A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20211 results in Negative / Null Result Report · page 101 of 674
Jeni L. Burnette, Crystal L. Hoyt, Nicholas R. Buttrick et al. · 2021 · International Journal of Psychology
Communications about the Coronavirus Disease 2019 (COVID-19) often employ metaphors, which can help people understand complex issues. For example, public health messages may focus on "fighting" the disease, attempting to rouse people to…
Kevin D. Floate, Paul C. Coghlin · 2010 · The Canadian Entomologist
Abstract Fluctuating asymmetries (FAs) are small random deviations between left- and right-side measurements of normally symmetrical traits in a given organism. Changes in FA have frequently been proposed as biomarkers for organisms…
Liv Cecilie Vestrheim Thomsen, Nina S. McCarthy, Phillip E. Melton et al. · 2016 · Journal of Hypertension
OBJECTIVE: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later in life.…
Antonija Perović, Nora Nikolac, Marina Njire Bratičević et al. · 2017 · Biochemia Medica
INTRODUCTION: Scuba diving represents a combination of exercise and changes in environmental conditions. This study aimed to evaluate changes in haematological parameters after recreational scuba diving in order to identify clinically significant changes. MATERIALS AND METHODS: The study included males, 17 recreational divers, median age (range) 41 (30-52) years. Blood samples were taken before diving, immediately after diving to 30 meters for 30 minutes, 3 hours and 6 hours after diving. Complete blood counts were analyzed on the Cell Dyn Ruby haematology analyzer. Statistical significance be
Sascha Otto · 2011 · International Journal of Economics and Finance
We analyze the speculative efficiency of the six base metals traded at the London Metal Exchange (LME) for the post-Tin Crisis period from 1991-2008. Especially the influence of different futures contracts on the one side and different underlyings on the other side provides economic insights for market participants like hedgers and speculators. We focus on the 3-month and 15-month futures contracts for all six base metals and conduct single-contract test for every base metal applying an ARMA process. This system is expanded to the multi-contract case, modeling the forecast error as an ARMAX pr
Klára Marečková, Amy Miles, Zhijie Liao et al. · 2022 · NeuroImage Clinical
BACKGROUND: Prenatal stress influences brain development and mood disorder vulnerability. Brain structural covariance network (SCN) properties based on inter-regional volumetric correlations may reflect developmentally-mediated shared…
John Keane, Wei Zhang, Chris H. Kim · 2010
We present an array-based system to accurately study variations in ROSC aging. Microsecond measurements for minimal BTI recovery, and frequency shift measurement resolution ranging down to the error floor of 0.07% are achieved with three…
E. M. Dunne, Lindsay Lee, Carly Reddington et al. · 2012 · Atmospheric chemistry and physics
Abstract. Observed correlations between short-term decreases in cosmic ray ionisation and cloud and aerosol properties have been attributed to short-term decreases in the ion-induced nucleation rate. We use a global aerosol microphysics model to determine whether a 10 day reduction of 15% in the nucleation rate could generate a statistically significant response in aerosol concentrations and optical properties. As an upper limit to the possible effect of changes in ion-induced nucleation rate, we perturb the total nucleation rate, which has been shown to generate particle concentrations and nu
Freija Verdoodt, Susanne K. Kjær, Christian Dehlendorff et al. · 2018 · British Journal of Cancer
BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a…
Ping‐Hong Yeh, Sara M. Lippa, Tracey A. Brickell et al. · 2022 · Brain Communications
Abstract The purpose of this study was to analyze quantitative diffusion tensor imaging measures across the spectrum of traumatic brain injury severity and evaluate their trajectories in military service members. Participants were 96 U.S. military service members and veterans who had sustained a mild traumatic brain injury [including complicated mild traumatic brain injury (n = 16) and uncomplicated mild traumatic brain injury (n = 68)], moderate-severe traumatic brain injury (n = 12), and controls (with or without orthopaedic injury, n = 39). All participants had been scanned at least twice,
Tae‐Young Pak, Susana Ferreira, Gregory Colson · 2016 · Population Health Metrics
BACKGROUND: Because people care about their weight relative to peers and society, obesity inequality plays a role in explaining obesity incidence and the impacts of being obese on subjective well-being. While the increase in obesity prevalence and mean body mass index (BMI) is well documented, the measurement of distributional changes and corresponding obesity inequality is yet to be fully explored. METHODS: The present study analyzed BMI data for adults aged 20 to 74 from the National Health and Nutritional Examination Survey (NHANES) I (1971-1974), II (1976-1980), III (1988-1994), and contin
Yaser Maddahi, Kourosh Zareinia, Liu Shi Gan et al. · 2016 · BioMed Research International
The use of robotic technology in the surgical treatment of brain tumour promises increased precision and accuracy in the performance of surgery. Robotic manipulators may allow superior access to narrow surgical corridors compared to freehand or conventional neurosurgery. This paper reports values and ranges of tool-tissue interaction forces during the performance of glioma surgery using an MR compatible, image-guided neurosurgical robot called neuroArm. The system, capable of microsurgery and stereotaxy, was used in the surgical resection of glioma in seven cases. neuroArm is equipped with for
Bart de Boer · 2010 · Journal of Evolutionary Psychology
This paper investigates the effect of larynx position on the articulatory abilities of a human-like vocal tract. Previous work has investigated models that were built to resemble the anatomy of existing species or fossil ancestors. This…
Sean Coulborn, Howard Bowman, R. Chris Miall et al. · 2020 · Frontiers in Human Neuroscience
Mind-wandering is associated with switching our attention to internally directed thoughts and is by definition an intrinsic, self-generated cognitive function. Interestingly, previous research showed that it may be possible to modulate its propensity externally, with transcranial direct current stimulation (tDCS) targeting different regions in the default mode and executive control networks. However, these studies used highly heterogeneous montages (targeting the dorsolateral prefrontal cortex (DLPFC), the right inferior parietal lobule (IPL), or both concurrently), often showed contradicting
Christian Bock, Thomas Gumbsch, Michael Moor et al. · 2018 · Bioinformatics
Motivation: Most modern intensive care units record the physiological and vital signs of patients. These data can be used to extract signatures, commonly known as biomarkers, that help physicians understand the biological complexity of…
Minghua Wu, Shervin Assassi, Gloria A. Salazar et al. · 2016 · Arthritis Research & Therapy
BACKGROUND: Systemic sclerosis (SSc)-related interstitial lung disease (ILD) has phenotypic similarities to lung involvement in idiopathic interstitial pneumonia (IIP). We aimed to assess whether genetic susceptibility loci recently identified in the large IIP genome-wide association studies (GWASs) were also risk loci for SSc overall or severity of ILD in SSc. METHODS: A total of 2571 SSc patients and 4500 healthy controls were investigated from the US discovery GWAS and additional US replication cohorts. Thirteen IIP-related selected single nucleotide polymorphisms (SNPs) were genotyped and
Samantha J. Heintzelman, Jason Trent, Laura A. King · 2014 · The Journal of Positive Psychology
Growing popular interest in positive psychology may have important implications for the measurement of well-being. Five studies tested the prediction that well-being ratings are influenced by desirability bias. In Study 1, participants (N…
Shane J. J. McCrea · 2017 · International Journal of Dentistry
Here we present an analysis of patient perceptions and expectations to dental implant placement and their prosthetic reconstruction, to then consider whether they have an effect on long-term satisfaction levels. A Post-Treatment Completion Questionnaire was designed to analyse whether patient satisfaction is influenced by age and/or gender; has an effect on patient-reported self-confidence levels; contributes to increased levels of oral hygiene; provides further insight into the average pain levels during and after the surgical intervention; or influences further acceptance of dental implant s
Qingyu Shi, Fang Wang, Dan Feng · 2020 · IEEE Transactions on Network and Service Management
Datacenter network load balancing schemes handle network traffic generated by massive different applications. Some packet-based or flowlet-based schemes capture traffic bursts for load balancing. But frequent rerouting within a flow can…
Jason M. Schon, Jacob D. Mikula, Jonathon D. Backus et al. · 2016 · Foot & Ankle International
BACKGROUND: The effect of ankle positioning during suture-button fixation for syndesmosis repair on range of motion (ROM) and anatomic reduction has yet to be investigated. The purpose of this cadaveric study was to compare the effects of…
Yuli Wang · 2019 · UNC Libraries
The human small intestinal epithelium possesses a distinct crypt-villus architecture and tissue polarity in which proliferative cells reside inside crypts while differentiated cells are localized to the villi. Indirect evidence has shown…
Jorma J. de Ronde, Christiaan Klijn, Arno Velds et al. · 2010 · BMC Research Notes
BACKGROUND: Most approaches used to find recurrent or differential DNA Copy Number Alterations (CNA) in array Comparative Genomic Hybridization (aCGH) data from groups of tumour samples depend on the discretization of the aCGH data to gain, loss or no-change states. This causes loss of valuable biological information in tumour samples, which are frequently heterogeneous. We have previously developed an algorithm, KC-SMART, that bases its estimate of the magnitude of the CNA at a given genomic location on kernel convolution (Klijn et al., 2008). This accounts for the intensity of the probe sign
Mark A. Straccia, Adam R. Teed, Perri L. Katzman et al. · 2021 · Psychological Medicine
BACKGROUND: Although potential links between oxytocin (OT), vasopressin (AVP), and social cognition are well-grounded theoretically, most studies have included all male samples, and few have demonstrated consistent effects of either neuropeptide on mentalizing (i.e. understanding the mental states of others). To understand the potential of either neuropeptide as a pharmacological treatment for individuals with impairments in social cognition, it is important to demonstrate the beneficial effects of OT and AVP on mentalizing in healthy individuals. METHODS: = 186) of healthy individuals, we exa
Lawrence Grierson, Samantha Winemaker, Alan Taniguchi et al. · 2020 · Perspectives on Medical Education
INTRODUCTION: The medical education community has implemented writing exercises that foster critical analysis and nurture reflective capacity. The REFLECT rubric (Wald et al. 2012) was developed to address the challenge of assessing these written reflections. The objective of this replication work is to explore the reproducibility of the reliability characteristics presented by the REFLECT developers. METHODS: Five raters evaluated narratives written by medical students and experienced clinicians using the REFLECT rubric. Reliability across rubric domains was determined via intraclass correlat
Marina Terkourafi, Benjamin Weissman, Joseph Roy · 2020 · International Review of Pragmatics
Abstract Research on the effect of face-orientation on scalar implicatures has claimed that face-threatening contexts are one type of context in which scalar implicatures are not warranted. However, that research has been based on the two…
Manou Sommen, Guy Van Camp, Balázs Liktor et al. · 2014 · Otology & Neurotology
BACKGROUND/HYPOTHESIS: Otosclerosis is a frequent cause of hearing impairment characterized by abnormal resorption and deposition of bone in the human otic capsule. It is a disease of complex etiopathogenesis that is caused by both…
Dinggang Zhou, Liping Xu, Shiwu Gao et al. · 2016 · Frontiers in Plant Science
Cry1Ac transgenic sugarcane provides a promising way to control stem-borer pests. Biosafety assessment of soil ecosystem for cry1Ac transgenic sugarcane is urgently needed because of the important role of soil microorganisms in nutrient transformations and element cycling, however little is known. This study aimed to explore the potential impact of cry1Ac transgenic sugarcane on rhizosphere soil enzyme activities and microbial community diversity, and also to investigate whether the gene flow occurs through horizontal gene transfer. We found no horizontal gene flow from cry1Ac sugarcane to soi
Brittany N. Neilson, Curtis M. Craig, Raelyn Y. Curiel et al. · 2020 · Human Factors The Journal of the Human Factors and Ergonomics Society
OBJECTIVE: The aim of this study is to replicate Berto's (2005) heavily cited work on attention restoration. BACKGROUND: Nature interventions have gained increased interest for improving performance of attentionally demanding tasks. Berto…
Yasushi Tojo, Yasuhiro Koh, Masayuki Amano et al. · 2010 · Antimicrobial Agents and Chemotherapy
Natural products with macrocyclic structural features often display intriguing biological properties. Molecular design incorporating macrocycles may lead to molecules with unique protein-ligand interactions. We generated novel human…
John Redmond, Helen O. McCarthy, Paul Buchanan et al. · 2022 · Biomaterials Advances
While 2D culture presents a useful tool for cancer research, it fails to replicate the tumor microenvironment as it lacks proper three-dimensional cell-cell/cell-matrix interactions, often resulting in exaggerated responses to therapeutic agents. 3D models that aim to overcome the issues associated with 2D culture research offer a new frontier for cancer research with cell growth, morphology and genetic properties that more closely match in vivo cancers. Herein, we aim to develop a collagen-based scaffold that supports the attachment and proliferation of breast cancer (BC) cells as a 3D cultur