Negative / Null Result ReportOpen accessEngineering
Suribabu Conety Ravi, Neelakantan Thurvas Renganathan, Sivakumar Perumal et al. · 2019 · Drinking water engineering and science
Abstract. Pressure-driven analysis (PDA) of water distribution networks necessitates an assessment of the supplying capacity of a network within the minimum and required pressure ranges. Pressure-deficient conditions happen due to the uncertainty of nodal demands, failure of electromechanical components, diversion of water, aging of pipes, permanent increase in the demand at certain supply nodes, fire demand, etc. As the demand-driven analysis (DDA) solves the governing equations without any bound on pressure head, it fails to replicate the real scenario, particularly when the network experien
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Bo Xi, Yue Shen, Kathleen H. Reilly et al. · 2012 · Clinical Endocrinology
OBJECTIVE: Recent genome-wide association studies have identified a few single nucleotide polymorphisms (SNPs), which are associated with body mass index (BMI)/obesity. This study aimed to examine the identified associations among a…
View details →Negative / Null Result ReportOpen accessSocial Sciences
Ariel White, Anton Strezhnev, Christopher Lucas et al. · 2018 · Journal of Experimental Political Science
Abstract Prior research demonstrates that responses to surveys can vary depending on the race, gender, or ethnicity of the investigator asking the question. We build upon this research by empirically testing how information about…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Sjirk Geerts, Pieter Willem Botha, Vernon Visser et al. · 2013 · South African Journal of Botany
The legumes (Fabaceae) Genista monspessulana and Spartium junceum are major invaders in several other parts of the world, but not yet so in South Africa. We determine their current distributions in South Africa at different spatial scales, assess population structure (soil seed banks and size at reproduction) evaluate current management activities, and provide recommendations for control (including assessing the feasibility of nation-wide eradication). G. monspessulana occurs at nine localities in three quarter-degree cells, covering a total of 22.7 ha. S. junceum is much more widespread, occu
View details →Negative / Null Result ReportMedicine
Franca E. Dupuy, Adam R. Clarke, Robert J. Barry et al. · 2013 · Clinical EEG and Neuroscience
This study further investigated electroencephalogram (EEG) differences between girls with the Combined and Inattentive types of attention-deficit/hyperactivity disorder (AD/HD). We selected subjects with widely separated scores on…
View details →Negative / Null Result ReportOpen accessNeuroscience
María Valdés Hernández, Lucia Ballerini, Andreas Glatz et al. · 2019 · Brain Imaging and Behavior
Brain iron deposits (IDs) are indicative of microvessel dysfunction which may predispose to small vessel disease (SVD) brain damage and worsen cognition later in life. Visible perivascular spaces in the centrum semiovale (CSO-PVS) are SVD features linked with microvessel dysfunction. We examined possible associations of CSO-PVS volume and count with brain IDs and cognitive abilities in 700 community-dwelling individuals from the Lothian Birth Cohort 1936 who underwent detailed cognitive testing and multimodal brain MRI at mean age 72.7 years. Brain IDs were assessed automatically followed by m
View details →Negative / Null Result ReportOpen accessNeuroscience
Ryan Smith, Claire A. Lavalley, S Taylor et al. · 2023 · Journal of Psychiatry and Neuroscience
BACKGROUND: Decision-making under approach-avoidance conflict (AAC; e.g., sacrificing quality of life to avoid feared outcomes) may be affected in multiple psychiatric disorders. Recently, we used a computational (active inference) model…
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Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
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Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta et al. · 2021 · Nature Communications
Abstract A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and…
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Andrea Riboli, Fabio Esposito, Giuseppe Coratella · 2022 · Journal of Strength & Conditioning Research
Abstract Riboli, A, Esposito, F, and Coratella, G. Small-sided games in elite football: practical solutions to replicate the 4-min match-derived maximal intensities. J Strength Cond Res 37(2): 366–374, 2023—The purpose of the study was to…
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Ruella Rouf, Sara M. Karaba, Jenny Dao et al. · 2011 · Microbiology
The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars et al. · 2020 · Scientific Reports
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four
View details →Negative / Null Result ReportOpen accessEnergy
Casey M. Godwin, David C. Hietala, Aubrey R. Lashaway et al. · 2017 · Environmental Science & Technology
For algal biofuels to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and processing must maximize rates of biofuel production while simultaneously minimizing the consumption of nitrogen (N) and…
View details →Negative / Null Result ReportOpen accessMedicine
Yen‐Jen Chen, Hsien‐Te Chen, Horng‐Chaung Hsu · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Survival is a key factor physicians consider when selecting a treatment modality for the treatment of spinal metastases. Various assessment systems can predict length of survival and facilitate selection of the most appropriate treatment. Spinal palsy is a prognostic parameter in the Tokuhashi scoring system but not in the Tomita scoring system. A limitation of these scoring systems is that studies of them have included different tumor types. The aim of this study was to evaluate the usefulness of preoperative neurological status as a prognostic factor in non-small-cell lung cancer
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Jean C C Vila, Yang-Yu Liu, Alvaro Sanchez · 2020 · The ISME Journal
Abstract The taxonomic composition of microbial communities can vary substantially across habitats and within the same habitat over time. Efforts to build quantitative and predictive models of microbial population dynamics are underway,…
View details →Negative / Null Result Report
Marin L. Moravec, Georg F. Striedter, Nancy T. Burley · 2010 · Ethology
Abstract Parrots comprise one of the several taxa in which life‐long learning of new vocal signals used in intraspecific communication is known to occur routinely. The functions and evolutionary bases of this ability are largely unknown.…
View details →Negative / Null Result Report
Francisca Alves-Cardoso, Vanessa Campanacho · 2022 · Heritage
Advancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely…
View details →Negative / Null Result Report
Tao Zhang, Dan Gieseler, Rainer Jordan · 2016 · Polymer Chemistry
The influence of ambient laboratory light from common fluorescent lamps on AGET, ARGET, and classical ATRP reactions was investigated and significant differences were found except for ARGET ATRP.
View details →Negative / Null Result ReportOpen accessMedicine
Wanlong Ma, Hagop M. Kantarjian, Ke Zhang et al. · 2010 · BMC Medical Genetics
BACKGROUND: Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS. METHODS: We genotyped the EPO rS1617640 SNP in 189 patients with MDS, 257 with acute myeloid leukemia (AML), 106 with acute lymphoblastic leukemia, 97 with chronic lymphocytic leukemia, 353
View details →Negative / Null Result Report
Katherine D’Avignon, Michaël Kummert · 2015 · Journal of Thermal Science and Engineering Applications
To assess the potential of thermal energy storage systems using phase change materials (PCMs), numerical simulations rely on an enthalpy–temperature curve (or equivalent specific heat curve) to model the PCM thermal storage behavior. The…
View details →Negative / Null Result Report
Panagiotis Kerezoudis, Kathleen J Yost, Nicole M Tombers et al. · 2018 · Neurosurgery
Abstract BACKGROUND The diagnosis of vestibular schwannomas (VS) is associated with reduced patient quality of life (QOL). Minimal clinically important difference (MCID) was introduced as the lowest improvement in a patient-reported…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Juan Zeng, Yukun Li, Feifei Quan et al. · 2020 · Molecular Medicine Reports
Propofol, a commonly used intravenous anesthetic agent during surgery, has relatively widespread pharmacological actions. Previous studies have reported that propofol may act as an antitumor drug in several cancer types, such as pancreatic…
View details →Negative / Null Result ReportOpen accessMedicine
Francesca Faustini, Nicky Dunn, Nastya Kharlamova et al. · 2021 · Arthritis Research & Therapy
BACKGROUND: Anti-drug antibodies (ADAs) can impact on the efficacy and safety of biologicals, today used to treat several chronic inflammatory conditions. Specific patient groups may be more prone to develop ADAs. Rituximab is routinely used for ANCA-associated vasculitis (AAV) and as off-label therapy for systemic lupus erythematosus (SLE), but data on occurrence and predisposing factors to ADAs in these diseases is limited. OBJECTIVES: To elucidate the rate of occurrence, and risk factors for ADAs against rituximab in SLE and AAV. METHODS: ADAs were detected using a bridging electrochemilumi
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HAELIM PARK, PATRICK VAN HORN · 2015 · Journal of Money, Credit and Banking
We analyze the impact of contractionary monetary policy through increases in reserve requirements on bank lending. We compare the lending behavior of banks that were subject to the requirement increases in 1936–37, Federal Reserve member…
View details →Negative / Null Result ReportMedicine
Brintha K. Enestvedt, M. Brian Fennerty, A. Zaman et al. · 2011 · Alimentary Pharmacology & Therapeutics
BACKGROUND: In recent clinical trials (RCT) of bowel preparation, Golytely was more efficacious than MiraLAX. We hypothesised that there is a difference in adenoma detection between Golytely and MiraLAX. AIMS: To compare the adenoma…
View details →Negative / Null Result ReportOpen accessMedicine
Mathias Roth, Christoph Holtmann, Loay Daas et al. · 2021 · Cornea
PURPOSE: Fungal keratitis (FK) is a serious ophthalmic disease with a potentially devastating outcome that seems to be increasing in recent years. The use of contact lenses (CLs) was evaluated as a risk factor for FK to determine possible…
View details →Negative / Null Result Report
Li Sian Goh · 2021 · Criminology & Public Policy
Research Summary Despite the widespread interest that de‐escalation training has attracted in law enforcement contexts over the past few years, we know little about its effectiveness in reducing use of force incidents. This study seeks to…
View details →Negative / Null Result ReportOpen accessNeuroscience
A. V. Dyomina, Anna A. Kovalenko, Maria V. Zakharova et al. · 2022 · International Journal of Molecular Sciences
Metabotropic glutamate receptors (mGluRs) are expressed predominantly on neurons and glial cells and are involved in the modulation of a wide range of signal transduction cascades. Therefore, different subtypes of mGluRs are considered a promising target for the treatment of various brain diseases. Previous studies have demonstrated the seizure-induced upregulation of mGluR5; however, its functional significance is still unclear. In the present study, we aimed to clarify the effect of treatment with the selective mGluR5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on epile
View details →Negative / Null Result ReportOpen accessMedicine
Nan Bi, Jun Liang, Zongmei Zhou et al. · 2019 · JAMA Network Open
Importance: Treatment of locally advanced non-small cell lung cancer (NSCLC) remains challenging. The rationale of combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results of preclinical research and prospective clinical studies; however, no randomized clinical trial has provided evidence of a direct comparison with CCRT alone. Objective: To determine the effect of combined selective COX-2 inhibition with standard CCRT on survival among patients with unresectable stage III NSCLC. Design, Setting, and Participants: A single-center, open-label, ra
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Jayson L. Parker, Jillian Clare Köhler · 2010 · Journal of Pharmacy & Pharmaceutical Sciences
PURPOSE: To determine the risk of drug failure during clinical trial testing in Crohn's disease and determine what steps can be taken to improve outcomes. This is the first study to quantify such risk for a single disease. METHODS: Moderate to severe Crohn's disease was investigated by reviewing press releases from 1998 to June 2008. Clinical trial failure causes were classified as commercial or clinical and compared with industry expectations. The risk of failure was also reviewed based on whether the compound was a small molecule drug or a biologic. Lastly, the role of the sponsor was examin
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