Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jorma J. de Ronde, Christiaan Klijn, Arno Velds et al. · 2010 · BMC Research Notes
BACKGROUND: Most approaches used to find recurrent or differential DNA Copy Number Alterations (CNA) in array Comparative Genomic Hybridization (aCGH) data from groups of tumour samples depend on the discretization of the aCGH data to gain, loss or no-change states. This causes loss of valuable biological information in tumour samples, which are frequently heterogeneous. We have previously developed an algorithm, KC-SMART, that bases its estimate of the magnitude of the CNA at a given genomic location on kernel convolution (Klijn et al., 2008). This accounts for the intensity of the probe sign
View details →DOI: 10.1186/1756-0500-3-298Cited by 22 Negative / Null Result ReportOpen accessPsychology
Mark A. Straccia, Adam R. Teed, Perri L. Katzman et al. · 2021 · Psychological Medicine
BACKGROUND: Although potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically, most studies have included all male samples, and few have demonstrated consistent effects of either neuropeptide on mentalizing (i.e. understanding the mental states of others). To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP on mentalizing in healthy individuals. METHODS: = 186) of healthy individuals, we exa
View details →DOI: 10.1017/s0033291721004104Cited by 22 Negative / Null Result ReportOpen accessMedicine
Lawrence Grierson, Samantha Winemaker, Alan Taniguchi et al. · 2020 · Perspectives on Medical Education
INTRODUCTION: The medical education community has implemented writing exercises that foster critical analysis and nurture reflective capacity. The REFLECT rubric (Wald et al. 2012) was developed to address the challenge of assessing these written reflections. The objective of this replication work is to explore the reproducibility of the reliability characteristics presented by the REFLECT developers. METHODS: Five raters evaluated narratives written by medical students and experienced clinicians using the REFLECT rubric. Reliability across rubric domains was determined via intraclass correlat
View details →DOI: 10.1007/s40037-020-00611-2Cited by 22 Negative / Null Result ReportOpen accessNeuroscience
Marina Terkourafi, Benjamin Weissman, Joseph Roy · 2020 · International Review of Pragmatics
Abstract Research on the effect of face-orientation on scalar implicatures has claimed that face-threatening contexts are one type of context in which scalar implicatures are not warranted. However, that research has been based on the two…
View details →DOI: 10.1163/18773109-01201103Cited by 22 Negative / Null Result ReportOpen accessMedicine
Manou Sommen, Guy Van Camp, Balázs Liktor et al. · 2014 · Otology & Neurotology
BACKGROUND/HYPOTHESIS: Otosclerosis is a frequent cause of hearing impairment characterized by abnormal resorption and deposition of bone in the human otic capsule. It is a disease of complex etiopathogenesis that is caused by both…
View details →DOI: 10.1097/mao.0000000000000334Cited by 22 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Dinggang Zhou, Liping Xu, Shiwu Gao et al. · 2016 · Frontiers in Plant Science
Cry1Ac transgenic sugarcane provides a promising way to control stem-borer pests. Biosafety assessment of soil ecosystem for cry1Ac transgenic sugarcane is urgently needed because of the important role of soil microorganisms in nutrient transformations and element cycling, however little is known. This study aimed to explore the potential impact of cry1Ac transgenic sugarcane on rhizosphere soil enzyme activities and microbial community diversity, and also to investigate whether the gene flow occurs through horizontal gene transfer. We found no horizontal gene flow from cry1Ac sugarcane to soi
View details →DOI: 10.3389/fpls.2016.00265Cited by 22 Negative / Null Result ReportEnvironmental Science
Brittany N. Neilson, Curtis M. Craig, Raelyn Y. Curiel et al. · 2020 · Human Factors The Journal of the Human Factors and Ergonomics Society
OBJECTIVE: The aim of this study is to replicate Berto's (2005) heavily cited work on attention restoration. BACKGROUND: Nature interventions have gained increased interest for improving performance of attentionally demanding tasks. Berto…
View details →DOI: 10.1177/0018720820909287Cited by 22 Negative / Null Result ReportOpen accessMedicine
Yasushi Tojo, Yasuhiro Koh, Masayuki Amano et al. · 2010 · Antimicrobial Agents and Chemotherapy
Natural products with macrocyclic structural features often display intriguing biological properties. Molecular design incorporating macrocycles may lead to molecules with unique protein-ligand interactions. We generated novel human…
View details →DOI: 10.1128/aac.01766-09Cited by 22 Negative / Null Result ReportOpen accessEngineering
John Redmond, Helen O. McCarthy, Paul Buchanan et al. · 2022 · Biomaterials Advances
While 2D culture presents a useful tool for cancer research, it fails to replicate the tumor microenvironment as it lacks proper three-dimensional cell-cell/cell-matrix interactions, often resulting in exaggerated responses to therapeutic agents. 3D models that aim to overcome the issues associated with 2D culture research offer a new frontier for cancer research with cell growth, morphology and genetic properties that more closely match in vivo cancers. Herein, we aim to develop a collagen-based scaffold that supports the attachment and proliferation of breast cancer (BC) cells as a 3D cultur
View details →DOI: 10.1016/j.bioadv.2022.213157Cited by 22 Negative / Null Result ReportMedicine
Matthew R. Pearson, Mark A. Prince, Adrián J. Bravo · 2017 · Substance Use & Misuse
BACKGROUND: Protective behavioral strategies (PBS) can be used to reduce alcohol-related harm when drinking. Despite much research demonstrating that use of protective behavioral strategies (PBS) is associated with decreased alcohol…
View details →DOI: 10.1080/10826084.2016.1267222Cited by 22 Negative / Null Result ReportMedicine
Donghyok Kwon, Kyeong‐Cheol Shin, Seungtae Kim et al. · 2010 · The Journal of Microbiology
This study aimed to characterize the replication and pathogenic properties of a Korean pandemic (H1N1) 2009 influenza virus isolate in ferrets and mice. Ferrets infected with A/Korea/01/2009 (H1N1) virus showed mild clinical signs. The…
View details →DOI: 10.1007/s12275-010-0120-zCited by 22 Negative / Null Result ReportMedicine
TM Barber, Stephen Franks · 2010 · Expert Review of Endocrinology & Metabolism
Polycystic ovary syndrome (PCOS) is associated with obesity and manifests with reproductive, hyperandrogenic and metabolic features. Although the etiology of PCOS is complex and incompletely understood, genetics plays an important role…
View details →DOI: 10.1586/eem.10.32Cited by 22 Negative / Null Result ReportOpen accessNeuroscience
Adrienne L. Romer, Diego A. Pizzagalli · 2021 · Biological Psychiatry Global Open Science
A general psychopathology factor (p factor) captures shared variance across mental disorders in diverse samples and may partly reflect executive dysfunction. Higher p factor scores have been related to structural alterations within the…
View details →DOI: 10.1016/j.bpsgos.2021.06.002Cited by 22 Negative / Null Result ReportOpen accessMedicine
Amir Arastehfar, Farnaz Daneshnia, Hrant Hovhannisyan et al. · 2023 · mBio
ABSTRACT Small colony variants are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata— a major intracellular fungal pathogen—produces small and slow-growing respiratory-deficient colonies, termed “petite.” Despite reports of clinical petite C. glabrata strains, our understanding of petite behavior in the host remains obscure. Moreover, controversies exist regarding in-host petite fitness and its clinical relevance. Herein, we employed whole-genome sequencing (WGS), dual-RNAseq, and extensive ex vivo and
View details →DOI: 10.1128/mbio.01180-23Cited by 22 Negative / Null Result ReportOpen accessPsychology
Michał Król, Magdalena Ewa Król · 2019 · Journal of Neuroscience Psychology and Economics
Recent studies reported that the attraction effect, whereby inferior decoys cause choice reversals, fails to replicate if the choice options are presented in a pictorial rather than abstract numerical form. We argue that the pictorial…
View details →DOI: 10.1037/npe0000104Cited by 22 Negative / Null Result ReportOpen accessComputer Science
Andreas Ketterer, Satoya Imai, Nikolai Wyderka et al. · 2022 · Physical review. A/Physical review, A
We consider statistical methods based on finite samples of locally randomized measurements in order to certify different degrees of multiparticle entanglement in intermediate-scale quantum systems. We first introduce hierarchies of…
View details →DOI: 10.1103/physreva.106.l010402Cited by 22 Negative / Null Result Report
Waldemar Siemens, Joerg J. Meerpohl, Miriam S. Rohe et al. · 2022 · Research Synthesis Methods
Abstract Using the Hartung–Knapp method and 95% prediction intervals (PIs) in random‐effects meta‐analyses is recommended by experts but rarely applied. Therefore, we aimed to reevaluate statistically significant meta‐analyses using the…
View details →DOI: 10.1002/jrsm.1543Cited by 22 Negative / Null Result ReportOpen accessMedicine
Michael A. Mooney, Peter Ryabinin, Hannah E. Morton et al. · 2023 · JCPP Advances
Abstract Background attention‐deficit/hyperactivity disorder (ADHD) is associated with both polygenic liability and environmental exposures, both intrinsic to the family, such as family conflict, and extrinsic, such as air pollution. However, much less is known about the interplay between environmental and genetic risks relevant to ADHD—a better understanding of which could inform both mechanistic models and clinical prediction algorithms. Methods Two independent data sets, the population‐based Adolescent Brain Cognitive Development Study (ABCD) ( N = 11,876) and the case‐control Oregon‐ADHD‐1
View details →DOI: 10.1002/jcv2.12152Cited by 22 Negative / Null Result ReportOpen accessPsychology
André Luiz Souza, Arthur B. Markman · 2013 · eScholarship (California Digital Library)
A recent paper by Lev-Ari and Keysar (2010) reported that the processing fluency associated with non-native speech causes non-native speakers to sound less credible.The authors found that the same trivia statements were rated as less…
Negative / Null Result ReportOpen accessMedicine
Veronika V. Odintsova, Fiona A. Hagenbeek, Matthew Suderman et al. · 2019 · Nutrients
Breastfeeding has long-term benefits for children that may be mediated via the epigenome. This pathway has been hypothesized, but the number of empirical studies in humans is small and mostly done by using peripheral blood as the DNA source. We performed an epigenome-wide association study (EWAS) in buccal cells collected around age nine (mean = 9.5) from 1006 twins recruited by the Netherlands Twin Register (NTR). An age-stratified analysis examined if effects attenuate with age (median split at 10 years; n<10 = 517, mean age = 7.9; n>10 = 489, mean age = 11.2). We performed replication
View details →DOI: 10.3390/nu11112804Cited by 22 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mark O. Goodarzi, Nicholette D Palmer, Jinrui Cui et al. · 2019 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Genome-wide association studies have identified more than 450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). OBJECTIVE: To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed…
View details →DOI: 10.1210/clinem/dgz198Cited by 22 Negative / Null Result ReportOpen accessHealth Professions
Paul A. Gilbert, Scott D. Rhodes · 2012 · Hispanic Journal of Behavioral Sciences
Social support is protective for a variety of health outcomes, and individuals living outside their country of origin ("sojourners") might use social support in distinctive ways. The authors performed a confirmatory factor analysis of the…
View details →DOI: 10.1177/0739986312446290Cited by 22 Negative / Null Result ReportOpen accessPsychology
Sarah Kunkle, Manny Yip, Justin Hunt et al. · 2020 · JMIR Formative Research
BACKGROUND: Anxiety is an extremely prevalent condition, and yet, it has received notably less attention than depression and other mental health conditions from a research, clinical, and public health perspective. The COVID-19 pandemic has only exacerbated growing concerns about the burden of anxiety due to the confluence of physical health risks, economic stressors, social isolation, and general disruption of daily activities. OBJECTIVE: This study examines differences in anxiety outcomes by care modality (coaching, teletherapy and telepsychiatry, and combined care) within an on-demand mental
View details →DOI: 10.2196/24662Cited by 22 Negative / Null Result ReportOpen accessImmunology and Microbiology
C. M. Chang, Victoria M. Chia, Marc J. Gunter et al. · 2013 · Carcinogenesis
Inherited variation in genes that regulate innate immunity and inflammation may contribute to colorectal neoplasia risk. To evaluate this association, we conducted a nested case-control study of 451 colorectal cancer cases, 694 colorectal…
View details →DOI: 10.1093/carcin/bgt228Cited by 22 Negative / Null Result ReportOpen accessEnvironmental Science
Magnus Bergquist, Andréas Nilsson, Emma Ejelöv · 2019 · Sustainability
Setting up a contest is a popular means to promote pro-environmental behaviors. Yet, research on contest-based interventions is scarce while norm-based interventions have gained much attention. In two field experiments, we randomly assigned 79 apartments to either a contest-based or a norm-based electricity conservation intervention and measured kWh usage for 2 and 4 weeks, respectively. Results from both studies showed that contest-based interventions promote intensive but short-lived electricity saving. In Study 1 apartments assigned to a norm-based intervention showed more stable electricit
View details →DOI: 10.3390/su11020425Cited by 22 Negative / Null Result ReportOpen accessMedicine
Ángel Herráiz-Adillo, Viktor H. Ahlqvist, Sara Higueras‐Fresnillo et al. · 2023 · Frontiers in Cardiovascular Medicine
Background To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques. Methods Randomly recruited participants aged 50–64 years from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were analysed. According to the AHA definitions, two CVH scores were calculated: i) the LE8 score (0, worst CVH;
View details →DOI: 10.3389/fcvm.2023.1173550Cited by 22 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sergio Garnica-Galvez, Stefanie Korntner, Ioannis Skoufos et al. · 2021 · Cells
The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering. Despite the significant advancements in the field, the optimal macromolecular crowder still remains elusive. Herein, the physicochemical properties of different concentrations of different molecular weights hyaluronic acid (HA) and their influence on equine adipose-derived stem cell cultures were assessed. Within the different concentrations and molecular weight HAs, the 10 mg/mL 100 kDa and 500 kDa HAs exhibited the high
View details →DOI: 10.3390/cells10040859Cited by 22 Negative / Null Result Report
Kiana Christensen, Keegan M. Melstrom · 2021 · PLOS ONE
Squamates are ideal subjects for investigating relationships between diet and dental patterns because they exhibit wide dietary diversity, marked variation in dental shape, and are taxonomically abundant. Despite this, well-established…
View details →DOI: 10.1371/journal.pone.0257427Cited by 22 Negative / Null Result Report
HELENA FORSMAN · 2021 · International Journal of Innovation Management
While innovation is an attractive path, it is also a rocky path made up of numerous challenges, even failures. This study provides new knowledge for understanding innovation failure. It seeks answers to the question: What are the perceived…
View details →DOI: 10.1142/s1363919621501048Cited by 22 Negative / Null Result Report
John Guenther, Samuel Osborne · 2020 · The Australian Journal of Indigenous Education
Abstract Over the 10 years of ‘Closing the Gap’, several interventions designed to improve outcomes for Aboriginal and Torres Strait Islander students have been trialled. In 2014 the Australian Government announced the ‘Flexible Literacy…
View details →DOI: 10.1017/jie.2019.28Cited by 22 