing Mai, Ying Ning, Zhonglong Lin et al. · 2025 · Industrial Crops and Products

Many bacteria such as Bacillus , Pseudomonas , and Lactobacillus are widely present in flue-cured tobacco leaves during the aging process, indicating they play important roles in improving tobacco quality. In this study, we aimed to screen…

View details →DOI: 10.1016/j.indcrop.2025.121580Cited by 12
Negative / Null Result Report

Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection

Gabriela Yamazaki de Campos, Raquel Amorim Oliveira, Patrícia Kellen Martins Oliveira-Brito et al. · 2020 · PeerJ

Background The macrophage lineage is characterized by plasticity due to the acquisition of distinct functional phenotypes, and two major subsets are evaluated; classical M1 activation (strong microbicidal activity) and alternative M2…

View details →DOI: 10.7717/peerj.10295Cited by 12
Negative / Null Result ReportOpen accessMaterials Science

Machine Learning Methodologies Applied to Magnetocaloric Perovskites Discovery

Luis E. Castro-Anaya, Eduardo Marese, Jaime A. Lozano et al. · 2025 · Journal of Chemical Information and Modeling

High Resolution Image Download MS PowerPoint Slide Traditionally, designing novel materials involves exploring new compositions guided by insights from previous work, relying on a trial-and-error approach, where continuous synthesis and characterization proceed until the properties meet the improvements. This method is inefficient due to the challenges of exploring vast chemical spaces. In this study, a machine-learning-based methodology is developed to assist the design from available data in the literature, allowing us to test in silico more than 1.2 million compositions. Two databases with

View details →DOI: 10.1021/acs.jcim.4c01944Cited by 12
Negative / Null Result Report

Adding Cyclooxygenase Inhibitors to Immune Checkpoint Inhibitors Did Not Improve Outcomes in Metastatic Renal Cell Carcinoma

Yumeng Zhang, Premsai Kumar, Jacob J. Adashek et al. · 2022 · Cells

Modulating the cyclooxygenase 2 (COX-2) pathway has improved responses to immune checkpoint inhibitors (ICIs) in certain solid tumors, such as melanoma. Little is known about COX-2 inhibition in response to ICIs in metastatic renal cell…

View details →DOI: 10.3390/cells11162505Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

How to get rid of the belief bias: Boosting analytical thinking via pragmatics

Laura Macchi, Francesco Poli, Laura Caravona et al. · 2019 · Europe’s Journal of Psychology

The previous research attempts to reduce the influence of the belief bias on deductive thinking have often been unsuccessful and, when they succeeded, they failed to replicate. In this paper, we propose a new way to see an old problem. Instead of considering the analytical abilities of the respondent, we focus on the communicative characteristics of the experimental task. By changing the pragmatics into play through a subtle manipulation of the instruction of the syllogism problem, we obtained a strong improvement in the accuracy of the performance in both untrained and trained in logic respon

View details →DOI: 10.5964/ejop.v15i3.1794Cited by 12
Negative / Null Result ReportOpen accessMedicine

Selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC): informing clinical practice for multidisciplinary teams in England

Helen L. Reeves, John Reicher, Georgia Priona et al. · 2022 · Frontline Gastroenterology

Objective: Hepatocellular carcinoma (HCC) deaths are rising alarmingly. Many patients are unsuitable for available therapies. Poor response rates further hamper outcomes for those that are. Selective internal radiation therapy (SIRT) offers hope, although which patients benefit over standard approaches remains unclear. Design/method: As a quality/service improvement, we audited consecutive patients treated with SIRT (2015-2020) by the Newcastle upon Tyne Hospitals National Health Service Foundation Trust HCC multidisciplinary team. Indications, Barcelona clinic liver cancer (BCLC) stage, treat

View details →DOI: 10.1136/flgastro-2022-102137Cited by 12
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

New cycle, same old mistakes? Overlapping vs. discrete generations in long-term recurrent selection

Marlee R. Labroo, Jessica Rutkoski · 2022 · BMC Genomics

BACKGROUND: Recurrent selection is a foundational breeding method for quantitative trait improvement. It typically features rapid breeding cycles that can lead to high rates of genetic gain. Usually, generations are discrete in recurrent selection, which means that breeding candidates are evaluated and considered for selection for only one cycle. Alternately, generations can overlap, with breeding candidates considered for selection as parents for multiple cycles. With recurrent genomic selection but not phenotypic selection, candidates can be re-evaluated by using genomic estimated breeding v

View details →DOI: 10.1186/s12864-022-08929-3Cited by 12
Negative / Null Result ReportOpen accessMedicine

Efficacy and safety of combination behavioral activation for smoking cessation and varenicline for treating tobacco dependence among individuals with current or past major depressive disorder: A 2 × 2 factorial, randomized, placebo‐controlled trial

Brian Hitsman, George D. Papandonatos, Jackie K. Gollan et al. · 2023 · Addiction

BACKGROUND AND AIMS: Treatment of depression-related psychological factors related to smoking behavior may improve rates of cessation among adults with major depressive disorder (MDD). This study measured the efficacy and safety of 12…

View details →DOI: 10.1111/add.16209Cited by 12
Negative / Null Result ReportOpen accessComputer Science

Improving SAT-solving with Machine Learning

Haoze Wu · 2017

In this project, we aimed to improve the runtime of Minisat, a Conflict-Driven Clause Learning (CDCL) solver that solves the Propositional Boolean Satisfiability (SAT) problem. We first used a logistic regression model to predict the…

View details →DOI: 10.1145/3017680.3022464Cited by 11
Negative / Null Result Report

Change in sagittal alignment after decompression alone in patients with lumbar spinal stenosis without significant deformity: a prospective cohort study

Jamal Bech Bouknaitir, Leah Y. Carreon, Stig Brorson et al. · 2022 · Journal of Neurosurgery: Spine

OBJECTIVE The authors’ objective was to investigate whether sagittal balance improves in patients with spinal stenosis after decompression alone. METHODS This prospective longitudinal cohort study compared preoperative and 6-month…

View details →DOI: 10.3171/2021.10.spine21445Cited by 11
Negative / Null Result ReportMedicine

Radiotherapy Improves Survival of Patients With Lymphovascular Invasion in pT1b Esophageal Squamous Cell Cancer After Endoscopic Submucosal Dissection

Xu Yang, Lina Zhao, Anhui Shi et al. · 2023 · The American Journal of Gastroenterology

INTRODUCTION: Adjuvant radiotherapy is recommended for pT1b esophageal squamous cell cancer (ESCC) after endoscopic submucosal dissection (ESD). However, it is unclear whether additional radiotherapy can improve patient survival. This…

View details →DOI: 10.14309/ajg.0000000000002257Cited by 11
Negative / Null Result Report

Cholesterol Control Among Uninsured Adults Did Not Improve From 2001‐2004 to 2009‐2012 as Disparities With Both Publicly and Privately Insured Adults Doubled

Brent M. Egan, Jiexiang Li, Sara M. Sarasua et al. · 2017 · Journal of the American Heart Association

Background Low‐density lipoprotein cholesterol (LDL‐C) control is higher among insured than uninsured adults, but data on time trends and contributing factors are incomplete and important for improving health equity. Methods and Results…

View details →DOI: 10.1161/jaha.117.006105Cited by 11
Negative / Null Result Report

Did the COVID‐19 lockdown in Delhi and Kolkata improve the ambient air quality of the two cities?

Arindam Datta, Md. Hafizur Rahman, R. Suresh · 2021 · Journal of Environmental Quality

Abstract To control the spread of COVID‐19, the government of India imposed a nationwide lockdown on all nonessential activities from 22 Mar. to 3 May 2020. Daily ambient particulate matter ≤10 μm in diameter (PM 10 ), particulate matter…

View details →DOI: 10.1002/jeq2.20192Cited by 11
Negative / Null Result Report

Erector spinae plane block did not improve postoperative pain-related outcomes and recovery after video-assisted thoracoscopic surgery : a randomised controlled double-blinded multi-center trial

A. Clairoux, A. Moore, M. Caron-Goudreault et al. · 2024 · BMC Anesthesiology

Abstract Introduction There is a sizable niche for a minimally invasive analgesic technique that could facilitate ambulatory video-assisted thoracoscopic surgery (VATS). Our study aimed to determine the analgesic potential of a single-shot…

View details →DOI: 10.1186/s12871-024-02544-3Cited by 11
Negative / Null Result ReportOpen accessMedicine

Relaxin Does Not Improve Angiotensin II-Induced Target-Organ Damage

Nadine Haase, Julianna Rugor, Łukasz Przybył et al. · 2014 · PLoS ONE

Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) was given to 4 week-old dTGR and age-matched Sprague-Dawley rats (SD). Systolic blood pressure increas

View details →DOI: 10.1371/journal.pone.0093743Cited by 11
Negative / Null Result Report

Fibre supplementation to pre‐weaning piglet diets did not improve the resilience towards a post‐weaning enterotoxigenic E. coli challenge

Hubèrt van Hees, Dominiek Maes, Sam Millet et al. · 2020 · Journal of Animal Physiology and Animal Nutrition

Abstract Dietary fibre (DF) is implicated in gastrointestinal health of weaned piglets, either through its physiochemical properties, through modulation of gut microbiota and (or) improved gut integrity. We aimed to study the effect of DF…

View details →DOI: 10.1111/jpn.13475Cited by 11