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19,792 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportPsychology

Prospective Cohort Study Investigating Changes in Body Image, Quality of Life, and Self-Esteem Following Minimally Invasive Cosmetic Procedures

Joseph F. Sobanko, Julia Dai, Joel M. Gelfand et al. · 2018 · Dermatologic Surgery

BACKGROUND: Minimally invasive cosmetic injectable procedures are increasingly common. However, a few studies have investigated changes in psychosocial functioning following these treatments. OBJECTIVE: To assess changes in body image,…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX

Haijie Liu, Yang Hu, Yan Zhang et al. · 2022 · Alzheimer s Research & Therapy

BACKGROUND: Until now, Mendelian randomization (MR) studies have investigated the causal association of risk factors with Alzheimer's disease (AD) using large-scale AD genome-wide association studies (GWAS), GWAS by proxy (GWAX), and meta-analyses of GWAS and GWAX (GWAS+GWAX) datasets. However, it currently remains unclear about the consistency of MR estimates across these GWAS, GWAX, and GWAS+GWAX datasets. METHODS: Here, we first selected 162 independent educational attainment genetic variants as the potential instrumental variables (N = 405,072). We then selected one AD GWAS dataset (N = 63

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Negative / Null Result ReportOpen accessMedicine

Economic outcomes of percutaneous coronary intervention with drug‐eluting stents versus bypass surgery for patients with left main or three‐vessel coronary artery disease: One‐year results from the SYNTAX trial

David J. Cohen, Tara A. Lavelle, Ben van Hout et al. · 2011 · Catheterization and Cardiovascular Interventions

OBJECTIVES: To evaluate the cost-effectiveness of alternative approaches to revascularization for patients with three-vessel or left main coronary artery disease (CAD). BACKGROUND: Previous studies have demonstrated that, despite higher…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours

Małgorzata Bulkowska, Agata Rybicka, Kerem Mert Senses et al. · 2017 · BMC Cancer

BACKGROUND: MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies. Several common oncogenic microRNAs have been found for canine mammary cancer and human breast cancer. On account of this, large-scale profiling of microRNA expression in canine mammary cancer seems to be important for both dogs and humans. METHODS: Expression profiles of 317 microRNAs in 146 canine mammary tumours of different histological type, malignancy grade and clinical history (presence/absence of metastases)

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Negative / Null Result ReportOpen accessMedicine

Phase 2 study of eribulin mesylate as first-line therapy for locally recurrent or metastatic human epidermal growth factor receptor 2-negative breast cancer

Kristi McIntyre, Joyce O’Shaughnessy, Lee S. Schwartzberg et al. · 2014 · Breast Cancer Research and Treatment

Eribulin mesylate, a novel non-taxane microtubule dynamics inhibitor, is approved for treatment of metastatic breast cancer (MBC) in patients who have previously received at least 2 chemotherapeutic regimens for MBC that should have…

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Negative / Null Result Report

A Clinically Significant Difference on the COPM: A Review

Mary Ann McColl, Celine Boyer Denis, Kate-Lin Douglas et al. · 2023 · Canadian Journal of Occupational Therapy

Background. The Canadian Occupational Performance Measure (COPM) assists occupational therapists to identify occupational performance problems using a client-centred approach. Since its first publication in 1991, there has been abundant…

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Negative / Null Result ReportOpen accessMedicine

Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes

Marco Colombo, Stuart J. McGurnaghan, Luke A. K. Blackbourn et al. · 2020 · Diabetologia

Abstract Aims/hypothesis We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatinine ratio (ACR). Methods From the population-representative Scottish Diabetes Research Network Type 1 Bioresource (SDRNT1BIO) we sampled 50% and 25% of those with starting eGFR below and above 75 ml min −1 [1.73 m] −2 , respectively ( N = 1629), and with median 5.1 years of follow-up. Multiplexed ELISAs and single molecule array technology were used to measure nin

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Negative / Null Result ReportOpen accessHealth Professions

The Socioeconomic Determinants of Health: Economic Growth and Health in the OECD Countries during the Last Three Decades

Guillém López i Casasnovas, Marina Soley‐Bori · 2014 · International Journal of Environmental Research and Public Health

In times of economic crisis, most countries face the dual challenge of fighting unemployment while restraining social expenditures and closing budget deficits. The spending cuts and lack of employment affect a large number of decisions that have a direct or indirect impact on health. This impact is likely to be unevenly distributed among different groups within the population, and therefore not only health levels may be at risk, but also their distribution. The main purpose of this paper is to explore links between unemployment, economic growth, inequality, and health. We regress a measure of

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Negative / Null Result ReportOpen accessMedicine

The significant effect of the choice of ionic current integration method in cardiac electro‐physiological simulations

Pras Pathmanathan, Gary R. Mirams, James Southern et al. · 2011 · International Journal for Numerical Methods in Biomedical Engineering

Abstract Finite element (FE) cardiac electro‐physiology solvers commonly have ionic current determined at mesh nodes but required element interiors. We consider two interpolation approaches: (i) ionic current interpolation (ICI), where nodal ionic currents are linearly interpolated into the element and (ii) state variable interpolation (SVI), where cell model state variables are interpolated instead, from which the ionic current is evaluated. We explain why SVI leads to a method which is massively more computationally demanding than ICI (more than might originally be expected), and then demons

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Negative / Null Result ReportOpen accessPsychology

Neither action nor phonological video games make dyslexic children read better

Magdalena Łuniewska, Katarzyna Chyl, Agnieszka Dębska et al. · 2018 · Scientific Reports

The prevalence and long-term consequences of dyslexia make it crucial to look for effective and efficient ways of its therapy. Action video games (AVG) were implied as a possible remedy for difficulties in reading in Italian and English-speaking children. However, the studies examining the effectiveness of AVG application in dyslexia suffered from significant methodological weaknesses such as small sample sizes and lack of a control group with no intervention. In our study, we tested how two forms of training: based on AVG and on phonological non-action video games (PNAVG), affect reading in a

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

To Investigation the Relationship between Monetary, Fiscal Policy and Economic Growth in Iran: Autoregressive Distributed Lag Approach to Cointegration

Anvar Khosravi · 2010 · American Journal of Applied Sciences

Problem statement: It is important for policy makers to find affect of monetary and fiscal policy on economic growth and to know how those impacts on growth to present a effective policies. Approach: We apply the bounds testing (ARDL) approach and to cointegration which is more appropriate for estimation in small sample studies. The data span for the study is from 1960-2006, the empirical results found a cointegration relations between Growth, monetary policy and fiscal policy in Iran. Results: The results indicated the impact of Exchange rate and inflation on growth was negative, government e

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Negative / Null Result ReportOpen accessMedicine

Identification of complications that have a significant effect on length of stay after spine surgery and predictive value of 90-day readmission rate

Sanjay Yadla, George M. Ghobrial, Peter G. Campbell et al. · 2015 · Journal of Neurosurgery Spine

OBJECT: Complications after spine surgery have an impact on overall outcome and health care expenditures. The increased cost of complications is due in part to associated prolonged hospital stays. The authors propose that certain…

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Negative / Null Result ReportOpen accessMedicine

Metabolic cost of level, uphill, and downhill running in highly cushioned shoes with carbon-fiber plates

Clarissa S. Whiting, Wouter Hoogkamer, Rodger Kram · 2021 · Journal of sport and health science/Journal of Sport and Health Science

BACKGROUND: Compared to conventional racing shoes, Nike Vaporfly 4% running shoes reduce the metabolic cost of level treadmill running by 4%. The reduction is attributed to their lightweight, highly compliant, and resilient midsole foam…

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Negative / Null Result ReportOpen accessPsychology

Effectiveness of a Web-based and Mobile Therapy Chatbot on Anxiety and Depressive Symptoms in Subclinical Young Adults: Randomized Controlled Trial

Stanisław Karkosz, Robert Szymański, Katarzyna Sanna et al. · 2023 · JMIR Formative Research

BACKGROUND: There has been an increased need to provide specialized help for people with depressive and anxiety symptoms, particularly teenagers and young adults. There is evidence from a 2-week intervention that chatbots (eg, Woebot) are effective in reducing depression and anxiety, an effect that was not detected in the control group that was provided self-help materials. Although chatbots are a promising solution, there is limited scientific evidence for the efficacy of agent-guided cognitive behavioral therapy (CBT) outside the English language, especially for highly inflected languages. O

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Negative / Null Result ReportOpen accessEngineering

Respirable Silica Dust Suppression During Artificial Stone Countertop Cutting

Jared H Cooper, David L. Johnson, Margaret Phillips · 2014 · The Annals of Occupational Hygiene

PURPOSE: To assess the relative efficacy of three types of controls in reducing respirable silica exposure during artificial stone countertop cutting with a handheld circular saw. APPROACH: A handheld worm drive circular saw equipped with…

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Negative / Null Result ReportOpen accessMedicine

Reduced Frontoparietal Activity in Schizophrenia Is Linked to a Specific Deficit in Goal Maintenance: A Multisite Functional Imaging Study

Andrew Poppe, Deanna M. Barch, Cameron S. Carter et al. · 2016 · Schizophrenia Bulletin

Patients with schizophrenia (SZ) previously demonstrated specific deficits in an executive function known as goal maintenance, associated with reduced middle frontal gyrus (MFG) activity. This study aimed to validate a new tool-the Dot…

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Negative / Null Result ReportOpen accessDecision Sciences

Determinants of bank’s efficiency in an emerging economy: A data envelopment analysis approach

Saif Ullah, Abdul Majeed, József Popp · 2023 · PLoS ONE

This study aims to assess the influence of internal and external factors on the Efficiency of banks in Pakistan using the Data Envelopment Analysis Approach (DEA). Bank's Efficiency is measured through DEA Model using input and output variables. The input variable includes the number of employees, number of branches, administration expenses, non-interest expenses, and loan loss provisions. In contrast, the output variable consists of net interest income, net commissions, and total other income. This study considers the internal determinants of the bank's Efficiency as corporate governance, ent

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Negative / Null Result ReportOpen accessMedicine

Maternal and fetal genetic contribution to gestational weight gain

Nicole M. Warrington, Rebecca C. Richmond, Bjarke Fenstra et al. · 2017 · International Journal of Obesity

BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to

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Negative / Null Result ReportOpen accessEnvironmental Science

Exposure to Phthalates Affects Calcium Handling and Intercellular Connectivity of Human Stem Cell-Derived Cardiomyocytes

Nikki Gillum Posnack, Rabia Idrees, Hao Ding et al. · 2015 · PLoS ONE

BACKGROUND: The pervasive nature of plastics has raised concerns about the impact of continuous exposure to plastic additives on human health. Of particular concern is the use of phthalates in the production of flexible polyvinyl chloride (PVC) products. Di-2-ethylhexyl-phthalate (DEHP) is a commonly used phthalate ester plasticizer that imparts flexibility and elasticity to PVC products. Recent epidemiological studies have reported correlations between urinary phthalate concentrations and cardiovascular disease, including an increased risk of high blood pressure and coronary risk. Yet, there

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Negative / Null Result ReportMedicine

Blood Serotonin in Schizophrenie Children

Meredith F. Campbell, Eitan Friedman, William H. Green et al. · 2017 · International Pharmacopsychiatry

Blood serotonin levels were measured in schizophrenic children, all of whom showed manifestations of illness in the first 2 years of life, and controls. Serotonin levels were higher in patients (mean = 0.267 mug/ml) than in controls (mean…

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Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

The Impact of Covid-19 Pandemic on Stock Market Return Volatility: Evidence from Malaysia and Singapore

Jordan Ngu Chuan Yong, Sayyed Mahdi Ziaei, Kenneth Szulczyk · 2021 · Asian Economic and Financial Review

In this study, the volatility of two Asian stock markets, Bursa Malaysia and Singapore Exchange, is estimated. The analysis used data on daily closing prices of the indices of the respective stock markets between July 1, 2019 and August…

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Negative / Null Result ReportOpen accessMedicine

Machine learning-based prediction model for responses of bDMARDs in patients with rheumatoid arthritis and ankylosing spondylitis

Seulkee Lee, Seonyoung Kang, Yeonghee Eun et al. · 2021 · Arthritis Research & Therapy

BACKGROUND: Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analysis on important features. Moreover, machine learning is yet to be used to predict bDMARD responses in ankylosing spondylitis (AS). Thus, in this study, machine learning was used to predict such responses in RA and AS patients. METHODS: Data were retrieved from the Korean College of Rheumatology Biologics therapy (KOBIO) registry. The number of RA and AS patients in the traini

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