Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: effect on cognition and associations with mineral deposition
María Valdés Hernández; Lucia Ballerini; Andreas Glatz; Susana Muñoz Maniega; Alan J. Gow; Mark E. Bastin; John M. Starr; Ian J. Deary · 2019 · Brain Imaging and Behavior
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Brain iron deposits (IDs) are indicative of microvessel dysfunction which may predispose to small vessel disease (SVD) brain damage and worsen cognition later in life. Visible perivascular spaces in the centrum semiovale (CSO-PVS) are SVD features linked with microvessel dysfunction. We examined possible associations of CSO-PVS volume and count with brain IDs and cognitive abilities in 700 community-dwelling individuals from the Lothian Birth Cohort 1936 who underwent detailed cognitive testing and multimodal brain MRI at mean age 72.7 years. Brain IDs were assessed automatically followed by m
Abstract by María Valdés Hernández; Lucia Ballerini; Andreas Glatz; Susana Muñoz Maniega; Alan J. Gow; Mark E. Bastin; John M. Starr; Ian J. Deary, Brain Imaging and Behavior (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s11682-019-00128-1